Development of anti-cancer agents targeting R-spondin-LGR4/5/6-ZNRF3/RNF43 axis

• Project/Area Number: 15H04806
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: The University of Tokyo
• Principal Investigator: Fujishiro Mitsuhiro 東京大学, 医学部附属病院, 准教授 (70396745)
• Co-Investigator(Kenkyū-buntansha): 池田 祐一 東京大学, 医学部附属病院, 特任准教授 (10744419) ; 熊谷 英敏 東京大学, 医学部附属病院, 特任助教 (20281008) ; 山下 裕玄 東京大学, 医学部附属病院, 講師 (50599397) ; 森田 啓行 東京大学, 医学部附属病院, 講師 (60323573) ; 浅岡 良成 東京大学, 医学部附属病院, 助教 (90431858)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000); Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
• Keywords: Wntシグナル / R-spondin / 抗癌剤 / 低分子化合物ライブラリー / 腸管幹細胞 / R-spondin代替え低分子化合物 / 内科 / 消化器内科 / 下部消化管

Outline of Final Research Achievements

Utilizing a novel assay system targeting R-spondin-LGR4/5/6-ZNRF3/RNF43 axis, we first screened a small-molecule compound library to elucidate the R-spondin inhibitors as the anti-cancer agents and the R-spondin substitutes as the stimulating factors of intestinal stem cells. As the results, 60 compounds for inhibitor and one compound for stimulator became the candidates.
As the succeeding analysis, the stimulator was confirmed to act through R-spondin-LGR4/5/6-ZNRF3/RNF43 axis, which indicated that the compound would be a promising seed of agents in the field of gastrointestinal regenerative medicine.

Research Products

• [Journal Article] Transparency-enhancing technology allows three-dimensional assessment of gastrointestinal mucosa: A porcine model. (2018)
  • Author(s): Mizutani H, Ono S, Ushiku T, Kudo Y, Ikemura M, Kageyama N, Yamamichi N, Fujishiro M, Someya T, Fukayama M, Koike K, Onodera H.
  • Journal Title: Pathology International Volume: 68 Issue: 2 Pages: 102-108
  • DOI: 10.1111/pin.12627
  • Peer Reviewed
• [Journal Article] Nine primary malignant neoplasms-involving the esophagus, stomach, colon, rectum, prostate, and external ear canal-without microsatellite instability: a case report (2018)
  • Author(s): Arakawa Keiichi、Hata Keisuke、Yamamoto Yoko、Nishikawa Takeshi、Tanaka Toshiaki、Kiyomatsu Tomomichi、Kawai Kazushige、Nozawa Hiroaki、Yoshida Masafumi、Fukuhara Hiroshi、Fujishiro Mitsuhiro、Morikawa Teppei、Yamasoba Tatsuya、Koike Kazuhiko、Fukayama Masashi、Watanabe Toshiaki
  • Journal Title: BMC Cancer Volume: 18 Issue: 1 Pages: 24-24
  • DOI: 10.1186/s12885-017-3973-2
  • Peer Reviewed
• [Journal Article] Sessile serrated adenoma detection rate is correlated with adenoma detection rate (2018)
  • Author(s): Ohki Daisuke、Tsuji Yosuke、Shinozaki Tomohiro、Sakaguchi Yoshiki、Minatsuki Chihiro、Kinoshita Hiroto、Niimi Keiko、Ono Satoshi、Hayakawa Yoku、Yoshida Shuntaro、Yamada Atsuo、Kodashima Shinya、Yamamichi Nobutake、Hirata Yoshihiro、Ushiku Tetsuo、Fujishiro Mitsuhiro、Fukayama Masashi、Koike Kazuhiko
  • Journal Title: World J Gastrointest Oncol Volume: 10 Issue: 3 Pages: 82-90
  • DOI: 10.4251/wjgo.v10.i3.82
  • Peer Reviewed / Open Access
• [Journal Article] A multicenter, randomized controlled trial comparing the identification rate of stigmata of recent hemorrhage and rebleeding rate between early and elective colonoscopy in outpatient-onset acute lower gastrointestinal bleeding: study protocol for a randomized controlled trial (2018)
  • Author(s): Niikura R, Nagata N, Yamada A, Doyama H, Shiratori Y, Nishida T, Kiyotoki S, Yada T, Fujita T, Sumiyoshi T, Hasatani K, Mikami T, Honda T, Mabe K, Hara K, Yamamoto K, Takeda M, Takata M, Tanaka M, Shinozaki T, Fujishiro M, Koike K
  • Journal Title: Trials Volume: 19 Issue: 1 Pages: 214-214
  • DOI: 10.1186/s13063-018-2558-y
  • Peer Reviewed / Open Access
• [Journal Article] Heart Failure as an Aging-Related Phenotype (2018)
  • Author(s): Morita Hiroyuki、Komuro Issei
  • Journal Title: International Heart Journal Volume: 59 Issue: 1 Pages: 6-13
  • DOI: 10.1536/ihj.17-519
  • NAID: 130006321414
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Genetic basis of cardiomyopathy and the genotypes involved in prognosis and left ventricular reverse remodeling (2018)
  • Author(s): Tobita T, Nomura S, Fujita T, Morita H, Asano Y, Onoue K, Ito M, Imai Y, Suzuki A, Ko T, Satoh M, Fujita K, Naito AT, Furutani Y, Toko H, Harada M, Amiya E, Hatano M, Takimoto E, Shiga T, Nakanishi T, Sakata Y, Ono M, Saito Y, Takashima S, Hagiwara N, Aburatani H, Komuro I.
  • Journal Title: Sci Rep Volume: 8 Issue: 1 Pages: 20114-20119
  • DOI: 10.1038/s41598-018-20114-9
  • Peer Reviewed / Open Access
• [Journal Article] Cardiac rehabilitation protects against the expansion of abdominal aortic aneurysm (2018)
  • Author(s): Nakayama A, Morita H, Nagayama M, Hoshina K, Uemura Y, Tomoike H, Komuro I.
  • Journal Title: Journal of the American Heart Association Volume: 7 Issue: 5 Pages: 5-12
  • DOI: 10.1161/jaha.117.007959
  • Peer Reviewed / Open Access
• [Journal Article] Low density neutrophils (LDN) in postoperative abdominal cavity assist the peritoneal recurrence through the production of neutrophil extracellular traps (NETs) (2018)
  • Author(s): Kanamaru Rihito、Ohzawa Hideyuki、Miyato Hideyo、Matsumoto Shiro、Haruta Hidenori、Kurashina Kentaro、Saito Shin、Hosoya Yoshinori、Yamaguchi Hironori、Yamashita Hiroharu、Seto Yasuyuki、Lefor Alan Kawarai、Sata Naohiro、Kitayama Joji
  • Journal Title: Sci Rep. Volume: 8 Issue: 1 Pages: 632-632
  • DOI: 10.1038/s41598-017-19091-2
  • Peer Reviewed / Open Access
• [Journal Article] Laparoscopic and endoscopic cooperative surgery for gastrointestinal tumor (2017)
  • Author(s): Niimi Keiko、Ishibashi Rei、Mitsui Takashi、Aikou Susumu、Kodashima Shinya、Yamashita Hiroharu、Yamamichi Nobutake、Hirata Yoshihiro、Fujishiro Mitsuhiro、Seto Yasuyuki、Koike Kazuhiko
  • Journal Title: Ann Transl Med Volume: 5 Issue: 8 Pages: 187-187
  • DOI: 10.21037/atm.2017.03.35
  • Peer Reviewed
• [Journal Article] Evaluation of endoscopic submucosal dissection using a new endosurgical knife DN-D2718B: a first clinical feasibility study. (2017)
  • Author(s): Sakaguchi Y, Tsuji Y, Fujishiro M, Kataoka Y, Saito I, Shichijo S, Minatsuki C, Asada-Hirayama I, Yamaguchi D, Niimi K, Ono S, Kodashima S, Yamamichi N, Koike K.
  • Journal Title: Endosc Int Open. Volume: 5 Issue: 07 Pages: E670-E674
  • DOI: 10.1055/s-0043-111720
  • Peer Reviewed
• [Journal Article] Associations between drugs and small-bowel mucosal bleeding: Multicenter capsule-endoscopy study (2017)
  • Author(s): Niikura Ryota、Yamada Atsuo、Maki Koutarou、Nakamura Masanao、Watabe Hirotsugu、Fujishiro Mitsuhiro、Oka Shiro、Esaki Motohiro、Fujimori Shunji、Nakajima Atsushi、Ohmiya Naoki、Matsumoto Takayuki、Tanaka Shinji、Koike Kazuhiko、Sakamoto Choitsu
  • Journal Title: Dig Endosc Volume: 30 Issue: 1 Pages: 79-89
  • DOI: 10.1111/den.12922
  • NAID: 130007519801
  • Peer Reviewed
• [Journal Article] Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis (2017)
  • Author(s): Yamada Atsuo、Niikura Ryota、Maki Koutarou、Nakamura Masanao、Watabe Hirotsugu、Fujishiro Mitsuhiro、Oka Shiro、Fujimori Shunji、Nakajima Atsushi、Ohmiya Naoki、Matsumoto Takayuki、Tanaka Shinji、Koike Kazuhiko、Sakamoto Choitsu
  • Journal Title: PLoS One Volume: 12 Issue: 8 Pages: e0182586-e0182586
  • DOI: 10.1371/journal.pone.0182586
  • Peer Reviewed
• [Journal Article] Design paper: Japan Endoscopy Database (JED): A prospective, large database project related to gastroenterological endoscopy in Japan (2017)
  • Author(s): Matsuda Koji、Tanaka Kiyohito、Fujishiro Mitsuhiro、Saito Yutaka、Ohtsuka Kazuo、Oda Ichiro、Katada Chikatoshi、Kato Masayuki、Kida Mitsuhiro、Kobayashi Kiyonori、Hoteya Shu、Horimatsu Takahiro、Kodashima Shinya、Matsuda Takahisa、Muto Manabu、Yamamoto Hironori、Ryozawa Shomei、Iwakiri Ryuichi、Kutsumi Hiromu、et al
  • Journal Title: Dig Endosc Volume: 30 Issue: 1 Pages: 5-19
  • DOI: 10.1111/den.12964
  • NAID: 130007498917
  • Peer Reviewed
• [Journal Article] First progress report on the Japan Endoscopy Database project (2017)
  • Author(s): Kodashima Shinya、Tanaka Kiyohito、Matsuda Koji、Fujishiro Mitsuhiro、Saito Yutaka、Ohtsuka Kazuo、Oda Ichiro、Katada Chikatoshi、Kato Masayuki、Kida Mitsuhiro、Kobayashi Kiyonori、Hoteya Shu、Horimatsu Takahiro、Matsuda Takahisa、Muto Manabu、Yamamoto Hironori、Ryozawa Shomei、Iwakiri Ryuichi、Kutsumi Hiromu、et al
  • Journal Title: Dig Endosc Volume: 30 Issue: 1 Pages: 20-28
  • DOI: 10.1111/den.12963
  • Peer Reviewed
• [Journal Article] Evaluation of image-enhanced endoscopic technology using advanced diagnostic endoscopy for the detection of early gastric cancer: a pilot study (2017)
  • Author(s): Yamaguchi Daisuke、Kodashima Shinya、Fujishiro Mitsuhiro、Ono Satoshi、Niimi Keiko、Mochizuki Satoshi、Tsuji Yosuke、Asada-Hirayama Itsuko、Sakaguchi Yoshiki、Shichijo Satoki、Minatsuki Chihiro、Yamamichi Nobutake、Koike Kazuhiko
  • Journal Title: Endosc Int Open Volume: 05 Issue: 09 Pages: C2-C2
  • DOI: 10.1055/s-0043-119930
  • Peer Reviewed
• [Journal Article] Is it possible to perform gastric endoscopic submucosal dissection without discontinuation of a single antiplatelet of thienopyridine derivatives? (2017)
  • Author(s): Ono Satoshi、Myojo Masahiro、Harada Hideaki、Tsuji Kunihiro、Murakami Daisuke、Suehiro Satoshi、Doyama Hisashi、Ando Jiro、Saito Itaru、Fujishiro Mitsuhiro、Komuro Issei、Koike Kazuhiko
  • Journal Title: Endosc Int Open Volume: 05 Issue: 09 Pages: E943-E949
  • DOI: 10.1055/s-0043-116381
  • Peer Reviewed
• [Journal Article] Colonoscopy reduces colorectal cancer mortality: A multicenter, long-term, colonoscopy-based cohort study (2017)
  • Author(s): Niikura Ryota、Hirata Yoshihiro、Suzuki Nobumi、Yamada Atsuo、Hayakawa Yoku、Suzuki Hirobumi、Yamamoto Shinzo、Nakata Ryo、Komatsu Junko、Okamoto Makoto、Kodaira Makoto、Shinozaki Tomohiro、Fujishiro Mitsuhiro、Watanabe Toshiaki、Koike Kazuhiko
  • Journal Title: PLoS One Volume: 12 Issue: 9 Pages: e0185294-e0185294
  • DOI: 10.1371/journal.pone.0185294
  • Peer Reviewed
• [Journal Article] Three novel BMPR2 mutations associated with advanced pulmonary arterial hypertension (2017)
  • Author(s): Hara Hironori、Takeda Norifumi、Morita Hiroyuki、Hatano Masaru、Amiya Eisuke、Maki Hisataka、Minatsuki Shun、Taki Mizuri、Shiraishi Yasuyuki、Fujiwara Takayuki、Maemura Sonoko、Komuro Issei
  • Journal Title: Human Genome Variation Volume: 4 Issue: 1 Pages: 17010-17010
  • DOI: 10.1038/hgv.2017.10
  • Peer Reviewed
• [Journal Article] A novel mutation of NFIX causes Sotos-like syndrome (Malan syndrome) complicated with thoracic aortic aneurysm and dissection (2017)
  • Author(s): Oshima Tsukasa、Hara Hironori、Takeda Norifumi、Hasumi Eriko、Kuroda Yukiko、Taniguchi Go、Inuzuka Ryo、Nawata Kan、Morita Hiroyuki、Komuro Issei
  • Journal Title: Human Genome Variation Volume: 4 Issue: 1 Pages: 17022-17022
  • DOI: 10.1038/hgv.2017.22
  • Peer Reviewed
• [Journal Article] Omega-3 Polyunsaturated Fatty Acid and Coronary Atherosclerotic Plaques (2017)
  • Author(s): Nakao Tomoko、Morita Hiroyuki
  • Journal Title: International Heart Journal Volume: 58 Issue: 6 Pages: 837-839
  • DOI: 10.1536/ihj.17-552
  • NAID: 130006251669
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Cost-Effectiveness Analysis of Cardiovascular Disease Treatment in Japan (2017)
  • Author(s): Kodera Satoshi、Kiyosue Arihiro、Ando Jiro、Akazawa Hiroshi、Morita Hiroyuki、Watanabe Masafumi、Komuro Issei
  • Journal Title: International Heart Journal Volume: 58 Issue: 6 Pages: 847-852
  • DOI: 10.1536/ihj.17-365
  • NAID: 130006251670
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed
• [Journal Article] Identification of MYLK3 mutations in familial dilated cardiomyopathy (2017)
  • Author(s): Tobita Takashige、Nomura Seitaro、Morita Hiroyuki、Ko Toshiyuki、Fujita Takanori、Toko Haruhiro、Uto Kenta、Hagiwara Nobuhisa、Aburatani Hiroyuki、Komuro Issei
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 17495-17495
  • DOI: 10.1038/s41598-017-17769-1
  • Peer Reviewed / Open Access
• [Journal Article] Authors' response to "Compound heterozygous Fukutin mutation-related non-compaction" by Finsterer and Zarrouk-Mahjoub. (2017)
  • Author(s): Amiya E, Morita H, Ishiura H, Tsuji S, Komuro I.
  • Journal Title: Int J Cardiol Volume: Apr 15 Pages: 233-233
  • DOI: 10.1016/j.ijcard.2017.01.107
  • Peer Reviewed
• [Journal Article] Gastric Cancer With Primitive Enterocyte Phenotype: An Aggressive Subgroup of Intestinal-type Adenocarcinoma. (2017)
  • Author(s): Yamazawa S, Ushiku T, Shinozaki-Ushiku A, Hayashi A, Iwasaki A, Abe H, Tagashira A, Yamashita H, Seto Y, Aburatani H, Fukayama M.
  • Journal Title: Am J Surg Pathol Volume: 41 Issue: 7 Pages: 989-997
  • DOI: 10.1097/pas.0000000000000869
  • Peer Reviewed / Open Access
• [Journal Article] Lymphogenous metastasis to the transverse colon that originated from signet-ring cell gastric cancer: A case report and review of the literature (2017)
  • Author(s): Sonoda Hirofumi、Kawai Kazushige、Yamaguchi Hironori、Murono Koji、Kaneko Manabu、Nishikawa Takeshi、Otani Kensuke、Sasaki Kazuhito、Yasuda Koji、Tanaka Toshiaki、Kiyomatsu Tomomichi、Hata Keisuke、Nozawa Hiroaki、Ishihara Soichiro、Aikou Susumu、Yamashita Hiroharu、et al.
  • Journal Title: Clin Res Hepatol Gastroenterol. Volume: 41 Issue: 6 Pages: e81-e86
  • DOI: 10.1016/j.clinre.2017.04.002
  • Peer Reviewed
• [Journal Article] Results of a nationwide questionnaire-based survey on nutrition management following gastric cancer resection in Japan (2017)
  • Author(s): Shimizu Nobuyuki、Hatao Fumihiko、Fukatsu Kazuhiko、Aikou Susumu、Yamagata Yukinori、Mori Kazuhiko、Yamashita Hiroharu、Nomura Sachiyo、Seto Yasuyuki
  • Journal Title: Surg Today. Volume: 47 Issue: 12 Pages: 1460-1468
  • DOI: 10.1007/s00595-017-1552-4
  • Peer Reviewed
• [Journal Article] Reply to: LODDS or negative to positive lymph nodes ratio? (2017)
  • Author(s): Yamashita Hiroharu、Deng Jingyu、Liang Han、Seto Yasuyuki
  • Journal Title: Surgery. Volume: 162 Issue: 5 Pages: 1190-1191
  • DOI: 10.1016/j.surg.2017.05.002
  • Peer Reviewed
• [Journal Article] Numeric pathologic lymph node classification shows prognostic superiority to topographic pN classification in esophageal squamous cell carcinoma (2017)
  • Author(s): Sugawara Kotaro、Yamashita Hiroharu、Uemura Yukari、Mitsui Takashi、Yagi Koichi、Nishida Masato、Aikou Susumu、Mori Kazuhiko、Nomura Sachiyo、Seto Yasuyuki
  • Journal Title: Surgery. Volume: 162 Issue: 4 Pages: 846-856
  • DOI: 10.1016/j.surg.2017.06.013
  • Peer Reviewed
• [Journal Article] Comparison of Prognostic Abilities Among Preoperative Laboratory Data Indices in Patients with Resectable Gastric and Esophagogastric Junction Adenocarcinoma (2017)
  • Author(s): Urabe Masayuki、Yamashita Hiroharu、Watanabe Toshiaki、Seto Yasuyuki
  • Journal Title: World J Surg. Volume: 42 Issue: 1 Pages: 185-194
  • DOI: 10.1007/s00268-017-4146-9
  • Peer Reviewed
• [Journal Article] A surgical case of radiotherapy induced esophageal perforation accompanying pyogenic spondylodiscitis: a case report (2017)
  • Author(s): Yoshimura Shuntaro、Mori Kazuhiko、Kawasaki Koichiro、Tanabe Asami、Aikou Susumu、Yagi Koichi、Nishida Masato、Yamashita Hiroharu、Nomura Sachiyo、Fukushima Masayoshi、Yamashita Hideomi、Yamauchi Yasuhiro、Seto Yasuyuki
  • Journal Title: Surgical Case Reports Volume: 3 Issue: 1 Pages: 1-5
  • DOI: 10.1186/s40792-017-0368-1
  • Peer Reviewed / Open Access
• [Journal Article] Feasibility of Laparoscopic Gastrectomy for Elderly Gastric Cancer Patients: Meta-analysis of Non-Randomised Controlled Studies. (2017)
  • Author(s): Zong L, Deng J, Wang J, Wu A, Wang J, Sun Z, Maeda M, Abe M, Wang W, Jiang Z, Seto Y and Ji J.
  • Journal Title: Oncotarget8(31):51878-51887 Volume: 8(31) Issue: 31 Pages: 51878-51887
  • DOI: 10.18632/oncotarget.16691
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Decrease in <i>PSCA</i> expression caused by <i>Helicobacter pylori</i> infection may promote progression to severe gastritis (2017)
  • Author(s): Toyoshima Osamu、Tanikawa Chizu、Yamamoto Ryuta、Watanabe Hidenobu、Yamashita Hiroharu、Sakitani Kosuke、Yoshida Shuntaro、Kubo Michiaki、Matsuo Keitaro、Ito Hidemi、Koike Kazuhiko、Seto Yasuyuki、Matsuda Koichi
  • Journal Title: Oncotarget. Volume: 9 Issue: 3 Pages: 3936-3945
  • DOI: 10.18632/oncotarget.23278
  • Peer Reviewed / Open Access
• [Journal Article] Detrimental effects of specific Periodontopathic bacterial infection on tachyarrhythmia compared to Bradyarrhythmia (2017)
  • Author(s): Aoyama Norio、Suzuki Jun-ichi、Kobayashi Naho、Hanatani Tomoya、Ashigaki Norihiko、Yoshida Asuka、Shiheido Yuka、Sato Hiroki、Kumagai Hidetoshi、Ikeda Yuichi、Akazawa Hiroshi、Komuro Issei、Minabe Masato、Izumi Yuichi、Isobe Mitsuaki
  • Journal Title: BMC Cardiovascular Disorders Volume: 17 Issue: 1 Pages: 267-267
  • DOI: 10.1186/s12872-017-0703-2
  • Peer Reviewed / Open Access
• [Journal Article] Specific periodontopathic bacterial infection affects hypertension in male cardiovascular disease patients (2017)
  • Author(s): Aoyama Norio、Suzuki Jun-ichi、Kumagai Hidetoshi、Ikeda Yuichi、Akazawa Hiroshi、Komuro Issei、Minabe Masato、Izumi Yuichi、Isobe Mitsuaki
  • Journal Title: Heart Vessels. Volume: 33 Issue: 2 Pages: 198-204
  • DOI: 10.1007/s00380-017-1042-z
  • Peer Reviewed
• [Journal Article] Periodontitis deteriorates peripheral arterial disease in Japanese population via enhanced systemic inflammation (2017)
  • Author(s): Aoyama N, Suzuki JI, Kobayashi N, Hanatani T, Ashigaki N, Yoshida A, Shiheido Y, Sato H, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Izumi Y, Isobe M
  • Journal Title: Heart Vessels Volume: 32 Issue: 11 Pages: 1314-1319
  • DOI: 10.1007/s00380-017-1003-6
  • Peer Reviewed
• [Journal Article] Generation and characterization of an antagonistic monoclonal antibody against an extracellular domain of mouse DP2 (CRTH2/GPR44) receptors for prostaglandin D2 (2017)
  • Author(s): Nagata N, Iwanari H, Kumagai H, Kusano-Arai O, Ikeda Y, Aritake K, Hamakubo T, Urade Y
  • Journal Title: PLoS One Volume: 12 Issue: 4 Pages: 0175452-0175452
  • DOI: 10.1371/journal.pone.0175452
  • NAID: 120007129138
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure. (2017)
  • Author(s): Kamo T, Akazawa H, Suda W, Saga-Kamo A, Shimizu Y, Yagi H, Liu Q, Nomura S, Naito AT, Takeda N, Harada M, Toko H, Kumagai H, Ikeda Y, Takimoto E, Suzuki JI, Honda K, Morita H, Hattori M, Komuro I.
  • Journal Title: PLoS One. Volume: 12 Issue: 3 Pages: 0174099-0174099
  • DOI: 10.1371/journal.pone.0174099
  • Peer Reviewed / Open Access
• [Journal Article] Role of Hormone-sensitive Lipase in Leptin-Promoted Fat Loss and Glucose Lowering (2017)
  • Author(s): Takanashi M, Taira Y, Okazaki S, Takase S, Kimura T, Li CC, Xu PF, Noda A, Sakata I, Kumagai H, Ikeda Y, Iizuka Y, Yahagi N, Shimano H, Osuga JI, Ishibashi S, Kadowaki T, Okazaki H
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 24 Issue: 11 Pages: 1105-1116
  • DOI: 10.5551/jat.39552
  • NAID: 130006191603
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Journal Article] A peptide vaccine targeting angiotensin II attenuates the cardiac dysfunction induced by myocardial infarction. (2017)
  • Author(s): Watanabe R, Suzuki JI, Wakayama K, Maejima Y, Shimamura M, Koriyama H, Nakagami H, Kumagai H, Ikeda Y, Akazawa H, Morishita R, Komuro I, Isobe M.
  • Journal Title: Sci Rep. Volume: 7 Issue: 1 Pages: 43920-43920
  • DOI: 10.1038/srep43920
  • Peer Reviewed / Open Access
• [Journal Article] A Periodontal pathogen Porphyromonas gingivalis deteriorates Isoproterenol-Induced myocardial remodeling in mice (2017)
  • Author(s): Sato H, Suzuki JI, Aoyama N, Watanabe R, Kaneko M, Shiheido Y, Yoshida A, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Isobe M, Izumi Y
  • Journal Title: Hypertens Res. Volume: 40 Issue: 1 Pages: 35-40
  • DOI: 10.1038/hr.2016.114
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Re-evaluating the prognostic validity of the negative to positive lymph node ratio in node-positive gastric cancer patients (2017)
  • Author(s): Yamashita Hiroharu、Deng Jingyu、Liang Han、Seto Yasuyuki
  • Journal Title: Surgery. Volume: 161 Issue: 6 Pages: 1588-1596
  • DOI: 10.1016/j.surg.2016.12.018
  • Peer Reviewed
• [Journal Article] How should we define the no. 3b lesser curvature lymph node? (2017)
  • Author(s): Yamashita Hiroharu、Yagi Koichi、Seto Yasuyuki
  • Journal Title: Gastric Cancer Volume: 20 Issue: 3 Pages: 558-559
  • DOI: 10.1007/s10120-016-0638-9
  • Peer Reviewed
• [Journal Article] High impact of methylation accumulation on metachronous gastric cancer: 5-year follow-up of a multicentre prospective cohort study. (2017)
  • Author(s): Maeda M, Nakajima T, Oda I, Shimazu T, Yamamichi N, Maekita T, Asada K, Yokoi C, Ando T, Yoshida T et al
  • Journal Title: GUT Volume: in press Issue: 9 Pages: 1721-1723
  • DOI: 10.1136/gutjnl-2016-313387
  • Peer Reviewed / Open Access
• [Journal Article] Periodontitis and myocardial hypertrophy (2017)
  • Author(s): Suzuki J, Sato H, Kaneko M, Yoshida A, Aoyama N, Akimoto S, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, IzumiY, Isobe M, Komuro I
  • Journal Title: Hypertens Res Volume: [Epub ahead of print] Issue: 4 Pages: 324-328
  • DOI: 10.1038/hr.2016.146
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Endoscopic gastric atrophy is strongly associated with gastric cancer development after Helicobacter pylori eradication (2017)
  • Author(s): O. Toyoshima, Y. Yamaji, S. Yoshida, S. Matsumoto, H. Yamashita, T. Kanazawa, K. Hata
  • Journal Title: Surg Endosc Volume: 31 Issue: 5 Pages: 2140-2148
  • DOI: 10.1007/s00464-016-5211-4
  • Peer Reviewed / Open Access
• [Journal Article] Overexpression and gene amplification of PD-L1 in cancer cells and PD-L1(+) immune cells in Epstein-Barr virus-associated gastric cancer: the prognostic implications. (2017)
  • Author(s): Saito R, Abe H, Kunita A, Yamashita H, Seto Y, Fukayama M
  • Journal Title: Mod Pathol Volume: 30 Issue: 3 Pages: 427-439
  • DOI: 10.1038/modpathol.2016.202
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Correct Diagnosis of Wild-Type Transthyretin-Related Amyloidosis Followed by the Introduction of a Novel Therapy in a Patient With Cardiac Wall Thickening of Unknown Cause (2017)
  • Author(s): Sawada N, Nakayama A, Takahashi M, Tanaka M, Morita H, Akazawa H, Komuro I.
  • Journal Title: International Heart Journal Volume: 58 Issue: 1 Pages: 147-150
  • DOI: 10.1536/ihj.16-224
  • NAID: 130005330526
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed
• [Journal Article] Pretreatment Neutrophil to Lymphocyte Ratio Independently Predicts Disease-specific Survival in Patients With Resectable Gastroesophageal Junction and Gastric Cancer (2016)
  • Author(s): M. Urabe, H. Yamashita, Y. Seto
  • Journal Title: Ann Surg Volume: - Issue: 6 Pages: e76-e77
  • DOI: 10.1097/sla.0000000000001596
  • Peer Reviewed
• [Journal Article] Guidelines for endoscopic managements of non-variceal upper gastrointestinal bleeding. (2016)
  • Author(s): Fujishiro M, Iguchi M, Kakushima N, Kato M, Sakata Y, Hoteya S, Kataoka M, Shimaoka S, Yahagi N, Fujimoto K.
  • Journal Title: Dig Endosc. Volume: 28 Issue: 4 Pages: 363-378
  • DOI: 10.1111/den.12639
  • Peer Reviewed / Open Access
• [Journal Article] Re-bleeding After Endoscopic Hemostasis for Peptic Ulcer Bleeding: Is eNough SAID or Are Other Factors Important? (2016)
  • Author(s): Fujishiro M, Ikeda Y.
  • Journal Title: Dig Dis Sci. Volume: 61 Issue: 6 Pages: 1424-1425
  • DOI: 10.1007/s10620-016-4098-1
  • Peer Reviewed
• [Journal Article] Successful closure of a large perforation during colorectal endoscopic submucosal dissection by application of polyglycolic acid sheets and fibrin glue. (2016)
  • Author(s): Sakaguchi Y, Tsuji Y, Yamamichi N, Fujishiro M, Koike K.
  • Journal Title: Gastrointest Endos. Volume: 84 Issue: 2 Pages: 374-375
  • DOI: 10.1016/j.gie.2016.03.787
  • Peer Reviewed
• [Journal Article] Registration Committee for Esophageal Cancer of the Japan Esophageal Society. Comprehensive Registry of Esophageal Cancer in Japan, 2009. (2016)
  • Author(s): Tachimori Y, Ozawa S, Numasaki H, Fujishiro M, Matsubara H, Oyama T, Shinoda M, Toh Y, Udagawa H, Uno T
  • Journal Title: Esophagus. Volume: 13 Issue: 2 Pages: 110-137
  • DOI: 10.1007/s10388-016-0531-y
  • Peer Reviewed / Open Access
• [Journal Article] Tumor Content Chart-Assisted HER2/CEP17 Digital PCR Analysis of Gastric Cancer Biopsy Specimens. (2016)
  • Author(s): Matsusaka K, Ishikawa S, Nakayama A, Ushiku T, Nishimoto A, Urabe M, Kaneko N, Kunita A, Kaneda A, Aburatani H, Fujishiro M, Seto Y, Fukayama M.
  • Journal Title: PLoS One Volume: 11 Issue: 4 Pages: e0154430-e0154430
  • DOI: 10.1371/journal.pone.0154430
  • Peer Reviewed / Open Access
• [Journal Article] Triamcinolone Injection and Shielding with Polyglycolic Acid Sheets and Fibrin Glue for Postoperative Stricture Prevention after Esophageal Endoscopic Resection: A Pilot Study. (2016)
  • Author(s): Sakaguchi Y, Tsuji Y, Fujishiro M, Kataoka Y, Takeuchi C, Yakabi S, Saito I, Shichijo S, Minatsuki C, Asada-Hirayama I, Yamaguchi D, Niimi K, Ono S, Kodashima S, Yamamichi N, Koike K.
  • Journal Title: Am J Gastroenterol. Volume: 111 Issue: 4 Pages: 581-583
  • DOI: 10.1038/ajg.2016.60
  • Peer Reviewed
• [Journal Article] Rapid and sensitive detection of early esophageal squamous cell carcinoma with fluorescence probe targeting dipeptidylpeptidase IV. (2016)
  • Author(s): Onoyama H, Kamiya M, Kuriki Y, Komatsu T, Abe H, Tsuji Y, Yagi K, Yamagata Y, Aikou S, Nishida M, Mori K, Yamashita H, Fujishiro M, Nomura S, Shimizu N, Fukayama M, Koike K, Urano Y, Seto Y
  • Journal Title: Sci Rep. Volume: 6 Issue: 1 Pages: 26399-26399
  • DOI: 10.1038/srep26399
  • Peer Reviewed / Open Access
• [Journal Article] Endoscopic ultrasound-guided fine-needle aspiration skill acquisition of gastrointestinal submucosal tumor by trainee endoscopists: A pilot study. (2016)
  • Author(s): Niimi K, Goto O, Kawakubo K, Nakai Y, Minatsuki C, Asada-Hirayama I, Mochizuki S, Ono S, Kodashima S, Yamamichi N, Isayama H, Fujishiro M, Koike K.
  • Journal Title: Endosc Ultrasound. Volume: 5 Issue: 3 Pages: 157-164
  • DOI: 10.4103/2303-9027.183970
  • Peer Reviewed / Open Access
• [Journal Article] Bleeding after endoscopic submucosal dissection: Risk factors and preventive methods. (2016)
  • Author(s): Kataoka Y, Tsuji Y, Sakaguchi Y, Minatsuki C, Asada-Hirayama I, Niimi K, Ono S, Kodashima S, Yamamichi N, Fujishiro M, Koike K
  • Journal Title: World J Gastroenterol. Volume: 22 Issue: 26 Pages: 5927-5935
  • DOI: 10.3748/wjg.v22.i26.5927
  • Peer Reviewed / Open Access
• [Journal Article] Congress report: Exchange of opinions in Tokyo, 2016 between Japan Gastroenterological Endoscopy Society (JGES) and counterparts from abroad. (2016)
  • Author(s): Fujishiro M, Yasuda I.
  • Journal Title: Dig Endosc. Volume: 28 Issue: 6 Pages: 642-644
  • DOI: 10.1111/den.12703
  • Peer Reviewed
• [Journal Article] Current Practices in the Management of Antithrombotic Therapy During the Periendoscopic Period for Patients With Cardiovascular Disease (2016)
  • Author(s): Ono S, Saito I, Ikeda Y, Fujishiro M, Komuro I, Koike K.
  • Journal Title: International Heart Journal Volume: 57 Issue: 5 Pages: 530-534
  • DOI: 10.1536/ihj.16-057
  • NAID: 130005266608
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Updated evidence on endoscopic resection of early gastric cancer from Japan. (2016)
  • Author(s): Fujishiro M, Yoshida S, Matsuda R, Narita A, Yamashita H, Seto Y.
  • Journal Title: Gastric Cancer. Volume: 20 Issue: S1 Pages: 39-44
  • DOI: 10.1007/s10120-016-0647-8
  • Peer Reviewed
• [Journal Article] Magnifying endoscopy with narrow-band imaging is more accurate for determination of horizontal extent of early gastric cancers than chromoendoscopy (2016)
  • Author(s): Asada-Hirayama Itsuko、Kodashima Shinya、Sakaguchi Yoshiki、Ono Satoshi、Niimi Keiko、Mochizuki Satoshi、Tsuji Yosuke、Minatsuki Chihiro、Shichijo Satoki、Matsuzaka Keisuke、Ushiku Tetsuo、Fukayama Masashi、Yamamichi Nobutake、Fujishiro Mitsuhiro、Koike Kazuhiko
  • Journal Title: Endosc Int Open. Volume: 04 Issue: 06 Pages: E690-E698
  • DOI: 10.1055/s-0042-107068
  • Peer Reviewed
• [Journal Article] Current state of practice for colonic diverticular bleeding in 37 hospitals in Japan: A multicenter questionnaire study (2016)
  • Author(s): Niikura Ryota、Nagata Naoyoshi、Doyama Hisashi、Ota Ryosuke、Ishii Naoki、Mabe Katsuhiro、Nishida Tsutomu、Hikichi Takuto、Sumiyama Kazuki、Nishikawa Jun、Uraoka Toshio、Kiyotoki Shu、Fujishiro Mitsuhiro、Koike Kazuhiko
  • Journal Title: World J Gastrointest Endosc. Volume: 8 Issue: 20 Pages: 785-785
  • DOI: 10.4253/wjge.v8.i20.785
  • Peer Reviewed
• [Journal Article] Safety and Effectiveness of Endovenous Laser Ablation Combined With Ligation for Severe Saphenous Varicose Veins in Japanese Patients (2016)
  • Author(s): Izumi M, Ikeda Y, Yamashita H, Asaoka Y, Fujishiro M, Shin M, Abo Y.
  • Journal Title: International Heart Journal Volume: 57 Issue: 1 Pages: 87-90
  • DOI: 10.1536/ihj.15-282
  • NAID: 130005120984
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Toll-like receptor 4 signaling has a critical role in Porphyromonas gingivalis-accelerated neointimal formation after arterial injury in mice. (2016)
  • Author(s): Kobayashi N, Suzuki JI, Aoyama N, Sato H, Akimoto S, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Izumi Y, Isobe M.
  • Journal Title: Hypertens Res Volume: 39 Issue: 10 Pages: 717-722
  • DOI: 10.1038/hr.2016.58
  • Peer Reviewed
• [Journal Article] Projections from single NUCB2/nesfatin-1 neuron in paraventricular nucleus to different brain regions involved in feeding (2016)
  • Author(s): Maejima Y, Kumamoto K, Takenoshita S, Shimomura K
  • Journal Title: Ｂｒａｉｎ Ｓｔｒｕｃｔｕｒｅ ａｎｄ Ｆｕｎｃｔｉｏｎ Volume: ｉｎ ｐｒｅｓｓ Pages: 123-137
  • DOI: 10.1016/j.yjmcc.2016.03.017
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Periodontitis May Deteriorate Sinus of Valsalva Dilatation in Marfan Syndrome Patients (2016)
  • Author(s): Suzuki J, Imai Y, Aoki M, Fujita D, Takeda N, Aoyama N, Wakayama K, Ikeda Y, Kumagai H, Akazawa H, Izumi Y, Isobe M, Komuro I, Hirata Y
  • Journal Title: International Heart Journal Volume: 57 Issue: 4 Pages: 456-460
  • DOI: 10.1536/ihj.15-395
  • NAID: 130006895913
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Understanding vascular diseases: Lessons from premature aging syndromes (2016)
  • Author(s): Ikeda Y, Kumagai H, Motozawa Y, Suzuki J, Akazawa H, Komuro I
  • Journal Title: Can J Cardiol Volume: 32 Issue: 5 Pages: 1-9
  • DOI: 10.1016/j.cjca.2015.12.003
  • Peer Reviewed
• [Journal Article] Growth Differentiation Factor 15 (GDF15) as a Reliable Biomarker for Cardiovascular Risk Assessment (2016)
  • Author(s): Ikeda Y1, Kumagai H, Motozawa Y, Suzuki J
  • Journal Title: International Heart Journal Volume: 57 Issue: 1 Pages: 1-2
  • DOI: 10.1536/ihj.15-324
  • NAID: 130005120988
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Early endoscopic management for early bowel obstruction after gastrectomy: a case report (2016)
  • Author(s): K. Higashizono, S. Aikou, K. Yagi, K. Mori, H. Yamashita, S. Nomura, Y. Seto
  • Journal Title: Surg Case Rep Volume: 2 Issue: 1 Pages: 35-35
  • DOI: 10.1186/s40792-016-0164-3
  • Peer Reviewed / Open Access
• [Journal Article] Radical esophagectomy for a 92-year-old woman with granulocyte colony-stimulating factor-producing esophageal squamous cell carcinoma: a case report. (2016)
  • Author(s): Kitani M, Yamagata Y, Tanabe A, Yagi K, Aikou S, Kiyokawa T, Nishida M, Yamashita H, Mori K, Nomura S, Seto Y.
  • Journal Title: World J Surg Oncol. Volume: 14 Issue: 1 Pages: 264-264
  • DOI: 10.1186/s12957-016-1023-1
  • Peer Reviewed / Open Access
• [Journal Article] Risk of metastasis in adenocarcinoma of the esophagus: a multicenter retrospective study in a Japanese population. (2016)
  • Author(s): Ishihara R, Oyama T, Terai S, Ozawa S, Kawano T, Seto Y et al.
  • Journal Title: J Gastroenterol. Volume: Oct 18. Issue: 7 Pages: 800-808
  • DOI: 10.1007/s00535-016-1275-0
  • Peer Reviewed
• [Journal Article] Increasing the Number of Examined Lymph Nodes is a Prerequisite for Improvement in the Accurate Evaluation of Overall Survival of Node-Negative Gastric Cancer Patients (2016)
  • Author(s): Deng Jingyu、Yamashita Hiroharu、Seto Yasuyuki、Liang Han
  • Journal Title: Ann Surg Oncol. Volume: 24 Issue: 3 Pages: 745-753
  • DOI: 10.1245/s10434-016-5513-8
  • Peer Reviewed
• [Journal Article] Results of a nation-wide retrospective study of lymphadenectomy for esophagogastric junction carcinoma (2016)
  • Author(s): Yamashita Hiroharu、On behalf of the Japanese Gastric Cancer Association and the Japan Esophageal Society、Seto Yasuyuki、Sano Takeshi、Makuuchi Hiroyasu、Ando Nobutoshi、Sasako Mitsuru
  • Journal Title: Gastric Cancer. Volume: 20 Issue: S1 Pages: 69-83
  • DOI: 10.1007/s10120-016-0663-8
  • Peer Reviewed
• [Journal Article] Surgery after intraperitoneal and systemic chemotherapy for gastric cancer with peritoneal metastasis or positive peritoneal cytology findings (2016)
  • Author(s): Ishigami Hironori、Yamaguchi Hironori、Yamashita Hiroharu、Asakage Masahiro、Kitayama Joji
  • Journal Title: Gastric Cancer. Volume: 20 Issue: S1 Pages: 128-134
  • DOI: 10.1007/s10120-016-0684-3
  • Peer Reviewed
• [Journal Article] The impact of direct-acting antivirals on early tumor recurrence after radiofrequency ablation in hepatitis C-related hepatocellular carcinoma. (2016)
  • Author(s): Minami T, Tateishi R, Nakagomi R, Fujiwara N, Sato M, Enooku K, Nakagawa H, Asaoka Y, Kondo Y, Shiina S, Koike K
  • Journal Title: J Hepatol. Volume: 65 Issue: 6 Pages: 1272-1273
  • DOI: 10.1016/j.jhep.2016.07.043
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion. (2016)
  • Author(s): Ikenoue T, Terakado Y, Nakagawa H, Hikiba Y, Fujii T, Matsubara D, Noguchi R, Zhu C, Yamamoto K, Kudo Y, Asaoka Y, Yamaguchi K, Ijichi H, Tateishi K, Fukushima N, Maeda S, Koike K, Furukawa Y
  • Journal Title: Sci Rep Volume: 印刷中 Issue: 1 Pages: 23899-23899
  • DOI: 10.1038/srep23899
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Utility of Cystatin C for Estimating Glomerular Filtration Rate in Patients With Muscular Dystrophy (2016)
  • Author(s): Kimura K, Morita H, Daimon M, Horio M, Kawata T, Nakao T, Hirokawa M, Kitao R, Watanabe D, Komori T, Nagata T, Takeda S, Komaki H, Segawa K, Nakajima T, Takenaka K, Komuro I
  • Journal Title: International Heart Journal Volume: 57 Issue: 3 Pages: 386-388
  • DOI: 10.1536/ihj.15-461
  • NAID: 130005153700
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Fukutin gene mutations that cause left ventricular noncompaction. (2016)
  • Author(s): Amiya E, Morita H, Hatano M, Nitta D, Hosoya Y, Maki H, Motozawa Y, Sato N, Ishiura H, Numakura S, Shintani Y, Kinugawa K, Takeda N, Shimizu J, Tsuji S, Komuro I.
  • Journal Title: International Journal of Cardiology Volume: 222 Pages: 727-729
  • DOI: 10.1016/j.ijcard.2016.08.011
  • Peer Reviewed
• [Journal Article] Heart failure complicated by alveolar hemorrhage due to vascular collapse and amyloid deposits in wild-type transthyretin amyloidosis. (2016)
  • Author(s): Kido Y, Takahashi M, Fukuma N, Kawata T, Tanaka A, Hayashi A, Shibahara J, Daimon M, Morita H, Akazawa H, Komuro I.
  • Journal Title: Cardiology Volume: 135 Issue: 4 Pages: 216-220
  • DOI: 10.1159/000446513
  • Peer Reviewed
• [Journal Article] Therapeutic Strategy for Heart Failure in Becker Muscular Dystrophy (2016)
  • Author(s): Kimura K, Morita H, Nakamura A, Takenaka K, Daimon M.
  • Journal Title: International Heart Journal Volume: 57 Issue: 5 Pages: 527-529
  • DOI: 10.1536/ihj.16-311
  • NAID: 130005266584
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] A strategy for genomic research on common cardiovascular diseases aiming at the realization of precision medicine; Personal insights and perspectives. (2016)
  • Author(s): Morita H, Komuro I.
  • Journal Title: Circ Res. Volume: 119 Pages: 900-903
  • Peer Reviewed
• [Journal Article] Neuromuscular Electrical Stimulation in Patients With Acute Myocardial Infarction (2016)
  • Author(s): Nakao T, Morita H.
  • Journal Title: International Heart Journal Volume: 57 Issue: 6 Pages: 659-660
  • DOI: 10.1536/ihj.16-498
  • NAID: 130005172026
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Impact of oral treatment on physical function in older patients hospitalized for heart failure: A randomized clinical trial. (2016)
  • Author(s): Ueda K, Kasao M, Shimamura M, Haruta H, Nitta S, Kaneko M, Uemura Y, Morita H, Komuro I, Shirai T.
  • Journal Title: PLoS ONE Volume: 11 Issue: 12 Pages: e0167933-e0167933
  • DOI: 10.1371/journal.pone.0167933
  • Peer Reviewed / Open Access
• [Journal Article] Low density of CD204-positive M2-type tumor-associated macrophages in Epstein-Barr virus-associated gastric cancer: a clinicopathologic study with digital image analysis (2016)
  • Author(s): T. Ichimura, H. Abe, T. Morikawa, H. Yamashita, S. Ishikawa, T. Ushiku, Y. Seto, M. Fukayama
  • Journal Title: Hum Pathol Volume: 56 Pages: 74-80
  • DOI: 10.1016/j.humpath.2016.06.002
  • Peer Reviewed
• [Journal Article] In Epstein-Barr virus-associated gastric carcinoma a high density of CD66b-positive tumor-associated neutrophils is associated with intestinal-type histology and low frequency of lymph node metastasis (2016)
  • Author(s): H. Abe, T. Morikawa, R. Saito, H. Yamashita, Y. Seto, M. Fukayama
  • Journal Title: Virchows Arch Volume: 468 Issue: 5 Pages: 539-548
  • DOI: 10.1007/s00428-016-1915-z
  • Peer Reviewed
• [Journal Article] Glucose metabolism in gastric cancer: The cutting-edge. (2016)
  • Author(s): Yuan LW, Yamashita H, Seto Y.
  • Journal Title: World J Gastroenterol. Volume: 22 Issue: 6 Pages: 2046-2059
  • DOI: 10.3748/wjg.v22.i6.2046
  • Peer Reviewed / Open Access
• [Journal Article] Is the transthoracic approach no longer a viable option for Siewert type II esophagogastric junction carcinoma? (2016)
  • Author(s): Yamashita H, Seto Y.
  • Journal Title: Translational Gastroenterology and Hepatology Volume: 1 Pages: 14-14
  • Peer Reviewed
• [Journal Article] Current therapies and investigational drugs for peripheral arterial disease (2016)
  • Author(s): Suzuki J, Shimamura M, Suda H, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Isobe M, Komuro I, Morishita R
  • Journal Title: Hypertens Res Volume: 39 Issue: 4 Pages: 183-191
  • DOI: 10.1038/hr.2015.134
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Angiotensin II receptor blocker irbesartan attenuates cardiac dysfunction induced by myocardial infarction in the presence of renal failure (2016)
  • Author(s): Watanabe R, Suzuki J, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Isobe M
  • Journal Title: Hypertens Res Volume: 39 Issue: 4 Pages: 237-244
  • DOI: 10.1038/hr.2015.141
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Comparative analysis of upper gastrointestinal endoscopy, double-contrast upper gastrointestinal barium X-ray radiography, and the titer of serum anti-Helicobacter pylori IgG focusing on the diagnosis of atrophic gastritis. (2016)
  • Author(s): Yamamichi N, Hirano C, Takahashi Y, Minatsuki C, Nakayama C, Matsuda R, Shimamoto T, Takeuchi C, Kodashima S, Ono S, Tsuji Y, Fujishiro M, Wada R, Mitsushima T, Koike K.
  • Journal Title: Gastric Cancer. Volume: 19 Issue: 2 Pages: 670-675
  • DOI: 10.1007/s10120-015-0515-y
  • NAID: 40020836534
  • Peer Reviewed
• [Journal Article] Guidelines for endoscopic submucosal dissection and endoscopic mucosal resection for early gastric cancer. (2016)
  • Author(s): Ono H, Yao K, Fujishiro M, Oda I, Nimura S, Yahagi N, Iishi H, Oka M, Ajioka Y, Ichinose M, Matsui T.
  • Journal Title: Dig Endosc. Volume: 28 Issue: 1 Pages: 3-15
  • DOI: 10.1111/den.12518
  • Peer Reviewed
• [Journal Article] Efficacy of lymph node dissection for each station based on esophageal tumor location. (2016)
  • Author(s): Tachimori Y, Ozawa S, Numasaki H, Fujishiro M, MatsubaraH, Oyama T, Shinoda M, Toh Y, Udagawa H, Uno T, The Registration Committee for Esophageal Cancer of the Japan Esophageal Society.
  • Journal Title: Esophagus. Volume: 13 Pages: 1-7
  • NAID: 40020807806
  • Peer Reviewed / Open Access
• [Journal Article] Flow Cytometric Quantification of Intraperitoneal Free Tumor Cells is a Useful Biomarker in Gastric Cancer Patients with Peritoneal Metastasis. (2015)
  • Author(s): Kitayama J, Emoto S, Yamaguchi H, Ishigami H, Onoyama H, Yamashita H, Seto Y, Matsuzaki K, Watanabe T.
  • Journal Title: Ann Surg Oncol. Volume: 22(7) Issue: 7 Pages: 2336-42
  • DOI: 10.1245/s10434-014-4238-9
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Phosphatidylserine-specific phospholipase A1 (PS-PLA1) expression in colorectal cancer correlates with tumor invasion and hematogenous metastasis. (2015)
  • Author(s): Iida Y, Sunami E, Yamashita H, Hiyoshi M, Ishihara S, Yamaguchi H, Inoue A, Makide K, Tsuno NH, Aoki J, Kitayama J, Watanabe T.
  • Journal Title: Anticancer Res. Volume: 35 Pages: 1459-1464
  • Peer Reviewed
• [Journal Article] Solitary fibrous tumor of the greater omentum, mimicking gastrointestinal stromal tumor of the small intestine: a case report. (2015)
  • Author(s): Urabe M, Yamagata Y, Aikou S, Mori K, Yamashita H, Nomura S, Shibahara J, Fukayama M, Seto Y.
  • Journal Title: Int Surg. Volume: 100 Issue: 5 Pages: 836-840
  • DOI: 10.9738/intsurg-d-14-00141.1
  • Peer Reviewed
• [Journal Article] Evaluation of 18F-FDG uptake for detecting lymph node metastasis of gastric cancer: a prospective pilot study for one-to-one comparison of radiation dose and pathological findings. (2015)
  • Author(s): Okumura Y, Aikou S, Onoyama H, Jinbo K, Yamagata Y, Mori K, Yamashita H, Nomura S, Takahashi M, Koyama K, Momose T, Abe H, Matsusaka K, Ushiku T, Fukayama M, Seto Y.
  • Journal Title: World J Surg Oncol. Volume: 13 Issue: 1 Pages: 327-327
  • DOI: 10.1186/s12957-015-0743-y
  • Peer Reviewed / Open Access
• [Journal Article] PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. (2015)
  • Author(s): Asaoka Y, Ijichi H, Koike K.
  • Journal Title: N Engl J Med. Volume: 373 Issue: 20 Pages: 1979-1979
  • DOI: 10.1056/nejmc1510353
  • Peer Reviewed
• [Journal Article] Serum Alpha-Fetoprotein Has High Specificity for the Early Detection of Hepatocellular Carcinoma After Hepatitis C Virus Eradication in Patients. (2015)
  • Author(s): Minami T, Tateishi R, Kondo M, Nakagomi R, Fujiwara N, Sato M, Uchino K, Enooku K, Nakagawa H, Asaoka Y, Kondo Y, Moriya K, Shiina S, Koike K.
  • Journal Title: Medicine (Baltimore). Volume: 94 Issue: 23 Pages: e901-e901
  • DOI: 10.1097/md.0000000000000901
  • Peer Reviewed / Open Access
• [Journal Article] Sarcopenia, Intramuscular Fat Deposition, and Visceral Adiposity Independently Predict the Outcomes of Hepatocellular Carcinoma (2015)
  • Author(s): Fujiwara N, Nakagawa H, Kudo Y, Tateishi R, Taguri M, Watadani T, Nakagomi R, Kondo M, Nakatsuka T, Minami T, Sato M, Uchino K, Enooku K, Kondo Y, Asaoka Y, Tanaka Y, Ohtomo K, Shiina S, Koike K
  • Journal Title: J Hepatol Volume: 62 Issue: 1 Pages: 131-140
  • DOI: 10.1016/j.jhep.2015.02.031
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Validation of the Japanese version of HFS-14, a disease-specific quality of life scale for patients suffering from hand-foot syndrome. (2015)
  • Author(s): Mikoshiba N, Yamamoto-Mitani N, Sato K, Asaoka Y, Ohki T, Ohata M, Miyashita M.
  • Journal Title: Support Care Cancer. Volume: 23 Issue: 9 Pages: 2739-2745
  • DOI: 10.1007/s00520-015-2638-4
  • Peer Reviewed
• [Journal Article] Comparison of improved prognosis between hepatitis B- and hepatitis C-related hepatocellular carcinoma. (2015)
  • Author(s): Minami T, Tateishi R, Shiina S, Nakagomi R, Kondo M, Fujiwara N, Mikami S, Sato M, Uchino K, Enooku K, Nakagawa H, Asaoka Y, Kondo Y, Yoshida H, Koike K.
  • Journal Title: Hepatol Res. Volume: epub Issue: 10
  • DOI: 10.1111/hepr.12468
  • Peer Reviewed
• [Journal Article] Neuromedin S-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms. (2015)
  • Author(s): Lee IT, Chang AS, Manandhar M, Shan Y, Fan J, Izumo M, Ikeda Y, Motoike T, Dixon S, Seinfeld JE, Takahashi JS, Yanagisawa M
  • Journal Title: Neuron Volume: 85 Issue: 5 Pages: 1086-1102
  • DOI: 10.1016/j.neuron.2015.02.006
  • Peer Reviewed / Open Access
• [Journal Article] Toward further prevention of bleeding after gastric endoscopic submucosal dissection. (2015)
  • Author(s): Mochizuki S, Ikeda Y, Arai T, Matsuo K
  • Journal Title: Dig Endosc. Volume: 27 Issue: 3 Pages: 295-297
  • DOI: 10.1111/den.12441
  • Peer Reviewed
• [Journal Article] Recent clinical management of antithrombotic agents for gastrointestinal endoscopy after revision of guidelines in Japan. (2015)
  • Author(s): Ono S, Fujishiro M, Ikeda Y, Komuro I, Koike K
  • Journal Title: Dig Endosc. Volume: 27 Issue: 6 Pages: 649-656
  • DOI: 10.1111/den.12498
  • Peer Reviewed
• [Journal Article] Quantitative measurement of GPCR endocytosis via pulse-chase covalent labeling (2015)
  • Author(s): Kumagai H, Ikeda Y, Motozawa Y, Fujishiro M, Okamura T, Fujio K, Okazaki H, Nomura S, Takeda N, Harada M, Toko H, Takimoto E, Akazawa H, Morita H, Suzuki J, Yamazaki T, Yamamoto K, Komuro I, Yanagisawa M
  • Journal Title: PLoS One Volume: 10 Issue: 5 Pages: e0129394-e0129394
  • DOI: 10.1371/journal.pone.0129394
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Monitoring beta-arrestin recruitment via beta-lactamase enzyme fragment complementation: purification of peptide E as a low-affinity ligand for mammalian bombesin receptors (2015)
  • Author(s): Ikeda Y*, Kumagai H*, Okazaki H, Fujishiro M, Motozawa Y, Nomura S, Takeda N, Toko H, Takimoto E, Akazawa H, Morita H, Suzuki J, Yamazaki T, Komuro I, Yanagisawa M (co-first author)
  • Journal Title: PLoS One Volume: 10 Issue: 6 Pages: e0127445-e0127445
  • DOI: 10.1371/journal.pone.0127445
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] SH2B1: a new player in the regulation of cardiac hypertrophic response in failing hearts. (2015)
  • Author(s): Ikeda Y, Takimoto E, Komuro I
  • Journal Title: Cardiovasc Res. Volume: 107 Issue: 2 Pages: 197-199
  • DOI: 10.1093/cvr/cvv172
  • Peer Reviewed
• [Journal Article] Acute Myocardial Infarction That Resulted From Poor Adherence to Medical Treatment for Giant Coronary Aneurysm (2015)
  • Author(s): Motozawa Y, Uozumi H, Maemura S, Nakata R, Yamamoto K, Takizawa M, Kumagai H, Ikeda Y, Komuro I, Ikenouchi H
  • Journal Title: International Heart Journal Volume: 56 Issue: 5 Pages: 551-554
  • DOI: 10.1536/ihj.15-155
  • NAID: 130005102122
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Biased Agonism of the Angiotensin II Type I Receptor (2015)
  • Author(s): Ikeda Y*, Kumagai H*, Motozawa Y*, Suzuki J, Komuro I (co-first author)
  • Journal Title: International Heart Journal Volume: 56 Issue: 5 Pages: 485-488
  • DOI: 10.1536/ihj.15-256
  • NAID: 130005102121
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] A food-derived flavonoid luteolin protects against angiotensin II-induced cardiac remodeling (2015)
  • Author(s): Nakayama A, Morita H, Nakao T, Yamaguchi T, Sumida T, Ikeda Y, Kumagai H, Motozawa Y, Takahashi T, Imaizumi A, Hashimoto T, Nagai R, Komuro I
  • Journal Title: PLoS One Volume: 10 Issue: 9 Pages: e0137106-e0137106
  • DOI: 10.1371/journal.pone.0137106
  • Peer Reviewed / Open Access
• [Journal Article] Next Generation ARBs (2015)
  • Author(s): Ikeda Y, Kumagai H, Motozawa Y, Suzuki J, Komuro I
  • Journal Title: International Heart Journal Volume: 56 Issue: 6 Pages: 585-586
  • DOI: 10.1536/ihj.15-295
  • NAID: 130005113065
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Polyglycolic acid sheets and fibrin glue decrease the risk of bleeding after endoscopic submucosal dissection of gastric neoplasms (with video). (2015)
  • Author(s): Tsuji Y, Fujishiro M, Kodashima S, Ono S, Niimi K, Mochizuki S, Asada-Hirayama I, Matsuda R, Minatsuki C, Nakayama C, Takahashi Y, Sakaguchi Y, Yamamichi N, Koike K.
  • Journal Title: Gastrointest Endosc. Volume: 81 Issue: 4 Pages: 906-912
  • DOI: 10.1016/j.gie.2014.08.028
  • Peer Reviewed
• [Journal Article] Polyglycolic acid sheets with fibrin glue can prevent esophageal stricture after endoscopic submucosal dissection. (2015)
  • Author(s): Sakaguchi Y, Tsuji Y, Ono S, Saito I, Kataoka Y, Takahashi Y, Nakayama C, Shichijo S, Matsuda R, Minatsuki C, Asada-Hirayama I, Niimi K, Kodashima S, Yamamichi N, Fujishiro M, Koike K.
  • Journal Title: Endoscopy. Volume: 47 Issue: 04 Pages: 336-340
  • DOI: 10.1055/s-0034-1390787
  • Peer Reviewed
• [Journal Article] Thienopyridine derivatives as risk factors for bleeding following high risk endoscopic treatments: Safe Treatment on Antiplatelets (STRAP) study. (2015)
  • Author(s): Ono S, Fujishiro M, Yoshida N, Doyama H, Kamoshida T, Hirai S, Kishihara T, Yamamoto Y, Sakae H, Imagawa A, Hirano M, Koike K.
  • Journal Title: Endoscopy Volume: 47 Issue: 07 Pages: 632-637
  • DOI: 10.1055/s-0034-1391354
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease: a large-scale cross-sectional study in Japan. (2015)
  • Author(s): Okushin K, Takahashi Y, Yamamichi N, Shimamoto T, Enooku K, Fujinaga H, Tsutsumi T, Shintani Y, Sakaguchi Y, Ono S, Kodashima S, Fujishiro M, Moriya K, Yotsuyanagi H, Mitsushima T, Koike K.
  • Journal Title: BMC Gastroenterol. Volume: 15 Issue: 1 Pages: 247-247
  • DOI: 10.1186/s12876-015-0247-9
  • Peer Reviewed / Open Access
• [Journal Article] Trend and risk factors of diverticulosis in Japan: age, gender, and lifestyle/metabolic-related factors may cooperatively affect on the colorectal diverticula formation. (2015)
  • Author(s): Yamamichi N, Shimamoto T, Takahashi Y, Sakaguchi Y, Kakimoto H, Matsuda R, Kataoka Y, Saito I, Tsuji Y, Yakabi S, Takeuchi C, Minatsuki C, Niimi K, Asada-Hirayama I, Nakayama C, Ono S, Kodashima S, Yamaguchi D, Fujishiro M, Yamaji Y, Wada R, Mitsushima T, Koike K.
  • Journal Title: PLoS One. Volume: 10 Issue: 4 Pages: e0123688-e0123688
  • DOI: 10.1371/journal.pone.0123688
  • Peer Reviewed / Open Access
• [Journal Article] Long-term efficacy and safety of rabeprazole in patients taking low-dose aspirin with a history of peptic ulcers: a phase 2/3, randomized, parallel-group, multicenter, extension clinical trial (2015)
  • Author(s): Fujishiro M, Higuchi K, Kato M, Kinoshita Y, Iwakiri R, Watanabe T, Takeuchi T, Sugisaki N, Okada Y, Ogawa H, Arakawa T, Fujimoto K
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 56 Issue: 3 Pages: 228-239
  • DOI: 10.3164/jcbn.15-1
  • NAID: 130005068182
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed / Open Access
• [Journal Article] Foam plombage: a novel technique for optimal fixation of polyglycolic acid sheets positioned using "clip and pull" after esophageal endoscopic submucosal dissection. (2015)
  • Author(s): Ono S, Sakaguchi Y, Tsuji Y, Kodashima S, Yamamichi N, Fujishiro M, Koike K
  • Journal Title: Endoscopy. Volume: 47 Issue: S 01 Pages: E435-E436
  • DOI: 10.1055/s-0034-1392612
  • Peer Reviewed
• [Journal Article] Preventing esophageal stricture after endoscopic submucosal dissection: steroid injection and shielding with polyglycolic acid sheets and fibrin glue. (2015)
  • Author(s): Kataoka Y, Tsuji Y, Sakaguchi Y, Kodashima S, Yamamichi N, Fujishiro M, Koike K.
  • Journal Title: Endoscopy. Volume: 47 Issue: S 01 Pages: E473-E474
  • DOI: 10.1055/s-0034-1392975
  • Peer Reviewed
• [Journal Article] Outcome of salvage surgery for colorectal cancer initially treated by upfront endoscopic therapy. (2015)
  • Author(s): Nozawa H, Ishihara S, Fujishiro M, Kodashima S, Ohtani K, Yasuda K, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Kazama S, Sunami E, Kitayama J, Watanabe T.
  • Journal Title: Surgery Volume: 159 Issue: 3 Pages: 713-20
  • DOI: 10.1016/j.surg.2015.09.008
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Comprehensive Registry of Esophageal Cancer in Japan, 2007 (2015)
  • Author(s): Tachimori Y, Ozawa S, Numasaki H, Fujishiro M, MatsubaraH, Oyama T, Shinoda M, Toh Y, Udagawa H, Uno T, The Registration Committee for Esophageal Cancer of the Japan Esophageal Society.
  • Journal Title: Esophagus. Volume: 12 Pages: 101-129
  • Peer Reviewed
• [Journal Article] Comprehensive Registry of Esophageal Cancer in Japan, 2008 (2015)
  • Author(s): Tachimori Y, Ozawa S, Numasaki H, Fujishiro M, MatsubaraH, Oyama T, Shinoda M, Toh Y, Udagawa H, Uno T, The Registration Committee for Esophageal Cancer of the Japan Esophageal Society.
  • Journal Title: Esophagus. Volume: 12 Pages: 130-157
  • Peer Reviewed
• [Journal Article] Video of the Month: A Novel Endoscopic Full-Thickness Resection for Early Gastric Cancer. (2015)
  • Author(s): Niimi K, Aikou S, Kodashima S, Yagi K, Oya S, Yamaguchi D, Yamashita H, Yamamichi N, Fujishiro M, Koike K, Seto Y.
  • Journal Title: Am J Gastroenterol. Volume: 110 Issue: 11 Pages: 1535-1535
  • DOI: 10.1038/ajg.2015.226
  • Peer Reviewed