Elucidation of the eusociality control structure of naked mole rat by using gnotobiotic technique
| Project/Area Number |
15H04604
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Integrative animal science
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
藤 英博 九州大学, 生体防御医学研究所, 特任講師 (10353468)
三浦 恭子 北海道大学, 遺伝子病制御研究所, 准教授 (80583062)
菊水 健史 麻布大学, 獣医学部, 教授 (90302596)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
|
|---|
| Keywords | 真社会性 / ハダカデバネズミ / ノトバイオート技術 / エピジェネティクス解析 / 腸内細菌叢 / ノトバイオートマウス / エピジェネティクス / 腸内細菌叢解析 / 不妊 / ノトバイオート / DNAメチル化 |
|---|
| Outline of Final Research Achievements |
The gut microbiota I of naked mole rat (worker、king、queen) and SPF mouse (Balb/c and C57BL/6) were compared. As the result of UniFrac analysis, naked mole rats had the peculiar gut microbiota. The gnotobiotic mice in this study were constructed by inoculating each gut microbiota (feces) of naked mole rat (worker and queen) to germ-free mouse (C57BL/6). The microbiota (feces) of guinea pig was used as a control. Sexual maturation tended to be delayed when transplanting the gut microbiota of queen naked mole rat rather than the control. Currently, we are conducting epigenetics analysis of the uterus and fallopian tube of queen naked mole rat with co-workers.
|
Report
(4 results)
Research Products
(1 results)
