Central command and exercise adherence: investigation of environmental and genetic factors
Project/Area Number |
15H04680
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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Research Institution | Shinshu University |
Principal Investigator |
Masuki Shizue 信州大学, 学術研究院医学系, 准教授 (70422699)
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Co-Investigator(Kenkyū-buntansha) |
上條 義一郎 和歌山県立医科大学, みらい医療推進学講座, 准教授 (40372510)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2016: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2015: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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Keywords | 運動習慣 / vasopressin V1a受容体 / 脳血流 / 筋血流 / 自発運動 / 昇圧応答 / 血圧反射 / サプリメント |
Outline of Final Research Achievements |
We previously reported that higher exercise adherence is the key to increasing physical fitness and improving lifestyle-related diseases. Therefore, we determined independent factors affecting adherence by multiple-regression analysis. As a result, in addition to previously reported factors, V1a receptor polymorphisms were independent determinants of lower adherence. As for the mechanism of lower exercise adherence via V1a receptors, we found that central pressor responses at the onset of exercise were impaired in V1a receptor knockout mice, resulting in reduced motivated locomotion. Accordingly, in this study, we examined 1) whether V1a receptors played an important role at the onset of exercise in humans, and 2) whether exercise training + supplementation improved central pressor responses.
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Report
(4 results)
Research Products
(71 results)
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[Journal Article] Effects of 5-aminolevulinic acid supplementation on exercise efficiency and home-based interval walking training achievement in older women2017
Author(s)
Masuki S, Morita A, Kamijo Y, Ikegawa S, Kataoka Y, Ogawa Y, Sumiyoshi E, Takahashi K, Tanaka T, Nakajima M, and Nose H.
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Journal Title
ALA-Porphyrin Science
Volume: in press
Related Report
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[Journal Article] Impact of 5-aminolevulinic acid with iron supplementation on exercise efficiency and home-based walking training achievement in older women.2016
Author(s)
Masuki S, Morita A, Kamijo Y, Ikegawa S, Kataoka Y, Ogawa Y, Sumiyoshi E, Takahashi K, Tanaka T, Nakajima M, Nose H.
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Journal Title
J Appl Physiol
Volume: 120
Issue: 1
Pages: 87-96
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effects of hypervolemia bu protein and glucose supplementation during aerobic training on thermal and arterial pressure regulations in hypertensive older men2016
Author(s)
Kataoka Y, Kamijo Y, Ogawa Y, Sumitoshi E, Nakae M, Ikegawa S, Manabe K, Morikawa M, Nagata M, Takasugi S, Masuki S, and Nose H
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Journal Title
J. Appl. Physiol.
Volume: 121
Issue: 4
Pages: 1021-1031
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Effects of 5-aminolevulinic acid supplementation on exercise efficiency and home-based interval walking training achievement in older women2016
Author(s)
Masuki S, Morita A, Kamijo Y, Ikegawa S, Kataoka Y, Ogawa Y, Sumiyoshi E, Takahashi K, Tanaka T, Nakajima M, and Nose H
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Journal Title
ALA-Porphyrin Science
Volume: in press
Related Report
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[Journal Article] The factors affecting adherence to a long-term interval walking training program in middle-aged and older people2015
Author(s)
Masuki S, Mori M, Tabara Y, Sakurai A, Hashimoto S, Morikawa M, Miyagawa K, Sumiyoshi E, Miki T, Higuchi K, and Nose H
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Journal Title
J. Appl. Physiol.
Volume: 118
Issue: 5
Pages: 595-603
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Effects of hypervolemia by protein and glucose supplementation during aerobic training on thermal and arterial pressure regulations in hypertensive older men2016
Author(s)
Kataoka Y, Kamijo Y, Ogawa Y, Sumiyoshi E, Nakae M, Ikegawa S, Manabe K, Morikawa M, Nagata M, Takasugi S, Masuki S, and Nose H
Organizer
The 6th International Sports Science Network Forum in Nagano 2016
Place of Presentation
ホテル ブエナビスタ(松本市)
Year and Date
2016-11-09
Related Report
Int'l Joint Research
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[Presentation] Impact of 5-aminolevulinic acid with iron supplementation on exercise efficiency and home-based walking training achievement in older women (The OKABE Award受賞, ALA and Porphyrin Research Society)2015
Author(s)
Masuki S, Morita A, Kamijo Y, Ikegawa S, Kataoka Y, Ogawa Y, Sumiyoshi E, Takahashi K, Tanaka T, Nakajima M, and Nose H
Organizer
The 3rd International ALA and Porphyrin Symposium (IAPS3)
Place of Presentation
Honolulu (USA)
Year and Date
2015-12-17
Related Report
Int'l Joint Research / Invited
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