Development of new early diagnosis, prevention and treatment of cardiovascular disease by clinical application of basic research

• Project/Area Number: 15H04816
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Tohoku University
• Principal Investigator: Satoh Kimio 東北大学, 高度教養教育・学生支援機構, 准教授 (80436120)
• Co-Investigator(Kenkyū-buntansha): 宮田 敏 東北大学, 医学系研究科, 准教授 (60360343)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2017: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
• Keywords: 循環器・高血圧 / 肺高血圧症 / 医歯薬学 / 内科系臨床医学 / 循環器内科学 / 分子血管学 / 臨床応用研究 / バイオマーカー / 創薬 / 基礎研究の臨床応用 / ハイスループットスクリーニング

Outline of Final Research Achievements

We have performed basic research using genetically modified mice and confirmed that CyPA is an important protein for the development of pulmonary hypertension (PH). Next, we developed a method for measuring the plasma CyPA concentration in patients with PH and confirmed that the concentration was elevated in patients compared with healthy controls. Moreover, patients with high plasma CyPA showed poorer prognosis compared with those with low CyPA levels. Third, we performed screening of therapeutic molecules focusing on inhibition of CyPA and extracellular CyPA receptor (basigin) by using high throughput screening system, and validated the effectiveness in animal models of PH.

Research Products

• [Int'l Joint Research] Medical University of South Carolina/University of South Carolina(米国)
• [Journal Article] Selenoprotein P promotes vascular smooth muscle cell proliferation and pulmonary hypertension -A possible novel therapeutic target- (2018)
  • Author(s): Kikuchi N, Satoh K, Kurosawa R, Yaoita N, Md. Elias Al-Mamun, Mohammad Abdul Hai Siddique, Omura J, Satoh T, Nogi M, Sunamura S, Miyata S, Shimokawa H.
  • Journal Title: Circulation Volume: in press
  • Peer Reviewed / Open Access
• [Journal Article] Sex differences in hemodynamic responses and long-term survival to optimal medical therapy in patients with pulmonary arterial hypertension. (2018)
  • Author(s): Kozu K, Sugimura K, Aoki T, Tatebe S, Yamamoto S, Yaoita N, Shimizu T, Nochioka K, Sato H, Konno R, Satoh K, Miyata S, Shimokawa H.
  • Journal Title: Heart Vessels. Volume: in press Issue: 8 Pages: 939-947
  • DOI: 10.1007/s00380-018-1140-6
  • Peer Reviewed / Open Access
• [Journal Article] Shrinking basic cardiovascular research in Japan: A tip of the iceberg. (2017)
  • Author(s): Shimokawa H, Kikuchi N, Satoh K.
  • Journal Title: Circ Res. Volume: 121 Issue: 4 Pages: 331-334
  • DOI: 10.1161/circresaha.117.310845
  • Peer Reviewed / Open Access
• [Journal Article] Development of Novel Therapies for Cardiovascular Diseases by Clinical Application of Basic Research (2017)
  • Author(s): Satoh K.
  • Journal Title: Circulation Journal Volume: 81 Issue: 11 Pages: 1557-1563
  • DOI: 10.1253/circj.CJ-17-1029
  • NAID: 130006179876
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] European Society of Cardiology (ESC) Annual Congress Report From Barcelona 2017 (2017)
  • Author(s): Satoh K, Takahashi J, Matsumoto Y, Tatebe S, Aoki T, Kikuchi Y, Hao K, Ohyama K, Nogi M, Suda A, Kasahara S, Sato K, Ichijo S, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 81 Issue: 12 Pages: 1758-1763
  • DOI: 10.1253/circj.CJ-17-1103
  • NAID: 130006219237
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive evaluation of the effectiveness and safety of balloon pulmonary angioplasty for inoperable chronic thrombo-embolic pulmonary hypertension: long-term effects and procedure-related complications. (2017)
  • Author(s): Aoki T, Sugimura K, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Konno R, Miyata S, Nochioka K, Satoh K, Shimokawa H.
  • Journal Title: Eur Heart J. Volume: 7 Issue: 42 Pages: 3152-3159
  • DOI: 10.1093/eurheartj/ehx530
  • Peer Reviewed / Open Access
• [Journal Article] The Efficacy of a Genetic Analysis of the <i>BMPR2</i> Gene in a Patient with Severe Pulmonary Arterial Hypertension and an Atrial Septal Defect Treated with Bilateral Lung Transplantation (2017)
  • Author(s): Tatebe S, Sugimura K, Aoki T, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Konno R, Satoh K, Fukuda K, Adachi O, Saito R, Nakanishi N, Morisaki H, Oyama K, Saiki Y, Okada Y, Shimokawa H.
  • Journal Title: Internal Medicine Volume: 56 Issue: 23 Pages: 3193-3197
  • DOI: 10.2169/internalmedicine.8686-16
  • NAID: 130006235510
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Activated TAFI promotes the development of chronic thromboembolic pulmonary hypertension -A possible novel therapeutic target- (2017)
  • Author(s): Satoh T, Satoh K, Yaoita N, Kikuchi N, Omura J, Kurosawa R, Numano K, Md. Elias-Al-Mamun, Mohammad Abdul Hai Siddique, Sunamura S, Nogi M, Suzuki K, Miyata S, Morser J, Shimokawa H.
  • Journal Title: Circ Res. Volume: 120 Issue: 8 Pages: 1246-1262
  • DOI: 10.1161/circresaha.117.310640
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] AMPKα2 regulates hypoxia-inducible factor-1α stability and neutrophil survival to promote vascular repair after ischemia. (2017)
  • Author(s): Satoh K
  • Journal Title: Circ Res. Volume: 120 Issue: 1 Pages: 8-10
  • DOI: 10.1161/circresaha.116.310217
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Prognostic impacts of plasma levels of cyclophilin A in patients with coronary artery disease. (2017)
  • Author(s): Ohtsuki T, Satoh K, Omura J, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Sunamura S, Yaoita N, Aoki T, Tatebe S, Sugimura K, Takahashi J, Miyata S, Shimokawa H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 37 Issue: 4 Pages: 685-693
  • DOI: 10.1161/atvbaha.116.308986
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice. (2017)
  • Author(s): Kina-Tanada M, Sakanashi M, Tanimoto A, Kaname T, Matsuzaki T, Noguchi K, Uchida T, Nakasone J, Kozuka C, Ishida M, Kubota H, Taira Y, Totsuka Y, Kina SI, Sunakawa H, Omura J, Satoh K, Shimokawa H, Yanagihara N, Maeda S, Ohya Y, Matsushita M, Masuzaki H, Arasaki A, Tsutsui M.
  • Journal Title: Diabetologia. Volume: 60 Issue: 6 Pages: 1138-1152
  • DOI: 10.1007/s00125-017-4259-6
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Crucial roles of nitric oxide synthases in β-adrenoceptor mediated bladder relaxation in mice. (2017)
  • Author(s): Satake Y, Satoh K, Nogi M, Omura J, Godo S, Miyata S, Saito H, Tanaka S, Ikumi Y, Yamashita S, Kaiho Y, Tsutsui M, Arai Y, Shimokawa H.
  • Journal Title: Am J Physiol. Volume: 312 Issue: 1 Pages: F33-F42
  • DOI: 10.1152/ajprenal.00137.2016
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Protective roles of endothelial AMP-activated protein kinase against hypoxia-induced pulmonary hypertension in mice. (2016)
  • Author(s): Omura J, Satoh K, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Otsuki T, Kozu K, Numano K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Miyata S, Hoshikawa Y, Okada Y, Shimokawa H.
  • Journal Title: Circ Res. Volume: 119 Issue: 2 Pages: 197-209
  • DOI: 10.1161/circresaha.115.308178
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Thrombin-activatable fibrinolysis inhibitor in chronic thromboembolic pulmonary hypertension. (2016)
  • Author(s): Yaoita N, Satoh K, Satoh T, Sugimura K, Tatebe S, Yamamoto S, Aoki T, Miura M, Miyata S, Kawamura T, Horiuchi H, Fukumoto Y, Shimokawa H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 36 Issue: 6 Pages: 1293-1301
  • DOI: 10.1161/atvbaha.115.306845
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Novel therapeutic targets of pulmonary hypertension. (2016)
  • Author(s): Yaoita N, Satoh K, Shimokawa H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 36 Issue: 12
  • DOI: 10.1161/atvbaha.116.308263
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] RhoA/Rho-kinase in the cardiovascular system. (2016)
  • Author(s): Shimokawa H, Sunamura S, Satoh K.
  • Journal Title: Circ Res. Volume: 118 Issue: 2 Pages: 352-366
  • DOI: 10.1161/circresaha.115.306532
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Basigin promotes cardiac fibrosis and failure in response to chronic pressure-overload in mice. (2016)
  • Author(s): Suzuki K, Satoh K, Ikeda S, Sunamura S, Otsuki T, Satoh T, Kikuchi N, Omura J, Kurosawa R, Nogi M, Numano K, Sugimura K, Aoki T, Tatebe S, Miyata S, Mukherjee R, Spinale FG, Kadomatsu K, Shimokawa H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 36 Issue: 4 Pages: 636-646
  • DOI: 10.1161/atvbaha.115.306686
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] SmgGDS as a crucial mediator of the inhibitory effects of statins on cardiac hypertrophy and fibrosis -Novel mechanism of the pleiotropic effects of statins- (2016)
  • Author(s): Kudo S, Satoh K, Nogi M, Suzuki K, Sunamura S, Omura J, Kikuchi N, Kurosawa R, Satoh T, Minami T, Ikeda S, Miyata S, Shimokawa H.
  • Journal Title: Hypertension Volume: 67 Issue: 5 Pages: 878-889
  • DOI: 10.1161/hypertensionaha.115.07089
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Statins up-regulate SmgGDS through β1-integrin/Akt1 pathway in endothelial cells. (2016)
  • Author(s): Minami T, Satoh K, Nogi M, Kudo S, Miyata S, Tanaka S, Shimokawa H. Statins up-regulate SmgGDS through β1-integrin/Akt1 pathway in endothelial cells.
  • Journal Title: Cardiovasc Res. Volume: 109 Issue: 1 Pages: 151-161
  • DOI: 10.1093/cvr/cvv253
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Deletion of LR11 attenuates hypoxia-induced pulmonary arterial smooth muscle cell proliferation with medial thickening in mice. (2016)
  • Author(s): Jiang L, Konishi H, Nurwidya F, Satoh K, Takahashi F, Ebinuma H, Fujimura K, Takasu K, Jiang M, Shimokawa H, Bujo H, Daida H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 36 Issue: 9 Pages: 1972-1979
  • DOI: 10.1161/atvbaha.116.307900
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Multiple Beneficial Effects of Balloon Pulmonary Angioplasty in Patients With Chronic Thromboembolic Pulmonary Hypertension (2016)
  • Author(s): Tatebe S, Sugimura K, Aoki T, Miura M, Nochioka K, Miyamichi-Yamamoto S, Yaoita N, Suzuki H, Sato H, Satoh K, Fukumoto Y, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 80 Issue: 4 Pages: 980-988
  • DOI: 10.1253/circj.CJ-15-1212
  • NAID: 130005139581
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Balloon Pulmonary Angioplasty Improves Biventricular Functions and Pulmonary Flow in Chronic Thromboembolic Pulmonary Hypertension (2016)
  • Author(s): Sato H, Ota H, Sugimura K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Satoh K, Takase K, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 80 Issue: 6 Pages: 1470-1477
  • DOI: 10.1253/circj.CJ-15-1187
  • NAID: 130005153583
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Effects of Balloon Pulmonary Angioplasty on Oxygenation in Patients With Chronic Thromboembolic Pulmonary Hypertension – Importance of Intrapulmonary Shunt – (2016)
  • Author(s): Aoki T, Sugimura K, Nochioka K, Miura M, Tatebe S, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Miyata S, Satoh K, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 80 Issue: 10 Pages: 2227-2234
  • DOI: 10.1253/circj.CJ-16-0254
  • NAID: 130005418994
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Pulmonary Arterial Hypertension Associated with Congenital Portosystemic Shunts Treated with Transcatheter Embolization and Pulmonary Vasodilators (2016)
  • Author(s): Sato H, Miura M, Yaoita N, Yamamoto S, Tatebe S, Aoki T, Satoh K, Ota H, Takase K, Sugimura K, Shimokawa H.
  • Journal Title: Internal Medicine Volume: 55 Issue: 17 Pages: 2429-2432
  • DOI: 10.2169/internalmedicine.55.6557
  • NAID: 130005262543
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Overview of the 80^th Annual Scientific Meeting of the Japanese Circulation Society – The Past, Present and Future of Cardiovascular Medicine in Japan – – The 5^th Anniversary of the Great East Japan Earthquake – (2016)
  • Author(s): Takahashi J, Satoh K, Fukuda K, Sugimura K, Matsumoto Y, Nakano M, Tsuburaya R, Aoki T, Hao K, Nishimiya K, Ito K, Sakata Y, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 80 Issue: 8 Pages: 1689-1694
  • DOI: 10.1253/circj.CJ-16-0644
  • NAID: 130005166099
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 喫煙と循環器疾患up to date: 喫煙による酸化ストレスと動脈硬化性疾患 (2016)
  • Author(s): 佐藤 公雄
  • Journal Title: 南江堂「循環器専門医」 Volume: 24 Pages: 134-138
  • Acknowledgement Compliant
• [Journal Article] PDE1C negatively regulates growth factor receptor degradation and promotes vascular smooth muscle cell proliferation. (2015)
  • Author(s): Satoh K, Kikuchi N, Kurosawa R, Shimokawa H.
  • Journal Title: Circ Res. Volume: 116 Issue: 7 Pages: 1098-1100
  • DOI: 10.1161/circresaha.115.306139
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cyclophilin A in Cardiovascular Homeostasis and Diseases (2015)
  • Author(s): Satoh K
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 235 Issue: 1 Pages: 1-15
  • DOI: 10.1620/tjem.235.1
  • NAID: 130004822422
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Rho-kinase inhibition during early cardiac development causes arrhythmogenic right ventricular cardiomyopathy in mice. (2015)
  • Author(s): Ellawindy A, Satoh K, Sunamura S, Kikuchi N, Suzuki K, Minami T, Ikeda S, Tanaka S, Shimizu T, Enkhjargal B, Miyata S, Taguchi Y, Handoh T, Kobayashi K, Kobayashi K, Nakayama K, Miura M, Shimokawa H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 35 Issue: 10 Pages: 2172-2184
  • DOI: 10.1161/atvbaha.115.305872
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 2015 ATVB plenary lecture: translational research on Rho-kinase in cardiovascular medicine. (2015)
  • Author(s): Shimokawa H, Satoh K.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 35 Issue: 8 Pages: 1756-1769
  • DOI: 10.1161/atvbaha.115.305353
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Light and dark of reactive oxygen species for vascular function. (2015)
  • Author(s): Shimokawa H, Satoh K.
  • Journal Title: J Cardiovasc Pharmacol. Volume: 65 Issue: 5 Pages: 412-418
  • DOI: 10.1097/fjc.0000000000000159
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 肺高血圧症の分子基盤 (2015)
  • Author(s): 佐藤 公雄、下川 宏明.
  • Journal Title: 科学評論社「循環器内科」特集/循環器疾患と分子遺伝学 Volume: 77 Pages: 285-291
  • Acknowledgement Compliant
• [Presentation] Selenoprotein P promotes the development of pulmonary arterial hypertension-A Possible Novel Therapeutic Target- (2018)
  • Author(s): Kikuchi N, Satoh K, Kurosawa R, Yaoita N, Elias-Al-Mamun M, Abdul Hai Siddique M, Omura J, Satoh T, Nogi M, Sunamura S, Miyata S, Saito Y, Hoshikawa Y, Okada Y, Shimokawa H.
  • Organizer: World Symposium on Pulmonary Hypertension (2018年2月27～3月1日, Nice, France)
  • Int'l Joint Research
• [Presentation] ADAMTS8 Promotes the Development of pulmonary arterial hypertension and right ventricular failure-A possible novel therapeutic target- (2018)
  • Author(s): Satoh K, Omura J, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Sunamura S, Ohtsuki T, Elias-Al-Mamun M, Abdul Hai Siddique M, Yaoita N, Miyata S, Hoshikawa Y, Okada Y, Shimokawa H.
  • Organizer: World Symposium on Pulmonary Hypertension (2018年2月27～3月1日, Nice, France)
  • Int'l Joint Research
• [Presentation] Identification of celastramycin as a novel therapeutic agent for pulmonary arterial hypertension -High-throughput screening of 5,562 compounds- (2018)
  • Author(s): Kurosawa R, Satoh K, Kikuchi N, Satoh T, Omura J, Nogi M, Sunamura S, Ohtsuki T, Yaoita N, Abdul Hai Siddique M, Elias-Al-Mamun M, Shimizu T, Shimokawa H.
  • Organizer: World Symposium on Pulmonary Hypertension (2018年2月27～3月1日, Nice, France)
  • Int'l Joint Research
• [Presentation] Different roles of myocardial ROCK1 and ROCK2 in response to chronic pressure-overload in mice. (2018)
  • Author(s): Sunamura S, Satoh K, Shimizu T, Suzuki K, Ikeda S, Kudo S, Omura J, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Ohtsuki T, Shimokawa H.
  • Organizer: World Symposium on Pulmonary Hypertension (2018年2月27～3月1日, Nice, France)
  • Int'l Joint Research
• [Presentation] Identification of Emetine as a Novel Therapeutic Agent for Pulmonary Hypertension in Rats -High-throughput Screening of 5,562 Compounds- (2018)
  • Author(s): Abdul Hai Siddique M, Satoh K, Kurosawa R, Elias-Al-Mamun M, Kikuchi N, Omura J, Satoh T, Nogi M, Sunamura S, Shimokawa H.
  • Organizer: World Symposium on Pulmonary Hypertension (2018年2月27～3月1日, Nice, France)
  • Int'l Joint Research
• [Presentation] Prognostic Impacts of Soluble Form of Basigin in Patients with Chronic Heart Failure -From a Prospective Large Clinical Trial with 1,147 Patients- (2018)
  • Author(s): Satoh K, Ohtsuki T, Miyata S, Miura M, Nochioka K, Sunamura S, Suzuki K, Nogi M, Kurosawa R, Omura J, Kikuchi N, Satoh T, Aoki T, Tatebe S, Sugimura K, Sakata Y, Shimokawa H.
  • Organizer: 第82回日本循環器学会学術集会（3月23日～25日、2018年、大阪市）
  • Int'l Joint Research
• [Presentation] Immunosuppressive Therapy Ameliorates Severe Pulmonary Hypertension and Refractory Vasospastic Angina in a Patient with Eosinophilic Granulomatosis with Polyangiitis (2018)
  • Author(s): Konno R, Tatebe S, Sugimura K, Satoh K, Aoki T, Yamamoto S, Sato H, Kozu K, Shimokawa H.
  • Organizer: 第82回日本循環器学会学術集会（3月23日～25日、2018年、大阪市）
  • Int'l Joint Research
• [Presentation] Rho-kinase and Cyclophilin A as Novel Therapeutic Targets for Cardiac Dysfunction and Post-Capillary Pulmonary Hypertension (2018)
  • Author(s): Sunamura S, Satoh K, Kurosawa R, Ohtsuki T, Kikuchi N, Md Elias Al-Mamun, Shimizu T, Ikeda S, Suzuki K, Satoh T, Omura J, Nogi M, Mohammad Abdul Hai Siddique, Miyata S, Miura M, Shimokawa H.
  • Organizer: 第82回日本循環器学会学術集会（3月23日～25日、2018年、大阪市）
  • Int'l Joint Research
• [Presentation] SmgGDS Prevents Thoracic Aortic Aneurysm Formation and Rupture by Phenotypic Preservation of Aortic Smooth Muscle Cells (2018)
  • Author(s): Nogi M, Satoh K, Sunamura S, Kikuchi N, Sato T, Kurosawa R, Omura J, Md Elias Al-Mamun, Mohammad Abdul Hai Siddique, Kudo S, Akiyama M, Kawamoto S, Saiki Y, Shimokawa H.
  • Organizer: 第82回日本循環器学会学術集会（3月23日～25日、2018年、大阪市）
  • Int'l Joint Research
• [Presentation] Normalization of Hemodynamic Responses to Exercise as a Final Goal of Balloon Pulmonary Angioplasty in Patients with CTEPH (2018)
  • Author(s): Aoki T, Sugimura K, Tatebe S, Yamamoto S, Shimizu T, Yaoita N, Sato H, Kouzu K, Konno R, Terui Y, Nochioka K, Satoh K, Shimokawa H.
  • Organizer: 第82回日本循環器学会学術集会（3月23日～25日、2018年、大阪市）
  • Int'l Joint Research
• [Presentation] Selenoprotein P Promotes Vascular Smooth Muscle Cell Proliferation and Pulmonary Hypertension -A Possible Novel Therapeutic Target- (2018)
  • Author(s): Kikuchi N, Satoh K, Kurosawa R, Yaoita N, Md. Elias Al-Mamun, Mohammad Abdul Hai Siddique, Omura J, Sato T, Nogi M, Sunamura S, Miyata S, Shimokawa H.
  • Organizer: 第82回日本循環器学会学術集会（3月23日～25日、2018年、大阪市）
  • Int'l Joint Research
• [Presentation] Sex Differences in Hemodynamic Responses and Long-term Survival to Optimal Medical Therapy in Patients with Pulmonary Arterial Hypertension (2018)
  • Author(s): Kozu K, Sugimura K, Aoki T, Tatebe S, Yamamoto S, Yaoita N, Shimizu T, Nochioka K, Sato H, Konno R, Satoh K, Miyata S, Shimokawa H.
  • Organizer: 第82回日本循環器学会学術集会（3月23日～25日、2018年、大阪市）
  • Int'l Joint Research
• [Presentation] Identification of Emetine as a Novel Therapeutic Agent for Pulmonary Hypertension in Rats -High-throughput Screening of 5,562 Compounds- (2018)
  • Author(s): Mohammad Abdul Hai Siddique, Satoh K, Kurosawa R, Md. Elias Al-Mamun, Kikuchi N, Omura J, Satoh T, Nogi M, Sunamura S, Shimokawa H.
  • Organizer: 第82回日本循環器学会学術集会（3月23日～25日、2018年、大阪市）
  • Int'l Joint Research
• [Presentation] Important Prognostic Impacts of Serum Levels of Adipsin in Patients with Coronary Artery Disease (2018)
  • Author(s): Ohtsuki T, Satoh K, Shimizu T, Ikeda S, Yaoita N, Sato T, Omura J, Kikuchi N, Kurosawa R, Sunamura S, Nogi M, Sugimura K, Aoki T, Tatebe S, Nochioka K, Yamamoto S, Takahashi J, Miyata S, Shimokawa H.
  • Organizer: 第82回日本循環器学会学術集会（3月23日～25日、2018年、大阪市）
  • Int'l Joint Research
• [Presentation] Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension -High-throughput Screening of 5,562 Compounds- (2018)
  • Author(s): Kurosawa R, Satoh K, Kikuchi N, Omura J, Sato T, Nogi M, Sunamura S, Al-Mamun Md. Elias, Mohammad Abdul Hai Siddique, Shimokawa H.
  • Organizer: 第82回日本循環器学会学術集会（3月23日～25日、2018年、大阪市）
  • Int'l Joint Research
• [Presentation] Clinical Profiles of Pregnant Women with Heart Disease (2018)
  • Author(s): Tatebe S, Sugimura K, Saito M, Sakata Y, Satoh K, Aoki T, Yamamoto S, Shimizu T, Sato H, Otsuki T, Kozu K, Konno R, Terui Y, Kawano K, Kimura M, Adachi O, Saiki Y, Shimokawa H.
  • Organizer: 第82回日本循環器学会学術集会（3月23日～25日、2018年、大阪市）
  • Int'l Joint Research
• [Presentation] Hepatitis C Virus Positivity Adversely Impacts Cardiac Functions and Long-term Prognosis in Patients with Adult Congenital Heart Disease (2018)
  • Author(s): Konno R, Tatebe S, Sugimura K, Satoh K, Aoki T, Yamamoto S, Shimizu T, Sato H, Kozu K, Terui Y, Adachi O, Kimura M, Saiki Y, Shimokawa H.
  • Organizer: 第82回日本循環器学会学術集会（3月23日～25日、2018年、大阪市）
  • Int'l Joint Research
• [Presentation] ＜YIAセッション＞左心不全に伴う肺高血圧症発症におけるROCK1とROCK2の役割分担の解明（最優秀賞受賞） (2018)
  • Author(s): 砂村慎一郎、佐藤公雄、黒澤 亮、大槻知広、菊地順裕、Md Elias AL-Mamun、清水 亨、池田尚平、鈴木康太、佐藤大樹、大村淳一、野木正道、Mohammad Abdul Hai Siddique、宮田 敏、下川宏明
  • Organizer: 第47回日本心脈管作動物質学会（2018年2月9日～10日、長崎市）
• [Presentation] 大動脈平滑筋細胞の形質保持を機序とした胸部大動脈瘤の形成と破裂に対するSmgGDS の予防的関与 (2018)
  • Author(s): 野木正道、佐藤公雄、工藤 俊、大村淳一、菊地順裕、佐藤大樹、砂村慎一郎、黒澤 亮、大槻知広、下川宏明
  • Organizer: 第47回日本心脈管作動物質学会（2018年2月9日～10日、長崎市）
• [Presentation] < Cournand and Comroe Young Investigator Award >Selenoprotein P promotes the development of pulmonary arterial hypertension-A Possible Novel Therapeutic Target- (2017)
  • Author(s): Kikuchi N, Satoh K, Kurosawa R, Yaoita N, Elias-Al-Mamun M, Abdul Hai Siddique M, Omura J, Satoh T, Nogi M, Sunamura S, Miyata S, Saito Y, Hoshikawa Y, Okada Y, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions (2017年11月11～15日, Anaheim, USA)
  • Int'l Joint Research
• [Presentation] Rivaroxaban prevents the development of chronic thromboembolic pulmonary hypertension in mice- Novel beneficial effects of the FXa inhibitor (2017)
  • Author(s): Elias-Al-Mamun M, Satoh K, Satoh T, Yaoita N, Abdul Hai Siddique M, Kikuchi N, Omura J, Kurosawa R, Sunamura S, Nogi M, Ohtsuki T, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions (2017年11月11～15日, Anaheim, USA)
  • Int'l Joint Research
• [Presentation] ADAMTS8 Promotes the Development of pulmonary arterial hypertension and right ventricular failure-A possible novel therapeutic target- (2017)
  • Author(s): Omura J, Satoh K, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Sunamura S, Ohtsuki T, Elias-Al-Mamun M, Abdul Hai Siddique M, Yaoita N, Miyata S, Hoshikawa Y, Okada Y, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions (2017年11月11～15日, Anaheim, USA)
  • Int'l Joint Research
• [Presentation] Plasma cyclophilin A as a useful biomarker for evaluation of the effects of balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension. (2017)
  • Author(s): Kozu K, Satoh K, Shimizu T, Aoki T, Tatebe S, Yamamoto S, Sato H, Ohtsuki T, Konno R, Miyata S, Sugimura K, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions (2017年11月11～15日, Anaheim, USA)
  • Int'l Joint Research
• [Presentation] Identification of celastramycin as a novel therapeutic agent for pulmonary arterial hypertension -High-throughput screening of 5,562 compounds- (2017)
  • Author(s): Kurosawa R, Satoh K, Kikuchi N, Satoh T, Omura J, Nogi M, Sunamura S, Ohtsuki T, Yaoita N, Abdul Hai Siddique M, Elias-Al-Mamun M, Shimizu T, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions (2017年11月11～15日, Anaheim, USA)
  • Int'l Joint Research
• [Presentation] Different roles of myocardial ROCK1 and ROCK2 in response to chronic pressure-overload in mice. (2017)
  • Author(s): Sunamura S, Satoh K, Shimizu T, Suzuki K, Ikeda S, Kudo S, Omura J, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Ohtsuki T, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions (2017年11月11～15日, Anaheim, USA)
  • Int'l Joint Research
• [Presentation] Prognostic impacts of plasma levels of cyclophilin A in patients with heart failure. (2017)
  • Author(s): Ohtsuki T, Satoh K, Shimizu T, Ikeda S, Yaoita N, Satoh T, Omura J, Kikuchi N, Kurosawa R, Sunamura S, Nogi M, Sugimura K, Aoki T, Tatebe S, Miyata S, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions (2017年11月11～15日, Anaheim, USA)
  • Int'l Joint Research
• [Presentation] Protective roles of small GTP-binding protein GDP dissociation stimulator against angiotensin II-induced thoracic aortic aneurysm formation and rupture in mice -A possible novel therapeutic target- (2017)
  • Author(s): Nogi M, Satoh K, Kudo S, Satoh T, Omura J, Kikuchi N, Sunamura S, Kurosawa R, Ohtsuki T, Elias-Al-Mamun M, Abdul Hai Siddique M, Akiyama M, Shunsuke K, Saiki Y, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions (2017年11月11～15日, Anaheim, USA)
  • Int'l Joint Research
• [Presentation] Identification of Emetine as a Novel Therapeutic Agent for Pulmonary Hypertension in Rats -High-throughput Screening of 5,562 Compounds- (2017)
  • Author(s): Abdul Hai Siddique M, Satoh K, Kurosawa R, Elias-Al-Mamun M, Kikuchi N, Omura J, Satoh T, Nogi M, Sunamura S, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions (2017年11月11～15日, Anaheim, USA)
  • Int'l Joint Research
• [Presentation] <Young Investigator Awards Session: Basic Science>Thrombin activatable fibrinolysis inhibitor promotes development of chronic thromboembolic pulmonary hypertension -A possible novel therapeutic target-. (2017)
  • Author(s): Satoh T, Satoh K, Yaoita N, Elias-Al-Mamun M, M.A.H. Siddique, Kikuchi N, Omura J, Kurosawa R, Sunamura S, Nogi M, Otsuki T, Miyata S, Shimokawa H.
  • Organizer: European Society Congress (ESC) Congress 2017 (2017年8月26～8月30日, Barcelona, Spain)
  • Int'l Joint Research
• [Presentation] <Best Posters Sessions> （Best Poster Award受賞）Balloon pulmonary angioplasty ameliorates long-term survival of patients with inoperable chronic thromboembolic pulmonary hypertension. (2017)
  • Author(s): Tatebe S, Sugimura K, Aoki T, Yamamoto S, Yaoita N, Sato H, Konno R, Satoh K, Shimokawa H.
  • Organizer: European Society Congress (ESC) Congress 2017 (2017年8月26～8月30日, Barcelona, Spain)
  • Int'l Joint Research
• [Presentation] <Best Posters Sessions> Protective roles of small GTP-binding protein GDP dissociation stimulator against angiotensin II-induced thoracic aortic aneurysm formation and rupture in mice -A possible novel therapeutic target-. (2017)
  • Author(s): Nogi M, Satoh K, Kudo S, Omura J, Kikuchi N, Satoh T, Sunamura S, Kurosawa R, Elias-Al-Mamun M, M.A.H. Siddique, Ohtsuki T, Shimokawa H.
  • Organizer: European Society Congress (ESC) Congress 2017 (2017年8月26～8月30日, Barcelona, Spain)
  • Int'l Joint Research
• [Presentation] <Interventions in the pulmonary circulation> （JCS-ESC Networking Event-Best Abstract Award受賞）Comprehensive evaluation of the effectiveness and safety of balloon pulmonary angioplasty for inoperable chronic thromboembolic pulmonary hypertension - long-term effects and complications. (2017)
  • Author(s): Aoki T, Sugimura K, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Konno R, Nochioka K, Satoh K, Shimokawa H.
  • Organizer: European Society Congress (ESC) Congress 2017 (2017年8月26～8月30日, Barcelona, Spain)
  • Int'l Joint Research
• [Presentation] <Moderated Posters Sessions>Rivaroxaban prevents the development of chronic thromboembolic pulmonary hypertension in mice- Novel beneficial effects of the FXa inhibitor-. (2017)
  • Author(s): Elias-Al-Mamun M, Satoh K, Satoh T, Yaoita N, M.A.H. Siddique, Kikuchi N, Omura J, Kurosawa R, Sunamura S, Nogi M, Ohtsuki T, Shimokawa H.
  • Organizer: European Society Congress (ESC) Congress 2017 (2017年8月26～8月30日, Barcelona, Spain)
  • Int'l Joint Research
• [Presentation] Protective Roles of Small GTP-binding Protein GDP Dissociation Stimulator Against Angiotensin II-induced Thoracic Aortic Aneurysm Formation and Rupture in Mice -A Possible Novel Therapeutic Target- (2017)
  • Author(s): Nogi M, Satoh K, Kudo S, Omura J, Kikuchi N, Satoh T, Sunamura S, Kurosawa R, Ohtsuki T, Suzuki K, Shimokawa H.
  • Organizer: Scientific Session 2017 of the Arteriosclerosis, Thrombosis and Vascular Biology/ Perihperal Vascular Disease Council (May 4-6, 2017, Minneapolis, USA)
  • Int'l Joint Research
• [Presentation] ＜八巻賞受賞講演＞致死性疾患肺高血圧症の全く新しい病因蛋白に着目した治療薬開発 (2017)
  • Author(s): 佐藤公雄
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会（2017年6月2～3日、札幌市）
• [Presentation] ＜シンポジウム＞糖尿病治療薬メトホルミンによる肺高血圧症治療の既存薬再開発 (2017)
  • Author(s): 大村淳一、佐藤公雄、菊地順裕、佐藤大樹、黒澤 亮、砂村慎一郎、野木正道、Md. Elias Al-Mamun、Mohammad Abdul Hai Siddique、下川宏明
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会（2017年6月2～3日、札幌市）
• [Presentation] ＜シンポジウム＞CTEPH における内服治療 (2017)
  • Author(s): 杉村宏一郎、青木竜男、建部俊介、山本沙織、矢尾板信裕、神津克也、佐藤 遥、紺野 亮、佐藤公雄、下川宏明
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会（2017年6月2～3日、札幌市）
• [Presentation] ＜シンポジウム＞血清中サイトカインによる血管内皮AMPK 抑制と肺高血圧促進機構 (2017)
  • Author(s): 大村淳一、佐藤公雄、菊地順裕、佐藤大樹、黒澤 亮、砂村慎一郎、野木正道、Md. Elias Al-Mamun、Mohammad Abdul Hai Siddique、下川宏明
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会（2017年6月2～3日、札幌市）
• [Presentation] ＜会長特別企画＞Identification of Novel Therapeutic Targets for Pulmonary Arterial Hypertension. (2017)
  • Author(s): Satoh K, Shimokawa H.
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会（2017年6月2～3日、札幌市）
• [Presentation] ＜YIA セッション（基礎・優秀演題）＞薬物スクリーニングによる新規肺高血圧治療薬Celastamycinの発見（YIA優秀賞受賞） (2017)
  • Author(s): 黒澤 亮、佐藤公雄、菊地順裕、大村淳一、佐藤大樹、Abdul Hai Siddique Mohammad、Elias Al-Mamun Md.、砂村慎一郎、野木正道、下川宏明
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会（2017年6月2～3日、札幌市）
• [Presentation] ＜YIA セッション（基礎・優秀演題）＞慢性血栓塞栓性肺高血圧症における新規病因蛋白TAFI の機能解析（YIA優秀賞受賞） (2017)
  • Author(s): 佐藤大樹、佐藤公雄、矢尾板信裕、Al-Mamun Md Elias、Siddique Mohammad Abdul Hai、菊地順裕、大村淳一、黒澤 亮、宮田 敏、下川宏明
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会（2017年6月2～3日、札幌市）
• [Presentation] ＜YIA セッション（基礎・優秀演題）＞新規病因蛋白セレノプロテインP による肺高血圧症促進機構（YIA最優秀賞受賞） (2017)
  • Author(s): 菊地順裕、佐藤公雄、黒澤 亮、Elias-Al-Mamun Md.、Abdul Hai Siddique Mohammad、大村淳一、佐藤大樹、野木正道、宮田 敏、下川宏明
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会（2017年6月2～3日、札幌市）
• [Presentation] 肺動脈性肺高血圧症における新規病因蛋白ADAMTS8 の機能解析 (2017)
  • Author(s): 大村淳一、佐藤公雄、菊地順裕、佐藤大樹、黒澤 亮、砂村慎一郎、野木正道、Md. Elias Al-Mamun、Mohammad Abdul Hai Siddique、下川宏明
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会（2017年6月2～3日、札幌市）
• [Presentation] Discovery of Emetine as a Novel Therapeutic Agent for PAH (2017)
  • Author(s): Mohammad Abdul Hai Siddique、佐藤公雄、黒澤 亮、Md. Elias Al-Mamun、菊地順裕、大村淳一、佐藤大樹、野木正道、砂村慎一郎、大槻知広、下川宏明
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会（2017年6月2～3日、札幌市）
• [Presentation] 担癌患者における肺塞栓症の凝固線溶系の特徴 (2017)
  • Author(s): 矢尾板信裕、杉村宏一郎、青木竜男、建部俊介、山本沙織、佐藤公雄、下川宏明
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会（2017年6月2～3日、札幌市）
• [Presentation] Rivaroxaban prevents the development of CTEPH in mice (2017)
  • Author(s): Md. Elias Al-Mamun、佐藤公雄、佐藤大樹、矢尾板信裕、Mohammad Abdul Hai Siddique、菊地順裕、大村淳一、黒澤 亮、砂村慎一郎、野木正道、下川宏明
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会（2017年6月2～3日、札幌市）
• [Presentation] バルーン肺動脈形成術後のCTEPH における運動負荷右心カテーテル (2017)
  • Author(s): 青木竜男、杉村宏一郎、建部俊介、山本沙織、矢尾板信裕、佐藤 遥、神津克也、紺野 亮、後岡広太朗、佐藤公雄、下川宏明
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会（2017年6月2～3日、札幌市）
• [Presentation] Inoperable CTEPH に対する BPA 治療の長期予後 (2017)
  • Author(s): 建部俊介、杉村宏一郎、青木竜男、山本沙織、矢尾板信裕、佐藤 遥、神津克也、紺野 亮、佐藤公雄、下川宏明
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会（2017年6月2～3日、札幌市）
• [Presentation] 体外式VAD と肺血管拡張薬療法を行った修正大血管転位症の1 例 (2017)
  • Author(s): 建部俊介、杉村宏一郎、青木竜男、山本沙織、矢尾板信裕、紺野 亮、佐藤公雄、安達 理、小山耕太郎、齋木佳克、下川宏明
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会（2017年6月2～3日、札幌市）
• [Presentation] 難治性冠攣縮性狭心症と著明な肺高血圧を合併したEGPA の1 例 (2017)
  • Author(s): 紺野 亮、建部俊介、杉村宏一郎、青木竜男、山本沙織、矢尾板信裕、佐藤 遥、神津克也、白井剛志、佐藤公雄、下川宏明
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会（2017年6月2～3日、札幌市）
• [Presentation] 慢性血栓塞栓性肺高血圧症に対する血管拡張薬中止の影響 (2017)
  • Author(s): 矢尾板信裕、杉村宏一郎、青木竜男、建部俊介、山本沙織、佐藤公雄、下川宏明
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会（2017年6月2～3日、札幌市）
• [Presentation] トレプロスティニルを皮下投与で導入した5 症例 (2017)
  • Author(s): 青木竜男、杉村宏一郎、建部俊介、山本沙織、矢尾板信裕、佐藤 遥、神津克也、紺野 亮、佐藤公雄、下川宏明
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会（2017年6月2～3日、札幌市）
• [Presentation] 右室形態変化を長期観察できた特発性肺動脈性肺高血圧症の2 症例 (2017)
  • Author(s): 佐藤 遥、杉村宏一郎、建部俊介、青木竜男、山本沙織、矢尾板信裕、神津克也、紺野 亮、佐藤公雄、大田英揮、下川宏明
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会（2017年6月2～3日、札幌市）
• [Presentation] 肺動脈性肺高血圧症の長期予後に対する右心機能と性差の関連 (2017)
  • Author(s): 神津克也、杉村宏一郎、青木竜男、建部俊介、山本沙織、矢尾板信裕、佐藤 遥、後岡広太朗、佐藤公雄、宮田 敏、下川宏明
  • Organizer: 第2回日本肺高血圧・肺循環学会学術集会（2017年6月2～3日、札幌市）
• [Presentation] 新規病因蛋白セレノプロテインPによる肺高血圧症促進機構 (2017)
  • Author(s): 菊地順裕、佐藤公雄、Md. Elias-Al-Mamun, Mohammad Abdul Hai Siddique, 大村淳一、佐藤大樹、野木正道、砂村慎一郎、宮田 敏、下川宏明
  • Organizer: 第70回日本酸化ストレス学会学術集会（2017年6月28日～29日、つくば市）
• [Presentation] ＜YIA 審査講演 基礎＞マウスの圧負荷心不全モデルにおけるROCK1とROCK2の役割の違い (2017)
  • Author(s): 砂村慎一郎、佐藤公雄、清水 亨、鈴木康太、池田尚平、大村淳一、菊地順裕、黒澤 亮、野木正道、下川宏明
  • Organizer: 第21回日本心不全学会学術集会（2017年10月12日～14日、秋田）
• [Presentation] アンダーソン・ファブリー病の診断における血漿中グロボトリアオシルスフィンゴシン測定の有用性 (2017)
  • Author(s): 杉村宏一郎、山本沙織、青木竜男、建部俊介、矢尾板信裕、佐藤 遥、神津克也、紺野亮、佐藤公雄、下川宏明
  • Organizer: 第21回日本心不全学会学術集会（2017年10月12日～14日、秋田）
• [Presentation] サイクロフィリンAによる心不全患者の長期予後予測 (2017)
  • Author(s): 大槻知広、佐藤公雄、矢尾板信裕、大村淳一、菊地順裕、黒澤 亮、砂村慎一郎、野木正道、宮田 敏、下川宏明
  • Organizer: 第21回日本心不全学会学術集会（2017年10月12日～14日、秋田）
• [Presentation] ＜シンポジウム＞心疾患合併妊娠の検討 －東北大学病院の経験－ (2017)
  • Author(s): 建部俊介、杉村宏一郎、青木竜男、山本沙織、齋藤昌利、川野研悟、木村正人、安達 理、佐藤公雄、下川宏明
  • Organizer: 第21回日本心不全学会学術集会（2017年10月12日～14日、秋田）
• [Presentation] 心臓MRIが診断に有用だった心アミロイドーシスの一例 (2017)
  • Author(s): 佐藤 遥、杉村宏一郎、青木竜男、建部俊介、山本沙織、清水 亨、佐藤公雄、福原規子、大田英揮、下川宏明
  • Organizer: 第21回日本心不全学会学術集会（2017年10月12日～14日、秋田）
• [Presentation] Development of Novel Therapies for Pulmonary Hypertension by Clinical Application of Basic Research. (2017)
  • Author(s): Satoh K, Shimokawa H.
  • Organizer: The 8th TAKAO International Symposium on Molecular Mechanism of Cardiopulmonary Disease (2017年10月6～8日, Matsue, Shimane)
  • Int'l Joint Research / Invited
• [Presentation] Development of Novel Therapies for Cardiovascular Diseases by Clinical Application of Basic Research. (2017)
  • Author(s): Satoh K, Shimokawa H.
  • Organizer: JCS-KSC Joint Symposium (Basic Research) Advances in Plaque Biology (2017年10月12～14日, Seoul, Korea)
  • Int'l Joint Research / Invited
• [Presentation] Selenoprotein P Promotes Vascular Smooth Muscle Cell Proliferation and Pulmonary Hypertension -A Possible Novel Therapeutic Target- (2016)
  • Author(s): Kikuchi N, Satoh K, Omura J, Satoh T, Kurosawa R, Nogi M, Sunamura S, Otsuki T, Numano K, Yaoita N, Tatebe S, Aoki T, Sugimura K, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: New Orleans , USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Safety of Balloon Pulmonary Angioplasty in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension -Detail Analyses of Procedure Related Complications- (2016)
  • Author(s): Aoki T, Sugimura K, Miura M, Tatebe S, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Satoh K, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: New Orleans , USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] A Disintegrin and Metalloproteinase With Thrombospondin Motifs 8 Downregulates AMP-activated Protein Kinase and Promotes Matrix Metalloproteinases Activation and Pulmonary Hypertension (Cardiopulmonary Best Abstract Award) (2016)
  • Author(s): Omura J, Satoh K, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Sunamura S, Ohtsuki T, Kozu K, Numano K, Sugimura K, Tatebe S, Aoki T, Suzuki K, Yaoita N, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: New Orleans , USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Thrombin Activatable Fibrinolysis Inhibitor Promotes Development of Chronic Thromboembolic Pulmonary Hypertension -A Possible Novel Therapeutic Target- （Travel Award） (2016)
  • Author(s): Satoh T, Satoh K, Yaoita N, Kikuchi N, Omura J, Kurosawa R, Sunamura S, Nogi M, Otsuki T, Numano K, Elias-Al-Mamun M, Mohammad Abdul Hai Siddique, Tatebe S, Aoki T, Sugimura K, John Morser and Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: New Orleans , USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Efficacy of Balloon Pulmonary Angioplasty in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension. (2016)
  • Author(s): Tatebe S, Sugimura K, Aoki T, Yamamoto S, Yaoita N, Kozu K, Sato H, Satoh K, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: New Orleans , USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Protective Roles of Small GTP-binding Protein GDP Dissociation Stimulator Against Angiotensin II-induced Thoracic Aortic Aneurysm Formation and Rupture in Mice -a Possible Novel Therapeutic Target-（Travel Award） (2016)
  • Author(s): Nogi M, Satoh K, Kudo S, Omura J, Kikuchi N, Satoh T, Sunamura S, Kurosawa R, Ohtsuki T, Numano K, Suzuki K, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: New Orleans , USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Celastramycin Inhibits Pulmonary Arterial Smooth Muscle Cell Proliferation and Ameliorates Hypoxia-induced Pulmonary Hypertension in Mice. (2016)
  • Author(s): Kurosawa R, Satoh K, Kikuchi N, Omura J, Satoh T, Nogi M, Sunamura S, Numano K, Suzuki K, Mohammad Abdul Hai Siddique, Elias-Al-Mamun M, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: New Orleans , USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Crucial Role of ROCK1 to Maintain Contractile Cardiac Function in Response to Chronic Pressure-Overload in Mice. (2016)
  • Author(s): Sunamura S, Satoh K, Suzuki K, Kudo S, Ikeda S, Kikuchi N, Omura J, Satoh T, Kurosawa R, Nogi M, Numano K, Shimizu T, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: New Orleans , USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Identification of Emetine as a Novel Therapeutic Agent for Pulmonary Hypertension in Rats -High-throughput Screening of 5,562 Compounds- (2016)
  • Author(s): Mohammad Abdul Hai Siddique, Satoh K, Kurosawa R, Elias-Al-Mamun M, Kikuchi N, Omura J, Satoh T, Nogi M, Sunamura S, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: New Orleans , USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Importance of acute hemodynamic effects of inhaled nitric oxide in optimization of heart failure treatment in patients with pulmonary hypertension owing to left heart disease. (2016)
  • Author(s): Tatebe S, Sugimura K, Aoki T, Miura M, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Satoh K, Shimokawa H.
  • Organizer: ESC Congress 2016
  • Place of Presentation: Roma, Italy
  • Year and Date: 2016-08-27
  • Int'l Joint Research
• [Presentation] Basigin promotes cardiac fibrosis and failure in response to chronic pressure-overload in mice. (2016)
  • Author(s): Suzuki K, Satoh K, Ikeda S, Sunamura S, Otsuki T, Satoh T, Omura J, Kurosawa R, Nogi M, Numano K, Sugimura K, Miyata S, Shimokawa H.
  • Organizer: ESC Congress 2016
  • Place of Presentation: Roma, Italy
  • Year and Date: 2016-08-27
  • Int'l Joint Research
• [Presentation] Selenoprotein P promotes vascular smooth muscle cell proliferation and pulmonary hypertension -A possible novel therapeutic target- (2016)
  • Author(s): Kikuchi N, Satoh K, Omura J, Satoh T, Kurosawa R, Nogi M, Otsuki T, Numano K, Kozu K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Shimokawa H.
  • Organizer: Scientific Session 2016 of the Arteriosclerosis, Thrombosis and Vascular Biology/ Perihperal Vascular Disease Council
  • Place of Presentation: Nashville, USA
  • Year and Date: 2016-05-05
  • Int'l Joint Research
• [Presentation] Cyclophilin A and Its Receptor Basigin Promote Vascular Smooth Muscle Proliferation and Pulmonary Hypertension ―Possible Novel Therapeutic Target Pathway― (2016)
  • Author(s): Satoh K, Sato T, Kikuchi N, Omura J, Kurosawa R, Suzuki K, Sugimura K, Aoki T, Tatebe S, Yamamoto S, Miura M, Yaoita N, Fukumoto Y, Miyata S, Nakamura K, Ito H, Kadomatsu K, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Crucial Role of Thrombin-Activated Fibrinolysis Inhibitor in the Pathogenesis of Chronic Thromboembolic Pulmonary Hypertension. (2016)
  • Author(s): Yaoita N, Satoh K, Sato T, Kikuchi N, Omura J, Kurosawa R, Nogi M, Otsuki T, Kouzu K, Numano K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Horiuchi H, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Crucial Roles of Rho-kinase, Cyclophilin A and Its Receptor, Basigin, for Cardiac Hypertrophy, Fibrosis and Failure―Novel Therapeutic Targets of Heart Failure― (2016)
  • Author(s): Satoh K, Suzuki K, Sunamura S , Otsuki T, Shimizu T, Ikeda I, Aoki T, Tatebe S, Sugimura K, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Pathophysiology and Treatment of Right Heart Failure in Patients with Pulmonary Hypertension. (2016)
  • Author(s): Tatebe S, Sugimura K, Aoki T, Miura M, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Satoh K, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Efficacy and Safety of Balloon Pulmonary Angioplasty in Patients with Inoperable Chronic Thromboembolic Pulmonary Hypertension. (2016)
  • Author(s): Sugimura K, Aoki T, Miura M, Tatebe S, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Satoh K, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Cyclophilin A: A Novel Biomarker for Patients with Coronary Artery Disease. (2016)
  • Author(s): Satoh K, Otsuki T, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Basigin Promotes Cardiac Fibrosis and Failure in Response to Chronic Pressure-Overload in Mice. (2016)
  • Author(s): Suzuki K, Satoh K, Ikeda S, Sunamura S, Otsuki T, Sato T, Kikuchi N, Omura J, Kurosawa R, Nogi M, Numano K, Sugimura K, Aoki T, Tatebe S, Miyata S, Mukherjee R, Francis G Spinale, Kadomatsu K, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Selenoprotein P Promotes Vascular Smooth Muscle Cell Proliferation and Pulmonary Hypertension ―A Possible Novel Therapeutic Target― (2016)
  • Author(s): Kikuchi N, Satoh K, Omura J, Sato T, Kurosawa R, Nogi M, Otsuki T, Numano K, Kouzu K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Involvement of Thrombin Activatable Fibrinolysis Inhibitor in the Pathogenesis of Chronic Thromboembolic Pulmonary Hypertension. (2016)
  • Author(s): Satoh T, Satoh K, Yaoita N, Kikuchi N, Omura J, Kurosawa R, Sunamura S, Nogi M, Suzuki K, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Prognostic Impacts of Plasma Levels of Cyclophilin A in Patients with Coronary Artery Disease. (2016)
  • Author(s): Otsuki T, Satoh K, Sugimura K Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kouzu K, Nihei T, Takahashi J, Miyata S, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Crucial Role of ROCK1 to Maintain Contractile Function in Response to Pressure-Overload in Mice. (2016)
  • Author(s): Sunamura S, Satoh K, Suzuki K, Ikeda S, Omura J, Kikuchi N, Sato Th, Kurosawa R, Nogi M, Numano K, Shimizu T, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Prognostic Impacts of Plasma Levels of Adipsin in Patients with Coronary Artery Disease. (2016)
  • Author(s): Otsuki T, Satoh K, Sugimura K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kouzu K, Nihei T, Takahashi J, Miyata S, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Plasma Cyclophilin A as a Useful Biomarker for the Effects of Percutaneous Transluminal Pulmonary Angioplasty in Patients with CTEPH. (2016)
  • Author(s): Kozu K, Satoh K, Sugimura K, Aoki T, Miura M, Tatebe S, Yamamoto S, Yaoita N, Suzuki H, Otsuki T, Sato H, Miyata S, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Effects of Percutaneous Transluminal Pulmonary Angioplasty on Oxygenation Capacity in Patients with Chronic Thromboembolic Pulmonary Hypertension. (2016)
  • Author(s): Aoki T, Sugimura K, Miura M, Tatebe S, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kouzu K, Satoh K, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Disruption of Endothelial AMP-activated Protein Kinase Worsens Hypoxia-induced Pulmonary Hypertension in Mice. (2016)
  • Author(s): Omura J, Satoh K, Kikuchi N, Sato T, Kurosawa R, Nogi M, Otsuki T, Kouzu K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Influence of Discontinuation of Medications after Successful Percutaneous Transluminal Pulmonary Angioplasty in Patients with Chronic Thromboembolic Pulmonary Hypertension. (2016)
  • Author(s): Yaoita N, Sugimura K, Aoki T, Tatebe S, Yamamoto S, Miura M, Satoh K, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Percutaneous Transluminal Pulmonary Angioplasty Improves Biventricular Functions and Pulmonary Flow in Patients with Inoperable Chronic Thromboembolic Pulmonary Hypertension. (2016)
  • Author(s): Sato H, Ota H, Sugimura K, Aoki T, Miura M, Tatebe S, Yamamoto S, Yaoita N, Suzuki H, Kouzu K, Satoh K, Takase K, Shimokawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] 肺動脈血管内皮AMPKは肺高血圧症の進行を抑制する (2016)
  • Author(s): 大村淳一、佐藤公雄、菊地順裕、佐藤大樹、黒澤亮、神津克也、青木竜男、建部俊介、杉村宏一郎、下川宏明
  • Organizer: 第45回日本心脈管作動物質学会学術集会
  • Place of Presentation: 阿波観光ホテル（徳島県徳島市）
  • Year and Date: 2016-02-05
• [Presentation] Selenoprotein P promotes vascular smooth muscle cell proliferation and pulmonary hypertension -A possible novel therapeutic target-（Travel Award受賞） (2015)
  • Author(s): Kikuchi N, Satoh K, Omura J, Satoh T, Kurosawa R, Nogi M, Otsuki T , NumanoK, Kozu K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] Effects of PTPA on respiratory functions in patients with CTEPH. (2015)
  • Author(s): Aoki T, Sugimura K, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Sato H, Satoh K, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] Thrombin-activated fibrinolysis inhibitor in chronic thromboembolic pulmonary hypertension. (2015)
  • Author(s): Yaoita N, Satoh K, Satoh T, Sugimura K, Tatebe S, Yamamoto S, Aoki T, Miura M, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] Basigin promotes cardiac fibrosis and failure in response to chronic pressure-overload in mice. （Travel Award受賞） (2015)
  • Author(s): Suzuki K, Satoh K, Sunamura S, Omura J, Kikuchi N, Satoh T, Kurosawa R, Kudo S, Ikeda S, Otuki T, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] Endothelial AMPK exerts protective effects against hypoxia-induced pulmonary hypertension in mice in vivo. (2015)
  • Author(s): Omura J, Satoh K, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Otsuki T, Kozu K, Numano K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] Crucial role of thrombin activatable fibrinolysis inhibitor in the pathogenesis of chronic thromboembolic pulmonary hypertension. (2015)
  • Author(s): Satoh T, Satoh K, Yaoita N, Kikuchi K, Omura J, Kurosawa R, Nogi M, Otsuki T, Kozu K, Numano K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] ROCK1 plays a crucial role to maintain cardiac function in response to chronic pressure-overload in mice. (2015)
  • Author(s): Sunamura S, Satoh K, Suzuki K, Kudo S, Ikeda S, Omura J, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Numano K, Shimizu T, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] Plasma cyclophilin A as a useful biomarker for evaluation of the effects of percutaneous transluminal pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension. (2015)
  • Author(s): Kozu K, Satoh K, Sugimura K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Otsuki T, Sato H, Miyata S, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] Basigin promotes cardiac fibrosis and failure in response to chronic pressure-overload in mice.＜YIA審査講演：基礎系＞（YIA受賞） (2015)
  • Author(s): Suzuki K, Satoh K, Omura J, Sato T, Kudo S, Otsuki T, Shimokawa H.
  • Organizer: 第19回日本心不全学会学術集会
  • Place of Presentation: グランフロント大阪（大阪市北区）
  • Year and Date: 2015-10-22
• [Presentation] Prognostic impacts of plasma levels of cyclophilin A in patients with heart failure.＜YIA審査講演：臨床系＞（Finalist） (2015)
  • Author(s): Otsuki T, Satoh K, Sugimura K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Miyata S, Shimokawa H.
  • Organizer: 第19回日本心不全学会学術集会
  • Place of Presentation: グランフロント大阪（大阪市北区）
  • Year and Date: 2015-10-22
• [Presentation] Crucial roles of Rho-kinase, cyclophilin A and its receptor, basigin, for cardiac hypertrophy, fibrosis and failure -novel therapeutic targets- ＜ワークショップ：心不全基礎研究の最前線＞ (2015)
  • Author(s): Satoh K, Suzuki K, Sunamura S, Otsuki T, Shimizu T,Ikeda S, Aoki T, Tatebe S, Sugimura K, Shimokawa H.
  • Organizer: 第19回日本心不全学会学術集会
  • Place of Presentation: グランフロント大阪（大阪市北区）
  • Year and Date: 2015-10-22
• [Presentation] ROCK1 plays a crucial role to maintain cardiac function in response to pressure-overload in mice. (2015)
  • Author(s): Sunamura S, Satoh K, Suzuki K, Omura J, Kikuchi N, Satoh T, Kurosawa R, Kudo S, Ikeda S, Shimokawa H.
  • Organizer: 第19回日本心不全学会学術集会
  • Place of Presentation: グランフロント大阪（大阪市北区）
  • Year and Date: 2015-10-22
• [Presentation] CTEPH における新規病因蛋白 TAFI の基礎的・臨床的機能解析＜YIAセッション＞ (2015)
  • Author(s): 佐藤大樹、佐藤公雄、矢尾板信裕、菊地順裕、大村淳一、黒澤亮、杉村宏一郎、中村一文、伊藤浩、下川宏明
  • Organizer: 第4回 日本肺循環学会・第3回日本肺高血圧学会学術集会
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2015-10-03
• [Presentation] OCTによるPHの診断＜シンポジウム：右心不全のイメージング＞ (2015)
  • Author(s): 建部俊介、杉村宏一郎、青木竜男、三浦正暢、山本沙織、矢尾板信裕、 鈴木秀明、佐藤遥、神克也、佐藤公雄、下川宏明
  • Organizer: 第4回 日本肺循環学会・第3回日本肺高血圧学会学術集会
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2015-10-03
• [Presentation] 当院における PTPA の成績と問題＜シンポジウム：TEPH 末梢型に対するバルーン拡張術の成績と問題点 /CTEPH に対する PEAおよび EPA の中期・遠隔成績＞ (2015)
  • Author(s): 杉村宏一郎、青木竜男、三浦正暢、建部俊介、山本沙織、矢尾板信裕、 鈴木秀明、佐藤遥、佐藤公雄、下川宏明
  • Organizer: 第4回 日本肺循環学会・第3回日本肺高血圧学会学術集会
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2015-10-03
• [Presentation] サイクロフィリン A による肺高血圧症促進機構とその臨床応用＜シンポジウム：肺高血圧治療薬の肺血管以外への作用を介した肺高血圧病態改善の可能性＞ (2015)
  • Author(s): 佐藤公雄、下川宏明
  • Organizer: 第4回 日本肺循環学会・第3回日本肺高血圧学会学術集会
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2015-10-03
• [Presentation] 肺動脈血管内皮 AMPK は肺高血圧症の進行を抑制する (2015)
  • Author(s): 大村淳一、佐藤公雄、菊地順裕、佐藤大樹、黒澤亮、神津克也、沼野和彦、青木竜男、建部俊介、杉村宏一郎、下川宏明
  • Organizer: 第4回 日本肺循環学会・第3回日本肺高血圧学会学術集会
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2015-10-03
• [Presentation] 化合物スクリーニングによる新規肺高血圧症治療薬の開発 (2015)
  • Author(s): 黒澤亮、佐藤公雄、菊地順裕、大村淳一、佐藤大樹、野木正道、沼野和彦、Mohammad Siddique、Elias Al-Mamun、杉村宏一郎、下川宏明
  • Organizer: 第4回 日本肺循環学会・第3回日本肺高血圧学会学術集会
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2015-10-03
• [Presentation] Diastolic pulmonary gradient による Group2 PH 患者の予後予測 (2015)
  • Author(s): 建部俊介、杉村宏一郎、青木竜男、三浦正暢、山本沙織、矢尾板信裕、鈴木秀明、佐藤遥、佐藤公雄、下川宏明
  • Organizer: 第4回 日本肺循環学会・第3回日本肺高血圧学会学術集会
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2015-10-03
• [Presentation] 新規病因蛋白セレノプロテイン P による肺高血圧症促進機構 (2015)
  • Author(s): 菊地順裕、佐藤公雄、大村淳一、佐藤大樹、黒澤亮、野木正道、大槻知広、建部俊介、青木竜男、杉村宏一郎、下川宏明
  • Organizer: 第4回 日本肺循環学会・第3回日本肺高血圧学会学術集会
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2015-10-03
• [Presentation] 慢性血栓塞栓性肺高血圧症における OFDI を用いた病変形態の観察 (2015)
  • Author(s): 青木竜男、杉村宏一郎、三浦正暢、建部俊介、矢尾板信裕、鈴木秀明、佐藤遥、神津克也、佐藤公雄、下川宏明
  • Organizer: 第4回 日本肺循環学会・第3回日本肺高血圧学会学術集会
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2015-10-03
• [Presentation] 慢性血栓塞栓性肺高血圧症の病因における TAFI の関与 (2015)
  • Author(s): 矢尾板信裕、佐藤公雄、佐藤大樹、杉村宏一郎、青木竜男、三浦正暢、建部俊介、福本義弘、下川宏明
  • Organizer: 第4回 日本肺循環学会・第3回日本肺高血圧学会学術集会
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2015-10-03
• [Presentation] CTEPHにおける経皮的肺動脈拡張術の呼吸機能への効果 (2015)
  • Author(s): 青木竜男、杉村宏一郎、三浦正暢、建部俊介、山本沙織、矢尾板信裕、鈴木秀明、佐藤遥、佐藤公雄、下川宏明
  • Organizer: 第4回 日本肺循環学会・第3回日本肺高血圧学会学術集会
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2015-10-03
• [Presentation] 血漿中サイクロフィリン A は PTPA 治療の有効性を反映する (2015)
  • Author(s): 佐藤公雄、杉村宏一郎、青木竜男、建部俊介、三浦正暢、矢尾板信裕、鈴木秀明、山本沙織、神津克也、大槻知広、下川宏明
  • Organizer: 第4回 日本肺循環学会・第3回日本肺高血圧学会学術集会
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2015-10-03
• [Presentation] 心臓 MRI を用いた経皮的肺動脈形成術の効果検討 (2015)
  • Author(s): 佐藤遥、大田英揮、杉村宏一郎、青木竜男、建部俊介、三浦正暢、山本沙織、矢尾板信裕、鈴木秀明、佐藤公雄、下川宏明
  • Organizer: 第4回 日本肺循環学会・第3回日本肺高血圧学会学術集会
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2015-10-03
• [Presentation] Selenoprotein P promotes vascular smooth muscle cell proliferation and pulmonary hypertension-a possible novel therapeutic target- (2015)
  • Author(s): Kikuchi N, Satoh K, Omura J, Satoh T, Kurosawa R, Nogi M, Tatebe S, Aoki T, Sugimura K, Shimokawa H. Selenoprotein P promotes vascular smooth muscle cell proliferation and pulmonary hypertension-a possible novel therapeutic target-
  • Organizer: ESC Congress 2015
  • Place of Presentation: London, UK
  • Year and Date: 2015-08-29
  • Int'l Joint Research
• [Presentation] Cardiac pacemaker stimulates the brain as well as the heart in humans &#8211;A PET functional study- (2015)
  • Author(s): Suzuki H, Satoh K, Tatebe S, Matsumoto M, Kondo M, Nakano M, Fukuda K, Hiraoka K, Tashiro M, Shimokawa H.
  • Organizer: ESC Congress 2015
  • Place of Presentation: London, UK
  • Year and Date: 2015-08-29
  • Int'l Joint Research
• [Presentation] Novel strategy for catheter interventional treatment of chronic thromboembolic pulmonary hypertension guided by optical coherence tomography imaging. (2015)
  • Author(s): Sugimura K, Aoki T, Miura M, Yaoita N, Satoh H, Satoh K, Shimokawa H.
  • Organizer: ESC Congress 2015
  • Place of Presentation: London, UK
  • Year and Date: 2015-08-29
  • Int'l Joint Research
• [Presentation] 膀胱収縮弛緩機構における各種NO産生合成酵素の機能的役割分担 (2015)
  • Author(s): 佐竹洋平、佐藤公雄、海法康裕、荒井陽一、下川宏明
  • Organizer: 第15回日本NO学会学術集会
  • Place of Presentation: 千里ライフサイエンスセンター（大阪府豊中市）
  • Year and Date: 2015-06-26
• [Presentation] 酸化ストレス分泌蛋白サイクロフィリンAは冠動脈疾患の長期予後を予測する (2015)
  • Author(s): 大槻知宏、佐藤公雄、杉村宏一郎、青木竜男、建部俊介、二瓶太郎、高橋 潤、宮田 敏、下川宏明
  • Organizer: 第68回日本酸化ストレス学会学術集会
  • Place of Presentation: かごしま県民交流センター（鹿児島県鹿児島市）
  • Year and Date: 2015-06-11
• [Presentation] SmgGDS as a Crucial Mediator of the Inhibitory Effects of Statins on Cardiac Hypertrophy and Fibrosis -Novel Mechanism of the Pleiotropic Effects of Statins- (2015)
  • Author(s): Kudo S, Satoh K, Nogi M, Suzuki K, Sunamura S, Omura J, Kikuchi N, Tanaka S, Minami T, Ikeda S, Shimokawa H.
  • Organizer: Scientific Session 2015 of the Arteriosclerosis, Thrombosis and Vascular Biology Council
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2015-05-08
  • Int'l Joint Research
• [Presentation] Plasma Levels of Cyclophilin A Correlate with Circulating Inflammatory Cytokines in Patients with Pulmonary Hypertension (2015)
  • Author(s): Otsuki T, Satoh K, Kikuchi N, Omura J, Kudo S, Sugimura K, Aoki T, Tatebe S, Shimokawa H.
  • Organizer: Scientific Session 2015 of the Arteriosclerosis, Thrombosis and Vascular Biology Council
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2015-05-08
  • Int'l Joint Research
• [Presentation] Plasma Cyclophilin A as a Useful Biomarker for Effective Percutaneous Transluminal Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension (2015)
  • Author(s): Satoh K, Sugimura K, Aoki T, Tatebe S, Shimizu T, Ikeda S, Yaoita N, Kudo S, Suzuki K, Omura J, Kikuchi N, Satoh T, Kurosawa R, Sunamura S, Otsuki T, Shimokawa H.
  • Organizer: Scientific Session 2015 of the Arteriosclerosis, Thrombosis and Vascular Biology Council
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2015-05-08
  • Int'l Joint Research
• [Presentation] Importance of acute hemodynamic responses to inhaled nitric oxide in patients with pulmonary hypertension due to left heart disease. (2015)
  • Author(s): Aoki T, Tatebe S, Sugimura K, Nochioka K, Miura M, Yamamoto S, Yaoita N, Sato H, Satoh K, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] Usefulness of optical coherence tomography imaging in management of chronic thromboembolic pulmonary hypertension. (2015)
  • Author(s): Sugimura K, Aoki T, Tatebe S, Miura M, Yaoita N, Sato H, Kato T, Satoh K, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] ＜Young Investigator's Award for International Students Finalists Lectures＞Combination therapy with fasudil and sildenafil ameliorates monocrotaline-induced pulmonary hypertension through synergistic inhibition of Rho-kinase. (2015)
  • Author(s): Elias-Al-Mamun M, Satoh K, Tanaka S, Shimizu T, Nergui S, Miyata S, Fukumoto Y, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] Plasma Cyclophilin A as a useful biomarker for effective percutaneous transluminal pulmonary angioplasty in chronic thromboembolic pulmonary hypertension. (2015)
  • Author(s): Satoh K , Sugimura K , Aoki T, Nochioka K, Tatebe S, Yamamoto S, Miura M, Shimizu T, Ikeda S, Yaoita N, Kudo S, Suzuki K, Omura J, Kikuchi N, Satoh T, Kurosawa R, Sunamura S, Nogi M, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] Basigin promotes cardiac fibrosis and failure in response to chronic pressure-overload in mice. (2015)
  • Author(s): Suzuki K, Satoh K, Sunamura S, Omura J, Kikuchi N, Satoh T, Kurosawa R, Kudo S, Ikeda S, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] Crucial role of SmgGDS in the inhibitory effects of statins on cardiac hypertrophy and fibrosis in mice. (2015)
  • Author(s): Kudo S, Satoh K, Suzuki K, Sunamura S, Nogi M, Kikuchi N, Ohmura J, Ikeda S, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] Endothelial cell-specific AMPK deletion accelerates hypoxia-induced pulmonary hypertension in mice in vivo. (2015)
  • Author(s): Omura J, Satoh K, Kikuchi N, Satoh T, Kurosawa R, Suzuki K, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] Plasma levels of Cyclophilin A correlate with circulating inflammatory cytokines in patients with pulmonary hypertension. (2015)
  • Author(s): Satoh K, Suzuki K, Omura J, Kikuchi N, Satoh T, Sunamura S, Kurosawa R, Nogi M, Shimizu T, Ikeda S, Yaoita N, Kudo S, Aoki T, Sugimura K, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] Involvement of thrombin-activated fibrinolysis inhibitor in chronic thromboembolic pulmonary hypertension. (2015)
  • Author(s): Yaoita N, Sato T, Satoh K, Sugimura K, Tatebe S, Yamamoto S, Aoki T, Miura M, Horiuchi H, Fukumoto Y, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] Effects of PTPA on respiratory functions in patients with chronic thromboembolic pulmonary hypertension―Possible importance of intra-pulmonary shunt― (2015)
  • Author(s): Aoki T, Sugimura K, Nochioka K, Tatebe S, Miura M, Yamamoto S, Yaoita N, Sato H, Satoh K, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] Usefulness of cardiac MRI for evaluating the effectiveness of percutaneous transluminal pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension. (2015)
  • Author(s): Sato H, Miura M, Sugimura K, Aoki T, Tatebe S, Yamamoto S, Yaoita N, Ota H, Satoh K, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] Evidence for activation of cerebral autonomic center in response to cardiac electrical stimulation in humans―New finding of cardio-cerebral connection― (2015)
  • Author(s): Suzuki H, Satoh K, Tatebe S, Matsumoto Y, Kondo M, Nakano M, Fukuda K, Watanuki S, Hiraoka K, Tashiro M, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] Effectiveness of vasodilator therapy for patients with inoperable chronic thromboembolic pulmonary hypertension in prior to percutaneous transluminal pulmonary angioplasty. (2015)
  • Author(s): Sugimura K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Sato H, Satoh K, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] Current status of the treatment for adult congenital heart disease associated with pulmonary arterial hypertension. (2015)
  • Author(s): Sato H, Tatebe S, Sugimura K, Aoki T, Miura M, Yaoita N, Nochioka K , Yamamoto S, Satoh K, Shimokawa H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Book] 特集/SGLT2心腎連関 解説 Cyclophilin A VoL.82 No.4, p.391～397.（2017年10月号） (2017)
  • Author(s): 佐藤 公雄、下川 宏明.
  • Total Pages: 7
  • Publisher: 科学評論社
• [Book] Diagnosis and Treatment of Pulmonary Hypertension. From Bench to Bedside (2017)
  • Author(s): Satoh K, Sugimura K, Shimokawa H.
  • Total Pages: 10
  • Publisher: Springer Nature, Singapore
• [Book] Reactive Oxygen Species in Cardiovascular System. Reactive Oxygen Species in Biology and Human Health. (2016)
  • Author(s): Shimokawa H, Satoh K.
  • Total Pages: 543
  • Publisher: CRC Press
• [Book] 循環器専門医 「喫煙と循環器疾患up to date: 喫煙による酸化ストレスと動脈硬化性疾患」 (2016)
  • Author(s): 佐藤 公雄.
  • Total Pages: 5
  • Publisher: 南江堂
• [Book] Cyclophilin A: Novel biomarker for oxidative stress and cardiovascular diseases. In: Preedy VR, Patel VB (eds), General Methods in Biomarker Research and Their Applications (2015)
  • Author(s): Satoh K, Shimokawa H.
  • Total Pages: 34
  • Publisher: Springer Reference, London
• [Book] 「循環器内科」 特集/循環器疾患と分子遺伝学 肺高血圧症の分子基盤 (2015)
  • Author(s): 佐藤 公雄、下川 宏明.
  • Total Pages: 7
  • Publisher: 科学評論社
• [Remarks] 東北大学循環器内科ホームページ
  • URL: http://www.cardio.med.tohoku.ac.jp/
• [Remarks] 東北大学循環器内科ホームページ
  • URL: http://www.cardio.med.tohoku.ac.jp
• [Patent(Industrial Property Rights)] セレノプロテインＰ活性阻害作用を有する成分を含有する、肺高血圧症の予防又は治療剤 (2017)
  • Inventor(s): 下川宏明、佐藤公雄、菊地順裕
  • Industrial Property Rights Holder: 下川宏明、佐藤公雄、菊地順裕
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017
  • Overseas
• [Patent(Industrial Property Rights)] 生薬成分を含む肺高血圧症の予防又は治療剤 (2017)
  • Inventor(s): 下川宏明, 佐藤公雄, 黒澤亮
  • Industrial Property Rights Holder: 下川宏明, 佐藤公雄, 黒澤亮
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017
  • Overseas
• [Patent(Industrial Property Rights)] 不飽和複素５員環含有化合物を含有する肺高血圧症の予防又は治療剤 (2017)
  • Inventor(s): 下川宏明, 佐藤公雄, 黒澤亮
  • Industrial Property Rights Holder: 下川宏明, 佐藤公雄, 黒澤亮
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017
  • Overseas
• [Patent(Industrial Property Rights)] PPARαアゴニストを含有する、肺高血圧症の予防又は治療剤 (2017)
  • Inventor(s): 下川宏明、佐藤公雄、佐藤大樹
  • Industrial Property Rights Holder: 下川宏明、佐藤公雄、佐藤大樹
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017
  • Overseas
• [Patent(Industrial Property Rights)] 生薬成分を含む肺高血圧症の予防又は治療剤 (2017)
  • Inventor(s): 下川宏明、佐藤公雄、黒澤亮
  • Industrial Property Rights Holder: 下川宏明、佐藤公雄、黒澤亮
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017
  • Overseas
• [Patent(Industrial Property Rights)] メベンダゾール及び／もしくはイトラコナゾール又はその塩を含有する、肺高血圧症の予防又は治療剤 (2017)
  • Inventor(s): 下川宏明、佐藤公雄、 大村淳一、菊地順裕、黒澤亮
  • Industrial Property Rights Holder: 下川宏明、佐藤公雄、 大村淳一、菊地順裕、黒澤亮
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2017-233034
  • Filing Date: 2017
• [Patent(Industrial Property Rights)] 肺高血圧症の検査方法 (2016)
  • Inventor(s): 下川宏明、佐藤公雄、菊地順裕
  • Industrial Property Rights Holder: 下川宏明、佐藤公雄、菊地順裕
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016
  • Acquisition Date: 2017
• [Patent(Industrial Property Rights)] セレノプロテインＰ活性阻害作用を有する成分を含有する、肺高血圧症の予防又は治療剤 (2016)
  • Inventor(s): 下川宏明、佐藤公雄、菊地順裕
  • Industrial Property Rights Holder: 下川宏明、佐藤公雄、菊地順裕
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-121034
  • Filing Date: 2016-06-17
• [Patent(Industrial Property Rights)] 生薬成分を含む肺高血圧症の予防又は治療剤 (2016)
  • Inventor(s): 下川宏明, 徳山英利, 佐藤公雄, 黒澤
  • Industrial Property Rights Holder: 下川宏明, 徳山英利, 佐藤公雄, 黒澤
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-120901
  • Filing Date: 2016-06-17
• [Patent(Industrial Property Rights)] 不飽和複素５員環含有化合物を含有する肺高血圧症の予防又は治療剤 (2016)
  • Inventor(s): 下川宏明, 大島吉輝, 佐藤公雄, 黒澤亮
  • Industrial Property Rights Holder: 下川宏明, 大島吉輝, 佐藤公雄, 黒澤亮
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-140474
  • Filing Date: 2016-07-15
• [Patent(Industrial Property Rights)] PPARαアゴニストを含有する、肺高血圧症の予防又は治療剤 (2016)
  • Inventor(s): 下川宏明、佐藤公雄、佐藤大樹
  • Industrial Property Rights Holder: 下川宏明、佐藤公雄、佐藤大樹
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-141942
  • Filing Date: 2016-07-20
• [Patent(Industrial Property Rights)] 生薬成分を含む肺高血圧症の予防又は治療剤 (2016)
  • Inventor(s): 下川宏明、佐藤公雄、黒澤亮
  • Industrial Property Rights Holder: 下川宏明、佐藤公雄、黒澤亮
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-160588
  • Filing Date: 2016-08-18
• [Patent(Industrial Property Rights)] サイクロフィリンAによる心血管疾患の検査方法 (2015)
  • Inventor(s): 下川宏明、佐藤公雄
  • Industrial Property Rights Holder: 下川宏明、佐藤公雄
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015
  • Acquisition Date: 2017
  • Overseas