The development of epicutaneous allergen-specific immunotherapy for inducing food allergy resistance and the immunological analysis of it's response mechanisms
| Project/Area Number |
15H04665
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
OKADA NAOKI 大阪大学, 薬学研究科, 教授 (90312123)
|
|---|
| Research Collaborator |
ITO Sayami
FUJISAWA Takao
NAGAO Mizuho
KUWABARA Yu
KAMIYAMA Fumio
QUAN Ying-Shu
SAITO Mio
ISHII Ken
HIROBE Sachiko
SUSAI Ryo
TAKEUCHI Honoka
EGUCHI Ryosuke
LU lu
NAKAGAWA Yusuke
KAWAKITA Takuto
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
|
|---|
| Keywords | アレルギー / 免疫療法 / 経皮投与 |
|---|
| Outline of Final Research Achievements |
Allergen-specific immunotherapy (AIT) is promising as a radical therapy for allergic diseases, and AIT is being accepted in food allergy. Currently, AIT is mainly performed by the subcutaneous injection (SCIT) which requires to visit a hospital for long time, and is difficult to continue the treatment for patients of children due to the injection pain. Thus, development of alternative administration route is required in AIT research field.
Skin has a high potential as a target site for AIT, because it not only function as a barrier to protect from foreign substances but also induces various immune responses. In the development of effective epicutaneous immunotherapy (EPIT), an device capable of efficiently delivering the allergen into the skin is indispensable.
In the present study, we acquired a proof-of-concept for the establishment of EPIT using allergen-containing hydrogel patch (HG). We also demonstrated our EPIT system was safe and effective in children with severe milk allergy.
|
Report
(4 results)
Research Products
(26 results)
-
-
-
-
-
-
-
-
-
[Presentation] 食物アレルギーに対する新規経皮免疫療法の開発2017
Author(s)
伊藤沙耶美, 廣部祥子, 桑原 優, 長尾みづほ, 藤澤隆夫, 齊藤美生, 権 英淑, 神山文男, 立花雅史, 中川晋作, 岡田直貴
Organizer
日本薬学会第137年会
Place of Presentation
仙台国際センター・東北大学川内北キャンパス (宮城県仙台市)
Year and Date
2017-03-24
Related Report
-
[Presentation] 重症牛乳アレルギーに対する経皮免疫療法の探索的臨床研究2017
Author(s)
伊藤沙耶美, 廣部祥子, 桑原 優, 長尾みづほ, 藤澤隆夫, 齊藤美生, 権 英淑, 神山文男, 立花雅史, 中川晋作, 岡田直貴
Organizer
第66回日本アレルギー学会学術大会
Related Report
-
-
[Presentation] 小児食物アレルギーに対する新規経皮免疫療法の開発2017
Author(s)
伊藤沙耶美, 桑原 優, 長尾みづほ, 藤澤隆夫, 齊藤美生, 権 英淑, 神山文男, 石井 健, 廣部祥子, 立花雅史, 中川晋作, 岡田直貴
Organizer
日本薬剤学会第32年会
Related Report
-
-
-
[Presentation] 重症牛乳アレルギーに対する新規経皮免疫療法の臨床研究2016
Author(s)
伊藤沙耶美, 廣部祥子, 桑原 優, 長尾みづほ, 藤澤隆夫, 齊藤美生, 権 英淑, 神山文男, 立花雅史, 中川晋作, 岡田直貴
Organizer
第15回次世代を担う若手ファーマ・バイオフォーラム2016
Place of Presentation
大阪大学大学院薬学研究科 (大阪府吹田市)
Year and Date
2016-09-10
Related Report
-
-
-
-
-
-
-
-
-
-
-
