| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
Staphylococcus aureus is a human pathogenic bacterium and causes clinical problems of drug resistance. To find novel therapeutic agents, it is important to understand the virulence mechanism of S. aureus. In this research project, we tried to identify novel virulence factors of S. aureus from hypothetical genes whose products are assumed to interact with RNA or nucleotide. We found that three rRNA methyltransferases and a nucleotide hydrolase contribute to S. aureus virulence. Investigations of these novel virulence factors have revealed new mechanism of S. aureus virulence via RNA and nucleotide.
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