Role of dedifferentiation on cancer development
| Project/Area Number |
15H04721
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | The University of Tokyo (2017)
Kyoto University (2015-2016) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | dedifferentiation / cancer / iPS cell / reprogramming / 脱分化 / 膵癌 / がん / iPS細胞 / 細胞初期化 / マウス / リプログラミング |
|---|
| Outline of Final Research Achievements |
The faithful shutdown of the somatic program occurs in the early stage of reprogramming. Here, we examined the effect of in vivo reprogramming on Kras-induced cancer development. We show that the transient expression of reprogramming factors in pancreatic acinar cells results in the transient repression of acinar cell enhancers. Notably, the transient expression of reprogramming factors in Kras mutant mice is sufficient to induce the rapid formation of pancreatic ductal adenocarcinoma. These results underscore a crucial role of dedifferentiation-associated epigenetic regulations in the initiation of pancreatic cancers.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Cellular context-dependent consequences of Apc mutations on gene regulation and cellular behavior.2017
Author(s)
Hashimoto K, Yamada Y, Semi K, Yagi M, Tanaka A, Itakura F, Aoki H, Kunisada T, Woltjen K, Haga H, Sakai Y, Yamamoto T, *Yamada Y.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 114
Issue: 4
Pages: 758-763
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Reducing DNA methylation suppresses colon carcinogenesis by inducing tumor cell differentiation. Carcinogenesis.2015
Author(s)
Hatano Y, Semi K, Hashimoto K, Lee MS, Hirata A, Tomita H, Kuno T, Takamatsu M, Aoki K, Taketo MM, Kim YJ, Hara A, Yamada Y.
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Journal Title
Carcinogenesis
Volume: 36
Issue: 7
Pages: 719-29
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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