| Budget Amount *help |
¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Outline of Final Research Achievements |
Hypomagnesemia causes discontinuation of treatment, but the mechanism of pathogenesis has not been fully clarified. In addition, there is no treatment method for hypomagnesemia. Drug discovery research may be delayed because the molecules of Mg2+ transporter were unknown. We investigated the abnormal mechanism of Mg2+ channel expression in hypomagnesemia and clarified the pathogenic mechanisms of drug-induced and inherited hypomagnesemia. In addition, we succeeded in identification of effective drugs for the treatment of hypomagnesemia. The present studies provide a development basis for a novel drug which prevents hypomagnesemia.
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