Mechanism of mutation in coronaviruses and analysis of their pathogenesis
| Project/Area Number |
15H04599
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
Maeda Ken 山口大学, 共同獣医学部, 教授 (90284273)
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| Research Collaborator |
TERADA Yutaka 大阪大学, 微生物病研究所, 博士研究員
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | コロナウイルス / 変異 / 病原性 / ネココロナウイルス / 猫伝染性腹膜炎 / フェレットコロナウイルス / イヌコロナウイルス / 猫コロナウイルス / 感染性クローン / 持続感染 / ADE / 犬コロナウイルス / S遺伝子 / 3abc遺伝子 / 遺伝子組み換え / 遺伝子欠損 |
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| Outline of Final Research Achievements |
1)Three Japanese FIPV were compared by examination of viral growth, ADE activity and reactivity with monoclonal antibodies. Furthermore, their complete genomes were determined. Successfully, infectious clone of C3663 was established. Now, it is expected that pathogenesis of FIP will be clarified using this infectious clone.
2)The mutations associated with pathogenesis of lethal FIPV were determined. These mutations were also confirmed in the shelter where FIP sporadically emerged. In future, it is possible to differentiate pathogenetic FIPV from less virulent feline coronaviruses by examination of this region.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Establishment of serological test to detect antibody against ferret coronavirus2016
Author(s)
Minami S, Terada Y, Shimoda H, Takizawa M, Onuma M, Ota A, Ota Y, Akabane Y, Tamukai K, Watanabe K, Naganuma Y, Kanagawa E, Nakamura K, Ohashi M, Takami Y, Miwa Y, Tanoue T, Ohwaki M, Ohta J, Une Y, Maeda K.
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Journal Title
Journal of Veterinary Medical Science
Volume: 78
Issue: 6
Pages: 1013-1017
DOI
NAID
ISSN
0916-7250, 1347-7439
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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