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Development of anti-cancer agents targeting R-spondin-LGR4/5/6-ZNRF3/RNF43 axis

Research Project

Project/Area Number 15H04806
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionThe University of Tokyo

Principal Investigator

Fujishiro Mitsuhiro  東京大学, 医学部附属病院, 准教授 (70396745)

Co-Investigator(Kenkyū-buntansha) 池田 祐一  東京大学, 医学部附属病院, 特任准教授 (10744419)
熊谷 英敏  東京大学, 医学部附属病院, 特任助教 (20281008)
山下 裕玄  東京大学, 医学部附属病院, 講師 (50599397)
森田 啓行  東京大学, 医学部附属病院, 講師 (60323573)
浅岡 良成  東京大学, 医学部附属病院, 助教 (90431858)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
KeywordsWntシグナル / R-spondin / 抗癌剤 / 低分子化合物ライブラリー / 腸管幹細胞 / R-spondin代替え低分子化合物 / 内科 / 消化器内科 / 下部消化管
Outline of Final Research Achievements

Utilizing a novel assay system targeting R-spondin-LGR4/5/6-ZNRF3/RNF43 axis, we first screened a small-molecule compound library to elucidate the R-spondin inhibitors as the anti-cancer agents and the R-spondin substitutes as the stimulating factors of intestinal stem cells. As the results, 60 compounds for inhibitor and one compound for stimulator became the candidates.
As the succeeding analysis, the stimulator was confirmed to act through R-spondin-LGR4/5/6-ZNRF3/RNF43 axis, which indicated that the compound would be a promising seed of agents in the field of gastrointestinal regenerative medicine.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (123 results)

All 2018 2017 2016 2015

All Journal Article (123 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 123 results,  Open Access: 54 results,  Acknowledgement Compliant: 13 results)

  • [Journal Article] Transparency-enhancing technology allows three-dimensional assessment of gastrointestinal mucosa: A porcine model.2018

    • Author(s)
      Mizutani H, Ono S, Ushiku T, Kudo Y, Ikemura M, Kageyama N, Yamamichi N, Fujishiro M, Someya T, Fukayama M, Koike K, Onodera H.
    • Journal Title

      Pathology International

      Volume: 68 Issue: 2 Pages: 102-108

    • DOI

      10.1111/pin.12627

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nine primary malignant neoplasms-involving the esophagus, stomach, colon, rectum, prostate, and external ear canal-without microsatellite instability: a case report2018

    • Author(s)
      Arakawa Keiichi、Hata Keisuke、Yamamoto Yoko、Nishikawa Takeshi、Tanaka Toshiaki、Kiyomatsu Tomomichi、Kawai Kazushige、Nozawa Hiroaki、Yoshida Masafumi、Fukuhara Hiroshi、Fujishiro Mitsuhiro、Morikawa Teppei、Yamasoba Tatsuya、Koike Kazuhiko、Fukayama Masashi、Watanabe Toshiaki
    • Journal Title

      BMC Cancer

      Volume: 18 Issue: 1 Pages: 24-24

    • DOI

      10.1186/s12885-017-3973-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sessile serrated adenoma detection rate is correlated with adenoma detection rate2018

    • Author(s)
      Ohki Daisuke、Tsuji Yosuke、Shinozaki Tomohiro、Sakaguchi Yoshiki、Minatsuki Chihiro、Kinoshita Hiroto、Niimi Keiko、Ono Satoshi、Hayakawa Yoku、Yoshida Shuntaro、Yamada Atsuo、Kodashima Shinya、Yamamichi Nobutake、Hirata Yoshihiro、Ushiku Tetsuo、Fujishiro Mitsuhiro、Fukayama Masashi、Koike Kazuhiko
    • Journal Title

      World J Gastrointest Oncol

      Volume: 10 Issue: 3 Pages: 82

    • DOI

      10.4251/wjgo.v10.i3.82

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A multicenter, randomized controlled trial comparing the identification rate of stigmata of recent hemorrhage and rebleeding rate between early and elective colonoscopy in outpatient-onset acute lower gastrointestinal bleeding: study protocol for a randomized controlled trial2018

    • Author(s)
      Niikura R, Nagata N, Yamada A, Doyama H, Shiratori Y, Nishida T, Kiyotoki S, Yada T, Fujita T, Sumiyoshi T, Hasatani K, Mikami T, Honda T, Mabe K, Hara K, Yamamoto K, Takeda M, Takata M, Tanaka M, Shinozaki T, Fujishiro M, Koike K
    • Journal Title

      Trials

      Volume: 19 Issue: 1 Pages: 214-214

    • DOI

      10.1186/s13063-018-2558-y

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heart Failure as an Aging-Related Phenotype2018

    • Author(s)
      Morita Hiroyuki、Komuro Issei
    • Journal Title

      International Heart Journal

      Volume: 59 Issue: 1 Pages: 6-13

    • DOI

      10.1536/ihj.17-519

    • NAID

      130006321414

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic basis of cardiomyopathy and the genotypes involved in prognosis and left ventricular reverse remodeling2018

    • Author(s)
      Tobita T, Nomura S, Fujita T, Morita H, Asano Y, Onoue K, Ito M, Imai Y, Suzuki A, Ko T, Satoh M, Fujita K, Naito AT, Furutani Y, Toko H, Harada M, Amiya E, Hatano M, Takimoto E, Shiga T, Nakanishi T, Sakata Y, Ono M, Saito Y, Takashima S, Hagiwara N, Aburatani H, Komuro I.
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 20114-20119

    • DOI

      10.1038/s41598-018-20114-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardiac rehabilitation protects against the expansion of abdominal aortic aneurysm2018

    • Author(s)
      Nakayama A, Morita H, Nagayama M, Hoshina K, Uemura Y, Tomoike H, Komuro I.
    • Journal Title

      Journal of the American Heart Association

      Volume: 7 Issue: 5 Pages: 5-12

    • DOI

      10.1161/jaha.117.007959

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Low density neutrophils (LDN) in postoperative abdominal cavity assist the peritoneal recurrence through the production of neutrophil extracellular traps (NETs)2018

    • Author(s)
      Kanamaru Rihito、Ohzawa Hideyuki、Miyato Hideyo、Matsumoto Shiro、Haruta Hidenori、Kurashina Kentaro、Saito Shin、Hosoya Yoshinori、Yamaguchi Hironori、Yamashita Hiroharu、Seto Yasuyuki、Lefor Alan Kawarai、Sata Naohiro、Kitayama Joji
    • Journal Title

      Sci Rep.

      Volume: 8 Issue: 1 Pages: 632-632

    • DOI

      10.1038/s41598-017-19091-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Laparoscopic and endoscopic cooperative surgery for gastrointestinal tumor2017

    • Author(s)
      Niimi Keiko、Ishibashi Rei、Mitsui Takashi、Aikou Susumu、Kodashima Shinya、Yamashita Hiroharu、Yamamichi Nobutake、Hirata Yoshihiro、Fujishiro Mitsuhiro、Seto Yasuyuki、Koike Kazuhiko
    • Journal Title

      Ann Transl Med

      Volume: 5 Issue: 8 Pages: 187-187

    • DOI

      10.21037/atm.2017.03.35

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of endoscopic submucosal dissection using a new endosurgical knife DN-D2718B: a first clinical feasibility study.2017

    • Author(s)
      Sakaguchi Y, Tsuji Y, Fujishiro M, Kataoka Y, Saito I, Shichijo S, Minatsuki C, Asada-Hirayama I, Yamaguchi D, Niimi K, Ono S, Kodashima S, Yamamichi N, Koike K.
    • Journal Title

      Endosc Int Open.

      Volume: 5 Issue: 07 Pages: E670-E674

    • DOI

      10.1055/s-0043-111720

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Associations between drugs and small-bowel mucosal bleeding: Multicenter capsule-endoscopy study2017

    • Author(s)
      Niikura Ryota、Yamada Atsuo、Maki Koutarou、Nakamura Masanao、Watabe Hirotsugu、Fujishiro Mitsuhiro、Oka Shiro、Esaki Motohiro、Fujimori Shunji、Nakajima Atsushi、Ohmiya Naoki、Matsumoto Takayuki、Tanaka Shinji、Koike Kazuhiko、Sakamoto Choitsu
    • Journal Title

      Dig Endosc

      Volume: 30 Issue: 1 Pages: 79-89

    • DOI

      10.1111/den.12922

    • NAID

      130007519801

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis2017

    • Author(s)
      Yamada Atsuo、Niikura Ryota、Maki Koutarou、Nakamura Masanao、Watabe Hirotsugu、Fujishiro Mitsuhiro、Oka Shiro、Fujimori Shunji、Nakajima Atsushi、Ohmiya Naoki、Matsumoto Takayuki、Tanaka Shinji、Koike Kazuhiko、Sakamoto Choitsu
    • Journal Title

      PLoS One

      Volume: 12 Issue: 8 Pages: e0182586-e0182586

    • DOI

      10.1371/journal.pone.0182586

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design paper: Japan Endoscopy Database (JED): A prospective, large database project related to gastroenterological endoscopy in Japan2017

    • Author(s)
      Matsuda Koji、Tanaka Kiyohito、Fujishiro Mitsuhiro、Saito Yutaka、Ohtsuka Kazuo、Oda Ichiro、Katada Chikatoshi、Kato Masayuki、Kida Mitsuhiro、Kobayashi Kiyonori、Hoteya Shu、Horimatsu Takahiro、Kodashima Shinya、Matsuda Takahisa、Muto Manabu、Yamamoto Hironori、Ryozawa Shomei、Iwakiri Ryuichi、Kutsumi Hiromu、et al
    • Journal Title

      Dig Endosc

      Volume: 30 Issue: 1 Pages: 5

    • DOI

      10.1111/den.12964

    • NAID

      130007498917

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] First progress report on the Japan Endoscopy Database project2017

    • Author(s)
      Kodashima Shinya、Tanaka Kiyohito、Matsuda Koji、Fujishiro Mitsuhiro、Saito Yutaka、Ohtsuka Kazuo、Oda Ichiro、Katada Chikatoshi、Kato Masayuki、Kida Mitsuhiro、Kobayashi Kiyonori、Hoteya Shu、Horimatsu Takahiro、Matsuda Takahisa、Muto Manabu、Yamamoto Hironori、Ryozawa Shomei、Iwakiri Ryuichi、Kutsumi Hiromu、et al
    • Journal Title

      Dig Endosc

      Volume: 30 Issue: 1 Pages: 20

    • DOI

      10.1111/den.12963

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of image-enhanced endoscopic technology using advanced diagnostic endoscopy for the detection of early gastric cancer: a pilot study2017

    • Author(s)
      Yamaguchi Daisuke、Kodashima Shinya、Fujishiro Mitsuhiro、Ono Satoshi、Niimi Keiko、Mochizuki Satoshi、Tsuji Yosuke、Asada-Hirayama Itsuko、Sakaguchi Yoshiki、Shichijo Satoki、Minatsuki Chihiro、Yamamichi Nobutake、Koike Kazuhiko
    • Journal Title

      Endosc Int Open

      Volume: 05 Issue: 09 Pages: C2-C2

    • DOI

      10.1055/s-0043-119930

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Is it possible to perform gastric endoscopic submucosal dissection without discontinuation of a single antiplatelet of thienopyridine derivatives?2017

    • Author(s)
      Ono Satoshi、Myojo Masahiro、Harada Hideaki、Tsuji Kunihiro、Murakami Daisuke、Suehiro Satoshi、Doyama Hisashi、Ando Jiro、Saito Itaru、Fujishiro Mitsuhiro、Komuro Issei、Koike Kazuhiko
    • Journal Title

      Endosc Int Open

      Volume: 05 Issue: 09 Pages: E943-E949

    • DOI

      10.1055/s-0043-116381

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Colonoscopy reduces colorectal cancer mortality: A multicenter, long-term, colonoscopy-based cohort study2017

    • Author(s)
      Niikura Ryota、Hirata Yoshihiro、Suzuki Nobumi、Yamada Atsuo、Hayakawa Yoku、Suzuki Hirobumi、Yamamoto Shinzo、Nakata Ryo、Komatsu Junko、Okamoto Makoto、Kodaira Makoto、Shinozaki Tomohiro、Fujishiro Mitsuhiro、Watanabe Toshiaki、Koike Kazuhiko
    • Journal Title

      PLoS One

      Volume: 12 Issue: 9 Pages: e0185294-e0185294

    • DOI

      10.1371/journal.pone.0185294

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three novel BMPR2 mutations associated with advanced pulmonary arterial hypertension2017

    • Author(s)
      Hara Hironori、Takeda Norifumi、Morita Hiroyuki、Hatano Masaru、Amiya Eisuke、Maki Hisataka、Minatsuki Shun、Taki Mizuri、Shiraishi Yasuyuki、Fujiwara Takayuki、Maemura Sonoko、Komuro Issei
    • Journal Title

      Human Genome Variation

      Volume: 4 Issue: 1 Pages: 17010-17010

    • DOI

      10.1038/hgv.2017.10

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel mutation of NFIX causes Sotos-like syndrome (Malan syndrome) complicated with thoracic aortic aneurysm and dissection2017

    • Author(s)
      Oshima Tsukasa、Hara Hironori、Takeda Norifumi、Hasumi Eriko、Kuroda Yukiko、Taniguchi Go、Inuzuka Ryo、Nawata Kan、Morita Hiroyuki、Komuro Issei
    • Journal Title

      Human Genome Variation

      Volume: 4 Issue: 1 Pages: 17022-17022

    • DOI

      10.1038/hgv.2017.22

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Omega-3 Polyunsaturated Fatty Acid and Coronary Atherosclerotic Plaques2017

    • Author(s)
      Nakao Tomoko、Morita Hiroyuki
    • Journal Title

      International Heart Journal

      Volume: 58 Issue: 6 Pages: 837-839

    • DOI

      10.1536/ihj.17-552

    • NAID

      130006251669

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cost-Effectiveness Analysis of Cardiovascular Disease Treatment in Japan2017

    • Author(s)
      Kodera Satoshi、Kiyosue Arihiro、Ando Jiro、Akazawa Hiroshi、Morita Hiroyuki、Watanabe Masafumi、Komuro Issei
    • Journal Title

      International Heart Journal

      Volume: 58 Issue: 6 Pages: 847-852

    • DOI

      10.1536/ihj.17-365

    • NAID

      130006251670

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of MYLK3 mutations in familial dilated cardiomyopathy2017

    • Author(s)
      Tobita Takashige、Nomura Seitaro、Morita Hiroyuki、Ko Toshiyuki、Fujita Takanori、Toko Haruhiro、Uto Kenta、Hagiwara Nobuhisa、Aburatani Hiroyuki、Komuro Issei
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 17495-17495

    • DOI

      10.1038/s41598-017-17769-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Authors' response to "Compound heterozygous Fukutin mutation-related non-compaction" by Finsterer and Zarrouk-Mahjoub.2017

    • Author(s)
      Amiya E, Morita H, Ishiura H, Tsuji S, Komuro I.
    • Journal Title

      Int J Cardiol

      Volume: Apr 15 Pages: 233-233

    • DOI

      10.1016/j.ijcard.2017.01.107

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gastric Cancer With Primitive Enterocyte Phenotype: An Aggressive Subgroup of Intestinal-type Adenocarcinoma.2017

    • Author(s)
      Yamazawa S, Ushiku T, Shinozaki-Ushiku A, Hayashi A, Iwasaki A, Abe H, Tagashira A, Yamashita H, Seto Y, Aburatani H, Fukayama M.
    • Journal Title

      Am J Surg Pathol

      Volume: 41 Issue: 7 Pages: 989-997

    • DOI

      10.1097/pas.0000000000000869

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lymphogenous metastasis to the transverse colon that originated from signet-ring cell gastric cancer: A case report and review of the literature2017

    • Author(s)
      Sonoda Hirofumi、Kawai Kazushige、Yamaguchi Hironori、Murono Koji、Kaneko Manabu、Nishikawa Takeshi、Otani Kensuke、Sasaki Kazuhito、Yasuda Koji、Tanaka Toshiaki、Kiyomatsu Tomomichi、Hata Keisuke、Nozawa Hiroaki、Ishihara Soichiro、Aikou Susumu、Yamashita Hiroharu、et al.
    • Journal Title

      Clin Res Hepatol Gastroenterol.

      Volume: 41 Issue: 6 Pages: e81-e86

    • DOI

      10.1016/j.clinre.2017.04.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Results of a nationwide questionnaire-based survey on nutrition management following gastric cancer resection in Japan2017

    • Author(s)
      Shimizu Nobuyuki、Hatao Fumihiko、Fukatsu Kazuhiko、Aikou Susumu、Yamagata Yukinori、Mori Kazuhiko、Yamashita Hiroharu、Nomura Sachiyo、Seto Yasuyuki
    • Journal Title

      Surg Today.

      Volume: 47 Issue: 12 Pages: 1460-1468

    • DOI

      10.1007/s00595-017-1552-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reply to: LODDS or negative to positive lymph nodes ratio?2017

    • Author(s)
      Yamashita Hiroharu、Deng Jingyu、Liang Han、Seto Yasuyuki
    • Journal Title

      Surgery.

      Volume: 162 Issue: 5 Pages: 1190-1191

    • DOI

      10.1016/j.surg.2017.05.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Numeric pathologic lymph node classification shows prognostic superiority to topographic pN classification in esophageal squamous cell carcinoma2017

    • Author(s)
      Sugawara Kotaro、Yamashita Hiroharu、Uemura Yukari、Mitsui Takashi、Yagi Koichi、Nishida Masato、Aikou Susumu、Mori Kazuhiko、Nomura Sachiyo、Seto Yasuyuki
    • Journal Title

      Surgery.

      Volume: 162 Issue: 4 Pages: 846-856

    • DOI

      10.1016/j.surg.2017.06.013

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of Prognostic Abilities Among Preoperative Laboratory Data Indices in Patients with Resectable Gastric and Esophagogastric Junction Adenocarcinoma2017

    • Author(s)
      Urabe Masayuki、Yamashita Hiroharu、Watanabe Toshiaki、Seto Yasuyuki
    • Journal Title

      World J Surg.

      Volume: 42 Issue: 1 Pages: 185-194

    • DOI

      10.1007/s00268-017-4146-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A surgical case of radiotherapy induced esophageal perforation accompanying pyogenic spondylodiscitis: a case report2017

    • Author(s)
      Yoshimura Shuntaro、Mori Kazuhiko、Kawasaki Koichiro、Tanabe Asami、Aikou Susumu、Yagi Koichi、Nishida Masato、Yamashita Hiroharu、Nomura Sachiyo、Fukushima Masayoshi、Yamashita Hideomi、Yamauchi Yasuhiro、Seto Yasuyuki
    • Journal Title

      Surgical Case Reports

      Volume: 3 Issue: 1 Pages: 1-5

    • DOI

      10.1186/s40792-017-0368-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Feasibility of Laparoscopic Gastrectomy for Elderly Gastric Cancer Patients: Meta-analysis of Non-Randomised Controlled Studies.2017

    • Author(s)
      Zong L, Deng J, Wang J, Wu A, Wang J, Sun Z, Maeda M, Abe M, Wang W, Jiang Z, Seto Y and Ji J.
    • Journal Title

      Oncotarget8(31):51878-51887

      Volume: 8(31) Issue: 31 Pages: 51878-51887

    • DOI

      10.18632/oncotarget.16691

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Decrease in <i>PSCA</i> expression caused by <i>Helicobacter pylori</i> infection may promote progression to severe gastritis2017

    • Author(s)
      Toyoshima Osamu、Tanikawa Chizu、Yamamoto Ryuta、Watanabe Hidenobu、Yamashita Hiroharu、Sakitani Kosuke、Yoshida Shuntaro、Kubo Michiaki、Matsuo Keitaro、Ito Hidemi、Koike Kazuhiko、Seto Yasuyuki、Matsuda Koichi
    • Journal Title

      Oncotarget.

      Volume: 9 Issue: 3 Pages: 3936-3945

    • DOI

      10.18632/oncotarget.23278

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detrimental effects of specific Periodontopathic bacterial infection on tachyarrhythmia compared to Bradyarrhythmia2017

    • Author(s)
      Aoyama Norio、Suzuki Jun-ichi、Kobayashi Naho、Hanatani Tomoya、Ashigaki Norihiko、Yoshida Asuka、Shiheido Yuka、Sato Hiroki、Kumagai Hidetoshi、Ikeda Yuichi、Akazawa Hiroshi、Komuro Issei、Minabe Masato、Izumi Yuichi、Isobe Mitsuaki
    • Journal Title

      BMC Cardiovascular Disorders

      Volume: 17 Issue: 1 Pages: 267-267

    • DOI

      10.1186/s12872-017-0703-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Specific periodontopathic bacterial infection affects hypertension in male cardiovascular disease patients2017

    • Author(s)
      Aoyama Norio、Suzuki Jun-ichi、Kumagai Hidetoshi、Ikeda Yuichi、Akazawa Hiroshi、Komuro Issei、Minabe Masato、Izumi Yuichi、Isobe Mitsuaki
    • Journal Title

      Heart Vessels.

      Volume: 33 Issue: 2 Pages: 198-204

    • DOI

      10.1007/s00380-017-1042-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Periodontitis deteriorates peripheral arterial disease in Japanese population via enhanced systemic inflammation2017

    • Author(s)
      Aoyama N, Suzuki JI, Kobayashi N, Hanatani T, Ashigaki N, Yoshida A, Shiheido Y, Sato H, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Izumi Y, Isobe M
    • Journal Title

      Heart Vessels

      Volume: 32 Issue: 11 Pages: 1314-1319

    • DOI

      10.1007/s00380-017-1003-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation and characterization of an antagonistic monoclonal antibody against an extracellular domain of mouse DP2 (CRTH2/GPR44) receptors for prostaglandin D22017

    • Author(s)
      Nagata N, Iwanari H, Kumagai H, Kusano-Arai O, Ikeda Y, Aritake K, Hamakubo T, Urade Y
    • Journal Title

      PLoS One

      Volume: 12 Issue: 4 Pages: 0175452-0175452

    • DOI

      10.1371/journal.pone.0175452

    • NAID

      120007129138

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure.2017

    • Author(s)
      Kamo T, Akazawa H, Suda W, Saga-Kamo A, Shimizu Y, Yagi H, Liu Q, Nomura S, Naito AT, Takeda N, Harada M, Toko H, Kumagai H, Ikeda Y, Takimoto E, Suzuki JI, Honda K, Morita H, Hattori M, Komuro I.
    • Journal Title

      PLoS One.

      Volume: 12 Issue: 3 Pages: 0174099-0174099

    • DOI

      10.1371/journal.pone.0174099

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of Hormone-sensitive Lipase in Leptin-Promoted Fat Loss and Glucose Lowering2017

    • Author(s)
      Takanashi M, Taira Y, Okazaki S, Takase S, Kimura T, Li CC, Xu PF, Noda A, Sakata I, Kumagai H, Ikeda Y, Iizuka Y, Yahagi N, Shimano H, Osuga JI, Ishibashi S, Kadowaki T, Okazaki H
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 24 Issue: 11 Pages: 1105-1116

    • DOI

      10.5551/jat.39552

    • NAID

      130006191603

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A peptide vaccine targeting angiotensin II attenuates the cardiac dysfunction induced by myocardial infarction.2017

    • Author(s)
      Watanabe R, Suzuki JI, Wakayama K, Maejima Y, Shimamura M, Koriyama H, Nakagami H, Kumagai H, Ikeda Y, Akazawa H, Morishita R, Komuro I, Isobe M.
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 43920-43920

    • DOI

      10.1038/srep43920

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Periodontal pathogen Porphyromonas gingivalis deteriorates Isoproterenol-Induced myocardial remodeling in mice2017

    • Author(s)
      Sato H, Suzuki JI, Aoyama N, Watanabe R, Kaneko M, Shiheido Y, Yoshida A, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Isobe M, Izumi Y
    • Journal Title

      Hypertens Res.

      Volume: 40 Issue: 1 Pages: 35-40

    • DOI

      10.1038/hr.2016.114

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Re-evaluating the prognostic validity of the negative to positive lymph node ratio in node-positive gastric cancer patients2017

    • Author(s)
      Yamashita Hiroharu、Deng Jingyu、Liang Han、Seto Yasuyuki
    • Journal Title

      Surgery.

      Volume: 161 Issue: 6 Pages: 1588-1596

    • DOI

      10.1016/j.surg.2016.12.018

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] How should we define the no. 3b lesser curvature lymph node?2017

    • Author(s)
      Yamashita Hiroharu、Yagi Koichi、Seto Yasuyuki
    • Journal Title

      Gastric Cancer

      Volume: 20 Issue: 3 Pages: 558-559

    • DOI

      10.1007/s10120-016-0638-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High impact of methylation accumulation on metachronous gastric cancer: 5-year follow-up of a multicentre prospective cohort study.2017

    • Author(s)
      Maeda M, Nakajima T, Oda I, Shimazu T, Yamamichi N, Maekita T, Asada K, Yokoi C, Ando T, Yoshida T et al
    • Journal Title

      GUT

      Volume: in press Issue: 9 Pages: 1721-1723

    • DOI

      10.1136/gutjnl-2016-313387

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Periodontitis and myocardial hypertrophy2017

    • Author(s)
      Suzuki J, Sato H, Kaneko M, Yoshida A, Aoyama N, Akimoto S, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, IzumiY, Isobe M, Komuro I
    • Journal Title

      Hypertens Res

      Volume: [Epub ahead of print] Issue: 4 Pages: 324-328

    • DOI

      10.1038/hr.2016.146

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Endoscopic gastric atrophy is strongly associated with gastric cancer development after Helicobacter pylori eradication2017

    • Author(s)
      O. Toyoshima, Y. Yamaji, S. Yoshida, S. Matsumoto, H. Yamashita, T. Kanazawa, K. Hata
    • Journal Title

      Surg Endosc

      Volume: 31 Issue: 5 Pages: 2140-2148

    • DOI

      10.1007/s00464-016-5211-4

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Overexpression and gene amplification of PD-L1 in cancer cells and PD-L1(+) immune cells in Epstein-Barr virus-associated gastric cancer: the prognostic implications.2017

    • Author(s)
      Saito R, Abe H, Kunita A, Yamashita H, Seto Y, Fukayama M
    • Journal Title

      Mod Pathol

      Volume: 30 Issue: 3 Pages: 427-439

    • DOI

      10.1038/modpathol.2016.202

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Correct Diagnosis of Wild-Type Transthyretin-Related Amyloidosis Followed by the Introduction of a Novel Therapy in a Patient With Cardiac Wall Thickening of Unknown Cause2017

    • Author(s)
      Sawada N, Nakayama A, Takahashi M, Tanaka M, Morita H, Akazawa H, Komuro I.
    • Journal Title

      International Heart Journal

      Volume: 58 Issue: 1 Pages: 147-150

    • DOI

      10.1536/ihj.16-224

    • NAID

      130005330526

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pretreatment Neutrophil to Lymphocyte Ratio Independently Predicts Disease-specific Survival in Patients With Resectable Gastroesophageal Junction and Gastric Cancer2016

    • Author(s)
      M. Urabe, H. Yamashita, Y. Seto
    • Journal Title

      Ann Surg

      Volume: - Issue: 6 Pages: e76-e77

    • DOI

      10.1097/sla.0000000000001596

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Guidelines for endoscopic managements of non-variceal upper gastrointestinal bleeding.2016

    • Author(s)
      Fujishiro M, Iguchi M, Kakushima N, Kato M, Sakata Y, Hoteya S, Kataoka M, Shimaoka S, Yahagi N, Fujimoto K.
    • Journal Title

      Dig Endosc.

      Volume: 28 Issue: 4 Pages: 363-378

    • DOI

      10.1111/den.12639

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Re-bleeding After Endoscopic Hemostasis for Peptic Ulcer Bleeding: Is eNough SAID or Are Other Factors Important?2016

    • Author(s)
      Fujishiro M, Ikeda Y.
    • Journal Title

      Dig Dis Sci.

      Volume: 61 Issue: 6 Pages: 1424-1425

    • DOI

      10.1007/s10620-016-4098-1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful closure of a large perforation during colorectal endoscopic submucosal dissection by application of polyglycolic acid sheets and fibrin glue.2016

    • Author(s)
      Sakaguchi Y, Tsuji Y, Yamamichi N, Fujishiro M, Koike K.
    • Journal Title

      Gastrointest Endos.

      Volume: 84 Issue: 2 Pages: 374-375

    • DOI

      10.1016/j.gie.2016.03.787

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Registration Committee for Esophageal Cancer of the Japan Esophageal Society. Comprehensive Registry of Esophageal Cancer in Japan, 2009.2016

    • Author(s)
      Tachimori Y, Ozawa S, Numasaki H, Fujishiro M, Matsubara H, Oyama T, Shinoda M, Toh Y, Udagawa H, Uno T
    • Journal Title

      Esophagus.

      Volume: 13 Issue: 2 Pages: 110-137

    • DOI

      10.1007/s10388-016-0531-y

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tumor Content Chart-Assisted HER2/CEP17 Digital PCR Analysis of Gastric Cancer Biopsy Specimens.2016

    • Author(s)
      Matsusaka K, Ishikawa S, Nakayama A, Ushiku T, Nishimoto A, Urabe M, Kaneko N, Kunita A, Kaneda A, Aburatani H, Fujishiro M, Seto Y, Fukayama M.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 4 Pages: e0154430-e0154430

    • DOI

      10.1371/journal.pone.0154430

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Triamcinolone injection and shielding with polyglycolic acid sheets and fibrin glue for postoperative stricture prevention after esophageal endoscopic resection: A pilot study2016

    • Author(s)
      Sakaguchi Y, Tsuji Y, Fujishiro M, Kataoka Y, Takeuchi C, Yakabi S, Saito I, Shichijo S, Minatsuki C, Asada-Hirayama I, Yamaguchi D, Niimi K, Ono S, Kodashima S, Yamamichi N, Koike K.
    • Journal Title

      Am J Gastroenterol.

      Volume: 111 Issue: 4 Pages: 581

    • DOI

      10.1038/ajg.2016.60

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid and sensitive detection of early esophageal squamous cell carcinoma with fluorescence probe targeting dipeptidylpeptidase IV.2016

    • Author(s)
      Onoyama H, Kamiya M, Kuriki Y, Komatsu T, Abe H, Tsuji Y, Yagi K, Yamagata Y, Aikou S, Nishida M, Mori K, Yamashita H, Fujishiro M, Nomura S, Shimizu N, Fukayama M, Koike K, Urano Y, Seto Y
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 26399-26399

    • DOI

      10.1038/srep26399

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endoscopic ultrasound-guided fine-needle aspiration skill acquisition of gastrointestinal submucosal tumor by trainee endoscopists: A pilot study2016

    • Author(s)
      Niimi K, Goto O, Kawakubo K, Nakai Y, Minatsuki C, Asada-Hirayama I, Mochizuki S, Ono S, Kodashima S, Yamamichi N, Isayama H, Fujishiro M, Koike K.
    • Journal Title

      Endosc Ultrasound.

      Volume: 5 Issue: 3 Pages: 157

    • DOI

      10.4103/2303-9027.183970

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bleeding after endoscopic submucosal dissection: Risk factors and preventive methods2016

    • Author(s)
      Kataoka Y, Tsuji Y, Sakaguchi Y, Minatsuki C, Asada-Hirayama I, Niimi K, Ono S, Kodashima S, Yamamichi N, Fujishiro M, Koike K
    • Journal Title

      World J Gastroenterol.

      Volume: 22 Issue: 26 Pages: 5927

    • DOI

      10.3748/wjg.v22.i26.5927

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Congress report: Exchange of opinions in Tokyo, 2016 between Japan Gastroenterological Endoscopy Society (JGES) and counterparts from abroad.2016

    • Author(s)
      Fujishiro M, Yasuda I.
    • Journal Title

      Dig Endosc.

      Volume: 28 Issue: 6 Pages: 642-644

    • DOI

      10.1111/den.12703

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current Practices in the Management of Antithrombotic Therapy During the Periendoscopic Period for Patients With Cardiovascular Disease2016

    • Author(s)
      Ono S, Saito I, Ikeda Y, Fujishiro M, Komuro I, Koike K.
    • Journal Title

      International Heart Journal

      Volume: 57 Issue: 5 Pages: 530-534

    • DOI

      10.1536/ihj.16-057

    • NAID

      130005266608

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Updated evidence on endoscopic resection of early gastric cancer from Japan.2016

    • Author(s)
      Fujishiro M, Yoshida S, Matsuda R, Narita A, Yamashita H, Seto Y.
    • Journal Title

      Gastric Cancer.

      Volume: 20 Issue: S1 Pages: 39-44

    • DOI

      10.1007/s10120-016-0647-8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Magnifying endoscopy with narrow-band imaging is more accurate for determination of horizontal extent of early gastric cancers than chromoendoscopy2016

    • Author(s)
      Asada-Hirayama Itsuko、Kodashima Shinya、Sakaguchi Yoshiki、Ono Satoshi、Niimi Keiko、Mochizuki Satoshi、Tsuji Yosuke、Minatsuki Chihiro、Shichijo Satoki、Matsuzaka Keisuke、Ushiku Tetsuo、Fukayama Masashi、Yamamichi Nobutake、Fujishiro Mitsuhiro、Koike Kazuhiko
    • Journal Title

      Endosc Int Open.

      Volume: 04 Issue: 06 Pages: E690-E698

    • DOI

      10.1055/s-0042-107068

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current state of practice for colonic diverticular bleeding in 37 hospitals in Japan: A multicenter questionnaire study2016

    • Author(s)
      Niikura Ryota、Nagata Naoyoshi、Doyama Hisashi、Ota Ryosuke、Ishii Naoki、Mabe Katsuhiro、Nishida Tsutomu、Hikichi Takuto、Sumiyama Kazuki、Nishikawa Jun、Uraoka Toshio、Kiyotoki Shu、Fujishiro Mitsuhiro、Koike Kazuhiko
    • Journal Title

      World J Gastrointest Endosc.

      Volume: 8 Issue: 20 Pages: 785-785

    • DOI

      10.4253/wjge.v8.i20.785

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Safety and Effectiveness of Endovenous Laser Ablation Combined With Ligation for Severe Saphenous Varicose Veins in Japanese Patients2016

    • Author(s)
      Izumi M, Ikeda Y, Yamashita H, Asaoka Y, Fujishiro M, Shin M, Abo Y.
    • Journal Title

      International Heart Journal

      Volume: 57 Issue: 1 Pages: 87-90

    • DOI

      10.1536/ihj.15-282

    • NAID

      130005120984

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Toll-like receptor 4 signaling has a critical role in Porphyromonas gingivalis-accelerated neointimal formation after arterial injury in mice.2016

    • Author(s)
      Kobayashi N, Suzuki JI, Aoyama N, Sato H, Akimoto S, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Izumi Y, Isobe M.
    • Journal Title

      Hypertens Res

      Volume: 39 Issue: 10 Pages: 717-722

    • DOI

      10.1038/hr.2016.58

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Projections from single NUCB2/nesfatin-1 neuron in paraventricular nucleus to different brain regions involved in feeding2016

    • Author(s)
      Maejima Y, Kumamoto K, Takenoshita S, Shimomura K
    • Journal Title

      Brain Structure and Function

      Volume: in press Pages: 123-137

    • DOI

      10.1016/j.yjmcc.2016.03.017

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Periodontitis May Deteriorate Sinus of Valsalva Dilatation in Marfan Syndrome Patients2016

    • Author(s)
      Suzuki J, Imai Y, Aoki M, Fujita D, Takeda N, Aoyama N, Wakayama K, Ikeda Y, Kumagai H, Akazawa H, Izumi Y, Isobe M, Komuro I, Hirata Y
    • Journal Title

      International Heart Journal

      Volume: 57 Issue: 4 Pages: 456-460

    • DOI

      10.1536/ihj.15-395

    • NAID

      130006895913

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Understanding vascular diseases: Lessons from premature aging syndromes2016

    • Author(s)
      Ikeda Y, Kumagai H, Motozawa Y, Suzuki J, Akazawa H, Komuro I
    • Journal Title

      Can J Cardiol

      Volume: 32 Issue: 5 Pages: 1-9

    • DOI

      10.1016/j.cjca.2015.12.003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth Differentiation Factor 15 (GDF15) as a Reliable Biomarker for Cardiovascular Risk Assessment2016

    • Author(s)
      Ikeda Y1, Kumagai H, Motozawa Y, Suzuki J
    • Journal Title

      International Heart Journal

      Volume: 57 Issue: 1 Pages: 1-2

    • DOI

      10.1536/ihj.15-324

    • NAID

      130005120988

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Early endoscopic management for early bowel obstruction after gastrectomy: a case report2016

    • Author(s)
      K. Higashizono, S. Aikou, K. Yagi, K. Mori, H. Yamashita, S. Nomura, Y. Seto
    • Journal Title

      Surg Case Rep

      Volume: 2 Issue: 1 Pages: 35-35

    • DOI

      10.1186/s40792-016-0164-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Radical esophagectomy for a 92-year-old woman with granulocyte colony-stimulating factor-producing esophageal squamous cell carcinoma: a case report.2016

    • Author(s)
      Kitani M, Yamagata Y, Tanabe A, Yagi K, Aikou S, Kiyokawa T, Nishida M, Yamashita H, Mori K, Nomura S, Seto Y.
    • Journal Title

      World J Surg Oncol.

      Volume: 14 Issue: 1 Pages: 264-264

    • DOI

      10.1186/s12957-016-1023-1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Risk of metastasis in adenocarcinoma of the esophagus: a multicenter retrospective study in a Japanese population.2016

    • Author(s)
      Ishihara R, Oyama T, Terai S, Ozawa S, Kawano T, Seto Y et al.
    • Journal Title

      J Gastroenterol.

      Volume: Oct 18. Issue: 7 Pages: 800-808

    • DOI

      10.1007/s00535-016-1275-0

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increasing the Number of Examined Lymph Nodes is a Prerequisite for Improvement in the Accurate Evaluation of Overall Survival of Node-Negative Gastric Cancer Patients2016

    • Author(s)
      Deng Jingyu、Yamashita Hiroharu、Seto Yasuyuki、Liang Han
    • Journal Title

      Ann Surg Oncol.

      Volume: 24 Issue: 3 Pages: 745-753

    • DOI

      10.1245/s10434-016-5513-8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Results of a nation-wide retrospective study of lymphadenectomy for esophagogastric junction carcinoma2016

    • Author(s)
      Yamashita Hiroharu、On behalf of the Japanese Gastric Cancer Association and the Japan Esophageal Society、Seto Yasuyuki、Sano Takeshi、Makuuchi Hiroyasu、Ando Nobutoshi、Sasako Mitsuru
    • Journal Title

      Gastric Cancer.

      Volume: 20 Issue: S1 Pages: 69-83

    • DOI

      10.1007/s10120-016-0663-8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surgery after intraperitoneal and systemic chemotherapy for gastric cancer with peritoneal metastasis or positive peritoneal cytology findings2016

    • Author(s)
      Ishigami Hironori、Yamaguchi Hironori、Yamashita Hiroharu、Asakage Masahiro、Kitayama Joji
    • Journal Title

      Gastric Cancer.

      Volume: 20 Issue: S1 Pages: 128-134

    • DOI

      10.1007/s10120-016-0684-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The impact of direct-acting antivirals on early tumor recurrence after radiofrequency ablation in hepatitis C-related hepatocellular carcinoma2016

    • Author(s)
      Minami T, Tateishi R, Nakagomi R, Fujiwara N, Sato M, Enooku K, Nakagawa H, Asaoka Y, Kondo Y, Shiina S, Koike K
    • Journal Title

      J Hepatol.

      Volume: 65 Issue: 6 Pages: 1272

    • DOI

      10.1016/j.jhep.2016.07.043

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion2016

    • Author(s)
      Ikenoue T, Terakado Y, Nakagawa H, Hikiba Y, Fujii T, Matsubara D, Noguchi R, Zhu C, Yamamoto K, Kudo Y, Asaoka Y, Yamaguchi K, Ijichi H, Tateishi K, Fukushima N, Maeda S, Koike K, Furukawa Y
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 23899-23899

    • DOI

      10.1038/srep23899

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Utility of Cystatin C for Estimating Glomerular Filtration Rate in Patients With Muscular Dystrophy2016

    • Author(s)
      Kimura K, Morita H, Daimon M, Horio M, Kawata T, Nakao T, Hirokawa M, Kitao R, Watanabe D, Komori T, Nagata T, Takeda S, Komaki H, Segawa K, Nakajima T, Takenaka K, Komuro I
    • Journal Title

      International Heart Journal

      Volume: 57 Issue: 3 Pages: 386-388

    • DOI

      10.1536/ihj.15-461

    • NAID

      130005153700

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fukutin gene mutations that cause left ventricular noncompaction2016

    • Author(s)
      Amiya E, Morita H, Hatano M, Nitta D, Hosoya Y, Maki H, Motozawa Y, Sato N, Ishiura H, Numakura S, Shintani Y, Kinugawa K, Takeda N, Shimizu J, Tsuji S, Komuro I.
    • Journal Title

      International Journal of Cardiology

      Volume: 222 Pages: 727

    • DOI

      10.1016/j.ijcard.2016.08.011

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heart failure complicated by alveolar hemorrhage due to vascular collapse and amyloid deposits in wild-type transthyretin amyloidosis.2016

    • Author(s)
      Kido Y, Takahashi M, Fukuma N, Kawata T, Tanaka A, Hayashi A, Shibahara J, Daimon M, Morita H, Akazawa H, Komuro I.
    • Journal Title

      Cardiology

      Volume: 135 Issue: 4 Pages: 216-220

    • DOI

      10.1159/000446513

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic Strategy for Heart Failure in Becker Muscular Dystrophy2016

    • Author(s)
      Kimura K, Morita H, Nakamura A, Takenaka K, Daimon M.
    • Journal Title

      International Heart Journal

      Volume: 57 Issue: 5 Pages: 527-529

    • DOI

      10.1536/ihj.16-311

    • NAID

      130005266584

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A strategy for genomic research on common cardiovascular diseases aiming at the realization of precision medicine; Personal insights and perspectives.2016

    • Author(s)
      Morita H, Komuro I.
    • Journal Title

      Circ Res.

      Volume: 119 Pages: 900-903

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuromuscular Electrical Stimulation in Patients With Acute Myocardial Infarction2016

    • Author(s)
      Nakao T, Morita H.
    • Journal Title

      International Heart Journal

      Volume: 57 Issue: 6 Pages: 659-660

    • DOI

      10.1536/ihj.16-498

    • NAID

      130005172026

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of oral treatment on physical function in older patients hospitalized for heart failure: A randomized clinical trial.2016

    • Author(s)
      Ueda K, Kasao M, Shimamura M, Haruta H, Nitta S, Kaneko M, Uemura Y, Morita H, Komuro I, Shirai T.
    • Journal Title

      PLoS ONE

      Volume: 11 Issue: 12 Pages: e0167933-e0167933

    • DOI

      10.1371/journal.pone.0167933

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Low density of CD204-positive M2-type tumor-associated macrophages in Epstein-Barr virus-associated gastric cancer: a clinicopathologic study with digital image analysis2016

    • Author(s)
      T. Ichimura, H. Abe, T. Morikawa, H. Yamashita, S. Ishikawa, T. Ushiku, Y. Seto, M. Fukayama
    • Journal Title

      Hum Pathol

      Volume: 56 Pages: 74-80

    • DOI

      10.1016/j.humpath.2016.06.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In Epstein-Barr virus-associated gastric carcinoma a high density of CD66b-positive tumor-associated neutrophils is associated with intestinal-type histology and low frequency of lymph node metastasis2016

    • Author(s)
      H. Abe, T. Morikawa, R. Saito, H. Yamashita, Y. Seto, M. Fukayama
    • Journal Title

      Virchows Arch

      Volume: 468 Issue: 5 Pages: 539-548

    • DOI

      10.1007/s00428-016-1915-z

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glucose metabolism in gastric cancer: The cutting-edge.2016

    • Author(s)
      Yuan LW, Yamashita H, Seto Y.
    • Journal Title

      World J Gastroenterol.

      Volume: 22 Issue: 6 Pages: 2046-2059

    • DOI

      10.3748/wjg.v22.i6.2046

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Is the transthoracic approach no longer a viable option for Siewert type II esophagogastric junction carcinoma?2016

    • Author(s)
      Yamashita H, Seto Y.
    • Journal Title

      Translational Gastroenterology and Hepatology

      Volume: 1 Pages: 14-14

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current therapies and investigational drugs for peripheral arterial disease2016

    • Author(s)
      Suzuki J, Shimamura M, Suda H, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Isobe M, Komuro I, Morishita R
    • Journal Title

      Hypertens Res

      Volume: 39 Issue: 4 Pages: 183-191

    • DOI

      10.1038/hr.2015.134

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Angiotensin II receptor blocker irbesartan attenuates cardiac dysfunction induced by myocardial infarction in the presence of renal failure2016

    • Author(s)
      Watanabe R, Suzuki J, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Isobe M
    • Journal Title

      Hypertens Res

      Volume: 39 Issue: 4 Pages: 237-244

    • DOI

      10.1038/hr.2015.141

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comparative analysis of upper gastrointestinal endoscopy, double-contrast upper gastrointestinal barium X-ray radiography, and the titer of serum anti-Helicobacter pylori IgG focusing on the diagnosis of atrophic gastritis2016

    • Author(s)
      Yamamichi N, Hirano C, Takahashi Y, Minatsuki C, Nakayama C, Matsuda R, Shimamoto T, Takeuchi C, Kodashima S, Ono S, Tsuji Y, Fujishiro M, Wada R, Mitsushima T, Koike K.
    • Journal Title

      Gastric Cancer.

      Volume: 19 Issue: 2 Pages: 670

    • DOI

      10.1007/s10120-015-0515-y

    • NAID

      40020836534

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Guidelines for endoscopic submucosal dissection and endoscopic mucosal resection for early gastric cancer.2016

    • Author(s)
      Ono H, Yao K, Fujishiro M, Oda I, Nimura S, Yahagi N, Iishi H, Oka M, Ajioka Y, Ichinose M, Matsui T.
    • Journal Title

      Dig Endosc.

      Volume: 28 Issue: 1 Pages: 3-15

    • DOI

      10.1111/den.12518

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of lymph node dissection for each station based on esophageal tumor location.2016

    • Author(s)
      Tachimori Y, Ozawa S, Numasaki H, Fujishiro M, MatsubaraH, Oyama T, Shinoda M, Toh Y, Udagawa H, Uno T, The Registration Committee for Esophageal Cancer of the Japan Esophageal Society.
    • Journal Title

      Esophagus.

      Volume: 13 Pages: 1-7

    • NAID

      40020807806

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Flow Cytometric Quantification of Intraperitoneal Free Tumor Cells is a Useful Biomarker in Gastric Cancer Patients with Peritoneal Metastasis.2015

    • Author(s)
      Kitayama J, Emoto S, Yamaguchi H, Ishigami H, Onoyama H, Yamashita H, Seto Y, Matsuzaki K, Watanabe T.
    • Journal Title

      Ann Surg Oncol.

      Volume: 22(7) Issue: 7 Pages: 2336-42

    • DOI

      10.1245/s10434-014-4238-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Phosphatidylserine-specific phospholipase A1 (PS-PLA1) expression in colorectal cancer correlates with tumor invasion and hematogenous metastasis.2015

    • Author(s)
      Iida Y, Sunami E, Yamashita H, Hiyoshi M, Ishihara S, Yamaguchi H, Inoue A, Makide K, Tsuno NH, Aoki J, Kitayama J, Watanabe T.
    • Journal Title

      Anticancer Res.

      Volume: 35 Pages: 1459-1464

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Solitary fibrous tumor of the greater omentum, mimicking gastrointestinal stromal tumor of the small intestine: a case report.2015

    • Author(s)
      Urabe M, Yamagata Y, Aikou S, Mori K, Yamashita H, Nomura S, Shibahara J, Fukayama M, Seto Y.
    • Journal Title

      Int Surg.

      Volume: 100 Issue: 5 Pages: 836-840

    • DOI

      10.9738/intsurg-d-14-00141.1

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of 18F-FDG uptake for detecting lymph node metastasis of gastric cancer: a prospective pilot study for one-to-one comparison of radiation dose and pathological findings.2015

    • Author(s)
      Okumura Y, Aikou S, Onoyama H, Jinbo K, Yamagata Y, Mori K, Yamashita H, Nomura S, Takahashi M, Koyama K, Momose T, Abe H, Matsusaka K, Ushiku T, Fukayama M, Seto Y.
    • Journal Title

      World J Surg Oncol.

      Volume: 13 Issue: 1 Pages: 327-327

    • DOI

      10.1186/s12957-015-0743-y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PD-1 blockade in tumors with mismatch-repair deficiency: To the editor [1]2015

    • Author(s)
      Asaoka Y, Ijichi H, Koike K.
    • Journal Title

      N Engl J Med.

      Volume: 373 Issue: 20 Pages: 1979

    • DOI

      10.1056/nejmc1510353

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum Alpha-Fetoprotein Has High Specificity for the Early Detection of Hepatocellular Carcinoma after Hepatitis C Virus Eradication in Patients2015

    • Author(s)
      Minami T, Tateishi R, Kondo M, Nakagomi R, Fujiwara N, Sato M, Uchino K, Enooku K, Nakagawa H, Asaoka Y, Kondo Y, Moriya K, Shiina S, Koike K.
    • Journal Title

      Medicine (Baltimore).

      Volume: 94 Issue: 23 Pages: e901-e901

    • DOI

      10.1097/md.0000000000000901

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sarcopenia, Intramuscular Fat Deposition, and Visceral Adiposity Independently Predict the Outcomes of Hepatocellular Carcinoma2015

    • Author(s)
      Fujiwara N, Nakagawa H, Kudo Y, Tateishi R, Taguri M, Watadani T, Nakagomi R, Kondo M, Nakatsuka T, Minami T, Sato M, Uchino K, Enooku K, Kondo Y, Asaoka Y, Tanaka Y, Ohtomo K, Shiina S, Koike K
    • Journal Title

      J Hepatol

      Volume: 62 Issue: 1 Pages: 131-140

    • DOI

      10.1016/j.jhep.2015.02.031

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Validation of the Japanese version of HFS-14, a disease-specific quality of life scale for patients suffering from hand-foot syndrome2015

    • Author(s)
      Mikoshiba N, Yamamoto-Mitani N, Sato K, Asaoka Y, Ohki T, Ohata M, Miyashita M.
    • Journal Title

      Support Care Cancer.

      Volume: 23 Issue: 9 Pages: 2739

    • DOI

      10.1007/s00520-015-2638-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of improved prognosis between hepatitis B- and hepatitis C-related hepatocellular carcinoma2015

    • Author(s)
      Minami T, Tateishi R, Shiina S, Nakagomi R, Kondo M, Fujiwara N, Mikami S, Sato M, Uchino K, Enooku K, Nakagawa H, Asaoka Y, Kondo Y, Yoshida H, Koike K.
    • Journal Title

      Hepatol Res.

      Volume: 45 Issue: 10

    • DOI

      10.1111/hepr.12468

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuromedin S-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms.2015

    • Author(s)
      Lee IT, Chang AS, Manandhar M, Shan Y, Fan J, Izumo M, Ikeda Y, Motoike T, Dixon S, Seinfeld JE, Takahashi JS, Yanagisawa M
    • Journal Title

      Neuron

      Volume: 85 Issue: 5 Pages: 1086-1102

    • DOI

      10.1016/j.neuron.2015.02.006

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Toward further prevention of bleeding after gastric endoscopic submucosal dissection.2015

    • Author(s)
      Mochizuki S, Ikeda Y, Arai T, Matsuo K
    • Journal Title

      Dig Endosc.

      Volume: 27 Issue: 3 Pages: 295-297

    • DOI

      10.1111/den.12441

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recent clinical management of antithrombotic agents for gastrointestinal endoscopy after revision of guidelines in Japan.2015

    • Author(s)
      Ono S, Fujishiro M, Ikeda Y, Komuro I, Koike K
    • Journal Title

      Dig Endosc.

      Volume: 27 Issue: 6 Pages: 649-656

    • DOI

      10.1111/den.12498

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative measurement of GPCR endocytosis via pulse-chase covalent labeling2015

    • Author(s)
      Kumagai H, Ikeda Y, Motozawa Y, Fujishiro M, Okamura T, Fujio K, Okazaki H, Nomura S, Takeda N, Harada M, Toko H, Takimoto E, Akazawa H, Morita H, Suzuki J, Yamazaki T, Yamamoto K, Komuro I, Yanagisawa M
    • Journal Title

      PLoS One

      Volume: 10 Issue: 5 Pages: e0129394-e0129394

    • DOI

      10.1371/journal.pone.0129394

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Monitoring beta-arrestin recruitment via beta-lactamase enzyme fragment complementation: purification of peptide E as a low-affinity ligand for mammalian bombesin receptors2015

    • Author(s)
      Ikeda Y*, Kumagai H*, Okazaki H, Fujishiro M, Motozawa Y, Nomura S, Takeda N, Toko H, Takimoto E, Akazawa H, Morita H, Suzuki J, Yamazaki T, Komuro I, Yanagisawa M (co-first author)
    • Journal Title

      PLoS One

      Volume: 10 Issue: 6 Pages: e0127445-e0127445

    • DOI

      10.1371/journal.pone.0127445

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] SH2B1: a new player in the regulation of cardiac hypertrophic response in failing hearts.2015

    • Author(s)
      Ikeda Y, Takimoto E, Komuro I
    • Journal Title

      Cardiovasc Res.

      Volume: 107 Issue: 2 Pages: 197-199

    • DOI

      10.1093/cvr/cvv172

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute Myocardial Infarction That Resulted From Poor Adherence to Medical Treatment for Giant Coronary Aneurysm2015

    • Author(s)
      Motozawa Y, Uozumi H, Maemura S, Nakata R, Yamamoto K, Takizawa M, Kumagai H, Ikeda Y, Komuro I, Ikenouchi H
    • Journal Title

      International Heart Journal

      Volume: 56 Issue: 5 Pages: 551-554

    • DOI

      10.1536/ihj.15-155

    • NAID

      130005102122

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biased Agonism of the Angiotensin II Type I Receptor2015

    • Author(s)
      Ikeda Y*, Kumagai H*, Motozawa Y*, Suzuki J, Komuro I (co-first author)
    • Journal Title

      International Heart Journal

      Volume: 56 Issue: 5 Pages: 485-488

    • DOI

      10.1536/ihj.15-256

    • NAID

      130005102121

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A food-derived flavonoid luteolin protects against angiotensin II-induced cardiac remodeling2015

    • Author(s)
      Nakayama A, Morita H, Nakao T, Yamaguchi T, Sumida T, Ikeda Y, Kumagai H, Motozawa Y, Takahashi T, Imaizumi A, Hashimoto T, Nagai R, Komuro I
    • Journal Title

      PLoS One

      Volume: 10 Issue: 9 Pages: e0137106-e0137106

    • DOI

      10.1371/journal.pone.0137106

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Next Generation ARBs2015

    • Author(s)
      Ikeda Y, Kumagai H, Motozawa Y, Suzuki J, Komuro I
    • Journal Title

      International Heart Journal

      Volume: 56 Issue: 6 Pages: 585-586

    • DOI

      10.1536/ihj.15-295

    • NAID

      130005113065

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Polyglycolic acid sheets and fibrin glue decrease the risk of bleeding after endoscopic submucosal dissection of gastric neoplasms (with video)2015

    • Author(s)
      Tsuji Y, Fujishiro M, Kodashima S, Ono S, Niimi K, Mochizuki S, Asada-Hirayama I, Matsuda R, Minatsuki C, Nakayama C, Takahashi Y, Sakaguchi Y, Yamamichi N, Koike K.
    • Journal Title

      Gastrointest Endosc.

      Volume: 81 Issue: 4 Pages: 906

    • DOI

      10.1016/j.gie.2014.08.028

    • URL

      https://pure.teikyo.jp/en/publications/4263d93b-9f2b-4185-ae6a-6578b13f4d05

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polyglycolic acid sheets with fibrin glue can prevent esophageal stricture after endoscopic submucosal dissection2015

    • Author(s)
      Sakaguchi Y, Tsuji Y, Ono S, Saito I, Kataoka Y, Takahashi Y, Nakayama C, Shichijo S, Matsuda R, Minatsuki C, Asada-Hirayama I, Niimi K, Kodashima S, Yamamichi N, Fujishiro M, Koike K.
    • Journal Title

      Endoscopy.

      Volume: 41 Issue: 4 Pages: 336-340

    • DOI

      10.1055/s-0034-1390787

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thienopyridine derivatives as risk factors for bleeding following high risk endoscopic treatments: Safe Treatment on Antiplatelets (STRAP) study.2015

    • Author(s)
      Ono S, Fujishiro M, Yoshida N, Doyama H, Kamoshida T, Hirai S, Kishihara T, Yamamoto Y, Sakae H, Imagawa A, Hirano M, Koike K.
    • Journal Title

      Endoscopy

      Volume: 47 Issue: 07 Pages: 632-637

    • DOI

      10.1055/s-0034-1391354

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease: A large-scale cross-sectional study in Japan2015

    • Author(s)
      Okushin K, Takahashi Y, Yamamichi N, Shimamoto T, Enooku K, Fujinaga H, Tsutsumi T, Shintani Y, Sakaguchi Y, Ono S, Kodashima S, Fujishiro M, Moriya K, Yotsuyanagi H, Mitsushima T, Koike K.
    • Journal Title

      BMC Gastroenterol.

      Volume: 15 Issue: 1 Pages: 247-247

    • DOI

      10.1186/s12876-015-0247-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trend and risk factors of diverticulosis in Japan: Age, gender, and lifestyle/metabolic-related factors may cooperatively affect on the colorectal diverticula formation2015

    • Author(s)
      Yamamichi N, Shimamoto T, Takahashi Y, Sakaguchi Y, Kakimoto H, Matsuda R, Kataoka Y, Saito I, Tsuji Y, Yakabi S, Takeuchi C, Minatsuki C, Niimi K, Asada-Hirayama I, Nakayama C, Ono S, Kodashima S, Yamaguchi D, Fujishiro M, Yamaji Y, Wada R, Mitsushima T, Koike K.
    • Journal Title

      PLoS One.

      Volume: 10 Issue: 4 Pages: e0123688-e0123688

    • DOI

      10.1371/journal.pone.0123688

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term efficacy and safety of rabeprazole in patients taking low-dose aspirin with a history of peptic ulcers: a phase 2/3, randomized, parallel-group, multicenter, extension clinical trial2015

    • Author(s)
      Fujishiro M, Higuchi K, Kato M, Kinoshita Y, Iwakiri R, Watanabe T, Takeuchi T, Sugisaki N, Okada Y, Ogawa H, Arakawa T, Fujimoto K
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 56 Issue: 3 Pages: 228-239

    • DOI

      10.3164/jcbn.15-1

    • NAID

      130005068182

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Foam plombage: A novel technique for optimal fixation of polyglycolic acid sheets positioned using clip and pull after esophageal endoscopic submucosal dissection2015

    • Author(s)
      Ono S, Sakaguchi Y, Tsuji Y, Kodashima S, Yamamichi N, Fujishiro M, Koike K
    • Journal Title

      Endoscopy.

      Volume: 47 Issue: S 01 Pages: E435-E436

    • DOI

      10.1055/s-0034-1392612

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preventing esophageal stricture after endoscopic submucosal dissection: Steroid injection and shielding with polyglycolic acid sheets and fibrin glue2015

    • Author(s)
      Kataoka Y, Tsuji Y, Sakaguchi Y, Kodashima S, Yamamichi N, Fujishiro M, Koike K.
    • Journal Title

      Endoscopy.

      Volume: 47 Issue: S 01 Pages: E473-E474

    • DOI

      10.1055/s-0034-1392975

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outcome of salvage surgery for colorectal cancer initially treated by upfront endoscopic therapy2015

    • Author(s)
      Nozawa H, Ishihara S, Fujishiro M, Kodashima S, Ohtani K, Yasuda K, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Kazama S, Sunami E, Kitayama J, Watanabe T.
    • Journal Title

      Surgery

      Volume: 159 Issue: 3 Pages: 713

    • DOI

      10.1016/j.surg.2015.09.008

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comprehensive Registry of Esophageal Cancer in Japan, 20072015

    • Author(s)
      Tachimori Y, Ozawa S, Numasaki H, Fujishiro M, MatsubaraH, Oyama T, Shinoda M, Toh Y, Udagawa H, Uno T, The Registration Committee for Esophageal Cancer of the Japan Esophageal Society.
    • Journal Title

      Esophagus.

      Volume: 12 Pages: 101-129

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive Registry of Esophageal Cancer in Japan, 20082015

    • Author(s)
      Tachimori Y, Ozawa S, Numasaki H, Fujishiro M, MatsubaraH, Oyama T, Shinoda M, Toh Y, Udagawa H, Uno T, The Registration Committee for Esophageal Cancer of the Japan Esophageal Society.
    • Journal Title

      Esophagus.

      Volume: 12 Pages: 130-157

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Video of the Month2015

    • Author(s)
      Niimi K, Aikou S, Kodashima S, Yagi K, Oya S, Yamaguchi D, Yamashita H, Yamamichi N, Fujishiro M, Koike K, Seto Y.
    • Journal Title

      Am J Gastroenterol.

      Volume: 110 Issue: 11 Pages: 1535

    • DOI

      10.1038/ajg.2015.226

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed

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Published: 2015-04-16   Modified: 2019-03-29  

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