Immunological aspects of cancer stem cell and spermatogenesis
| Project/Area Number |
15H04722
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Experimental pathology
|
|---|
| Research Institution | Sapporo Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
|
|---|
| Keywords | がん幹細胞 / 免疫療法 / 班精巣抗原 / がん精巣抗原 / 細胞障害性Ｔ細胞 / OR7C1 / BORIS / CTL |
|---|
| Outline of Final Research Achievements |
In this research project, we isolated highly tumorigenic cancer stem cells from human colon cancer, cervical cancer and lung cancer cells. We examined the expression profiles of cancer stem cells by cDNA microarry, and we found that numbers of testis-related genes are expressed in cancer stem cells. Those are OR7C1, BORIS SMCP and DNAJB8. Importantly, gene specific knockdown using siRNAs revealed that testis-related genes have important role in the maintenance of cancer stem cells. And we also identified testis-related gene products can be targeted by immunotherapy. These results indicate that immunotherapy targeting testis-related gene products is a promising approach to target cancer stem cells.
|
Report
(4 results)
Research Products
(21 results)
-
-
[Journal Article] ST6GALNAC1 plays important roles in enhancing cancer stem phenotypes of colorectal cancer via the Akt pathway2017
Author(s)
Ogawa T, Hirohashi Y, Murai A, Nishidate T, Okita K, Wang L, Ikehara Y, Satoyoshi T, Usui A, Kubo T, Nakastugawa M, Kanaseki T, Tsukahara T, Kutomi G, Furuhata T, Hirata K, Sato N, Mizuguchi T, Takemasa I, Torigoe T.
-
Journal Title
Oncotartget
Volume: 8
Pages: 112550-112564
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Identification of antigenic peptides from novel renal cancer stem-like cell antigen, DNAJB8.2017
Author(s)
Nishizawa S, Hirohashi Y, Kusumoto H, Wakamiya T, Iguchi T, Yamashita S, Iba A, Kikkawa K, Kohjimoto Y, Torigoe T, Hara I
-
Journal Title
Biochemical Biophysical Research Communication
Volume: 494
Pages: 693-699
DOI
Related Report
Peer Reviewed
-
[Journal Article] Comprehensive single-cell transcriptome analysis reveals heterogeneity in endometrioid adenocarcinoma tissues2017
Author(s)
Hashimoto S, Tabuchi Y, Yurino H, Hirohashi Y, Deshimaru S, Asano T, Mariya T, Oshima K, Takamura Y, Ukita Y, Ametani A, Kondo N, Monma N, Takeda T, Misu S, Okayama T, Ikeo K, Saito T, Kaneko S, Suzuki Y, Hattori M, Matsushima K, et al.
-
Journal Title
Scientific Rep.
Volume: 7
Pages: 14225-14225
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
[Journal Article] MAPK13 is preferentially expressed in gynecological cancer stem cells and has a role in the tumor-initiation.2016
Author(s)
Yasuda K, Hirohashi Y, Kuroda T, Takaya A, Kubo T, Kanaseki T, Tsukahara T, Hasegawa T, Saito T, Sato N, Torigoe T.
-
Journal Title
Biochem Biophys Res Commun
Volume: 472
Pages: 643-647
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Matrix metalloproteinase-10 regulates stemness of ovarian cancer stem-like cells by activation of canonical Wnt signaling and can be a target of chemotherapy-resistant ovarian cancer.2016
Author(s)
Mariya T, Hirohashi Y, Torigoe T, Tabuchi Y, Asano T, Saijo H, Kuroda T, Yasuda K, Mizuuchi M, Saito T, Sato N
-
Journal Title
Oncotarget
Volume: in press
Pages: 1-17
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Olfactory receptor family receptor, family 7, subfamily C, member 1 is a novel marker of colon cancer-initiating cells and is a potent target of immunotherapy.2016
Author(s)
Morita R, Hirohashi Y, Torigoe T, Inoda S, Takahashi A, Mariya T, Asanuma H, Tamura Y, Tsukahara T, Kanaseki T, Kubo T, Kutomi G, Mizuguchi T, Terui T, Ishitani K, Hashino S, Kondo T, Minagawa N, Takahashi N, Taketomi A, Todo S, Asaka M, Sato N.
-
Journal Title
Clin Cancer Res
Volume: in press
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is involved in cervical cancer stemness and can be a target of immunotherapy.2016
Author(s)
Asano T, Hirohashi Y, Torigoe T, Mariya T, Horibe R, Kuroda T, Tabuchi Y, Saijo H, Yasuda K, Mizuuchi M, Takahashi A, Asanuma H, Hasegawa T, Saito T, Sato N.
-
Journal Title
Oncotarget.
Volume: 7
Pages: 11223-11237
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
