Investigation of pathological mechanism and therapeutic strategies of frailty based on AgingDomino theory
| Project/Area Number |
15H04800
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小川 純人 東京大学, 医学部附属病院, 准教授 (20323579)
小島 太郎 東京大学, 医学部附属病院, 助教 (40401111)
石井 伸弥 東京大学, 医学部附属病院, 助教 (80710996)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Keywords | フレイル / 階層構造 / 老化 / 慢性炎症 / 大動脈瘤 / 認知症 / ホルモン / サルコペニア |
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| Outline of Final Research Achievements |
Based on AgingDomino theory that indicates hierarchical relationship in the process of cell/tissue aging leading frailty, the hypothesis of this study was that unraveling this relationship could innovate the preventive and therapeutic strategies of frailty or aging-related diseases. Especially, in this study, we found vascular aging is an upstream trigger for aging of other frailty-related cell/tissue and mechanistically, found that expansion of inflammation causes this relationship. In detail, in normal aging or senescence accelerated mice, vascular inflammation promoted aging-dependent changes or dysfunction of skeletal muscle and brain tissue. Also, enhancement of circulating inflammatory cytokines (e.g. IL-6) by vascular inflammation leads to exaggerated inflammatory response in downstream tissue through perturbation of systemic inflammatory regulation.
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Report
(4 results)
Research Products
(60 results)
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[Journal Article] Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer’s disease model mice2018
Author(s)
Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, Takatori S, Ouchi Y, Ikeuchi T, Makino M, Saido TC, Akishita M, Iwatsubo T, Hori Y, Tomita T
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Journal Title
EMBO Molecular Medicine
Volume: 10
Issue: 3
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Looking back to move forward: a twenty-year audit of herpes zoster in Asia-Pacific2017
Author(s)
Chen LK, Arai H, Chen LY, Chou MY, Djauzi S, Dong B, Kojima T, Kwon KT, Leong HN, Leung EM, Liang CK, Liu X, Mathai D, Pan JY, Peng LN, Poblete ER, Poi PJ, Reid S, Tantawichien T, Won CW
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Journal Title
BMC Infectious Disease
Volume: 17
Issue: 1
Pages: 213-213
DOI
Related Report
Open Access / Int'l Joint Research
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[Journal Article] Sleep Apnea and Circadian Extracellular Fluid Change as an Independent Factor for Nocturnal Polyuria2016
Author(s)
Niimi A, Suzuki M, Yamaguchi Y, Ishii M, Fujimura T, Nakagawa T, Fukuhara H, Kume H, Igawa Y, Akishita M, Homma Y
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Journal Title
J Urol
Volume: 196
Pages: 1183-9
Related Report
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[Journal Article] Screening Tool for Older Persons' Appropriate Prescriptions in Japanese: Report of the Japan Geriatrics Society Working Group on "Guidelines for medical treatment and its safety in the elderly"2016
Author(s)
Kojima T, Mizukami K, Tomita N, Arai H, Ohrui T, Eto M, Takeya Y, Isaka Y, Rakugi H, Sudo N, Arai H, Aoki H, Horie S, Ishii S, Iwasaki K, Takayama S, Suzuki Y, Matsui T, Mizokami F, Furuta K, Toba K, Akishita M
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Journal Title
Geriatrics and Gerontology International
Volume: 16
Issue: 9
Pages: 983-1001
DOI
Related Report
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[Journal Article] Suppressive Role of PPARγ-Regulated Endothelial Nitric Oxide Synthase in Adipocyte Lipolysis2015
Author(s)
Yamada Y, Eto M, Ito Y, Mochizuki S, Son BK, Ogawa S, Iijima K, Kaneki M, Kozaki K, Toba K, Akishita M, Ouchi Y
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Journal Title
PLoS One
Volume: 10
Issue: 8
Pages: e0136597-e0136597
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Eating alone as social disengagement is strongly associated with depressive symptoms in Japanese community-dwelling older adults2015
Author(s)
Kuroda A, Tanaka T, Hirano H, Ohara Y, Kikutani T, Furuya H, Obuchi SP, Kawai H, Ishii S, Akishita M, Tsuji T, Iijima K
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Journal Title
J Am Med Dir Assoc
Volume: 16
Issue: 7
Pages: 578-85
DOI
Related Report
Peer Reviewed
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