Development of novel glycan-based drug for cancer, COPD and Alzheimer's disease

• Project/Area Number: 15H04700
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Osaka International Cancer Institute (2017-2018); Institute of Physical and Chemical Research (2015-2016)
• Principal Investigator: Taniguchi Naoyuki 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 糖鎖オンコロジー部部長 (90002188)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
• Keywords: 糖鎖 / 糖転移酵素 / COPD / アルツハイマー病 / がん / レドックス

Outline of Final Research Achievements

We have developed the new glyco-compound to inhibit biosynthesis of cancer-related fucosylation. This compound suppressed invasiveness in the liver cancer cell lines. We also revealed molecular structure of GnT-V which is the glycosyltransferase to enhance cancer metastasis. This proved the unique character for GnT-V. For Alzheimer’s disease, we have identified GnT-III as the glycosyltransferase related to disease state, and performed screening study to discover compounds to inhibit GnT-III. In COPD study, we have produced more effective keratan sulfate disaccharide L4 polymer by chemosynthesis. This L4 polymer suppressed inflammatory response of immune cells by the stronger binding to C-type lectins.

Academic Significance and Societal Importance of the Research Achievements

本研究にて開発された新規糖化合物は、肝がん細胞の浸潤能を抑制するため、新規がん治療薬の候補として期待される。また糖鎖合成酵素GnT-Vの酵素機能の特異性を明らかにしたことにより、がんの転移におけるGnT-Vのより詳細な機能の解明が期待される。また糖鎖合成酵素GnT-IIIがアルツハイマー病に関連することを明らかにしたことは、その病態を理解する上で学術的意義が高い。また、ケラタン硫酸二糖L4の抗炎症性作用を明らかにしたことにより、COPDを含め、炎症性疾患の治療薬としての応用が期待される。

Research Products

• [Journal Article] Generation of the heterogeneity of extracellular vesicles by membrane organization and sorting machineries (2019)
  • Author(s): Harada Yoichiro、Suzuki Takehiro、Fukushige Tomoko、Kizuka Yasuhiko、Yagi Hirokazu、Yamamoto Mika、Kondo Kiyotaka、Inoue Hiromasa、Kato Koichi、Taniguchi Naoyuki、Kanekura Takuro、Dohmae Naoshi、Maruyama Ikuro
  • Journal Title: Biochimica et Biophysica Acta (BBA) - General Subjects Volume: 1863 Issue: 4 Pages: 681-691
  • DOI: 10.1016/j.bbagen.2019.01.015
  • Peer Reviewed
• [Journal Article] Implication of C-type lectin receptor langerin and keratan sulfate disaccharide in emphysema (2018)
  • Author(s): Kizuka Yasuhiko、Mishra Sushil、Yamaguchi Yoshiki、Taniguchi Naoyuki
  • Journal Title: Cellular Immunology Volume: 333 Pages: 80-84
  • DOI: 10.1016/j.cellimm.2018.07.004
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neural functions of bisecting GlcNAc. (2018)
  • Author(s): Kizuka Y, Taniguchi N
  • Journal Title: Glycoconj. J. Volume: ー Issue: 4 Pages: 345-351
  • DOI: 10.1007/s10719-018-9829-4
  • Peer Reviewed
• [Journal Article] High affinity sugar ligands of C-type lectin receptor langerin. (2018)
  • Author(s): Ota F, Hirayama T, Kizuka Y, Yamaguchi Y, Fujinawa R, Nagata M; Ismanto HS, Lepenies, Aretz J, Rademacher C, Seeberger PH; Angata T, Kitazume S, Yoshida K, Betsuyaku T, Kida K Yamasaki S, and Taniguchi N
  • Journal Title: BBA - General Subjects Volume: - Issue: 7 Pages: 1592-1601
  • DOI: 10.1016/j.bbagen.2018.04.004
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 1.Imamaki R. Ogawa K, Kizuka Y, Komi Y, Kojima S, Kotani N, Honke K, Honda T, Taniguchi N, and Kitazume S (2018)
  • Author(s): 1.Imamaki R. Ogawa K, Kizuka Y, Komi Y, Kojima S, Kotani N, Honke K, Honda T, Taniguchi N, and Kitazume S
  • Journal Title: Oncogene Volume: - Issue: 31 Pages: 4287-4299
  • DOI: 10.1038/s41388-018-0271-7
  • Peer Reviewed / Open Access
• [Journal Article] Metabolic control of T cell immune response through glycans in inflammatory bowel disease. (2018)
  • Author(s): Dias AM, Correia A, Pereira MS, Almeida CR, Alves I, Pinto V, Catarino TA, Mendes S, Leander M, Oliva-Teles MT, Maia L, Delerue-Matos C, Taniguchi N, Lima M, Pedroto I, Marcos-Pinto R, Lago P, Reis CA, Vilanova M, Pinho SS
  • Journal Title: Proc Natl Acad Sci U S A Volume: 115(20) Issue: 20
  • DOI: 10.1073/pnas.1720409115
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V (2018)
  • Author(s): Nagae Masamichi、Kizuka Yasuhiko、Mihara Emiko、Kitago Yu、Hanashima Shinya、Ito Yukishige、Takagi Junichi、Taniguchi Naoyuki、Yamaguchi Yoshiki
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 3380-3380
  • DOI: 10.1038/s41467-018-05931-w
  • Peer Reviewed / Open Access
• [Journal Article] Core fucose is essential glycosylation for CD14-dependent Toll-like receptor 4 and Toll-like receptor 2 signaling in macrophages (2018)
  • Author(s): Nakayama K, Wakamatsu K, Fujii H, Shinzaki S, Takamatsu S, Kitazume S, Kamada Y, Takehara T, Taniguchi N, Miyoshi E
  • Journal Title: J Biochem Volume: ー Issue: 3 Pages: 227-237
  • DOI: 10.1093/jb/mvy098
  • NAID: 40021845862
  • Peer Reviewed
• [Journal Article] Core fucosylation of the T cell receptor is required for T cell activation. (2018)
  • Author(s): 8.Liang W., Mao S., Sun S., Li M., Li Z., Yu R., Ma T., Gu J., Zhang J., Taniguchi N., Li W.
  • Journal Title: Front Immunol., Volume: 9 Pages: 78-78
  • DOI: 10.3389/fimmu.2018.00078
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification and characterization of UDP-mannose in human cell lines and mouse organs: Differential distribution across brain regions and organs (2018)
  • Author(s): Nakajima Kazuki、Kizuka Yasuhiko、Yamaguchi Yoshiki、Hirabayashi Yoshio、Takahashi Kazuo、Yuzawa Yukio、Taniguchi Naoyuki
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 495 Issue: 1 Pages: 401-407
  • DOI: 10.1016/j.bbrc.2017.10.173
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Sialylation of extracellular superoxide dismutase (EC-SOD) enhances furin-mediated cleavage and secretion (2017)
  • Author(s): Ota Fumi、Kizuka Yasuhiko、Nakano Miyako、Yamaguchi Yoshiki、Kitazume Shinobu、Ookawara Tomomi、Taniguchi Naoyuki
  • Journal Title: Glycobiology Volume: 27 Issue: 12 Pages: 1081-1088
  • DOI: 10.1093/glycob/cwx087
  • Peer Reviewed / Open Access
• [Journal Article] An Alkynyl-Fucose Halts Hepatoma Cell Migration and Invasion by Inhibiting GDP-Fucose-Synthesizing Enzyme FX, TSTA3 (2017)
  • Author(s): Kizuka Yasuhiko、Nakano Miyako、Yamaguchi Yoshiki、Nakajima Kazuki、Oka Ritsuko、Sato Keiko、Ren Chien-Tai、Hsu Tsui-Ling、Wong Chi-Huey、Taniguchi Naoyuki
  • Journal Title: Cell Chemical Biology Volume: 24 Issue: 12 Pages: 1467-1478
  • DOI: 10.1016/j.chembiol.2017.08.023
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Core fucose is critical for CD14-dependent Toll-like receptor 4 signaling (2017)
  • Author(s): 4.Iijima J, Kobayashi S, Kitazume S*, Kizuka Y, Fujinawa R, Korekane H, Shibata T, Saitoh S, Akashi-Takamura S, Miyake K, Miyoshi E, and Taniguch N
  • Journal Title: Glycobiology Volume: 2017 Issue: 11 Pages: 1006-1015
  • DOI: 10.1093/glycob/cwx075
  • Peer Reviewed / Open Access
• [Journal Article] Effect of spermine-derived AGEs on oxidative stress and polyamine metabolism (2017)
  • Author(s): A. Tsutsui, A. R. Pradipta, S. Kitazume, N. Taniguchi, K. Tanaka
  • Journal Title: Org. Biomol. Chem. Volume: 15 Issue: 32 Pages: 6720-6724
  • DOI: 10.1039/c7ob01346a
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] In-situ ligation of high- and low-affinity ligands to cell surface receptors enables highly selective recognition (2017)
  • Author(s): M. Taichi, S. Nomura, I. Nakase, R. Imamaki, Y. Kizuka, F. Ota, N. Dohmae, S. Kitazume, N. Taniguchi, K. Tanaka
  • Journal Title: Adv. Sci. Volume: - Issue: 11 Pages: 1700147-1700147
  • DOI: 10.1002/advs.201700147
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency. (2017)
  • Author(s): Ishii T, Angata T, Wan ES, Cho MH, Motegi T, Gao C, Ohtsubo K, Kitazume S, Gemma A, Pare PD, Lomas DA, Silverman EK, Taniguchi N, Kida K
  • Journal Title: Respirology Volume: 22 Issue: 4 Pages: 684-690
  • DOI: 10.1111/resp.12952
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cancer cell targeting driven by selective polyamine reactivity with glycine propargyl esters (2017)
  • Author(s): K. Vong, K. Tsubokura, Y. Nakao, T. Tanei, S. Noguchi, S. Kitazume, N. Taniguchi, K. Tanaka
  • Journal Title: Chem. Commun. Volume: 53 Issue: 60 Pages: 8403-8406
  • DOI: 10.1039/c7cc01934c
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Reactivity of anti-HNK-1 antibodies to branched O-mannose glycans associated with demyelination (2017)
  • Author(s): K. Sakuda, Y. Kizuka, Y. Yamaguchi, K. Tanaka, K. Ogiwara, T. Segawa, Y. Hagiwara, I. Matsuo, H. Ogawa, N. Taniguchi, S. Kitazume
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 487 Issue: 2 Pages: 450-456
  • DOI: 10.1016/j.bbrc.2017.04.085
  • Peer Reviewed / Open Access
• [Journal Article] Alteration of N-glycan expression profile and glycan pattern of glycoproteins in human hepatoma cells after HCV infection. (2017)
  • Author(s): Xiang T, Yang G, Liu X, Zhou Y, Fu Z, Lu F, Gu J, Taniguchi N, Tan Z, Chen X, Xie Y, Guan F, Zhang XL
  • Journal Title: Biochim Biophys Acta Volume: 1861 Issue: 5 Pages: 1036-1045
  • DOI: 10.1016/j.bbagen.2017.02.014
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Lethality of mice bearing a knockout of the Ngly1-gene is rescued by the additional deletion of the Engase gene. (2017)
  • Author(s): Fujihira H., Masahara-Negishi Y., Tamura M., Harada Y., Chengcheng H., Wakana S., Taniguchi N., Kondoh G., Yamashita T., Funakoshi Y. and Suzuki T.
  • Journal Title: PLOS Genetics Volume: 13 Issue: 4 Pages: 1-23
  • DOI: 10.1371/journal.pgen.1006696
  • Peer Reviewed / Open Access
• [Journal Article] The Inhibitory Role of α2,6-Sialylation in Adipogenesis. (2017)
  • Author(s): Kaburagi T, Kizuka Y, Kitazume S, Taniguchi N.
  • Journal Title: Journal of Biological Chemistry Volume: 292 Issue: 6 Pages: 2278-2286
  • DOI: 10.1074/jbc.m116.747667
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A keratan sulfate disaccharide prevents inflammation and the progression of emphysema in murine models. (2017)
  • Author(s): Gao C, Fujinawa R, Yoshida T, Ueno M, Ota F, Kizuka Y, Hirayama T, Korekane H, Kitazume S, Maeno T, Ohtsubo K, Yoshida K, Yamaguchi Y, Lepenies B, Aretz J, Rademacher C, Kabata H, Hegab AE, Seeberger PH, Betsuyaku T, Kida K, Taniguchi N.
  • Journal Title: American Journal of Physiology Lung Cellular and Molecular Physiology Volume: 312 Issue: 2 Pages: L268-L276
  • DOI: 10.1152/ajplung.00151.2016
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Epigenetic regulation of neural N-glycomics. (2016)
  • Author(s): Kizuka Y, Nakano M, Miura Y, Taniguchi N.
  • Journal Title: Proteomics Volume: 16 Issue: 22 Pages: 2854-2863
  • DOI: 10.1002/pmic.201600053
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] N-glycans of growth factor receptors: their role in receptor function and disease implications. (2016)
  • Author(s): Takahashi M, Hasegawa Y, Gao C, Kuroki Y, Taniguchi N.
  • Journal Title: Clinical Science Volume: 130 Issue: 20 Pages: 1781-1792
  • DOI: 10.1042/cs20160273
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] N-Glycosylation is essential for the secretion of extracellular superoxide dismutase. (2016)
  • Author(s): Ota F, Kizuka Y, Kitazume S, Adachi T, Taniguchi N.
  • Journal Title: FEBS Letters Volume: 590 Issue: 19 Pages: 3357-3367
  • DOI: 10.1002/1873-3468.12378
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Disease-associated glycans on cell surface proteins. (2016)
  • Author(s): Takahashi M, Kizuka Y, Ohtsubo K, Gu J, Taniguchi N.
  • Journal Title: Molecular Aspects of Medicine Volume: 51 Pages: 56-70
  • DOI: 10.1016/j.mam.2016.04.008
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Glycation vs. glycosylation: a tale of two different chemistries and biology in Alzheimer's disease. (2016)
  • Author(s): Taniguchi N, Takahashi M, Kizuka Y, Kitazume S, Shuvaev VV, Ookawara T, Furuta A.
  • Journal Title: Glycoconjugate Journal Volume: 33 Issue: 4 Pages: 487-497
  • DOI: 10.1007/s10719-016-9690-2
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] High-Sensitivity and Low-Toxicity Fucose Probe for Glycan Imaging and Biomarker Discovery. (2016)
  • Author(s): Kizuka Y, Funayama S, Shogomori H, Nakano M, Nakajima K, Oka R, Kitazume S, Yamaguchi Y, Sano M, Korekane H, Hsu TL, Lee HY, Wong CH, Taniguchi N.
  • Journal Title: Cell Chemical Biology Volume: 23 Issue: 7 Pages: 782-792
  • DOI: 10.1016/j.chembiol.2016.06.010
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Enzymes for N-Glycan Branching and Their Genetic and Nongenetic Regulation in Cancer. (2016)
  • Author(s): Kizuka Y, Taniguchi N.
  • Journal Title: Biomolecules Volume: 6 Issue: 2 Pages: 25-25
  • DOI: 10.3390/biom6020025
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Glyco-redox, a link between oxidative stress and changes of glycans: Lessons from research on glutathione, reactive oxygen and nitrogen species to glycobiology. (2016)
  • Author(s): N. Taniguchi, Y. Kizuka, S. Takamatsu, E. Miyoshi, C. Gao, K. Suzuki, S. Kitazume, K. Ohtsubo
  • Journal Title: Arch. Biochem. Biphys. Volume: 595 Pages: 72-80
  • DOI: 10.1016/j.abb.2015.11.024
  • Peer Reviewed / Open Access
• [Journal Article] Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions (2016)
  • Author(s): Kizuka Y, Nakano M, Kitazume S, Saito T, Saido TC, Taniguchi N
  • Journal Title: Biochemical Journal Volume: 473 Issue: 1 Pages: 21-30
  • DOI: 10.1042/bj20150607
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer (2016)
  • Author(s): Carvalho S, Catarino TA, Dias AM, Kato M, Almeida A, Hessling B, Figueiredo J, Gärtner F, Sanches JM, Ruppert T, Miyoshi E, Pierce M, Carneiro F, Kolarich D, Seruca R, Yamaguchi Y, Taniguchi N, Reis CA, Pinho SS
  • Journal Title: Oncogene Volume: - Issue: 13 Pages: 1619-1631
  • DOI: 10.1038/onc.2015.225
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Comparison of analytical methods for profiling N- and O-linked glycans from cultured cell lines : HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study (2016)
  • Author(s): Hiromi Ito et al.
  • Journal Title: Glycoconjugate J. Volume: 未定 Issue: 3 Pages: 405-415
  • DOI: 10.1007/s10719-015-9625-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Visualizing Trimming Dependence of Biodistribution and Kinetics with Homo- and Heterogeneous N-Glycoclusters on Fluorescent Albumin (2016)
  • Author(s): A. Ogura, T. Tahara, S. Nozaki, K. Morimoto, Y. Kizuka, S. Kitazume, M. Hara, S. Kojima, H. Onoe, A. Kurbangalieva, N. Taniguchi, Y. Watanabe, K. Tanaka
  • Journal Title: Sci. Rep. Volume: 6 Issue: 1 Pages: 21797-21797
  • DOI: 10.1038/srep21797
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] In vivo imaging of advanced glycation end products (AGEs) of albumin: first observations of significantly reduced clearance and liver deposition properties in mice (2016)
  • Author(s): Tsutsui A, Ogura A, Tahara T, Nozaki S, Urano S, Hara M, Kojima S, Kurbangalieva A, Onoe H, Watanabe Y, Taniguchi N, Tanaka K
  • Journal Title: Organic and Biomolecular Chemistry Volume: - Issue: 24 Pages: 5755-5760
  • DOI: 10.1039/c6ob00098c
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Core Fucosylation on T cells, Required for Activation of T-cell Receptor Signaling and Induction of Colitis in Mice, is Increased in Patients with Inflammatory Bowel Disease. (2016)
  • Author(s): Fujii H, Shinzaki S, Iijima H, Wakamatsu K, Iwamoto C, Sobajima T, Kuwahara R, Hiyama S, Hayashi Y, Takamatsu S, Uozumi N, Kamada Y, Tsujii M, Taniguchi N, Takehara T, Miyoshi E
  • Journal Title: Gastroenterology Volume: 未定 Issue: 7 Pages: 00297-3
  • DOI: 10.1053/j.gastro.2016.03.002
  • NAID: 40021255019
  • Peer Reviewed
• [Journal Article] Atomic visualization of a flipped-back conformation of bisected glycans bound to specific lectins (2016)
  • Author(s): Nagae M, Kanagawa M, Morita-Matsumoto K, Hanashima S, Kizuka Y, Taniguchi N, Yamaguchi Y.
  • Journal Title: Sci Rep. Volume: 6 (22973) Issue: 1 Pages: 1-11
  • DOI: 10.1038/srep22973
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Expression of Fucosyltransferase 8 Is Associated with an Unfavorable Clinical Outcome in Non-Small Cell Lung Cancers (2015)
  • Author(s): Honma R, Kinoshita I, Miyoshi E, Tomaru U, Matsuno Y, Shimizu Y, Takeuchi S, Kobayashi Y, Kaga K, Taniguchi N, Dosaka-Akita H
  • Journal Title: Oncology Volume: 88 Issue: 5 Pages: 298-305
  • DOI: 10.1159/000369495
  • Peer Reviewed
• [Journal Article] Expression of Fucosyltransferase 8 Is Associated with an Unfavorable Clinical Outcome in Non-Small Cell Lung Cancers (2015)
  • Author(s): Honma R, Kinoshita I, Miyoshi E, Tomaru U, Matsuno Y, Shimizu Y, Takeuchi S, Kobayashi Y, Kaga K, Taniguchi N, Dosaka-Akita H
  • Journal Title: Oncology Volume: 88 Issue: 14 Pages: 298-305
  • DOI: 10.18632/oncotarget.3725
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Clec4g (LSECtin) interacts with BACE1 and suppresses Aβ generation (2015)
  • Author(s): Kizuka Y, Kitazume S, Sato K, Taniguchi N
  • Journal Title: FEBS Letters Volume: 589 Issue: 13 Pages: 1418-1422
  • DOI: 10.1016/j.febslet.2015.04.060
  • Peer Reviewed / Open Access
• [Journal Article] Defining the interaction of human soluble lectin ZG16p and mycobacterial phosphatidylinositol mannosides (2015)
  • Author(s): 1.Shinya Hanashima, Sebastian Götze, Yan Liu, Akemi Ikeda, Kyoko Kojima-Aikawa, Naoyuki Taniguchi, Daniel Varón Silva, Ten Feizi, Peter H. Seeberger, Yoshiki Yamaguchi
  • Journal Title: ChemBioChem Volume: 16 Issue: 10 Pages: 1502-11
  • DOI: 10.1002/cbic.201500103
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Loss of α1,6-fucosyltransferase decreased hippocampal long-term potentiation: implications for core fucosylation in the regulation of AMPA receptor heteromerization and cellular signaling. (2015)
  • Author(s): Gu, W., Fukuda, T., Isaji, T., Hang, Q., Lee, H., Sakai, S., Morise, J., Mitoma, J., Higashi, H., Taniguchi, N., Yawo, H., Oka, S. and Gu, J.
  • Journal Title: J. Biol. Chem. Volume: 290 Issue: 28 Pages: 17566-75
  • DOI: 10.1074/jbc.m114.579938
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fucosylated surfactant protein-D is a biomarker candidate for the development of chronic obstructive pulmonary disease. (2015)
  • Author(s): Ito E., Oka R., Ishi T., Korekane H., Kurimoto A., Kizuka Y., Kitazume S., Ariki S., Takahashi M., Kuroki Y., Kida K., Taniguchi N.
  • Journal Title: Journal of Proteomics Volume: 127 Pages: 386-394
  • DOI: 10.1016/j.jprot.2015.07.011
  • Peer Reviewed
• [Journal Article] Cell surface and in vivo interaction of dendrimeric N-glycoclusters. (2015)
  • Author(s): M. Taichi, S. Kitazume, K. Vong, R. Imamaki, A. Kurbangalieva, N. Taniguchi, and K. Tanaka
  • Journal Title: Glycoconjugate J. Volume: 32 Issue: 7 Pages: 497-503
  • DOI: 10.1007/s10719-015-9594-6
  • Peer Reviewed / Open Access
• [Journal Article] Identification of matrix metalloproteinase inhibitors by chemical arrays. (2015)
  • Author(s): Kawatani M, Fukushima Y, Kondoh Y, Honda K, Sekine T, Yamaguchi Y, Taniguchi N, Osada H
  • Journal Title: Biosci Biotechnol Biochem Volume: 79 Issue: 10 Pages: 1597-1602
  • DOI: 10.1080/09168451.2015.1045829
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Symbol Nomenclature for Graphical Representations of Glycans. (2015)
  • Author(s): Varki A, et al.
  • Journal Title: Glycobiology Volume: 25 Issue: 12 Pages: 1323-1324
  • DOI: 10.1093/glycob/cwv091
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Systems medicine, personalized health and therapy (2015)
  • Author(s): Siest G, Auffray C, Taniguchi N, Ingelman-Sundberg M, Murray H, Visvikis-Siest S, Ansari M, Marc J, Jacobs P, Meyer U, Van Schaik RH, Muller MM, Wevers RA, Simmaco M, Kussmann M, Manolopoulos VG, Alizadeh BZ, Beastall G, Nemeth G
  • Journal Title: Pharmacogenomics Volume: 16 Issue: 14 Pages: 1527-1539
  • DOI: 10.2217/pgs.15.103
  • Peer Reviewed / Int'l Joint Research
• [Presentation] グルタチオン研究からシステム糖鎖生物学へ Old sake in a new bottle (2018)
  • Author(s): 谷口直之
  • Organizer: 日本NO学会日本酸化ストレス学会
• [Presentation] 糖鎖研究の目指すもの (2018)
  • Author(s): 谷口直之
  • Organizer: 第６５回日本生化学会近畿支部例会
• [Presentation] Systems Glycobiology in Disease and N-glycan Branching (2018)
  • Author(s): Naoyuki Taniguchi
  • Organizer: 24th IUBMB Congress & 15th FAOBMB Congress 2018
  • Int'l Joint Research
• [Presentation] Branching N-glycans in disease: biomarker discovery and therapeutic approach (2018)
  • Author(s): Naoyuki Taniguchi
  • Organizer: The 11th International Symposium on Glycosyltransferases (GlycoT 2018)
  • Int'l Joint Research
• [Presentation] Glycosyltransferases: Structure and Function (2018)
  • Author(s): Naoyuki Taniguchi
  • Organizer: The 11th International Symposium on Glycosyltransferases (GlycoT 2018)
  • Int'l Joint Research
• [Presentation] 糖鎖研究の目指すもの (2018)
  • Author(s): 谷口直之
  • Organizer: オリエンタル酵母長浜研究所研究会
• [Presentation] A unique N-glycan structure, bisecting GlcNAc and Alzheimer's disease (2018)
  • Author(s): Naoyuki Taniguchi
  • Organizer: 15th Meeting of the Asian-Pacific Society for Neurochemistry
  • Int'l Joint Research
• [Presentation] Sugar chains (Glycans) and Cancer (2018)
  • Author(s): 谷口直之
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] 糖鎖と病気の発症、診断、治療 (2018)
  • Author(s): 谷口直之
  • Organizer: 山口大学医学部講義
• [Presentation] コレクチンと補体系について（若宮信隆） (2018)
  • Author(s): 谷口直之
  • Organizer: 第28回日本メイラード学会年会
• [Presentation] Outline o Two-Year Strategic Plan for the HPP (2018)
  • Author(s): Naoyuki Taniguchi
  • Organizer: HUPO 2018
  • Int'l Joint Research
• [Presentation] Nutrient Regulation of Signaling and Here Expression by O-GIcNAc (Gerald W.Hart) (2018)
  • Author(s): 谷口直之
  • Organizer: 第16回糖鎖科学コンソーシアムシンポジウム
• [Presentation] Branching N-glycans and disease: approach from biochemistry to systems glycobiology (2018)
  • Author(s): Naoyuki Taniguchi
  • Organizer: 2018 Annual Meeting of the Society for Glycobiology
  • Int'l Joint Research
• [Presentation] Branching N-glycans in disease onset, biomarker discovery and therapeutics (2018)
  • Author(s): Naoyuki Taniguchi
  • Organizer: 1st Academic Seminar of IPRC & IGRC
  • Int'l Joint Research / Invited
• [Presentation] Keratan sulfate disaccharides prevent inflammation and emphysema progression in murine lung and its interaction with C-type lectin, langerin (2016)
  • Author(s): Naoyuki Taniguchi
  • Organizer: IUBMB meeting on Frontiers in Glycoscience
  • Place of Presentation: Academia sinica, Taiwan
  • Year and Date: 2016-12-12
  • Int'l Joint Research / Invited
• [Presentation] Sugar Modification of BACE1 regulates its localization and accelerates Alzheimer's disase (2016)
  • Author(s): Naoyuki Taniguchi
  • Organizer: 2nd Kloster Seeon Meeing on BACE Protease in Health Disease
  • Place of Presentation: Kloster Seeon, Germany
  • Year and Date: 2016-09-25
  • Int'l Joint Research / Invited
• [Presentation] A highly sensitive probe for fucosylated glycans for biomarker discovery (2016)
  • Author(s): Naoyuki Taniguchi
  • Organizer: 15th Human Proteome Organization World Congress (HUPO2016)
  • Place of Presentation: Taipei International Convention Center, Taiwan
  • Year and Date: 2016-09-18
  • Int'l Joint Research
• [Presentation] GlycosylationとRedox 制御のクロストーク (2016)
  • Author(s): 谷口 直之
  • Organizer: 第35回日本糖質学会年会
  • Place of Presentation: 高知市文化プラザ かるぽーと
  • Year and Date: 2016-09-01
  • Invited
• [Presentation] Role of N-glycans in disease: implication for pathogenesis of Alzheimer’s disease and its possible glycan-based therapeutics (2016)
  • Author(s): Naoyuki Taniguchi
  • Organizer: 2016 Glycobiology Meeting of China
  • Place of Presentation: 南通大学, 南通市、中国
  • Year and Date: 2016-08-06
  • Int'l Joint Research / Invited
• [Presentation] Role of branched N-glycans in disease: implication for pathogenesis of Alzheimer’s disease and its possible glycan-based therapeutics (2016)
  • Author(s): Naoyuki Taniguchi
  • Organizer: 10th International Symposium on Glycosyltransferases (GlycoT 2016)
  • Place of Presentation: Peter Gilgan Centre for Research and Learning, Toronto, Canada
  • Year and Date: 2016-06-19
  • Int'l Joint Research / Invited
• [Presentation] N-glycans in disease: implication for pathogenesis of COPD and Alzheimer’s disease and their possible therapeutics (2016)
  • Author(s): Naoyuki Taniguchi
  • Organizer: GlycoAR2016
  • Place of Presentation: Edelweiss Hotel, Villa General Belgrano, Cordova, Argentine
  • Year and Date: 2016-06-01
  • Int'l Joint Research / Invited
• [Presentation] Implication of N-glycan in pathogenesis of Alzheimer’s disease and its possible glycan-based therapeutics (2016)
  • Author(s): Naoyuki Taniguchi
  • Organizer: BBRC Symposium
  • Place of Presentation: Hilton New Orleans Riverside, USA
  • Int'l Joint Research
• [Presentation] N-Acetylglucosaminyltransfease III (GnT-III) is a novel drug target for Alzheimer’s disease (2015)
  • Author(s): Yasuhiko Kizuka, Miyako Nakano, Shinobu Kitazume , Tamao Endo and Naoyuki Taniguchi
  • Organizer: HUPO 2015
  • Place of Presentation: Vancouver Convention Center, Vancouver, Canada
  • Year and Date: 2015-09-28
  • Int'l Joint Research
• [Presentation] Keratan sulfate disaccharide and its derivative attenuate inflammation and the progression of emphysema in the murine lung by targeting to langerin, a C-type lectin (2015)
  • Author(s): Congxiao Gao, Reiko Fujinawa, Fumi Ota, Hiroaki Korekane, Shinobu Kitazume, Kazuaki Ohtsubo, Keiichi Yoshida, Yoshiki Yamguchi, and Naoyuki Taniguchi
  • Organizer: GLYCO23 - 23rd International Symposium on Glycoconjugates
  • Place of Presentation: Hotel Le Meridien Lav / Split, Croatia
  • Year and Date: 2015-09-17
  • Int'l Joint Research
• [Presentation] GLYCO-REDOX: NEW SAKE IN AN OLD BOTTLE (2015)
  • Author(s): Naoyuki Taniguchi
  • Organizer: 12th International Symposium on the Maillard Reaction
  • Place of Presentation: 東京大学伊藤国際学術研究センター（東京都文京区）
  • Year and Date: 2015-09-02
  • Int'l Joint Research / Invited
• [Presentation] 糖鎖、特に分岐型Ｎ－型糖鎖の生理的病態的役割 (2015)
  • Author(s): 谷口直之
  • Organizer: 第38回日本基礎老化学会大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-06-14
  • Invited
• [Book] Glycoscience: Basic Science to Applications - Insights from the Japan Consortium for Glycobiology and Glycotechnology - (2019)
  • Author(s): Taniguchi N, Endo T, Hirabayashi J, Nishihara S, Kadomatsu K, Akiyoshi K, Aoki-Kinoshita KF, eds.
  • Total Pages: 337
  • Publisher: Springer Singapore
  • ISBN: 9789811358555
• [Book] ベインズ・ドミニチャク生化学（原書4版） (2018)
  • Author(s): Baynes John W., Dominiczak Marek H, 谷口 直之, 岩井 一宏, 藤井 順逸, 本家 孝一 (担当:共著)
  • Total Pages: 728
  • Publisher: エルゼビア・ジャパン, 丸善出版 (発売)
  • ISBN: 9784621301692
• [Book] Essentials of Glycobiology, 3rd ed. - Ch. 9: N-Glycans (2016)
  • Author(s): Pamela Stanley, Naoyuki Taniguchi and Markus Aebi
  • Publisher: Cold Spring Harbor Laboratory Press
• [Book] Sugar Chain - Glycans and Chronic Obstructive Pulmonary Disease (COPD) (2015)
  • Author(s): Congxiao Gao and Naoyuki Taniguchi
  • Total Pages: 288
  • Publisher: Springer
• [Remarks]
  • URL: http://www.riken.jp/research/labs/grc/riken_max_planck/sys_glycobiol/