Studies on a feed for improving zinc nutrition by the use of zinc transporters
| Project/Area Number |
15H04501
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kyoto University |
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Principal Investigator |
Kambe Taiho 京都大学, 生命科学研究科, 准教授 (90303875)
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| Co-Investigator(Kenkyū-buntansha) |
宮前 友策 京都大学, 生命科学研究科, 助教 (30610240)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Keywords | 亜鉛欠乏 / トランスポーター / Zip4 / 大豆抽出物 / ソヤサポニンBb / 高齢者 / 亜鉛要求性酵素 / 栄養改善 / ZIP4 / ZNT1 / マーカー酵素 / 亜鉛トランスポーター / 亜鉛吸収促進因子 |
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| Outline of Final Research Achievements |
Adequate zinc intake is indispensable to maintain health, because zinc plays critical roles in a variety of physiological processes. In the small intestine, zinc transporters ZIP4 and ZNT1 play essential roles for zinc absorption, and thus food components with the activity of increasing ZIP4 or ZNT1 expression would be a potential enhancer of zinc absorption. We here found extracts prepared form several spices have the activity to increase the abundance of both human and mouse ZIP4. Unfortunately, we found no extracts to increase ZNT1 expression. We found it difficult to evaluate whether or not food extracts have positive effects on zinc absorption in rats, because of low sensitivity to measure zinc absorption rates through ZIP4 and ZNT1. We found several enzymes activities nicely correlated with zinc levels in the diets, even in the case of low zinc diets. The activities would be useful as a marker for evaluation of zinc absorption rates.
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Report
(4 results)
Research Products
(59 results)
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[Journal Article] The isoflavone fraction from soybean presents mRNA maturation inhibition activity2017
Author(s)
Kurata M, Murata Y, Momma K, Fouad Ali Mursi I, Takahashi M, Miyamae Y, Kambe T, Nagao M, Narita H, Shibuya Y, Masuda S
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Journal Title
Biosci Biotechnol Biochem
Volume: 81
Issue: 3
Pages: 551-554
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The PP-motif in luminal loop 2 of ZnT transporters plays a pivotal role in TNAP activation2016
Author(s)
Fujimoto S, Tsuji T, Fujiwara T, Takeda T, Merriman C, Fukunaka A, Nishito Y, Fu D, Hoch E, Sekler I, Fukue K, Miyamae Y, Masuda S, Nagao M, Kambe T
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Journal Title
Biochem. J
Volume: 473
Issue: 17
Pages: 2611-2621
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Direct Comparison of Manganese Detoxification/Efflux Proteins and Molecular Characterization of ZnT10 Protein as a Manganese Transporter2016
Author(s)
Nishito Y, Tsuji N, Fujishiro H, Takeda T, Yamazaki T, Teranishi F, Okazaki F, Matsunaga A, Tuschl K, Rao R, Kono S, Miyajima H, Narita H, Himeno S, Kambe T
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Journal Title
J. Biol. Chem.
Volume: 291
Issue: 28
Pages: 14773-14787
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Novel mutations in SLC30A2 involved in the pathogenesis of transient neonatal zinc deficiency2016
Author(s)
Itsumura N, Kibihara Y, Fukue K, Miyata A, Fukushima K, Tamagawa-Mineoka R, Katoh N, Nishito Y, Ishida R, Narita H, Kodama H, Kambe T
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Journal Title
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Properties of Zip4 accumulation during zinc deficiency and its usefulness to evaluate zinc status: a study of the effects of zinc deficiency during lactation2016
Author(s)
Hashimoto A, Nakagawa M, Tsujimura N, Miyazaki S, Kizu K, Goto T, Komatsu Y, Matsunaga A, Shirakawa H, Narita H, Kambe T, Komai M
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Journal Title
Am J Physiol Regul Integr Comp Physiol
Volume: 310
Issue: 5
Pages: R459-R468
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Ethambutol neutralizes lysosomes and causes lysosomal zinc accumulation.2015
Author(s)
Yamada D, Saiki S, Furuya N, Ishikawa K, Imamichi Y, Kambe T, Fujimura T, Ueno T, Koike M, Sumiyoshi K, Hattori N
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Journal Title
Biochem Biophys Res Commun.
Volume: 471
Issue: 1
Pages: 109-116
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Soybean extracts increase cell surface ZIP4 abundance and cellular zinc levels: a potential novel strategy to enhance zinc absorption by ZIP4 targeting2015
Author(s)
2)Hashimoto, A., Ohkura, K., Takahashi, M., Kizu, K., Narita, H., Enomoto, S., Miyamae, Y., Masuda, S., Nagao, M., Irie, K., Ohigashi, H., Andrews, G. K., Kambe, T.
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Journal Title
Biochemical Journal
Volume: 472
Issue: 2
Pages: 183-193
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Altered expression of two zinc transporters, SLC30A5 and SLC30A6, underlies a mammary gland disorder of reduced zinc secretion into milk.2015
Author(s)
Kumar L, Michalczyk A, McKay J, Ford D, Kambe T, Hudek L, Varigios G, Taylor PE, Ackland ML.
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Journal Title
Genes Nutr.
Volume: 10
Issue: 5
Pages: 487-487
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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