Bioactive compounds from plants collected in Okinawa and subtropical areas, and their genetic engineering application
| Project/Area Number |
15H04651
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Yasuda Women's University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
川上 晋 安田女子大学, 薬学部, 助教 (10611311)
杉本 幸子 広島大学, 医歯薬保健学研究科(薬), 准教授 (60549012)
松浪 勝義 広島大学, 医歯薬保健学研究科(薬), 教授 (70379890)
稲垣 昌宣 安田女子大学, 薬学部, 准教授 (90274480)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | 生物活性天然物 / 沖縄 / 亜熱帯 / Ａｒｔａｂｏｔｒｙｓ ｓｉａｍｅｎｓｉｓ / カーラウェーク / バンレイシ科 / 天然物化学 / 生物活性 / 生合成 / 天然活性物質 / 亜熱帯産植物 |
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| Outline of Final Research Achievements |
About 60% of medicines, currently used, are related with natural products. Some are used as they are and some are derives or mimics of natural products. The first step is to explore new compounds or known ones with biological activities. The results mainly depend on choice of plants and when considered the thick density of plant species, those in the subtropical of tropical areas are quite promising. Thus, Okinawa and Ogasawara areas are chosen as candidates. The senior investigator of this project is engaged in the research for the plants collected in Okinawa. Okinawa area is considered as a biodiversity hot spot and thus many endemic plants wildly grow. New or biologically active compounds were investigated from plants collected in Okinawa islands or from other tropical areas. When such compounds were obtained from some plants, their biosynthetic genes are examined and the DNA of these plants is modified using genetic engineering method to produce unknown or unnatural compounds.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] The first isolation of 25,26,27-trisnor-3β-acetoxycycloartan-24-oic acid and the absolute configuration of 3R,4R-1,2-O-di-caffeoyl quinic acid from Artemisia japonica2017
Author(s)
Phan Minh Giang, Nguyen Thi Binh, Tran Thi Thanh Nhan, Ho Thi Thuy, Vu Minh Trang, Phan Tong Son, Hideaki Otsuka and Katsuyoshi Matsunami
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Journal Title
Chemistry of Natural Compounds
Volume: 53
Issue: 4
Pages: 674-677
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Microtropins Q–W, <i>ent</i>-Labdane Glucosides: Microtropiosides G–I, Ursane-Type Triterpene Diglucoside and Flavonol Glycoside from the Leaves of <i>Microtropis japonica</i>2017
Author(s)
Saori Terazawa, Yuka Uemura, Yuka Koyama, Susumu Kawakami, Sachiko Sugimoto, Katsuyoshi Matsunami, Hideaki Otsuka, Takakazu Shinzato, Masatoshi Kawahata and Kentaro Yamaguchi
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Journal Title
Chemical and Pharmaceutical Bulletin
Volume: 65
Issue: 10
Pages: 930-939
DOI
NAID
ISSN
0009-2363, 1347-5223
Related Report
Peer Reviewed
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