Studies on TTX loop in marine ecosystem - an enigma of missing links among TTX-bearing organisms
| Project/Area Number |
15H04552
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Aquatic life science
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| Research Institution | Nihon University |
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Principal Investigator |
ITOI Shiro 日本大学, 生物資源科学部, 准教授 (30385992)
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| Co-Investigator(Kenkyū-buntansha) |
杉田 治男 日本大学, 生物資源科学部, 教授 (50139052)
鈴木 美和 日本大学, 生物資源科学部, 准教授 (70409069)
高谷 智裕 長崎大学, 水産・環境科学総合研究科(水産), 教授 (90304972)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | フグ毒 / テトロドトキシン / TTXループ / オオツノヒラムシ / ツノヒラムシ属 / TTX / クサフグ / 食物連鎖（食物網） / ヒラムシ / トラフグ / フグ毒ループ |
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| Outline of Final Research Achievements |
We revealed the presence of numerous Takifugu pardalis eggs in the intestinal contents of another pufferfish, Takifugu niphobles, suggesting that T. niphobles ingested the toxic eggs of another pufferfish T. pardalis to toxify themselves more efficiently. Additionally, the toxic goby Yongeichthys criniger and the milkspotted pufferfish Chelonodon patoca fed on the toxic flatworm Planocera multitentaculata. These results suggest that concentrated TTX is pooled in the TTX loop among the TTX-bearing organisms, which are the predators at higher trophic levels in the food web.
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| Academic Significance and Societal Importance of the Research Achievements |
これまでフグ毒は、細菌を生産者とする食物連鎖（網）を通じてフグの体内に蓄積されると考えられていた。一方、細菌が生産するフグ毒の量が少ないことから、フグが持つ毒量を説明できないとの指摘があった。本研究の成果は、フグ毒を保有する高次捕食者間でフグ毒をやり取りしている事例を複数報告し、フグ毒がこれら高次捕食者間で循環していることを提案した。本研究の成果は、未解明な部分が多く残されていたフグの毒化機構に新たな考え方を導入することが期待される。
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Report
(5 results)
Research Products
(52 results)
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[Journal Article] Seasonal changes in the tetrodotoxin content of the flatworm Planocera multitentaculata2017
Author(s)
Yamada R, Tsunashima T, Takei M, Sato T, Wajima Y, Kawase M, Oshikiri S, Kajitani Y, Kosoba K, Ueda H, Abe K, Itoi S, Sugita H
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Journal Title
Marine Drugs
Volume: 15
Issue: 3
Pages: 56-56
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Transcriptome analysis of tetrodotoxin sensing and action of tetrodotoxin in central nervous system of tiger puffer Takifugu rubripes juveniles2017
Author(s)
Okita, K., Tan, E., Satone, H., Kinoshita, S., Asakawa, S., Ojima, D., Yamazaki, H., Sakiyama, K., Takatani, T., Arakawa, O., Hagiwara, A., Sakakura, Y.
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Journal Title
Fisheries Science
Volume: 83
Issue: 3
Pages: 401-412
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] 交雑フグの毒性2015
Author(s)
高谷智裕・鈴木重則・望岡典隆・荒川修
Organizer
平成27年度日本水産学会秋季大会
Place of Presentation
東北大学（仙台市）
Year and Date
2015-09-22
Related Report
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[Presentation] Transcriptome Analysis of Tetrodotoxin Sensing and Action of Tetrodotoxin in the Brain of Tiger Puffer Takifugu rubripes by Next-Generation Sequencing2015
Author(s)
Okita K, Satone H, Tan E, Kinoshita S, Asakawa S, Yamazaki H, Sakiyama K, Takatani T, Arakawa O, Hagiwara A, Sakakura Y
Organizer
145th American Fisheries Society Annual Meeting
Place of Presentation
Portland, Oregon, USA
Year and Date
2015-08-16
Related Report
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