Study on precise stereoscopic control method by intramolecular crosslinking of bioactive peptide
| Project/Area Number |
15H04494
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
Chiba Kazuhiro 東京農工大学, (連合)農学研究科(研究院), 教授 (20227325)
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| Co-Investigator(Kenkyū-buntansha) |
岡田 洋平 東京農工大学, 工学(系)研究科(研究院), 助教 (80749268)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | ペプチド / 化学合成 / 立体構造 / 生物活性 / 電解反応 / 架橋 / 非天然型 / 電解合成 / 生体分子 / 合成化学 / 生体材料 / 生物活性物質 / ジスルフィド結合 / 有機化学 / 天然物化学 / 有機電子移動 / 液相合成 |
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| Outline of Final Research Achievements |
It is essential to develop a new chemical synthesis method that can convert peptide related substances into precisely designed structures including the stereochemistry required for the expression of activity. In this study, a novel peptide molecular cyclization method and intramolecular crosslinking formation control method are established, preconditionally controlled with three or more pairs of crosslinks at arbitrary positions in the molecule, using Conotoxin as a model. In addition, it was aimed to establish a novel chemical synthesis method capable of obtaining a peptide with high purity and high yield. As a result, we developed a new method to relax the rigid structure (conformation) of the chain peptide which interferes with the ring-forming reaction and remove the barrier of intramolecular crosslinking derived from the rigid conformation of the peptide. Based on these results, it was succeeded in developing a precise control method of a new three-dimensional structure.
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Report
(4 results)
Research Products
(33 results)
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[Book] Organic Electrochemistry, Fifth Edition2015
Author(s)
Kazuhiro Chiba, Yohei Okada, Kevin Lam, William E. Geiger, Paola Ceroni, Alberto Cerdi, Margherita Venturi, Cyarille Costentin, Marc Robert, Jean-Michel Saveant and others
Total Pages
1716
Publisher
CRC Press
Related Report
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