| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
|
|---|
| Outline of Final Research Achievements |
Brain-gut interactions are reciprocal communication between brain and gut. Brain-gut interactions forms major pathophysiology of irritable bowel syndrome (IBS). This research clarified that visceral pain sensitivity and negative emotion relate to sensitivity to the corticotropin-releasing hormone (CRH) in the brain regions, that IBS pathophysiology is aggravated by activation of CRH receptor 1, and that distribution of gene polymorphism of CRH receptor 2 in IBS patients is different from that in healthy controls. Further research to identify the substances that regulate brain-gut interactions and IBS is warranted.
|
