New activation pathway for inflammasome
| Project/Area Number |
15H04730
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SUZUKI Toshihiko 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (10292848)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | インフラマゾーム / 慢性炎症 / カスパーゼ-1 / 慢性炎症炎症 |
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| Outline of Final Research Achievements |
Inflammasome is macromolecule complexes in the host cells upon being activated by pathogen infection or metabolites in the body. Caspase-1 activation is finely regulated by inflammasome that forms with Nod-like receptors (NLRs), and then activated caspase-1 can cleave pro-IL-1 or IL-18, and convert their bioactive cytokines. Among NLRs, NLRP3 is involved in chronic inflammatory diseases such as type II Diabetes or gout, because NLRP3 inflammasome can be activated by several metabolites including saturated fatty acids, cholesterol or uric acids crystals. In this work, we found new signaling pathway for activating NLRP3 inflammasome. The lysosome integrity-galectin-3 accumulation-NLRP3 activation axis may provide important insights into NLRP3 inflammasome activation in host cells.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication.2018
Author(s)
Maruzuru Y, Ichinohe T, Sato R, Miyake K, Okano T, Suzuki T, Koshiba T, Koyanagi N, Tsuda S, Watanabe M, Arii J, Kato A, Kawaguchi Y.
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Journal Title
Cell Host Microbe.
Volume: 23
Issue: 2
Pages: 254-265
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Complete Genome Sequences of Low-Passage Virulent and High-Passage Avirulent Variants of Pathogenic Leptospira interrogans Serovar Manilae strain UP-MMC-NIID, originally Isolated from a patient with severe Leptospirosis, determined using PacBio Single Molecule, Real-Time Technology.2015
Author(s)
Satou K, Shimoji M, Tamotsu H, Juan A, Ashimine N, Shinzato M, Toma C, Nohara T, Shiroma A, Nakano K, Teruya K, Terabayashi Y, Ohki S, Koizumi N, Okano S, Suzuki T, Hirano T.
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Journal Title
Genome Announc
Volume: 3
Issue: 4
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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