The mechanism of immune regulatory function of B cells and its pathologic significance
| Project/Area Number |
15H04746
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Kyushu University (2017)
Osaka University (2015-2016) |
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Principal Investigator |
Yoshihiro Baba 九州大学, 生体防御医学研究所, 教授 (20415269)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Keywords | B細胞 / IL-10 / 自己免疫 / 制御性B細胞 / 多発性硬化症 / 炎症 / プラズマブラスト |
|---|
| Outline of Final Research Achievements |
B cells can suppress autoimmunity by secreting interleukin-10 (IL-10). Although subpopulations of splenic B lineage cells are reported to express IL- 10 in vitro, the identity of IL-10-producing B cells with regulatory function in vivo remains unknown. By using IL-10 reporter mice, we found that plasmablasts in the draining lymph nodes (dLNs), predominantly expressed IL-10 during experimental autoimmune encephalomyelitis (EAE). We purified these plasmablasts and performed global gene expression profiling of them. We identified a unique gene expression pattern in IL-10+ plasmabalsts. Then, we focused on one of the genes and generated its B cell-specific knock out mice. Mice lacking the gene had an increase of germinal center B cells and produced autoantibodies. These data suggest that the gene contributes to B cell tolerance.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] The activated conformation of integrin β7 as a target for multiple myeloma-specific chimeric antigen receptor T cell therapy.2017
Author(s)
Hosen N, Matsunaga Y, Hasegawa K, Matsuno H, Nakamura Y, Makita M, Watanabe K, Yoshida M, Satoh K, Morimoto S, Fujiki F, Nakajima H, Nakata J, Nishida S, Tsuboi A, Oka Y, Manabe M, Ichihara H, Aoyama Y, Mugitani A, Nakao T, Hino M, Uchibori R, Ozawa K, Baba Y, et al.
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Journal Title
Nat. Med.
Volume: 23
Issue: 12
Pages: 1436-1443
DOI
Related Report
Peer Reviewed
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[Journal Article] LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation.2016
Author(s)
Morimoto K, Baba Y, Shinohara H, Kang S, Nojima S, Kimura T, Ito D, Yoshida Y, Maeda Y, Sarashina-Kida H, Nishide M, Hosokawa T, Kato Y, Hayama Y, Kinehara Y, Okuno T, Takamatsu H, Hirano T, Shima Y, Narazaki M, Kurosaki T, Toyofuku T, Kumanogoh A.
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 25738-25738
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis.2016
Author(s)
Ohmi Y, Ise W, Harazono A, Takakura D, Fukuyama H, Baba Y, Narazaki M, Shoda H, Takahashi N, Ohkawa Y, Ji S, Sugiyama F, Fujio K, Kumanogoh A, Yamamoto K, Kawasaki N, Kurosaki T, Takahashi Y, Furukawa K.
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Journal Title
Nature Communications
Volume: in press
Issue: 1
Pages: 11205-11205
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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