Crosstalk of inflammatory responses and microRNA expression induced by particulate matters and application for risk assessment
| Project/Area Number |
15H04784
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene and public health
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| Research Institution | Mie University |
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Principal Investigator |
Hiraku Yusuke 三重大学, 医学系研究科, 講師 (30324510)
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| Co-Investigator(Renkei-kenkyūsha) |
OMAE KAZUYUKI 慶應義塾大学, 名誉教授 (60118924)
TANAKA AKIYO 九州大学, 医学研究院, 講師 (10136484)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | 粒子状物質 / 炎症 / マイクロRNA / 石綿 / 発がん / リスク評価 / インジウム / カーボンブラック / ナノ素材 / 線維化 |
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| Outline of Final Research Achievements |
Particlate matters are accumulated in the respiratory systems by inhalation exposure and induce chronic inflammation, leading to carcinogenesis and fibrosis. To clarify the mechanism of diseases caused by these materials, we examined the association of inflammatory responses and the expression of microRNA (miRNA). In lung tissues of indium-exposed rats, miR-21 expression was predicted to target prostaglandin dehydrogenase, leading to augmentation of inflammatory responses. In the sera of indium-exposed rats, several inflammatory cytokines were upregulated and supposed to involve downregulation of miRNAs in lung tissues. These results raise a possibility that these miRNAs and related inflammatory molecules can be potential biomarkers to evaluate the risk of individuals exposed to harmful particulate matters.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Oxidative DNA damage induced by pirarubicin, an anthracycline anticancer agent, in the presence of copper(II)2018
Author(s)
Mizutani H, Nishimoto A, Hotta S, Ikemura K, Imai M, Miyazawa D, Ohta K, Ikeda Y, Maeda T, Yoshikawa M, Hiraku Y, Kawanishi S
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Journal Title
Anticancer Res.
Volume: 未定
Related Report
Peer Reviewed
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[Journal Article] Pirarubicin, an Anthracycline Anticancer Agent, Induces Apoptosis Through Generation of Hydrogen Peroxide.2017
Author(s)
Mizutani H, Hotta S, Nishimoto A, Ikemura K, Miyazawa D, Ikeda Y, Maeda T, Yoshikawa M, Hiraku Y, Kawanishi S.
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Journal Title
Anticancer Res.
Volume: 37
Issue: 11
Pages: 6063-6069
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Exposure assessment and heart rate variability monitoring in workers handling titanium dioxide particles-a pilot study.2016
Author(s)
Ichihara S, Li W, Omura S, Fujitani Y, Liu Y, Wang Q, Hiraku Y, Hisanaga N, Wakai K, Ding X, Kobayashi T, Ichihara G.
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Journal Title
J. Nanopart. Res.
Volume: 18
Issue: 3
Pages: 52-52
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Inflammation-related DNA damage in relation to the expression of cancer stemness markers in human nasopharyngeal carcinoma2015
Author(s)
Wang S, Ma N, Kawanishi S, Zhao W, Midorikawa K, Hiraku Y, Oikawa S, Zhang Z, Huang G, Murata M.
Organizer
SFRR-E/SNFS Meeting Stuttgart 2015: Redox Biology Meets Nutrition
Place of Presentation
University of Hohenheim, Stuttgart, Germany
Year and Date
2015-09-01
Related Report
Int'l Joint Research
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