Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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Outline of Final Research Achievements |
Based on our previous result that cardiac function is mediated through suppression of autophagy by phosphorylating Beclin1 by Mst1, we explored novel low molecular compounds which can competitively inhibit Beclin1-Bcl2/xL interaction that is enhanced by phosphorylation of Beclin1. As a result, we could identified such a compound. According to in vivo experiments, that compound could effectively alleviates cardiac disfunction in transverse aortic constriction mouse models.
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