Elucidation of disease pathogenesis associated with dysregulated lipid metabolism and their potential therapeutic applications
| Project/Area Number |
15H04648
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Keio University (2016-2017)
Institute of Physical and Chemical Research (2015) |
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Principal Investigator |
ARITA Makoto 慶應義塾大学, 薬学部(芝共立), 教授 (80292952)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Keywords | 脂質代謝 / 抗炎症作用 / リピドミクス / 生理活性物質 / 脂質 / 生理活性 / 代謝 |
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| Outline of Final Research Achievements |
In this study, we identified omega-3 eicosapentaenoic acid (EPA)-derived bioactive metabolite, namely 17,18-EpETE, that possess anti-inflammatory and/or anti-allergic actions in vivo. Moreover, we identified cytochrome P450 (CYP) enzymes that play rate-limiting roles in controlling active conversion of EPA into 17,18-EpETE. These findings will elucidate the physiological importance of this metabolic pathway of omega-3 fatty acids in controlling inflammation and related diseases. Also we demonstrated the importance of fatty acid balance and their metabolic interactions in many disease models by using the advanced LC-MS/MS-based lipidomics system.
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Report
(4 results)
Research Products
(63 results)
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[Journal Article] Alveolar macrophages drive hepatocellular carcinoma lung metastasis by generating leukotriene B4.2018
Author(s)
Nosaka T, Baba T, Tanabe Y, Sasaki S, Nishimura T, Imamura Y, Yurino H, Hashimoto S, Arita M, Nakamoto Y, Mukaida N.
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Journal Title
J Immunol
Volume: 200
Issue: 5
Pages: 1839-1852
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] 17,18-EpETE-GPR40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques2017
Author(s)
Nagatake T, Shiogama Y, Inoue A, Kikuta J, Honda T, Tiwari P, Kishi T, Yanagisawa A, Isobe Y, Matsumoto N, Shimojou M, Morimoto S, Suzuki H, Hirata S, Steneberg P, Edlund H, Aoki J, Arita M, Kiyono H, Yasutomi Y, Ishii M, Kabashima K, Kunisawa J
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Journal Title
Journal of Allergy and Clinical Immunology
Volume: S0091-6749
Issue: 2
Pages: 32949-32944
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Resolvin D1 is immunoresolvent of lung inflammation caused by pseudominas aeruginosa acute and chronic infections.2017
Author(s)
Codagnone M, Cianci E, Lamolinara A, Mari VC, Nespoli A, Isopi E, Mattoscio D, Arita M, Bragonzi A, Iezzi M, Romano M, Recchiuti A.
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Journal Title
Mucosal Immunol
Volume: in press
Issue: 1
Pages: 35-49
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Gut microbiota promotes obesity-associated liver cancer through PGE2-mediated suppression of antitumor immunity.2017
Author(s)
Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo M, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N.
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Journal Title
Cancer Discov
Volume: in press
Issue: 5
Pages: 522-538
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Maternal dietary imbalance between omega-6 and omega-3 polyunsaturated fatty acids impairs neocortical development via epoxy metabolites.2016
Author(s)
Sakayori N, Kikkawa T, Tokuda H, Kiryu E, Yoshizaki K, Kawashima H, Yamada T, Arai H, Kang JX, Katagiri H, Shibata H, Innis SM, Arita M, Osumi N.
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Journal Title
Stem Cells.
Volume: 34(2)
Issue: 2
Pages: 470-482
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut2015
Author(s)
J. Kunisawa, M. Arita, T. Hayasaka, T. Harada, R. Iwamoto, R. Nagasawa, S. Shikata, T. Nagatake, H. Suzuki, E. Hashimoto, Y. Kurashima, Y. Suzuki, H. Arai, M. Setou, and H. Kiyono
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Journal Title
Sci Rep
Volume: 5
Issue: 1
Pages: 9750-9750
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Eosinophil-mediated signaling attenuates inflammatory responses in experimental colitis.2015
Author(s)
Masterson JC, McNamee EN, Fillon SA, Hosford L, Harris R, Fernando SD, Jedlicka P, Iwamoto R, Jacobsen E, Protheroe C, Eltzschig HK, Colgan SP, Arita M, Lee JJ, Furuta GT.
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Journal Title
Gut
Volume: 64
Issue: 8
Pages: 1236-1247
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] ω３脂肪酸の分子栄養学2015
Author(s)
有田誠
Organizer
第３８回日本基礎老化学会大会
Place of Presentation
パシフィコ横浜（神奈川県・横浜市）
Year and Date
2015-06-14
Related Report
Invited
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[Presentation] 脂肪酸代謝と炎症の制御2015
Author(s)
有田誠
Organizer
第５８回日本糖尿病学会年次学術集会
Place of Presentation
海峡メッセ下関（山口県・下関市）
Year and Date
2015-05-23
Related Report
Invited
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