Identification of biomarkers to predict HCC development after successful treatment of viral hepatitis

• Project/Area Number: 15H04809
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kanazawa University
• Principal Investigator: HONDA Masao 金沢大学, 保健学系, 教授 (00272980)
• Co-Investigator(Kenkyū-buntansha): 堀本 勝久 国立研究開発法人産業技術総合研究所, 創薬分子プロファイリング研究センター, 副研究センター長 (40238803)
• Co-Investigator(Renkei-kenkyūsha): YAMASHITA Taro 金沢大学, 附属病院, 准教授 (90377432) ; SHIMAKAMI Tetsuro 金沢大学, 附属病院, 特任教授 (50436820)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: 癌 / ゲノム / マイクロアレイ / 血管内皮 / shear stress / メチル化

Outline of Final Research Achievements

The aim of this study is the identification of biomarkers to predict HCC development after successful treatment of viral hepatitis. By the methylation and gene expression analysis, we identified that gene X mainly expressed in endothelial cells and could be a potential biomarker for HCC. Interestingly, gene X was induced by ER stress and shear stress in cultured endothelial cells, in addition, over expression of gene X induced inflammatory cytokines such as IL1B, IL6 and IL8. Gene X enhanced tumor formation in xenograft tumor model in NOD/SCID mice. Moreover, high expression of gene X was associated with poor progression free survival and over whole survivals. Therefore, the expression of gene X was useful biomarker for the prediction of HCC after successful therapy for viral hepatitis.

Research Products

• [Journal Article] Peretinoin, an Acyclic Retinoid, Inhibits Hepatitis B Virus Replication by Suppressing Sphingosine Metabolic Pathway In Vitro. (2018)
  • Author(s): 1.Murai K, Shirasaki T, Honda M, Shimizu R, Shimakami T, Nakasho S, Shirasaki N, Okada H, Sakai Y, Yamashita T, Kaneko S.
  • Journal Title: International Journal of Molecular Sciences. Volume: 19(2) Issue: 2 Pages: 108-108
  • DOI: 10.3390/ijms19020108
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Light alcohol consumption has the potential to suppress hepatocellular injury and liver fibrosis in non-alcoholic fatty liver disease. (2018)
  • Author(s): K Yamada, E Mizukoshi, T Seike, R Horii, M Kitahara, H Sunagozaka, K Arai, T Yamashita, M Honda, S Kaneko.
  • Journal Title: PLoS One Volume: 13 Issue: 1 Pages: e0191026-e0191026
  • DOI: 10.1371/journal.pone.0191026
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population. (2017)
  • Author(s): Kawashima M, Honda M, Nakamura M. et al.
  • Journal Title: Hum Mol Genet. Volume: - Pages: 650-659
  • DOI: 10.1093/hmg/ddw406
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Differential hepatitis C virus RNA target site selection and host factor activities of naturally occurring miR-122 3' variants. (2017)
  • Author(s): Yamane D, Selitsky SR, Shimakami T, Li Y, Zhou M, Honda M, Sethupathy P, Lemon SM.
  • Journal Title: Nucleic Acids Res. Volume: - Pages: 4743-4755
  • DOI: 10.1093/nar/gkw1332
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genome-wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection. (2017)
  • Author(s): Matsuura K, Honda M, et al.
  • Journal Title: Gastroenterology. Volume: - Issue: 6 Pages: 1383-1394
  • DOI: 10.1053/j.gastro.2017.01.041
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model. (2017)
  • Author(s): K Takegoshi, M Honda, H Okada, R Takabatake, N Matsuzawa-Nagata, JS Campbell, M Nishikawa, T Shimakami, T Shirasaki, Y Sakai, T Yamashita, T Takamura, T Tanaka, S Kaneko.
  • Journal Title: Oncotarget Volume: 印刷中 Issue: 11 Pages: 18191-18205
  • DOI: 10.18632/oncotarget.15304
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle. (2017)
  • Author(s): H Misu, H Takayama, Y Saito, Y Mita, A Kikuchi, K Ishii, K Chikamoto, T Kanamori, N Tajima, F Lan, Y Takeshita, M Honda, M Tanaka, S Kato, N Matsuyama, Y Yoshioka, Iwayama K, Tokuyama K, Akazawa N, Maeda S, Takekoshi K, Matsugo S, Noguchi N, S Kaneko, T Takamura.
  • Journal Title: Nature Med Volume: 23 Issue: 4 Pages: 508-516
  • DOI: 10.1038/nm.4295
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hepatitis B virus X protein induces hepatic stem cell-like features in hepatocellular carcinoma by activating KDM5B. (2017)
  • Author(s): Wang X, Oishi N, Shimakami T, Yamashita T, Honda M, Murakami S, Kaneko S.
  • Journal Title: World J Gastroenterol Volume: 23 Issue: 18 Pages: 3252-3261
  • DOI: 10.3748/wjg.v23.i18.3252
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] De Novo Emergence of Mesenchymal Stem-Like CD105+ Cancer Cells by Cytotoxic Agents in Human Hepatocellular Carcinoma. (2017)
  • Author(s): Nomura Y, Yamashita T, Oishi N, Nio K, Hayashi T, Yoshida M, Hayashi T, Hashiba T, Asahina Y, Okada H, Sunagozaka H, Takatori H, Honda M, Kaneko S.
  • Journal Title: Transl Oncol. Volume: - Issue: 2 Pages: 184-189
  • DOI: 10.1016/j.tranon.2017.01.005
  • Peer Reviewed / Open Access
• [Journal Article] Peretinoin, an acyclic retinoid, suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic high-fat diet (2017)
  • Author(s): Okada H, Takabatake R, Honda M, Takegoshi K, Yamashita T, Nakamura M, Shirasaki T, Sakai Y, Shimakami T, Nagata N, Takamura T, Tanaka T, Kaneko S.
  • Journal Title: Oncotarget Volume: 8 Issue: 25 Pages: 39978-39993
  • DOI: 10.18632/oncotarget.18116
  • Peer Reviewed / Open Access
• [Journal Article] Beneficial Effect of Maintaining Hepatic Reserve during Chemotherapy on the Outcomes of Patients with Hepatocellular Carcinoma. (2017)
  • Author(s): Terashima T, Yamashita T, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S.
  • Journal Title: Liver Cancer Volume: 6 Issue: 3 Pages: 236-249
  • DOI: 10.1159/000472262
  • Peer Reviewed / Open Access
• [Journal Article] Ribavirin suppresses hepatic lipogenesis through inosine monophosphate dehydrogenase inhibition: Involvement of adenosine monophosphate-activated protein kinase-related kinases and retinoid X receptor α. (2017)
  • Author(s): S Satoh, K Mori, D Onomura, Y Ueda, H Dansako, M Honda, S Kaneko, M Ikeda, N Kato.
  • Journal Title: Hepatol Commun Volume: 1 Issue: 6 Pages: 550-563
  • DOI: 10.1002/hep4.1065
  • Peer Reviewed / Open Access
• [Journal Article] Reactivation of hepatitis B virus from an isolated anti-HBc positive patient after eradication of hepatitis C virus with direct-acting antiviral agents (2017)
  • Author(s): Suda Tsuyoshi、Shimakami Tetsuro、Shirasaki Takayoshi、Yamashita Tatsuya、Mizukoshi Eishiro、Honda Masao、Kaneko Shuichi
  • Journal Title: J Hepatol Volume: 67 Issue: 5 Pages: 1108-1111
  • DOI: 10.1016/j.jhep.2017.07.014
  • Peer Reviewed / Open Access
• [Journal Article] A Novel mTOR Inhibitor; Anthracimycin for the Treatment of Human Hepatocellular Carcinoma. (2017)
  • Author(s): Hayashi T, Yamashita T, Okada H, Oishi N, Sunagozaka H, Nio K, Hayashi T, Hara Y, Asahina Y, Yoshida M, Hashiba T, Suda T, Shirasaki T, Igarashi Y, Miyanouchi K, Yamashita T, Honda M, Kaneko S
  • Journal Title: Anticancer Res Volume: 37 Issue: 7 Pages: 3397-3403
  • DOI: 10.21873/anticanres.11706
  • Peer Reviewed / Open Access
• [Journal Article] Serum Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts hepatocellular carcinoma incidence and recurrence in nucleos(t)ide analogue therapy for chronic hepatitis B. (2017)
  • Author(s): Kawaguchi K, Honda M, Ohta H, Terashima T, Shimakami T, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Komura T, Unoura M, Kaneko S
  • Journal Title: J Gastroenterol Volume: ePub ahead Issue: 6 Pages: 740-751
  • DOI: 10.1007/s00535-017-1386-2
  • Peer Reviewed / Open Access
• [Journal Article] HBcrAg predicts hepatocellular carcinoma development: An analysis using time-dependent receiver operating characteristics. (2017)
  • Author(s): Kawaguchi K, Honda M, Kaneko S
  • Journal Title: Translational Cancer Research Volume: -
  • Peer Reviewed / Open Access
• [Journal Article] Sorafenib suppresses extrahepatic metastasis de novo in hepatocellular carcinoma through inhibition of mesenchymal cancer stem cells characterized by the expression of CD90. (2017)
  • Author(s): 5.Yoshida M, Yamashita T, Okada H, Oishi N, Nio K, Hayashi T, Nomura Y, Hayashi T, Asahina Y, Ohwada M, Sunagozaka H, Takatori H, Colombo F, Porretti L, Honda M, Kaneko S.
  • Journal Title: Scientific Reports. Volume: 12;7(1) Issue: 1 Pages: 11292-11292
  • DOI: 10.1038/s41598-017-11848-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The in vivo antitumor effects of type I-interferon against hepatocellular carcinoma: the suppression of tumor cell growth and angiogenesis. (2017)
  • Author(s): Enomoto H, Tao L, Eguchi R, Sato A, Honda M, Kaneko S, Iwata Y, Nishikawa H, Imanishi H, Iijima H, Tsujimura T, Nishiguchi S
  • Journal Title: Sci Rep. Volume: 7 Issue: 1 Pages: 12189-12189
  • DOI: 10.1038/s41598-017-12414-3
  • Peer Reviewed / Open Access
• [Journal Article] Sporadic PCDH18 somatic mutations in EpCAM-positive hepatocellular carcinoma. (2017)
  • Author(s): Hayashi T, Yamashita T, Okada H, Nio K, Hara Y, Nomura Y, Hayashi T, Asahina Y, Yoshida M, Oishi N, Sunagozaka H, Takatori H, Honda M, Kaneko S
  • Journal Title: Cancer Cell Int Volume: 17 Issue: 1 Pages: 94-94
  • DOI: 10.1186/s12935-017-0467-x
  • Peer Reviewed / Open Access
• [Journal Article] Clinical features of cystatin A expression in patients with pancreatic ductal adenocarcinoma. (2017)
  • Author(s): Komura T, Takabatake H, Harada K, Yamato M, Miyazawa M, Yoshida K, Honda M, Wada T, Kitagawa H, Ohta T, Kaneko S, Sakai Y.
  • Journal Title: Cancer Sci Volume: 108 Issue: 11 Pages: 2122-2129
  • DOI: 10.1111/cas.13396
  • Peer Reviewed / Open Access
• [Journal Article] Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo. (2017)
  • Author(s): Funaki M, Kitabayashi J, Shimakami T, Nagata N, Sakai Y, Takegoshi K, Okada H, Murai K, Shirasaki T, Oyama T, Yamashita T, Ota T, Takuwa Y, Honda M, Kaneko S.
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 16978-16978
  • DOI: 10.1038/s41598-017-17285-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum cytokine profiles predict survival benefits in patients with advanced hepatocellular carcinoma treated with sorafenib: a retrospective cohort study. (2017)
  • Author(s): Hayashi T, Yamashita T, Terashima T, Suda T, Okada H, Asahina Y, Hayashi T, Hara Y, Nio K, Sunagozaka H, Takatori H, Arai K, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kaneko S.
  • Journal Title: BMC Cancer Volume: 17 Issue: 1 Pages: 870-870
  • DOI: 10.1186/s12885-017-3889-x
  • Peer Reviewed / Open Access
• [Journal Article] The CD45+ fraction in murine adipose tissue derived stromal cells harbors immune-inhibitory inflammatory cells. (2017)
  • Author(s): Nasti A, Sakai Y, Seki A, Buffa GB, Komura T, Mochida H, Yamato M, Yoshida K, Ho TTB, Takamura M, Usui S, Wada T, Honda M, Kaneko S.
  • Journal Title: Eur J Immunol. Volume: 47 Issue: 12 Pages: 2163-2174
  • DOI: 10.1002/eji.201646835
  • NAID: 120006454989
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Induction of IFN-lambda3 as an additional effect of nucleotide, not nucleoside, analogues: a new potential target for HBV infection (2016)
  • Author(s): Murata, K. Asano, M. Matsumoto, A. Sugiyama, M. Nishida, N. Tanaka, E. Inoue, T. Sakamoto, M. Enomoto, N. Shirasaki, T. Honda, M. Kaneko, S. Gatanaga, H. Oka, S. Kawamura, Y. I. Dohi, T. Shuno, Y. Yano, H. Mizokami, M.
  • Journal Title: Gut Volume: - Issue: 2 Pages: 362-371
  • DOI: 10.1136/gutjnl-2016-312653
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] HBcrAg predicts hepatocellular carcinoma development: An analysis using time-dependent receiver operating characteristics. (2016)
  • Author(s): Kawaguchi K, Honda M, Kaneko S.
  • Journal Title: Transl Cancer Res. Volume: 5(S2) Issue: S2 Pages: S216-S220
  • DOI: 10.21037/tcr.2016.08.13
  • Peer Reviewed / Open Access
• [Journal Article] Response to chemotherapy improved hepatic reserve for patients with hepatocellular carcinoma and Child-Pugh B cirrhosis. (2016)
  • Author(s): Terashima T, Yamashita T, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S.
  • Journal Title: Cancer Sci. Volume: 107(9) Issue: 9 Pages: 1263-1269
  • DOI: 10.1111/cas.12992
  • NAID: 120005851362
  • Peer Reviewed / Open Access
• [Journal Article] Efficient Suppression of Hepatitis C Virus Replication by Combination Treatment with miR-122 Antagonism and Direct-acting Antivirals in Cell Culture Systems. (2016)
  • Author(s): Liu F, Shimakami T, Murai K, Shirasaki T, Funaki M, Honda M, Murakami S, Yi M, Tang H, Kaneko S.
  • Journal Title: Sci Rep. Volume: 6 Issue: 1 Pages: 30939-30939
  • DOI: 10.1038/srep30939
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Jagged1 DNA Copy Number Variation Is Associated with Poor Outcome in Liver Cancer. (2016)
  • Author(s): Kawaguchi K, Honda M, Yamashita T, Okada H, Shirasaki T, Nishikawa M, Nio K, Arai K, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S.
  • Journal Title: Am J Pathol. Volume: 186(8) Issue: 8 Pages: 2055-2067
  • DOI: 10.1016/j.ajpath.2016.04.011
  • NAID: 120005899105
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Post-progression survival and progression-free survival in patients with advanced hepatocellular carcinoma treated by sorafenib. (2016)
  • Author(s): Terashima T, Yamashita T, Takata N, Nakagawa H, Toyama T, Arai K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S.
  • Journal Title: Hepatol Res. Volume: 印刷中 Issue: 7 Pages: 650-656
  • DOI: 10.1111/hepr.12601
  • NAID: 120005704530
  • Peer Reviewed / Open Access
• [Journal Article] Altered gene expression in T-cell receptor signalling in peripheral blood leucocytes in acute coronary syndrome predicts secondary coronary events. (2016)
  • Author(s): Takashima S, Usui S, Kurokawa K, Kitano T, Kato T, Murai H, Furusho H, Oda H, Maruyama M, Nagata Y, Usuda K, Kubota K, Takeshita Y, Sakai Y, Honda M, Kaneko S, Takamura M.
  • Journal Title: Open Heart. Volume: 3(1) Issue: 1 Pages: e000400-e000400
  • DOI: 10.1136/openhrt-2016-000400
  • NAID: 120005830627
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Potential efficacy of therapies targeting intrahepatic lesions after sorafenib treatment of patients with hepatocellular carcinoma. (2016)
  • Author(s): Yamashita T, Horii R, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S.
  • Journal Title: BMC Cancer. Volume: 16(1) Issue: 1 Pages: 338-338
  • DOI: 10.1186/s12885-016-2380-4
  • Peer Reviewed / Open Access
• [Journal Article] Molecular Mechanism Underlying the Suppression of CPB2 Expression Caused by Persistent Hepatitis C Virus RNA Replication. (2016)
  • Author(s): Sejima H, Satoh S, Dansako H, Honda M, Kaneko S, Ikeda M, Kato N.
  • Journal Title: Acta Med Okayama. Volume: 70(2) Pages: 75-88
  • NAID: 120005749825
  • Peer Reviewed / Open Access
• [Journal Article] Understanding of HLA-conferred susceptibility to chronic hepatitis B infection requires HLA genotyping-based association analysis. (2016)
  • Author(s): N. Nishida (他37名, 山本31番目)
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 24767-24767
  • DOI: 10.1038/srep24767
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hepatitis B Virus (HBV) Core-Related Antigen During Nucleos(t)ide Analog Therapy Is Related to Intra-hepatic HBV Replication and Development of Hepatocellular Carcinoma. (2016)
  • Author(s): Honda M, Shirasaki T, Terashima T, Kawaguchi K, Nakamura M, Oishi N, Wang X, Shimakami T, Okada H, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S.
  • Journal Title: J Infect Dis Volume: 213 Issue: 7 Pages: 1096-1106
  • DOI: 10.1093/infdis/jiv572
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Small tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C. (2015)
  • Author(s): Selitsky SR, Baran-Gale J, Honda M, Yamane D, Masaki T, Fannin EE, Guerra B, Shirasaki T, Shimakami T, Kaneko S, Lanford RE, Lemon SM, Sethupathy P.
  • Journal Title: Sci Rep. Volume: 5 Issue: 1 Pages: 7675-7675
  • DOI: 10.1038/srep07675
  • Peer Reviewed / Open Access
• [Journal Article] Characteristics of hepatic fatty acid compositions in patients with nonalcoholic steatohepatitis. (2015)
  • Author(s): Yamada K, Mizukoshi E, Sunagozaka H, Arai K, Yamashita T, Takeshita Y, Misu H, Takamura T, Kitamura S, Zen Y, Nakanuma Y, Honda M, Kaneko S.
  • Journal Title: Liver Int. Volume: 35(2) Issue: 2 Pages: 582-90
  • DOI: 10.1111/liv.12685
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide association study identifies a PSMD3 variant associated with neutropenia in interferon-based therapy for chronic hepatitis C. (2015)
  • Author(s): Iio E, Matsuura K, Nishida N, Maekawa S, Enomoto N, Nakagawa M, Sakamoto N, Yatsuhashi H et al.
  • Journal Title: Hum Genet Volume: 134 Issue: 3 Pages: 279-289
  • DOI: 10.1007/s00439-014-1520-7
  • Peer Reviewed / Open Access
• [Journal Article] TSU-68 Ameliorates Hepatocellular Carcinoma Growth by Inhibiting Microenvironmental Platelet-derived Growth Factor Signaling. (2015)
  • Author(s): Hara Y, Yamashita T, Oishi N, Nio K, Hayashi T, Nomura Y, Yoshida M, Hayashi T, Hashiba T, Asahina Y, Kondo M, Okada H, Sunagozaka H, Honda M, Kaneko S.
  • Journal Title: Anticancer Res. Volume: 35 Pages: 1423-1431
  • Peer Reviewed / Open Access
• [Journal Article] Inflammatory Features of Pancreatic Cancer Highlighted byMonocytes/Macrophages and CD4+ T cells with Clinical Impact. (2015)
  • Author(s): Komura T, Sakai Y, Harada K, Kawaguchi K, Takabatake H, Kitagawa H, Wada T, Honda M, Ohta T, Nakanuma Y, Kaneko S.
  • Journal Title: Cancer Sci. Volume: 106(6) Issue: 6 Pages: 672-86
  • DOI: 10.1111/cas.12663
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of microRNA-214 ameliorates hepatic fibrosis and tumor incidence in platelet-derived growth factor C transgenic mice. (2015)
  • Author(s): H Okada, M Honda, JS Campbell, K Takegoshi, Y Sakai, T Yamashita, T Shirasaki, R Takabatake, M Nakamura, T Tanaka, S Kaneko.
  • Journal Title: Cancer Sci Volume: 106 Issue: 9 Pages: 1143-1152
  • DOI: 10.1111/cas.12730
  • NAID: 120005830608
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Response to Importance of confounding factors in assessing fatty acid compositions in patients with non-alcoholic steatohepatitis (2015)
  • Author(s): Yamada K, Mizukoshi E, Sunagozaka H, Arai K, Yamashita T, Takeshita Y, Misu H, Takamura T, Kitamura S, Zen Y, Nakanuma Y, Honda M, Kaneko S
  • Journal Title: Liver Int Volume: 35 Issue: 6 Pages: 1773-1773
  • DOI: 10.1111/liv.12755
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Defeating EpCAM(+) liver cancer stem cells by targeting chromatin remodeling enzyme CHD4 in human hepatocellular carcinoma. (2015)
  • Author(s): Nio K, Yamashita T, Okada H, Kondo M, Hayashi T, Hara Y, Nomura Y, Zeng SS, Yoshida M, Hayashi T, Sunagozaka H, Oishi N, Honda M, Kaneko S
  • Journal Title: J. Hepatology Volume: 5 Issue: 5 Pages: 1164-72
  • DOI: 10.1016/j.jhep.2015.06.009
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Transcriptomic Analysis of Chronic Hepatitis B and C and Liver Cancer Reveals MicroRNA-Mediated Control of Cholesterol Synthesis Programs. (2015)
  • Author(s): Selitsky SR, Dinh TA, Toth CL, Kurtz CL, Honda M, Struck BR, Kaneko S, Vickers KC, Lemon SM, Sethupathy P.
  • Journal Title: MBio. Volume: 6 Issue: 6
  • DOI: 10.1128/mbio.01500-15
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Autoantibody status and histological variables influence biochemical response to treatment and long-term outcomes in Japanese patients with primary biliary cirrhosis. (2014)
  • Author(s): Nakamura M, Kondo H, Tanaka A, Komori A, Ito M, Yamamoto K, Ohira H, Zeniya M, Hashimoto E, Honda M, Kaneko S, Ueno Y, Kikuchi K, Shimoda S, Harada K, Arai K, Miyake Y, Abe M, Taniai M, Saibara T, Sakisaka S, Takikawa H, Onji M, Tsubouchi H, Nakanuma Y, Ishibashi H.
  • Journal Title: Hepatol Res. Volume: - Issue: 8 Pages: 846-855
  • DOI: 10.1111/hepr.12423
  • Peer Reviewed / Open Access
• [Journal Article] Blood neutrophil to lymphocyte ratio as a predictor in patients with advanced hepatocellular carcinoma treated with hepatic arterial infusion chemotherapy. (2014)
  • Author(s): Terashima T, Yamashita T, Iida N, Yamashita T, Nakagawa H, Arai K, Kitamura K, Kagaya T, Sakai Y, Mizukoshi E, Honda M, Kaneko S.
  • Journal Title: Hepatol Res. Volume: - Issue: 9 Pages: 949-959
  • DOI: 10.1111/hepr.12436
  • Peer Reviewed / Open Access
• [Presentation] Polyprenoic acid, the first-discovered hepatocyte nuclear factor 4 alpha-activating ligand, inhibits liver carcinogenesis. (2017)
  • Author(s): Taro Yamashita, Hikari Okada, Masao Honda, and Shuichi Kaneko
  • Organizer: AASLD 2017
  • Int'l Joint Research
• [Presentation] Unexpected Enhancement of Replication Capacity by Simeprevir for Simeprevir-Resistant Variants in Genotype 1a Hepatitis C Virus (2017)
  • Author(s): Tetsuro Shimakami, Kazuhisa Murai, Christoph Welsh, Takayosi Shirasaki, Masao Honda, and Shuichi Kaneko
  • Organizer: AASLD 2017
  • Int'l Joint Research
• [Presentation] Genome-wide methylation analysis identified a new intrahepatic angiogenesis marker associated with induction of tumorigenesis after successful eradication of HCV (2017)
  • Author(s): Masashi Nishikawa, Masao Honda, Hikari Okada, Kazunori Kawaguchi, Rika Horii, Tetsuro Shimakami, Kuniaki Arai, Taro Yamashita, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, and Shuichi Kaneko
  • Organizer: AASLD 2017
  • Int'l Joint Research
• [Presentation] Nucleos(t)ide analogues and interferon affect intranuclear HBV genome in vitro via Notch signaling modification, independent of the ubiquitin-proteasome system (2017)
  • Author(s): Kazunori Kawaguchi, Zijing Wang, Masao Honda, Takayoshi Shirasaki, Hikari Okada, Tetsuro Shimakami, Kouki Nio, Kuniaki Arai, Taro Yamashita, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Shuichi Kaneko
  • Organizer: AASLD 2017
  • Int'l Joint Research
• [Presentation] Notch signaling inhibition is associated with degradation of intrahepatic HBV by ITCH in an ubiquitin-dependent manner (2017)
  • Author(s): Zijing Wang, Kazunori Kawaguchi, Masao Honda, Hikari Okada, Takayoshi Shirasaki, Tetsuro Shimakami, Shuichi Kaneko
  • Organizer: AASLD 2017
  • Int'l Joint Research
• [Presentation] A liver-derived secretory protein, LECT2, activates plasmacytoid dendritic cells and protects hepatocytes from HBV infection (2017)
  • Author(s): Takayoshi Shirasaki, Masao Honda, Kazuhisa Murai, Tetsuro Shimakami, Miwako Narita, Hirofumi Misu, Toshinari Takamura, Seishi Murakami, Shuichi Kaneko
  • Organizer: AASLD 2017
  • Int'l Joint Research
• [Presentation] Inhibitory effect of acyclic retinoid on hepatitis B virus replication (2017)
  • Author(s): Ryogo Shimizu, Masao Honda, Takayoshi Shirasaki, Tetsuro Shimakami, Kazuhisa Murai, Shuichi Kaneko
  • Organizer: AASLD 2017
  • Int'l Joint Research
• [Presentation] Osteopontin regulates IFN signaling and HCV replication in cancer stem cells (2017)
  • Author(s): Ryougo Shimizu, Masao Honda, Takayoshi Shirasaki, Tetsuro Shimakami, Taro Yamashita, Shuichi Kaneko
  • Organizer: AASLD 2017
  • Int'l Joint Research
• [Presentation] MicroRNA-10a is associated with the impaired liver functions in patients with advanced stage of chronic hepatitis C (2017)
  • Author(s): Rika Horii, Masao Honda, Takayoshi Shirasaki, Tetsuro Shimakami, Ryogo Shimizu, Shuichi Kaneko
  • Organizer: AASLD 2017
  • Int'l Joint Research
• [Presentation] Identification of novel HLA-A24-restricted endogenous CTL epitopes derived from HBV genotype C (2017)
  • Author(s): Eishiro Mizukosh, Kiichiro Kaji, Kazumi Fushimi, MasaakiKithara, Noriho Iida, Masao Honda, Shuichi Kaneko
  • Organizer: AASLD 2017
  • Int'l Joint Research
• [Presentation] Regulation of Hepatitis C Virus Infection by Long Non-Coding RNA (2017)
  • Author(s): Jyuria Kitabayashi, Tetsuro Shimakami, Takayosi Shirasaki, Kazuhisa Murai, Masao Honda, and Shuichi Kaneko
  • Organizer: AASLD 2017
  • Int'l Joint Research
• [Presentation] The utility of the serum C16:1n7/C16:0 ratio as a diagnostic marker of non-alcoholic steatohepatitis (2017)
  • Author(s): Eishiro Mizukoshi, Takuya Seike, Rika Horii, Takeshi Terashima, Norio iida, Masaaki Kitahara, Hajime Sunagozaka, Kuniaki Arai, Tatsuya Yamashita, Masao Honda, Shuichi Kaneko
  • Organizer: AASLD 2017
  • Int'l Joint Research
• [Presentation] Immunomodulation of aggressive liver cancer by EpCAM+ cancer stem cells thorough the activation of CCL20-CCR6 axis. (2017)
  • Author(s): Mika Ohwada, TaroYamashita, Hikari Okada, Kouki Nio, Masao Honda and Shuichi Kaneko
  • Organizer: AASLD 2017
  • Int'l Joint Research
• [Presentation] Serum Cytokine Profiles Predict Survival Benefits in Patients with Advanced Hepatocellular Carcinoma Treated with Sorafenib: a Retrospective Cohort Study (2017)
  • Author(s): Tsuyoshi Suda, Tomoyuki Hayashi, Taro Yamashita, Hikari Okada,Yoshirou Asahina, Takehiro Hayashi, Yasumasa Hara, Kouki Nio, Takeshi Terashima, Hajime Sunagozaka,Hajime Takatori, Kuniaki Arai1, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko
  • Organizer: AASLD 2017
  • Int'l Joint Research
• [Presentation] 7. mRNA for selenoprotein P, a hepatokine, binds RIG-I protein and inhibits the RIG-I-mediated type I interferon response (2017)
  • Author(s): Kazuhisa Murai, Masao Honda, Tetsuro Shimakami, Takayoshi Shirasaki, Hirofumi Misu, Toshinari Takamura, Stanley M. Lemon, Seishi Murakami, Shuichi Kaneko
  • Organizer: AASLD 2017
  • Int'l Joint Research
• [Presentation] IFN-λ3 induces dendritic cell maturation independent of type I IFN (2017)
  • Author(s): Shiho Tanaka, Masao Honda, Kazuhisa Murai, Tetsuro Shimakami, Takayoshi Shirasaki, Seishi Murakami, Shuichi Kaneko
  • Organizer: AASLD 2017
  • Int'l Joint Research
• [Presentation] Promoted liver fibrosis and malignant phenotype in HCV/PDGF-C transgenic mouse are accompanied by abnormal expression of the glycolysis-related gene pyruvate kinase M (2017)
  • Author(s): Hikari Okada, Masao Honda, Jean S Campbell, Yoshio Sakai, Taro Yamashita, Kazunori Kawaguchi, Takuji Tanaka, Shuichi Kaneko
  • Organizer: AASLD 2017
  • Int'l Joint Research
• [Presentation] C型肝細胞癌根治治療後の肝炎ウイルス治療の 意義と宿主因子 (2016)
  • Author(s): 本多政夫、方堂祐治、金子周一
  • Organizer: JDDW2016
  • Place of Presentation: 神戸コンベンションセンター（兵庫県神戸市）
  • Year and Date: 2016-11-03
• [Presentation] Pyruvate kinase muscle (PKM)の肝炎・肝癌病態における役割 (2016)
  • Author(s): 本多政夫、岡田 光、金子周一
  • Organizer: 第52回日本肝臓学会総会
  • Place of Presentation: ホテルニューオータニ幕張（千葉県千葉市）
  • Year and Date: 2016-05-19
• [Presentation] インスリン抵抗性因子セレノプロテインP（SeP)のHCV複製及び自然免疫応答に与える影響 (2016)
  • Author(s): 本多政夫、村居和寿、金子周一
  • Organizer: 第102回日本消化器病学会総会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2016-04-21
• [Presentation] Innate immunity during HCV infection (2016)
  • Author(s): 本多政夫
  • Organizer: The 3rd International symposium on viral Hepatitis
  • Place of Presentation: 成都（中国）
• [Presentation] Peretinoin, an acyclic retinoid, suppresses steatohepatitis and development of tumorigenesis by activated Atg16L1-dependent autophagy in mice fed an atherogenic high-fat diet (2015)
  • Author(s): Hikari Okada, Masao Honda, Kai Takegoshi, Taro Yamashita, Naoto Matsuzawa,Toshinari Takamura, Takuji Tanaka, Shuichi Kaneko
  • Organizer: The Liver Meeting (AALSD) 2015
  • Place of Presentation: サンフランシスコ（アメリカ）
  • Year and Date: 2015-11-13
  • Int'l Joint Research
• [Presentation] Hepatitis B virus X protein stimulates HBV replication by regulating transcription factors associated with DNA or histone methylation (2015)
  • Author(s): Naoki Oishi, Xuyang Wang, Kazunori Kawaguchi, Masao Honda, Seishi Murakami, Shuichi Kaneko
  • Organizer: The Liver Meeting (AALSD) 2015
  • Place of Presentation: サンフランシスコ（アメリカ）
  • Year and Date: 2015-11-13
  • Int'l Joint Research
• [Presentation] Effective prevention of direct-acting antiviral-resistant hepatitis C virus by combination with LNA-anti-miR-122 therapy in cell culture (2015)
  • Author(s): Fanwei Liu, Tetsuro Shimakami, Kazuhisa Murai, Takayuki Shirasaki, Masaya Funaki, Masao Honda, Hong Tang, Seishi Murakami, Shuichi Kaneko
  • Organizer: 22nd International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: ストラスブール（フランス）
  • Year and Date: 2015-10-09
  • Int'l Joint Research