Improving the tolerance to heat stress in animals through integrating control of host and gut microbiota with improved feed ingredients
| Project/Area Number |
15H04582
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Animal production science
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大塚 彰 鹿児島大学, 農水産獣医学域農学系, 教授 (10233173)
陶山 佳久 東北大学, 農学研究科, 准教授 (60282315)
喜久里 基 東北大学, 農学研究科, 准教授 (90613042)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | ストレス制御 / タンパク質分解制御 / 免疫能制御 / 腸内細菌叢制御 / アナカルド酸 / 暑熱ストレス / 胸腺 / インターロイキン6 / エネルギー代謝 / 免疫変化 / 腸内細菌叢 |
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| Outline of Final Research Achievements |
The objectives of this research are to clarify the mechanism underlying decreasing body weight and feed efficiency in broiler chickens exposed to heat stress, and to develop feed ingredients to improve the reduced performance. Heat exposure to chickens was found to induce increased proteolysis of skeletal muscles via more mitochondrial ROS generation and decreased CD3-positive cell in the spleen so that metabolic and immune systems remarkably enhance energy requirement to maintain homeostasis. Streptococcus appears to be the less dominant genus in the ileum of heat-stressed chickens. Feeding diets supplemented with cashew nut shell liquid (CNSL) causes broiler chicken to alleviate reductions of body weight and feed intake when exposed to heat, partially via control of intestinal immune-related gene expression.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Oleuropein induces mitochondrial biogenesis and decreases reactive oxygen species generation in cultured avian muscle cells, possibly via an up-regulation of peroxisome proliferator-activated receptor γ coactivator-1α2016
Author(s)
Kikusato, M., Muroi, M., Uwabe, Y., Furukawa,K., and Toyomizu, M.
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Journal Title
Animal Science Journal
Volume: 87
Issue: 11
Pages: 1371-1378
DOI
Related Report
Peer Reviewed
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