Development of breast cancer prognosis tool using the National Clinical Database-Breast Cancer Registry in Japan

• Project/Area Number: 15H04796
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical and hospital managemen
• Research Institution: Tokai University
• Principal Investigator: TOKUDA Yutaka 東海大学, 医学部, 教授 (20163975)
• Co-Investigator(Kenkyū-buntansha): 木下 貴之 国立研究開発法人国立がん研究センター, 中央病院, 科長 (00225004) ; 岩本 高行 岡山大学, 大学病院, 助教 (40627238) ; 新倉 直樹 東海大学, 医学部, 准教授 (60459469) ; 河合 賢朗 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (80513530) ; 宮田 裕章 東京大学, 医学部附属病院, 特任教授 (70409704) ; 隈丸 拓 東京大学, 医学部附属病院, 特任講師 (00511461)
• Research Collaborator: ANAN Keisei
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000); Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
• Keywords: 医療の質 / がん登録 / 医療の均てん化

Outline of Final Research Achievements

The National Clinical Database (NCD) Breast Cancer Registry in Japan is a nationwide prospective web-based registry and covered more than 90% of annually diagnosed breast cancer patients in 2014. The NCD Breast Cancer Registry has systematically collected accurate data to develop a standardized database for improvement of quality and evaluation of healthcare outcome.
The NCD has established a feedback system for the hospital QIs (Quality Indicator) via web. Eight QIs were chosen based on a clinical practice guideline so far. Especially on the issues of postoperative radiotherapy, significant differences in QIs were recognized between authorized and non-authorized institutions.

Research Products

• [Journal Article] Body mass index and survival after diagnosis of invasive breast cancer: a study based on the Japanese National Clinical Database-Breast Cancer Registry. (2016)
  • Author(s): Kawai M, Tomotaki A, Miyata H, Iwamoto T, Niikura N, Anan K, Hayashi N, Aogi K, Ishida T, Masuoka H, Iijima K, Masuda S, Tsugawa K, Kinoshita T, Nakamura S, Tokuda Y
  • Journal Title: Cancer Medicine Volume: 5 Issue: 6 Pages: 1328-1340
  • DOI: 10.1002/cam4.678
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Changes in tumor expression of HER2 and hormone receptors status after neoadjuvant chemotherapy in 21 755 patients from the Japanese breast cancer registry (2016)
  • Author(s): Niikura N, Sakatani T, Arima N, Ohi Y, Honma N, Kanomata N, Yoshida K, Kadoya T, Tamaki K, Kumaki N et al:
  • Journal Title: Annals of oncology Volume: 27(3) Issue: 3 Pages: 480-487
  • DOI: 10.1093/annonc/mdv611
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive prognostic report of the Japanese Breast Cancer Society Registry in 2004. (2016)
  • Author(s): Kinoshita T, Fukui N, Anan K, Iwamoto T, Niikura N, Kawai M, Hayashi N, Tsugawa K, Aogi K, Ishida T, Masuoka H, Masuda S, Iijima K, Nakamura S, Tokuda Y.
  • Journal Title: Breast Cancer Volume: 23 Issue: 1 Pages: 39-49
  • DOI: 10.1007/s12282-015-0644-5
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Comprehensive prognostic report of the Japanese Breast Cancer Society Registry in 2005. (2016)
  • Author(s): Anan K, Fukui N, Kinoshita T, Iwamoto T, Niikura N, Kawai M, Hayashi N, Tsugawa K, Aogi K, Ishida T, Masuoka H, Masuda S, Iijima K, Nakamura S, Tokuda Y
  • Journal Title: Breast Cancer Volume: 23 Issue: 1 Pages: 50-61
  • DOI: 10.1007/s12282-015-0645-4
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Comprehensive prognostic report of the Japanese Breast Cancer Society registry in 2006 (2016)
  • Author(s): Iwamoto T, Fukui N, Kinoshita T, Anan K, Niikura N, Kawai M, Hayashi N, Tsugawa K, Aogi K, Ishida T, Masuoka H, Masuda S, Iijima K, Nakamura S, Tokuda Y
  • Journal Title: Breast Cancer Volume: 23 Issue: 1 Pages: 62-72
  • DOI: 10.1007/s12282-015-0646-3
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Distinct breast cancer characteristics between screen- and self-detected breast cancers recorded in the Japanese Breast Cancer Registry. (2016)
  • Author(s): Iwamoto T, Kumamaru H, Miyata H, Tomotaki A, Niikura N, Kawai M, Anan K, Hayashi N, Masuda S, Tsugawa K, Aogi K, Ishida T, Masuoka H, Iijima K, Matsuoka J, Doihara H, Kinoshita T, Nakamura S, Tokuda Y
  • Journal Title: Breast Cancer Research and Treatment Volume: 156 Issue: 3 Pages: 485-494
  • DOI: 10.1007/s10549-016-3770-7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Young adult breast cancer patients have a poor prognosis independent of prognostic clinicopathological factors: a study from the Japanese Breast Cancer Registry. (2016)
  • Author(s): Kataoka A, Iwamoto T, Tokunaga E, Tomotaki A, Kumamaru H, Miyata H, Niikura N, Kawai M, Anan K, Hayashi N, Masuda S, Tsugawa K, Aogi K, Ishida T, Masuoka H, Iijima K, Kinoshita T, Nakamura S, Tokuda Y
  • Journal Title: Breast Cancer Research and Treatment Volume: 160 Issue: 1 Pages: 163-172
  • DOI: 10.1007/s10549-016-3984-8
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Role of postmastectomy radiotherapy after neoadjuvant chemotherapy in breast cancer patients: a study from the Japanese Breast Cancer Registry. (2017)
  • Author(s): Minoru Miyashita, Naoki Niikura, Hiraku Kumamaru, Hiroaki Miyata, Takanori Ishida, Takayuki Kinoshita, Hitoshi Tsuda, Seigo Nakamura, Yutaka Tokuda
  • Organizer: San Antonio Breast Cancer Symposium
  • Int'l Joint Research