Analysis of inhibitory effect of food-derived substances inducing regulatory T cells and B cells on immune and inflammatory response and its molecular basis
| Project/Area Number |
15H04498
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Food science
|
|---|
| Research Institution | Nippon Veterinary and Life Science University (2017)
The University of Tokyo (2015-2016) |
|---|
Principal Investigator |
Totsuka Mamoru 日本獣医生命科学大学, 応用生命科学部, 教授 (70227601)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
|
|---|
| Keywords | 制御性Ｔ細胞 / 制御性B細胞 / フィトケミカル / フラボノイド / 免疫抑制作用 / インターロイキン10 / 抗炎症効果 / Foxp3 / 制御性T細胞 / プロバイオティクス / 制御性Ｂ細胞 / 大腸炎モデル / 抗炎症 |
|---|
| Outline of Final Research Achievements |
Focusing on the immune-modulating functions of food factors, we searched for those inducing or activating regulatory T cells (Tregs) or regulatory B cells (Bregs), which have immune-suppressive functions. The mechanisms of action of the food factors and anti-inflammatory activity in vivo were investigated. We found several flavonoids having such an immune-modulating functions, and observed the suppressive effects of these factors on an animal model of inflammatory bowel diseases. Food factors with immune-suppressive functions are expected to prevent or ameliorate allergies and also lifestyle diseases developing on the basis of chronic inflammation.
|
Report
(4 results)
Research Products
(19 results)
