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Analysis of inhibitory effect of food-derived substances inducing regulatory T cells and B cells on immune and inflammatory response and its molecular basis

Research Project

Project/Area Number 15H04498
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionNippon Veterinary and Life Science University (2017)
The University of Tokyo (2015-2016)

Principal Investigator

Totsuka Mamoru  日本獣医生命科学大学, 応用生命科学部, 教授 (70227601)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords制御性T細胞 / 制御性B細胞 / フィトケミカル / フラボノイド / 免疫抑制作用 / インターロイキン10 / 抗炎症効果 / Foxp3 / 制御性T細胞 / プロバイオティクス / 制御性B細胞 / 大腸炎モデル / 抗炎症
Outline of Final Research Achievements

Focusing on the immune-modulating functions of food factors, we searched for those inducing or activating regulatory T cells (Tregs) or regulatory B cells (Bregs), which have immune-suppressive functions. The mechanisms of action of the food factors and anti-inflammatory activity in vivo were investigated. We found several flavonoids having such an immune-modulating functions, and observed the suppressive effects of these factors on an animal model of inflammatory bowel diseases. Food factors with immune-suppressive functions are expected to prevent or ameliorate allergies and also lifestyle diseases developing on the basis of chronic inflammation.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (19 results)

All 2018 2017 2016 2015

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 6 results,  Acknowledgement Compliant: 2 results) Presentation (9 results) (of which Int'l Joint Research: 3 results,  Invited: 5 results)

  • [Journal Article] Anserine/Carnosine Supplementation Preserves Blood Flow in the Prefrontal Brain of Elderly People Carrying APOE e4.2018

    • Author(s)
      Qiong Ding, Kitora Tanigawa, Jun Kaneko, Mamoru Totsuka, Yoshinori Katakura, Etsuko Imabayashi, Hiroshi Matsuda, Tatsuhiro Hisatsune.
    • Journal Title

      Aging and Disease

      Volume: 9 Issue: 3 Pages: 334-334

    • DOI

      10.14336/ad.2017.0809

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Establishment of intestinal epithelial cell line derived from fetal mouse colon and its immune-related characteristics - Comparison with mouse small intestinal epithelial cell line.2018

    • Author(s)
      Taku Iwamoto, Mamoru Totsuka, Kiyoshi Yamada, Tetsuro Emoto, Ryo Hatano, Makoto Shimizu
    • Journal Title

      Cytotechnology

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of apple condensed tannins on expression of interleukin 6 by murine intestinal epithelial cell line MoS13 cells.2018

    • Author(s)
      Peng Li, Mamoru Totsuka, Yasuharu Ishiharaa, Ayako Aoki-Yoshida, Makoto Shimizu
    • Journal Title

      Cytotechnology

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunomodulation by food: impact on gut immunity and immune cell function2018

    • Author(s)
      Hachimura Satoshi、Totsuka Mamoru、Hosono Akira
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 82 Issue: 4 Pages: 584-599

    • DOI

      10.1080/09168451.2018.1433017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] RNA and a cell wall component of Enterococcus faecalis IC-1 are required for phagocytosis and interleukin 12 production by the mouse macrophage cell line J774.12017

    • Author(s)
      Nakase Junpei、Ukawa Yuuichi、Takemoto Syoji、Kubo Takayoshi、Sagesaka Yuko M.、Aoki-Yoshida Ayako、Totsuka Mamoru
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 81 Issue: 6 Pages: 1099-1105

    • DOI

      10.1080/09168451.2017.1295799

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anserine/Carnosine Supplementation Suppresses the Expression of the Inflammatory Chemokine CCL24 in Peripheral Blood Mononuclear Cells from Elderly People2017

    • Author(s)
      Katakura Yoshinori、Totsuka Mamoru、Imabayashi Etsuko、Matsuda Hiroshi、Hisatsune Tatsuhiro
    • Journal Title

      Nutrients

      Volume: 9 Issue: 11 Pages: 1199-1199

    • DOI

      10.3390/nu9111199

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 腸の構造と働き2017

    • Author(s)
      戸塚 護
    • Journal Title

      日本栄養士会雑誌

      Volume: 60 Pages: 654-656

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Catechol Groups Enable Reactive Oxygen Species Scavenging-Mediated Suppression of PKD-NFkappaB-IL-8 Signaling Pathway by Chlorogenic and Caffeic Acids in Human Intestinal Cells2017

    • Author(s)
      Hee Soon Shin, Hideo Satsu, Min-Jung Bae, Mamoru Totsuka and Makoto Shimizu
    • Journal Title

      Nutrients

      Volume: 9(2) Issue: 2 Pages: 165-165

    • DOI

      10.3390/nu9020165

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enhancement of oral tolerance induction in DO11.10 mice by Lactobacillus gasseri OLL2809 via increase of effector regulatory T cells2016

    • Author(s)
      Ayako Aoki-Yoshida, Kiyoshi Yamada, Satoshi Hachimura, Toshihiro Sashihara, Shuji Ikegami, Makoto Shimizu, Mamoru Totsuka
    • Journal Title

      PLoS ONE

      Volume: 11(7) Issue: 7 Pages: e0158643-e0158643

    • DOI

      10.1371/journal.pone.0158643

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effect of Anserine/Carnosine Supplementation on Verbal Episodic Memory in Elderly People2016

    • Author(s)
      Tatsuhiro Hisatsune, Jun Kaneko, Hiroki Kurashige, Yuan Cao, Hideo Satsu,
    • Journal Title

      Journal of Alzheimer’s Disease

      Volume: 50 Issue: 1 Pages: 149-159

    • DOI

      10.3233/jad-150767

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 鶏肉イミダゾールジペプチドの高齢者の脳老化改善に対する効果2017

    • Author(s)
      谷川 輝虎、丁 瓊、金子 順、戸塚 護、片倉 喜範、今林 悦子、松田 博史、久恒 辰博
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Modulatory effect of dietary phytochemicals on immune cells with immune-suppressive functions2017

    • Author(s)
      Mamoru Totsuka
    • Organizer
      World Federation of Chinese Medicine Societies - the Conference of the Establishment of the Expert Committee of Mongolian Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Carnosine enhances intestinal IgA antibody production in mice2016

    • Author(s)
      Cao Yuan, Junya Uchida, Yuichi Tsuda, Hideo Satsu, Makoto Shimizu, Mamoru Totsuka
    • Organizer
      the 2016 World Life Science Conference (WLSC2016)
    • Place of Presentation
      China National Convention Center(北京、中華人民共和国)
    • Year and Date
      2016-11-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗原刺激下におけるエリオジクチオールの制御性T細胞分化およびサイトカイン応答への影響2016

    • Author(s)
      松田 幸、青木 綾子、 戸塚 護
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 制御性B細胞のIL-10産生増強効果を示すフラボノイドの作用機構の解析2016

    • Author(s)
      堀内 準矢、 葉 鎮豪、 清水 誠、 戸塚 護
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 腸管における炎症反応と免疫応答制御2016

    • Author(s)
      戸塚 護
    • Organizer
      第98回日本栄養・食糧学会関東支部退会シンポジウム
    • Place of Presentation
      東京農業大学世田谷キャンパス
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Enhancement of oral tolerance induction by probiotics: different immunosuppressive mechanisms by different probiotic strains2015

    • Author(s)
      Mamoru Totsuka and Ayako Aoki
    • Organizer
      The 6th International Conference on Food Factors (ICoFF 2015)
    • Place of Presentation
      COEX, Seoul, Republic of Korea
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 食品因子によるT細胞機能分化および 腸管上皮細胞機能の制御(日本食品免疫学会賞受賞講演)2015

    • Author(s)
      戸塚 護
    • Organizer
      日本食品免疫学会2015年度大会
    • Place of Presentation
      東京大学 伊藤謝恩ホール
    • Year and Date
      2015-10-15
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] プロバイオティクスによる経口免疫寛容誘導の強化2015

    • Author(s)
      戸塚 護、青木 綾子
    • Organizer
      第19回腸内細菌学会
    • Place of Presentation
      北里大学 薬学部コンベンションホール
    • Year and Date
      2015-06-18
    • Related Report
      2015 Annual Research Report
    • Invited

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Published: 2015-04-16   Modified: 2019-03-29  

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