Preventive effects on metabolic syndrome through adipose tissue browning induced by marine carotenoids
| Project/Area Number |
15H04545
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Aquatic life science
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
岡松 優子 北海道大学, 獣医学研究院, 講師 (90527178)
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| Research Collaborator |
KATSUKI Ami
OHUCHI Yuka
TYA Daisuke
TATEYAMA Riho
AKITA Tomoki
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 海洋性カロテノイド / 脂肪組織 / 褐色化 / ミトコンドリア因子 / UCP1 / フコキサンチン / メタボリックシンドローム予防 / プロジェニター細胞 / ベージュ細胞 / 褐色脂肪細胞 / ミトコンドリア / 脂肪細胞 / エネルギー代謝 |
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| Outline of Final Research Achievements |
Fucoxanthin contained in brown seaweeds suppressed weight gain of white adipose tissue (WAT) through induction of mitochondrion factors including uncoupling protein 1 (UCP1) in adipose tissues. In diet-induce obese mice fed fucoxanthin, fatty acid oxidation was promoted. Induction of the brown adipocyte-like phenotype was also observed in C3H10T1/2 adipocytes treated with fucoxanthin metabolites. PGC-1alpha is suggested to be a critical factor to induce browning in white adipocytes by fucoxanthin. On the other hand, the number of progenitor cells to differentiate into beige adipocytes was demonstrated to decrease with aging.
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Report
(4 results)
Research Products
(43 results)
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[Presentation] 海藻カロテノイドの機能性2016
Author(s)
細川雅史
Organizer
第70回日本栄養・食糧学会大会
Place of Presentation
武庫川女子大学中央キャンパス、兵庫県、西宮
Year and Date
2016-05-13
Related Report
Invited
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[Presentation] 寒冷暴露時の褐色細胞組織増生機構2015
Author(s)
深野圭伍，岡松優子，小林純子，坂上浩，木村和弘
Organizer
第20回アディポサイエンス・シンポジウム
Place of Presentation
千里ライフサイエンスセンター、大阪府、豊中市
Year and Date
2015-08-22
Related Report
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