The mechanisms of chronic inflammation by Gateway Reflex and inflammation amplifier
| Project/Area Number |
15H04741
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | 炎症アンプ / ゲートウェイ反射 / ストレス / 炎症 / ゲート反射 / 血液脳関門 |
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| Outline of Final Research Achievements |
A correlation between pain intensity and the pathogenesis of inflammation is poorly established and still unclear. In this application, we elucidated that a pain evoked relapse of multiple sclerosis. Moreover, we revealed that brain micro-inflammation around specific vessels caused by chronic-stress could be switch to activate new neural pathway to regulate organ homeostasis. In addition, we identified positive-regulator of inflammation amplifier by genome wide screening. Among them, we focused on BCR and Rbm10, and clarified the mechanisms of inflammation amplifier.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit.2017
Author(s)
Arima, Y., T. Ohki, N. Nishikawa, K. Higuchi, M. Ota, Y. Tanaka, J. Nio-Kobayashi, M. Elfeky, R. Sakai, Y. Mori, T. Kawamoto, A. Stofkova, Y. Sakashita, Y. Morimoto, M. Kuwatani, T. Iwanaga, Y. Yoshioka, N. Sakamoto, A. Yoshimura, M. Takiguchi, S. Sakoda, M. Prinz, D. Kamimura, M. Murakami.
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Journal Title
eLife
Volume: 6:e25517
Pages: 1-27
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Rbm10 regulates inflammation development via alternative splicing of Dnmt3b.2017
Author(s)
Atsumi T, Suzuki H, Jiang JJ, Okuyama Y, Nakagawa I, Ota M, Tanaka Y, Ohki T, Katsunuma K, Nakajima K, Hasegawa Y, Ohara O, Ogura H, Arima Y, Kamimura D, Murakami M.
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Journal Title
Int Immunol.
Volume: 29(12)
Issue: 12
Pages: 581-591
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Breakpoint cluster region-mediated inflammation is dependent on casein kinase II.2016
Author(s)
Meng, J., J-J Jiang, T. Atsumi, H. Bando, Y. Okuyama, L. Sabharwal, I. Nakagawa, H. Higuchi, M. Ota, M. Okawara, R. Ishitani, O. Nureki, D. Higo, Y. Arima, H. Ogura, D. Kamimura and M. Murakami.
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Journal Title
J Immunol.
Volume: 197(8)
Issue: 8
Pages: 3111-3119
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Control of chronic inflammation by the inflammation amplifier and gateway reflexes.2016
Author(s)
Ota, M., D. Kamimura, I. Nakagawa, H. Higuchi, Y. Tanaka, M. Fujita, S. Hiratsuka, M. Okawara, K. Murakami, T. Atsumi, Y. Arima and M. Murakami.
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Journal Title
Advances in Medicine and Biology.
Volume: 104: Chapter 4
Pages: 65-86
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Strong TCR-mediated signals suppress integrated stress responses induced by KDELR1 deficiency in naive T cells.2016
Author(s)
Kamimura, D. Y. Arima, M. Tsuruoka, J-J Jiang, H. Bando, J. Meng, L. Sabharwal, A. Stofkova, N. Nishikawa, K. Higuchi, H. Ogura, T. Atsumi, M. Murakami.
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Journal Title
Int Immunol.
Volume: 28(3)
Issue: 3
Pages: 117-126
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Naive T cell homeostasis regulated by stress responses and TCR signaling.2015
Author(s)
Kamimura, D., T. Atsumi, A. Stofkova, N. Nishikawa, T. Ohki, H. Suzuki, K. Katsunuma, J-J Jiang, H. Bando, J. Meng, L. Sabharwal, H. Ogura, T. Hirano, Y. Arima, M. Murakami.
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Journal Title
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model2015
Author(s)
Arima, Y., D. Kamimura, T. Atsumi, M. Harada, T. Kawamoto, N. Nishikawa, A. Stofkova1, T. Ohki, K. Higuchi, Y. Morimoto, P. Wieghofer, Y. Okada, Y. Mori, S. Sakoda, S. Saika, Y. Yoshioka, I. Komuro, T. Yamashita, T. Hirano, M. Prinz, M. Murakami.
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Journal Title
eLife
Volume: 4
Pages: 1-23
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR.2015
Author(s)
Kamimura, D., K. Katsunuma, Y. Arima, T. Atsumi, J-J Jiang, H. Bando, J. Meng, L. Sabharwal, A. Stofkova, N. Nishikawa, H. Suzuki, H. Ogura, N. Ueda, M. Tsuruoka, M. Harada, J. Kobayashi, T. Hasegawa, H. Yoshida, H. Koseki, I. Miura, S. Wakana, K. Nishida, H. Kitamura, T. Fukada, T. Hirano, and M. Murakami
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Journal Title
Nat. Commun.
Volume: 6
Issue: 1
Pages: 7474-7474
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Book] Multiple Sclerosis2015
Author(s)
Kamimura, D., Y. Arima, T. Atsumi, J. Meng, L. Sabharwal, H. Bando, J-J. Jiang, ES. Huseby, M. Murakami.
Total Pages
538
Publisher
Elsevier
Related Report
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