| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Outline of Final Research Achievements |
Recent studies suggested that the erythroid growth factor erythropoietin (EPO) has roles beyond its canonical erythropoietic function. This study aimed to elucidate in vivo function of EPO in non-erythropoietic cells, and demonstrated roles of EPO in cardiovascular protection and metabolic regulation in mice. Additionally, the mechanism that EPO promotes iron use synchronized with erythropoiesis was unveiled. Our previous studies discovered that embryonic neural cells express the EPO gene, which is known to be mainly produced by adult kidneys. This study added information that the proximal upstream region of the EPO gene directs EPO production in embryonic neural cells. Furthermore, immortalized cell lines derived from the EPO-producing neural cells were established, and analyses of the cell lines demonstrated that the EPO-producing neural cells consist of various types of neural cells. These results imply additional roles of EPO beyond erythropoiesis and propose their molecular bases.
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