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Multilateral Research on the Mechanisms of Inherited Arrhythmias

Research Project

Project/Area Number 15H04818
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cardiovascular medicine
Research InstitutionShiga University of Medical Science

Principal Investigator

Horie Minoru  滋賀医科大学, 医学部, 教授 (90183938)

Co-Investigator(Kenkyū-buntansha) 大野 聖子  滋賀医科大学, 学内共同利用施設等, 特任講師 (20610025)
伊藤 英樹  滋賀医科大学, 医学部, 助教 (30402738)
牧山 武  京都大学, 医学研究科, 助教 (30528302)
林 秀樹  滋賀医科大学, 医学部, 非常勤講師 (70464188)
芦原 貴司  滋賀医科大学, 医学部, 講師 (80396259)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords遺伝性不整脈 / 循環器 / 高血圧 / 遺伝学 / 遺伝子 / 機能解析 / 循環器・高血圧 / コピー数変動 / SCN5A / ブルガダ症候群
Outline of Final Research Achievements

Variants of genes encoding a variety of ion channels or their associated proteins, determining the heart impulse conduction, excitation and contraction, were found to cause inherited arrhythmias, such as long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, progressive cardiac conduction defect, and short QT syndrome. This line of study offered a typical example that the scientific progress in genetics prompted the discovery of new genes responsible for human diseases and elucidated their specific molecular mechanisms of pathogenicity. By employing the multilateral approaches such as conventional patch-clamp and other physiological analyses in a heterologous expression system, patients-derived iPS-cardiomyocytes, and integrated computer simulation method, we investigated the pathological mechanisms underlying these inherited arrhythmias.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (216 results)

All 2018 2017 2016 2015 Other

All Journal Article (99 results) (of which Int'l Joint Research: 55 results,  Peer Reviewed: 97 results,  Open Access: 74 results,  Acknowledgement Compliant: 11 results) Presentation (101 results) (of which Int'l Joint Research: 81 results,  Invited: 5 results) Book (15 results) Remarks (1 results)

  • [Journal Article] Bradycardia Is a Specific Phenotype of Catecholaminergic Polymorphic Ventricular Tachycardia Induced by <i>RYR2</i> Mutations2018

    • Author(s)
      Miyata Kazuaki、Ohno Seiko、Itoh Hideki、Horie Minoru
    • Journal Title

      Internal Medicine

      Volume: 57 Issue: 13 Pages: 1813-1817

    • DOI

      10.2169/internalmedicine.9843-17

    • NAID

      130007387124

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2018-07-01
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of Coronary Artery Calcification with Estimated Coronary Heart Disease Risk from Prediction Models in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)2018

    • Author(s)
      Tai P, Fujiyoshi A, Arima H, Tanaka-Mizuno S, Hisamatsu T, Kadowaki S, Kadota A, Zaid M, Sekikawa A, Yamamoto T, Horie M, Miura K, Ueshima H
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 25 Issue: 6 Pages: 477-489

    • DOI

      10.5551/jat.42416

    • NAID

      130007382558

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2018-06-01
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Not all rotors, effective ablation targets for nonparoxysmal atrial fibrillation, are included in areas suggested by conventional indirect indicators of atrial fibrillation drivers: ExTRa Mapping project2018

    • Author(s)
      Sakata K, Okuyama Y, Ozawa T, Haraguchi R, Nakazawa K, Tsuchiya T, Horie M, Ashihara T
    • Journal Title

      Journal of Arrhythmia

      Volume: 34 Issue: 2 Pages: 176184-176184

    • DOI

      10.1002/joa3.12036

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Copy number variations of SCN5A in Brugada syndrome2018

    • Author(s)
      Sonoda Keiko、Ohno Seiko、Ozawa Junichi、Hayano Mamoru、Hattori Tetsuhisa、Kobori Atsushi、Yahata Mitsuhiko、Aburadani Isao、Watanabe Seiichi、Matsumoto Yuichi、Makiyama Takeru、Horie Minoru
    • Journal Title

      Heart Rhythm

      Volume: - Issue: 8 Pages: 1179-1188

    • DOI

      10.1016/j.hrthm.2018.03.033

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum magnesium, phosphorus, and calcium levels and subclinical calcific aortic valve disease: A population-based study.2018

    • Author(s)
      Hisamatsu T, Miura K, Fujiyoshi A, Kadota A, Miyagawa N, Satoh A, Zaid M, Yamamoto T, Horie M, Ueshima H.
    • Journal Title

      Atherosclerosis

      Volume: 未定 Pages: 145-152

    • DOI

      10.1016/j.atherosclerosis.2018.03.035

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A challenge for mutation specific risk stratification in long QT syndrome type 12018

    • Author(s)
      Yagi Noriaki、Itoh Hideki、Hisamatsu Takashi、Tomita Yukinori、Kimura Hiromi、Fujii Yusuke、Makiyama Takeru、Horie Minoru、Ohno Seiko
    • Journal Title

      Journal of Cardiology

      Volume: 18 Issue: 1 Pages: 30012-1

    • DOI

      10.1016/j.jjcc.2017.12.011

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A hERG mutation E1039X produced a synergistic lesion on IKs together with KCNQ1-R174C mutation in a LQTS family with three compound mutations2018

    • Author(s)
      Wu Jie、Mizusawa Yuka、Ohno Seiko、Ding Wei-Guang、Higaki Takashi、Wang Qi、Kohjitani Hirohiko、Makiyama Takeru、Itoh Hideki、Toyoda Futoshi、James Andrew F.、Hancox Jules C.、Matsuura Hiroshi、Horie Minoru
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 3129-3129

    • DOI

      10.1038/s41598-018-21442-6

    • NAID

      120006529715

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Population pharmacokinetics and pharmacogenomics of apixaban in Japanese adult patients with atrial fibrillation.2018

    • Author(s)
      Ueshima S, Hira D, Kimura Y, Fujii R, Tomitsuka C, Yamane T, Tabuchi Y, Ozawa T, Itoh H, Ohno S, Horie M, Terada T, Katsura T.
    • Journal Title

      Br. J. Clin. Pharmacol.

      Volume: - Issue: 6 Pages: 1301-1312

    • DOI

      10.1111/bcp.13561

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Restoration of mutant hERG stability by inhibition of HDAC62018

    • Author(s)
      Li Peili、Kurata Yasutaka、Endang Mahati、Ninomiya Haruaki、Higaki Katsumi、Taufiq Fikri、Morikawa Kumi、Shirayoshi Yasuaki、Horie Minoru、Hisatome Ichiro
    • Journal Title

      J mol Cell cardiol

      Volume: 115 Pages: 158-169

    • DOI

      10.1016/j.yjmcc.2018.01.009

    • NAID

      120007170666

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Novel intracellular transport-refractory mutations in KCNH2 identified in patients with symptomatic long QT syndrome2018

    • Author(s)
      Fukumoto Daisuke、Ding Wei-Guang、Wada Yuko、Fujii Yusuke、Ichikawa Mari、Takayama Koichiro、Fukuyama Megumi、Kato Koichi、Itoh Hideki、Makiyama Takeru、Omatsu-Kanbe Mariko、Matsuura Hiroshi、Horie Minoru、Ohno Seiko
    • Journal Title

      Journal of Cardiology

      Volume: 71 Issue: 4 Pages: 401-408

    • DOI

      10.1016/j.jjcc.2017.10.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Self-reported Sleep Duration and Subclinical Atherosclerosis in a General Population of Japanese Men2018

    • Author(s)
      Suzuki S, Arima H, Miyazaki S, Fujiyoshi A, Kadota A, Takashima N, Hisamatsu T, Kadowaki S, Zaid M, Torii S, Horie M, Murata K, Miura K, Ueshima H
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 25 Issue: 2 Pages: 186-198

    • DOI

      10.5551/jat.40527

    • NAID

      130006328445

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Utility of phase standard deviation and histogram bandwidth by "Heart Function View" analysis as a clinical indicator of heart failure.2018

    • Author(s)
      Tomita Y, Nakae I, Hayashi H, Ozawa T, Horie M.
    • Journal Title

      Ann Nucl Cardiol

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Different responses to exercise between Andersen?Tawil syndrome and catecholaminergic polymorphic ventricular tachycardia2017

    • Author(s)
      Inoue Yuko Y、Aiba Takeshi、Kawata Hiro、Sakaguchi Tomoko、Mitsuma Wataru、Morita Hiroshi、Noda Takashi、Takaki Hiroshi、Toyohara Keiko、Kanaya Yoshiaki、Itoi Toshiyuki、Mitsuhashi Takeshi、Sumitomo Naokata、Cho Yongkeun、Yasuda Satoshi、Kamakura Shiro、Kusano Kengo、Miyamoto Yoshihiro、Horie Minoru、Shimizu Wataru
    • Journal Title

      Europace

      Volume: 印刷中 Issue: 10 Pages: 1675-1682

    • DOI

      10.1093/europace/eux351

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gene-Based Risk Stratification for Cardiac Disorders in LMNA Mutation Carriers.2017

    • Author(s)
      Nishiuchi S, Makiyama T, Aiba T, Nakajima K, Hirose S, Kohjitani H, Yamamoto Y, Harita T, Hayano M, Wuriyanghai Y, Chen J, Sasaki K, Yagihara N, Ishikawa T, Onoue K, Murakoshi N, Watanabe I, Ohkubo K, Watanabe H, Ohno S, Doi T, Shizuta S, Minamino T, et.al
    • Journal Title

      Circ Cardiovasc Genet.

      Volume: 6 Issue: 6

    • DOI

      10.1161/circgenetics.116.001603

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Refractory ventricular fibrillations after surgical repair of atrial septal defects in a patient with CACNA1C gene mutation - case report2017

    • Author(s)
      Kojima Ai、Shikata Fumiaki、Okamura Toru、Higaki Takashi、Ohno Seiko、Horie Minoru、Uchita Shunji、Kawanishi Yujiro、Namiguchi Kenji、Yasugi Takumi、Izutani Hironori
    • Journal Title

      J Cardiothorac Surg.

      Volume: 12 Issue: 1 Pages: 118-118

    • DOI

      10.1186/s13019-017-0683-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Macro-pro-B-type natriuretic peptide (proBNP) and hidden macro-N-terminal proBNP:Case report.2017

    • Author(s)
      Nakagawa Y, Nishikimi T, Sakai H, Ohno S, Kinoshita H, Inazumi H, Moriuchi K, Kuwahara K, Horie M, Kimura T.
    • Journal Title

      Clinical Biochemistry

      Volume: 52 Pages: 148-152

    • DOI

      10.1016/j.clinbiochem.2017.10.019

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] on behalf of the CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators. Single-session Versus Staged Procedures for Elective Multi-vessel Percutaneous Coronary Intervention.2017

    • Author(s)
      Toyota T, Morimoto T, Shiomi H, Yamaji K, Ando K, Ono K, Shizuta S, Saito N, Kato T, Kaji S, Furukawa Y, Nakagawa Y, Kadota K, Horie M, Kimura T,
    • Journal Title

      Heart.

      Volume: Nov 16. Issue: 11 Pages: 936-944

    • DOI

      10.1136/heartjnl-2017-312117

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unique genetic background and outcome of non-Caucasian Japanese probands with arrhythmogenic right ventricular dysplasia/cardiomyopathy2017

    • Author(s)
      Wada Yuko、Ohno Seiko、Aiba Takeshi、Horie Minoru
    • Journal Title

      Mol Genet Genomic Med.

      Volume: 5 Issue: 6 Pages: 639-651

    • DOI

      10.1002/mgg3.311

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Arrhtyhmia risk and β-blocker therapy in pregnant women with long QT syndrome.2017

    • Author(s)
      Ishibashi K, Horie M, et al.
    • Journal Title

      Heart

      Volume: 印刷中 Issue: 17 Pages: 0-0

    • DOI

      10.1136/heartjnl-2016-310617

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of ABCB1, ABCG2, and CYP3A5 polymorphisms on plasma trough concentrations of apixaban in Japanese patients with atrial fibrillation2017

    • Author(s)
      Satoshi Ueshima, Daiki Hira, Ryo Fujii, Yuuma Kimura, Chiho Tomitsuka, Takuya Yamane, Yohei Tabuchi, Tomoya Ozawa, Hideki Itoh, Minoru Horie, Tomohiro Terada, Toshiya Katsura
    • Journal Title

      Pharmacogenetics and Genomics

      Volume: 27 Issue: 9 Pages: 329-336

    • DOI

      10.1097/fpc.0000000000000294

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The relationship between J waves and contact of lung cancer with the heart.2017

    • Author(s)
      Hayashi H, Wu Q, Horie M
    • Journal Title

      Ann Noninvasive Electrocardiol

      Volume: 印刷中 Issue: 5

    • DOI

      10.1111/anec.12433

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drug-induced fatal arrhythmias: Acquired long QT and Brugada syndromes2017

    • Author(s)
      Turker Isik、Ai Tomohiko、Itoh Hideki、Horie Minoru
    • Journal Title

      Pharmacol Ther

      Volume: 176 Pages: 48-59

    • DOI

      10.1016/j.pharmthera.2017.05.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Heart failure in patients with arrhythmogenic right ventricular cardiomyopathy: What are the risk factors?2017

    • Author(s)
      Kimura Y、Noda T、Matsuyama T、Otsuka Y、Kamakura T、Wada M、Ishibashi K、Inoue Y、Miyamoto K、Okamura H、Nagase S、Aiba T、Kamakura S、Noguchi T、Anzai T、Satomi K、Wada Y、Ohno S、Horie M、Shimizu W、Yasuda S、Shimokawa H、Kusano K
    • Journal Title

      Int J Cardio

      Volume: 241 Pages: 288-294

    • DOI

      10.1016/j.ijcard.2017.04.061

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long QT syndrome presents not only as QT prolongation but also as abnormal T-wave morphology2017

    • Author(s)
      Horie Minoru
    • Journal Title

      Heart Rhythm.

      Volume: 14 Issue: 8 Pages: 1171-1172

    • DOI

      10.1016/j.hrthm.2017.04.032

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Progressive Atrial Conduction Defects Associated With Bone Malformation Caused by a Connexin-45 Mutation.2017

    • Author(s)
      Seki A, Ishikawa T, Daumy X, Mishima H, Barc J, Sasaki R, Nishii K, Saito K, Urano M, Ohno S, Otsuki S, Kimoto H, Baruteau AE, Thollet A, Fouchard S, Bonnaud S, Parent P, Shibata Y, Perrin JP, Le Marec H, Hagiwara N, Mercier S, Horie M, Probst V, Yoshiura KI, Redon R, Schott JJ, Makita N.
    • Journal Title

      J Am Coll Cardiol.

      Volume: 70 Issue: 3 Pages: 358-370

    • DOI

      10.1016/j.jacc.2017.05.039

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Development of a Patient-Derived Induced Pluripotent Stem Cell Model for the Investigation of <i>SCN5A</i>-D1275N-Related Cardiac Sodium Channelopathy2017

    • Author(s)
      Hayano M, Makiyama T
    • Journal Title

      Circulation Journal

      Volume: 81 Issue: 12 Pages: 1783-1791

    • DOI

      10.1253/circj.CJ-17-0064

    • NAID

      130006219109

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genotype-phenotype correlation of SCN5A mutation for clinical and electrocardiographic characteristics of probands with Brugada syndrome: Japanese Multicenter Registry.2017

    • Author(s)
      Yamagata K, Horie M, et al.
    • Journal Title

      Circulation

      Volume: 印刷中 Issue: 23 Pages: 0-0

    • DOI

      10.1161/circulationaha.117.027983

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Incidence and Prognostic Impact of Heart Failure Hospitalization During Follow-Up After Primary Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction.2017

    • Author(s)
      Taniguchi T, Shiomi H, Morimoto T, Watanabe H, Ono K, Shizuta S, Kato T, Saito N, Kaji S, Ando K, Kadota K, Furukawa Y, Nakagawa Y, Horie M, Kimura T
    • Journal Title

      The American journal of cardiology

      Volume: 119 Pages: 1729-1739

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Allele-specific Ablation Rescues Electrophysiological Abnormalities in a Human iPS Cell Model of Long-QT Syndrome with a CALM2 Mutation.2017

    • Author(s)
      Yamamoto Y, Horie M, et al.
    • Journal Title

      Human Molecular Genetics

      Volume: 印刷中 Issue: 9 Pages: 1670-1677

    • DOI

      10.1093/hmg/ddx073

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ad hoc vs. Non-ad hoc Percutaneous Coronary Intervention Strategies in Patients With Stable Coronary Artery Disease2017

    • Author(s)
      Toyota T, Horie M, et al.
    • Journal Title

      Circulation Journal

      Volume: 81 Issue: 4 Pages: 458-467

    • DOI

      10.1253/circj.CJ-16-0987

    • NAID

      130005475829

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Flecainide ameliorates arrhythmogenicity through NCX flux in Andersen-Tawil syndrome-iPS cell-derived cardiomyocytes.2017

    • Author(s)
      Kuroda Y, Yuasa S, Watanabe Y, Ito S, Egashira T, ・・・Horie M, Kamiya K, Fukuda K.
    • Journal Title

      Biochemistry and Biophysics Reports

      Volume: 9 Pages: 245-256

    • DOI

      10.1016/j.bbrep.2017.01.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Guidelines for Therapeutic Drug Monitoring of Cardiovascular Drugs Clinical Use of Blood Drug Concentration Monitoring (JCS 2015) ― Digest Version ―2017

    • Author(s)
      Aonuma K, Horie M, et al.
    • Journal Title

      Circulation Journal

      Volume: 81 Issue: 4 Pages: 581-612

    • DOI

      10.1253/circj.CJ-66-0138

    • NAID

      130005475851

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardiac conduction defects and brugada syndrome: A Family with overlap syndrome carrying a nonsense SCN5A mutation.2017

    • Author(s)
      Aoki H, Nakamura T, Horie M, Ohno S, Makiyama T, Takemura T
    • Journal Title

      Journal of Arrhythmia

      Volume: 33 Issue: 1 Pages: 35-39

    • DOI

      10.1016/j.joa.2016.05.007

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sick sinus syndrome with HCN4 mutations shows early onset and frequent association with atrial fibrillation and left ventricular noncompaction.2017

    • Author(s)
      Ishikawa T, Horie M, et al.
    • Journal Title

      Heart Rhythm

      Volume: 印刷中 Issue: 5 Pages: 717-724

    • DOI

      10.1016/j.hrthm.2017.01.020

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elimination of ventricular arrhythmia in catecholaminergic polymorphic ventricular tachycardia by targeting “catecholamine-sensitive area”: a dominant-subordinate relationship between origin sites of bidirectional ventricular premature contractions.2017

    • Author(s)
      Shirai Y, Horie M, et al.
    • Journal Title

      PACE

      Volume: 印刷中 Issue: 5 Pages: 600-604

    • DOI

      10.1111/pace.13006

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incidence and Prognostic Impact of Heart Failure Hospitalization During Follow-up after Primary Percutaneous Coronary Intervention in ST-segment Elevation Myocardial Infarction.2017

    • Author(s)
      Taniguchi T, Horie M, et al.
    • Journal Title

      American Journal of Cardiology

      Volume: 印刷中 Issue: 11 Pages: 1729-1739

    • DOI

      10.1016/j.amjcard.2017.03.013

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Utility of phase standard deviation and histogram bandwidth by "Heart Function View" analysis as a clinical indicator of heart failure.2017

    • Author(s)
      Tomita Y, Nakae I, Hayashi H, Ozawa T, Horie M
    • Journal Title

      Annals of Nuclear Medicine

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Flecainide suppresses an arrhythmogenic substrate through NCX flux modulation in Andersen-Tawil syndrome-induced pluripotent stem cell-derived cardiomyocytes.2017

    • Author(s)
      Kuroda Y, Horie M, et al.
    • Journal Title

      Biochemistry and Biophysics Research

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of a KCNH2 variant in genotyped long QT syndrome: Romano-Ward syndrome under double mutations and acquired long QT syndrome under heterozygote.2017

    • Author(s)
      Fujii Y, Horie M, et al.
    • Journal Title

      J Cardiol

      Volume: 印刷中 Issue: 1 Pages: 74-79

    • DOI

      10.1016/j.jjcc.2016.09.010

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significance of integrated in silico 2-dimensional transmural ventricular wedge preparation models of human non-failing and failing hearts for evaluation of drug candidates cardiac safety.2017

    • Author(s)
      Kubo T, Horie M, et al.
    • Journal Title

      Journal of Pharmacological and Toxicological Methods

      Volume: 83 Pages: 30-41

    • DOI

      10.1016/j.vascn.2016.08.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative analysis of PKP2 and neighbouring genes in a patient with arrhythmogenic right ventricular cardiomyopathy caused by heterozygous PKP2 deletion.2017

    • Author(s)
      Sonoda K, Horie M, et al.
    • Journal Title

      Europace

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ad-hoc Versus Non-ad-hoc percutaneous coronary intervention strategies in patients with stable coronary artery disease.2017

    • Author(s)
      Toyota T,Horie M, et al.
    • Journal Title

      Circ J

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Flecainide ameliorates arrhythmogenicity through NCX flux in Andersen-Tawil syndrome-iPS cell-derived cardiomyocytes.2017

    • Author(s)
      Kuroda Y, Horie M, et al.
    • Journal Title

      Biochemistry and Biophysics Reports.

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extensive Ca2+ leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca2+ hypersensitivity.2016

    • Author(s)
      Uehara A, Horie M, et al.
    • Journal Title

      Journal of General Physiology

      Volume: 149 Issue: 2 Pages: 199-218

    • DOI

      10.1085/jgp.201611624

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multigenerational Inheritance of Long QT Syndrome Type 2 in a Japanese Family2016

    • Author(s)
      Ichikawa M, Ohno S, Fujii Y, Ozawa J, Sonoda K, Fukuyama M, Kato K, Kimura H, Itoh H, Hayashi H, Horie M.
    • Journal Title

      Internal Medicine

      Volume: 55 Issue: 3 Pages: 259-262

    • DOI

      10.2169/internalmedicine.55.6014

    • NAID

      130005122603

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cardiac sodium channel mutation associated with epinephrine-induced QT prolongation and sinus node dysfunction.2016

    • Author(s)
      Chen J, Makiyama T, Wuriyanghai Y, Ohno S, Sasaki K, Hayano M, Harita T, Nishiuchi S, Yamamoto Y, Ueyama T, Shimizu A, Horie M, Kimura T.
    • Journal Title

      Heart Rhythm

      Volume: 13(1) Issue: 1 Pages: 289-298

    • DOI

      10.1016/j.hrthm.2015.08.021

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lipoprotein-associated phospholipase A2 related to the risk of subclinical atherosclerosis independent of small low density lipoprotein particles in a general Japanese population.2016

    • Author(s)
      Ueshima H, Kadowaki T, Fujiyoshi A, Miura K, Ohkubo T, Kadota A, Kadowaki S, Nakamura Y, Miyagawa N, Okamura T, Kita Y, Takashima N, Kashiwagi A, Maegawa H, Horie M, Yamamoto T, et ai.
    • Journal Title

      Athelosclerosis

      Volume: 246 Pages: 141-147

    • DOI

      10.1016/j.atherosclerosis.2015.12.027

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficacy of Antiarrhythmic Drugs Short-Term Use After Catheter Ablation for Atrial Fibrillation (EAST-AF) trial.2016

    • Author(s)
      Kaitani K, Inoue k, Kobori A, Nakazawa Y, Ozawa T, et al.
    • Journal Title

      European Heart Journal.

      Volume: 7 Issue: 7 Pages: 610-618

    • DOI

      10.1093/eurheartj/ehv501

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Practical applicability of landiolol, an ultra-short-acting β1-selective blocker, for rapid atrial and ventricular tachyarrhythmias with left ventricular dysfunction.2016

    • Author(s)
      Wada Y, Aiba T, Tsujita Y, Itoh H, Wada M, Nakajima I, Ishibashi K, Okamura H, Miyamoto K, Noda T, Sugano Y, Kanzaki, Toshihisa Anzai, Kengo Kusano H, Yasuda S, Horie M, Ogawa H
    • Journal Title

      Journal of Arrhythmia

      Volume: (32) Issue: 2 Pages: 82-88

    • DOI

      10.1016/j.joa.2015.09.002

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Culprit Vessel-Only vs. Staged Multivessel Percutaneous Coronary Intervention Strategies in Patients With Multivessel Coronary Artery Disease Undergoing Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction2016

    • Author(s)
      Toyota T, Shiomi H, Taniguchi T, Morimoto T, Furukawa Y, Nakagawa Y, Horie M, Kimura T.
    • Journal Title

      Circulation Journal

      Volume: 80 Issue: 2 Pages: 371-378

    • DOI

      10.1253/circj.CJ-15-0493

    • NAID

      130005120893

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation and management of bradycardia in neonates and children.2016

    • Author(s)
      Baruteau AE, Perryd JC, Sanatanie S, Horie M, Walshg EP, Dubin AM.
    • Journal Title

      European Journal of Pediatrics.

      Volume: 175 Issue: 2 Pages: 151-61

    • DOI

      10.1007/s00431-015-2689-z

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification2016

    • Author(s)
      Zaid M, Miura K, Fujiyoshi A, Abbott RD, Hisamatsu T, Kadota A, Arima H, Kadowaki S, Torii S, Miyagawa N, Suzuki S, Takashima N, Ohkubo T, Sekikawa A, Maegawa H, Horie M, Nakamura Y, Okamura T, Ueshima H; SESSA Research Group.
    • Journal Title

      J Clin Lipidol.

      Volume: 10 Issue: 5 Pages: 1195

    • DOI

      10.1016/j.jacl.2015.12.027

    • URL

      https://pure.teikyo.jp/en/publications/3426d83f-a4d5-40ae-800b-cbf00855e0d3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy.2016

    • Author(s)
      Freyermuth F, Rau F, Kokunai Y, Linke T, Sellier C, Nakamori M, Kino Y,.......Zimmer T, Furling D, Takahashi MP, Charlet-Berguerand N.
    • Journal Title

      Nat Commun.

      Volume: 7 Issue: 1 Pages: 11067-11067

    • DOI

      10.1038/ncomms11067

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Impact of Updated Diagnostic Criteria for Long QT Syndrome on Clinical Detection of Diseased Patients: Results from Study of Patients Carrying Gene Mutations.2016

    • Author(s)
      Hayashi K, Horie M, et al.
    • Journal Title

      JACC Clin Electrophysiol

      Volume: 2 Pages: 279-287

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of Insulin Resistance to Prevalence and Progression of Coronary Artery Calcification Beyond Metabolic Syndrome Components: Shiga Epidemiological Study of Subclinical Atherosclerosis.2016

    • Author(s)
      Yamazoe M, Hisamatsu T, Miura K, Kadowaki S, Zaid M, Kadota A, Torii S, Miyazawa I, Fujiyoshi A, Arima H, Sekikawa A, Maegawa H, Horie M, Ueshima H; SESSA Research Group.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 36 Issue: 8 Pages: 1703-1708

    • DOI

      10.1161/atvbaha.116.307612

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The genetics underlying acquired long QT syndrome: impact for genetic screening.2016

    • Author(s)
      Itoh H, Crotti L, Aiba T, Spazzolini C, Denjoy I, Fressart V, Hayashi K, Nakajima T, Ohno S, Makiyama T, Wu J, Hasegawa K, Mastantuono E, Dagradi F, Pedrazzini M, Yamagishi M, Berthet M, Murakami Y, Shimizu W, Guicheney P, Schwartz PJ, Horie M.
    • Journal Title

      European Heart Journal

      Volume: 37 (18) Issue: 18 Pages: 1456-1464

    • DOI

      10.1093/eurheartj/ehv695

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intravascular Ultrasound Guidance vs. Angiographic Guidance in Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction – Long-Term Clinical Outcomes From the CREDO-Kyoto AMI Registry –2016

    • Author(s)
      Nakatsuma K1, Shiomi H, Morimoto T, Ando K, Kadota K, Watanabe H, Taniguchi T, Yamamoto T, Furukawa Y, Nakagawa Y, Horie M, Kimura T.
    • Journal Title

      Circulation Journal

      Volume: 80 Issue: 2 Pages: 477-484

    • DOI

      10.1253/circj.CJ-15-0870

    • NAID

      130005120921

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) Associated With Ryanodine Receptor (RyR2) Gene Mutations – Long-Term Prognosis After Initiation of Medical Treatment –2016

    • Author(s)
      Kawata H, Horie M, et al.
    • Journal Title

      Circulation Journal

      Volume: 80 Issue: 9 Pages: 1907-1915

    • DOI

      10.1253/circj.CJ-16-0250

    • NAID

      130005406854

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular Genetics Have Opened a New Era for Arrhythmia Research, but also Pandora’s Box?2016

    • Author(s)
      Horie M
    • Journal Title

      Journal of Arrhythmia

      Volume: 32 Issue: 5 Pages: 313-314

    • DOI

      10.1016/j.joa.2016.07.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetics of Brugada syndrome.2016

    • Author(s)
      uang J-M, Horie M
    • Journal Title

      Journal of Arrhythmia

      Volume: 32 Issue: 5 Pages: 418-425

    • DOI

      10.1016/j.joa.2016.07.012

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The genetic background of arrhythmogenic right ventricular cardiomyopathy2016

    • Author(s)
      Seiko Ohno
    • Journal Title

      Journal of Arrhythmia

      Volume: 未定 Issue: 5 Pages: 398-403

    • DOI

      10.1016/j.joa.2016.01.006

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A type 2 ryanodine receptor variant associated with reduced Ca2+ release and short-coupled torsade de pointe ventricular arrhythmia.2016

    • Author(s)
      Fujii Y, Horie M, et al.
    • Journal Title

      Heart Rhythm

      Volume: 14 Issue: 1 Pages: 98-107

    • DOI

      10.1016/j.hrthm.2016.10.015

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Variants in the SCN5A Promoter Associated With Various Arrhythmia Phenotypes.2016

    • Author(s)
      Yagihara N,Minamino T,33名中28番
    • Journal Title

      J Am Heart Assoc.

      Volume: 19 Issue: 9 Pages: 644-650

    • DOI

      10.1161/jaha.116.003644

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pediatric Cohort With Long QT Syndrome – <i>KCNH2</i> Mutation Carriers Present Late Onset But Severe Symptoms –2016

    • Author(s)
      Ozawa, J. Ohno, S. Horie M, et al.
    • Journal Title

      Circulation Journal

      Volume: 80 Issue: 3 Pages: 696-702

    • DOI

      10.1253/circj.CJ-15-0933

    • NAID

      130005128459

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Smoking, Smoking Cessation, and Measures of Subclinical Atherosclerosis in Multiple Vascular Beds in Japanese Men2016

    • Author(s)
      Hisamatsu T, Miura K, Arima H, Kadota A, Kadowaki S, Torii S, Suzuki S, Miyagawa N, Sato A, Yamazoe M, Fujiyoshi A, Ohkubo T, Yamamoto T, Murata K, Abbott RD, Sekikawa A, Horie M, Ueshima H; Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group
    • Journal Title

      J Am Heart Assoc.

      Volume: 5 Issue: 9

    • DOI

      10.1161/jaha.116.003738

    • NAID

      120005952637

    • URL

      https://pure.teikyo.jp/en/publications/3b250448-a793-472a-ba32-23047c9906a7

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A novel SCN5A variant associate with drug-induced Brugada Syndrome2016

    • Author(s)
      Turker I, Horie M, et al.
    • Journal Title

      Plos ONE

      Volume: 11 Issue: 8 Pages: e0161872-e0161872

    • DOI

      10.1371/journal.pone.0161872

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge.2016

    • Author(s)
      Antzelevitch C, Horie M, et al.
    • Journal Title

      Heart Rhythm.

      Volume: 13 Issue: 10 Pages: e295-e324

    • DOI

      10.1016/j.hrthm.2016.05.024

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Inherited catecholaminergic polymorphic ventricular tachycardia due to RYR2 mutation.2016

    • Author(s)
      Watanabe T, Ohno S, Shirai M, Endoh A, Hongo T, Ueta I, Yoshimoto J
    • Journal Title

      Pediatr Int

      Volume: 58 Issue: 6 Pages: 512-515

    • DOI

      10.1111/ped.12910

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early repolarization and risk of arrhythmia events in long QT syndrome.2016

    • Author(s)
      Hasegawa K, Watanabe H, Hisamatsu T, Ohno S, Itoh H, Ashihara T, Hayashi H, Makiyama T, Minamino T, Horie M.
    • Journal Title

      Int J Cardiol.

      Volume: 223 Pages: 540-542

    • DOI

      10.1016/j.ijcard.2016.08.215

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phenotypic Variability of <i>ANK2</i> Mutations in Patients With Inherited Primary Arrhythmia Syndromes2016

    • Author(s)
      Ichikawa M, Horie M, et al.
    • Journal Title

      Circulation Journal

      Volume: 80 Issue: 12 Pages: 2435-2442

    • DOI

      10.1253/circj.CJ-16-0486

    • NAID

      130005284992

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Patient-Specific Human Induced Pluripotent Stem Cell Model Assessed with Electrical Pacing Validates S107 as a Potential Therapeutic Agent for Catecholaminergic Polymorphic Ventricular Tachycardia2016

    • Author(s)
      Sasaki K, Makiyama T, Yoshida Y, Wuriyanghai Y, Kamakura T, Nishiuchi S, Hayano M, Harita T, Yamamoto Y, Kohjitani H, Hirose S, Chen J, Kawamura M, Ohno S, Itoh H, Takeuchi A, Matsuoka S, Miura M, Sumitomo N, Horie M, Yamanaka S, Kimura T
    • Journal Title

      PLoS One

      Volume: 11 Issue: 10 Pages: e0164795-e0164795

    • DOI

      10.1371/journal.pone.0164795

    • NAID

      120005860036

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Partial IK1 blockade destabilizes spiral wave rotation center without inducing wave breakup and facilitates termination of reentrant arrhythmias in ventricles2016

    • Author(s)
      Kushiyama Y, Honjo H, Niwa R, Takanari H, Yamazaki M, Takemoto Y, Sakuma I, Kodama I, Kamiya K
    • Journal Title

      American Journal of Physiology Heart and Circulatory Physiology

      Volume: 311 Issue: 1 Pages: 750-758

    • DOI

      10.1038/srep34198

    • NAID

      120005946586

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The relationship between skeletal muscle and ventilatory response to exercise in myocardial infarction.2016

    • Author(s)
      Hayashi H, Horie M, et al.
    • Journal Title

      IJC Metabolic and Endocrine

      Volume: 12 Pages: 14-18

    • DOI

      10.1016/j.ijcme.2016.05.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge: Endorsed by the Asia Pacific Heart Rhythm Society (APHRS), the European Heart Rhythm Association (EHRA), the Heart Rhythm Society (HRS), and the Latin American Society of Cardiac Pacing and Electrophysiology (Sociedad Latinoamericana de Estimulacifin Cardiaca y Electrofsiologia [SOLAECE]).2016

    • Author(s)
      Antzelevitch C, Horie M, et al.
    • Journal Title

      Europace

      Volume: 13 Pages: 315-339

    • DOI

      10.1093/europace/euw235

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] J-wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge.2016

    • Author(s)
      Antzelevitch C, Horie M, et al.
    • Journal Title

      J Arrhythm

      Volume: 32 Issue: 5 Pages: 315-339

    • DOI

      10.1016/j.joa.2016.07.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular pathogenesis of long QT syndrome type 12016

    • Author(s)
      Wu J, Ding W-G, Horie M
    • Journal Title

      Journal of Arrhythmia

      Volume: 32 Issue: 5 Pages: 381-388

    • DOI

      10.1016/j.joa.2015.12.006

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serum level of LOX-1 ligand containing ApoB is associated with increased carotid intima-media thickness in Japanese community-dwelling men, especially those with hypercholesterolemiaLOX-1 ligand and IMT in Japanese2016

    • Author(s)
      Okamura T, Miura K, Sawamura T, Kadota A, Hisamatsu T, Fujiyoshi A, Miyamatsu N, Takashima N, Miyagawa N, Kadowaki T, Ohkubo T, Murakami Y, Nakamura Y, Ueshima H.
    • Journal Title

      J Clin Lipidol.

      Volume: 10 Issue: 1 Pages: 172

    • DOI

      10.1016/j.jacl.2015.10.010

    • URL

      https://pure.teikyo.jp/en/publications/7c88a248-4c44-44ca-ac79-d273547d7caf

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Lipoprotein-associated phospholipase A2 related to the risk of subclinical atherosclerosis independent of small low density lipoprotein particles in a general Japanese population.2016

    • Author(s)
      Ueshima H, Kadowaki T, Fujiyoshi A, Miura K, Ohkubo T, Kadota A, Kadowaki S, Nakamura Y, Miyagawa N, Okamura T, Kita Y, Takashima N, Kashiwagi A, Maegawa H, Horie M, Yamamoto T, Kimura T, Kita T, for the ACCESS and SESSA Research Group.
    • Journal Title

      Submitted to Athelosclerosis.

      Volume: 246 Pages: 141-147

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Quantitative Analysis of PKP2 and Neighboring Genes in a Patient with Arrhythmogenic Right Ventricular Cardiomyopathy Caused by Heterozygous PKP2 Deletion.2016

    • Author(s)
      Sonoda K, Ohno S, Otsuki S, Kato K, Fukuyama M, Yagihara N, Watanabe H, Hayashi H, Minamino T, Horie M.
    • Journal Title

      Europace. Mar

      Volume: 22

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification.2016

    • Author(s)
      Zaid M, Miura K, Fujiyoshi A, Abbott RD, Hisamatsu T, Kadota A, Arima H, Kadowaki S, Torii S, Miyagawa N, Suzuki S, Takashima N, Ohkubo T, Sekikawa A, Maegawa H, Horie M, Nakamura Y, Okamura T, Ueshima H, for the SESSA Research group.
    • Journal Title

      Journal of Clinical Lipidology.

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] LMNA cardiomyopathy detected in Japanese arrhythmogenic right ventricular cardiomyopathy cohort.2016

    • Author(s)
      Kato K, Takahashi N, Fujii Y, Umehara A, Nishiuchi S, Makiyama T, Ohno S, Horie M
    • Journal Title

      J Cardiol

      Volume: 印刷中 Issue: 4 Pages: 346-51

    • DOI

      10.1016/j.jjcc.2015.10.013

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular pathogenesis of long QT syndrome type 1.2016

    • Author(s)
      Wu J, Ding W-G, Horie M.
    • Journal Title

      ournal of Arrhythmia

      Volume: in press

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cardiac Sodium Channel Mutation Associated with Epinephrine-Induced QT Prolongation and Sinus Node Dysfunction.2016

    • Author(s)
      Chen J, Makiyama T, Wuriyanghai Y, Ohno S, Sasaki K, Hayano M, Harita T, Nishiuchi S, Yamamoto Y, Ueyama T, Shimizu A, Horie M, Kimura T.
    • Journal Title

      Heart Rhythm.

      Volume: 13 Pages: 289-298

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Novel SCN10A variants associated with Brugada syndrome2015

    • Author(s)
      Fukuyama M, Ohno S, Makiyama T, Horie M.
    • Journal Title

      Europace

      Volume: 0 Issue: 6 Pages: 0-0

    • DOI

      10.1093/europace/euv078

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Asymmetry of parental origin in Long QT syndrome. Preferential maternal transmission of KCNQ1 variants linked to channel dysfunction.2015

    • Author(s)
      Itoh H, Berthet M, Fressart V, Denjoy I, Maugenre S, Klug D, Mizusawa Y, Makiyama T, Hofman N, Shimizu W, Wilde AAM, Schulze-Bahr E, Horie M, Tezenas du Montcel S, Guicheney P.
    • Journal Title

      European Journal of Human Genetics

      Volume: - Issue: 8 Pages: 1160-6

    • DOI

      10.1038/ejhg.2015.257

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The Genetics Underlying Acquired Long QT Syndrome. Impact on Management.2015

    • Author(s)
      Itoh H, Crotti L, Aiba T, Spazzplini C, Denjoy I, Fressart V, Hayashi K, Nakajima T, Ohno S, Makiyama T, Wu J, Hasegawa K, Mastantuono E, Dagradi F, Pedrazzini M, Yamagishi M, Berthet M, Murakami Y, Shimizu W, Guicheney P, Schwartz PJ, Horie M.
    • Journal Title

      European Heart Journal

      Volume: 28

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Long-term outcomes associated with prolonged PR interval in the general Japanese population2015

    • Author(s)
      Hisamatsu T, Miura K, Fujiyoshi A, Okamura T, Ohkubo T, Nagasawa SY, Horie M, Okayama A, Ueshima H,
    • Journal Title

      International Journal of Cardiology.

      Volume: 184 Issue: 1 Pages: 291

    • DOI

      10.1016/j.ijcard.2015.02.028

    • URL

      https://pure.teikyo.jp/en/publications/064434b6-524c-4283-a4e9-caf3189b263f

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] L&ouml;ffler Endocarditis and Lacking Heart2015

    • Author(s)
      Sawayama Y, Itoh H, Sakai H, Horie M.
    • Journal Title

      Internal Medicine

      Volume: 54 Issue: 23 Pages: 3093-3093

    • DOI

      10.2169/internalmedicine.54.5622

    • NAID

      130005112846

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between Pulse Wave Velocity and Coronary Artery Calcification in Japanese men2015

    • Author(s)
      Torii S, Arima H, Ohkubo T, Fujiyoshi A, Kadota A, Takashima N, Kadowaki S, Hisamatsu T, Saito Y, Miyagawa N, Zaid M, Murakami Y, Abbott R, Horie M, Miura K, Ueshima H.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 22 Issue: 12 Pages: 1266-1277

    • DOI

      10.5551/jat.30247

    • NAID

      130005112368

    • ISSN
      1340-3478, 1880-3873
    • URL

      https://pure.teikyo.jp/en/publications/7924101e-30b2-4418-a8c8-01c7ccb73d07

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical efficacy of thrombus aspiration on 5-year clinical outcomes in patients with ST-segment elevation acute myocardial infarction undergoing percutaneous coronary intervention.2015

    • Author(s)
      Watanabe H, .et al. Horie M.
    • Journal Title

      J Am Heart Assoc.

      Volume: 4 Issue: 6

    • DOI

      10.1161/jaha.115.001962

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Antiplatelet therapy discontinuation and the risk of serious cardiovascular events after coronary stenting: observations from the CREDO-Kyoto Registry Cohort-2.2015

    • Author(s)
      Watanabe H, Morimoto T, Natsuaki M, Furukawa Y, Nakagawa Y, Kadota K, Yamaji K, Ando K, Shizuta S, Shiomi H, Tada T, Tazaki J, Kato Y, Hayano M, Abe M, Tamura T, Shirotani M, Miki S, Matsuda M, Takahashi M, Ishii K, Tanaka M, Aoyama T, Doi O, Horie M, et ai.
    • Journal Title

      PLoS One

      Volume: 10(4) Issue: 4 Pages: e0124314-e0124314

    • DOI

      10.1371/journal.pone.0124314

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The association of J wave and ventricular tachycardia before device implantation with device interventions for ventricular tachyarrhythmia.2015

    • Author(s)
      Hayashi H, Horie M.
    • Journal Title

      J Electrocardiol.

      Volume: 48 Issue: 4 Pages: 721-728

    • DOI

      10.1016/j.jelectrocard.2015.04.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Adenosine triphosphate-guided pulmonary vein isolation for atrial fibrillation: the UNmasking Dormant Electrical Reconduction by Adenosine TriPhosphate (UNDER-ATP) trial.2015

    • Author(s)
      Kobori A, Shizuta S, Inoue K, Kaitani K, Morimoto T, Nakazawa Y, Ozawa T, et al.
    • Journal Title

      European Heart Journal.

      Volume: 7 Pages: 3276-3287

    • DOI

      10.1093/eurheartj/ehv457

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficacy and safety of flecainide for ventricular arrhythmias in patients with Andersen-Tawil syndrome with KCNJ2 mutations.2015

    • Author(s)
      Miyamoto K, Aiba T, Kimura H, Hayashi H, Ohno S, Yasuoka C, Tanioka Y, Tsuchiya T, Yoshida Y, Hayashi H, Tsuboi I, Nakajima I, Ishibashi K, Okamura H, Noda T, Ishihara M, Anzai T, Yasuda S, Miyamoto Y, Kamakura S, Kusano K, Ogawa H, Horie M, Shimizu W.
    • Journal Title

      Heart Rhythm

      Volume: 12 Issue: 3 Pages: 596-603

    • DOI

      10.1016/j.hrthm.2014.12.009

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical and Pathological Impact of Tissue Fibrosis on Lethal Arrhythmic Events in Hypertrophic Cardiomyopathy Patients With Impaired Systolic Function2015

    • Author(s)
      Wada Y, Aiba T, T Matsuyama, I Nakajima, Ishibashi K, Miyamoto K, Yamada Y, Okamura H, Noda T, Satomi K, Morita Y, Kanzaki H, Kusano K, Anzai T, Kamakura S, Ishibashi-Ueda H, Shimizu Wataru, Horie M, Yasuda S, Ogawa H.
    • Journal Title

      Circulation Journal

      Volume: 79 Issue: 8 Pages: 1733-1741

    • DOI

      10.1253/circj.CJ-15-0104

    • NAID

      130005089375

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mosaic KCNJ2 mutation in Andersen-Tawil syndrome: targeted deep sequencing is useful for the detection of mosaicism.2015

    • Author(s)
      Hasegawa K, Ohno S, Kimura H, Itoh H, Makiyama T, Yoshida Y, Horie M.
    • Journal Title

      Clin Genet

      Volume: 87 Issue: 3 Pages: 279-83

    • DOI

      10.1111/cge.12357

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Common Mutation of Long QT Syndrome Type 1 in Japan2015

    • Author(s)
      Itoh H, Dochi K, Shimizu W, Denjoy I, Ohno S, Aiba T, Kimura H, Kato K, Fukuyama M, Hasagawa K, Schulze-Bahr E, Guicheney P, Horie M.
    • Journal Title

      Circulation Journal

      Volume: 79 Issue: 9 Pages: 2026-2030

    • DOI

      10.1253/circj.CJ-15-0342

    • NAID

      130005095315

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Novel SCN10A Variants Associated with Brugada Syndrome.2015

    • Author(s)
      Fukuyama M, Ohno S, Makiyama T, Horie M.
    • Journal Title

      Europace

      Volume: 4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Gender Differences in the Inheritance Mode of RYR2 Mutations in Catecholaminergic Polymorphic Ventricular Tachycardia Patients.2015

    • Author(s)
      Seiko Ohno, Kanae Hasegawa, Minoru Horie
    • Journal Title

      PlosOne

      Volume: 10 Issue: 6 Pages: 6-6

    • DOI

      10.1371/journal.pone.0131517

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Identification of novel long QT syndrome-associated mutations by targeted sequencing analyses.2017

    • Author(s)
      Watanabe R, Ohno S, Aiba T et al.
    • Organizer
      European Society of Human Genetics Conference.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cardiac Sodium Channelopathy: overlapping syndromes and diverse mechanisms.2017

    • Author(s)
      Horie M
    • Organizer
      TSOC meeting
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Not All Non-Paroxysmal Atrial Fibrillation Drivers Are Included in Complex Fractionated Electrogram Area or Low Voltage Area: ExTRa Mapping Project.2017

    • Author(s)
      akata K, Okuyama Y, Ozawa T, Tsuchiya T, Haraguchi R, Nakazawa K, Horie M, Ashihara T
    • Organizer
      4th International Congress on Electrocardiology/17th Congress of the International Society for Holter and Noninvasive Electrocardiology.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ExTRa Mapping-guided non-passive activation ablation is very effective for non-paroxysmal AF.2017

    • Author(s)
      Ashihara T, Sakata K, Okuyama Y, Ozawa T, Tsuchiya T, Haraguchi R, Horie M
    • Organizer
      Heart Rhythm
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular Genetics Have Opened a New Era for Arrhythmia Research, but Also Pandora's Box?2017

    • Author(s)
      Horie M
    • Organizer
      APHRS2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cardiac Ryanodine Receptor Channel and Inherited Arrhythmia Syndrome.2017

    • Author(s)
      Horie M.
    • Organizer
      APHRS2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Exercise Inducible Polymorphic Ventricular Tachycardia Depending on the Different RYR2 Mutation Spectrum2017

    • Author(s)
      Wada Y, Ohno S, Wuriyanghai Y, Makiyama T, Horie M
    • Organizer
      APHRS2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel N-Terminal KCNH2 Mutations Identified in Symptomatic Long QT Syndrome Patients.2017

    • Author(s)
      Fukumoto D, Ohno S, Wada Y, Fujii Y, Ichikawa M, Takayama K, Fukuyama M, Itoh H, Ding WG, Matsuura H, Horie M
    • Organizer
      APHRS2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Modelling Long-QT Syndrome Type 3 Associated with Near-Miss Sudden Infant Death Syndrome Using Human-Induced Pluripotent Stem Cells.2017

    • Author(s)
      Hirose S, Makiyama T, Melgari D, Wu J, Yokoi F, Wuriyanghai Y, Kohjitani H, Yamamoto Y, Nishiuchi S, Hayano M, Harita T, Yoshimoto J, Ohno S, Yoshida Y, Horie M, Kimura T
    • Organizer
      APHRS2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] KCNJ3 N496H A Rare Variant in Japanese as a Cause of Susceptible Gene for Ventricular Fibrillation in Overlap Syndromes between LQT and CPVT.2017

    • Author(s)
      Aiba T, Ohno S, Ono M, Shigemizu D, Toyoda F, Miake J, Hagiwara A, Shinohara T, Okumura S, Toda T, Satake W, Tsunoda T, Shimamoto K, Sekine A, Takahashi A, Miyamoto Y, Tanaka T, Kusano K, Horie M, Shimizu W.
    • Organizer
      APHRS2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gene-Based Risk Stratification for Cardiac Disorders in LMNA Mutation Carriers.2017

    • Author(s)
      Nishiuchi S, Makiyama T, Aiba T, Nakajima K, Ishikawa T, Murakoshi N, Watanabe H, Ohno S, Doi T, Shizuta S, Minamino T, Saito Y, Oginosawa Y, Nogami A, Aonuma K, Kusano K, Makita N, Shimizu W, Horie M, Kimura T
    • Organizer
      APHRS2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] lL-cis-Diltiazem Ameliorates Impaired Calcium Channel Inactivation in a Patient-Specific Stem Cell Model of Long-QT Syndrome with a Calmodulin Mutation.2017

    • Author(s)
      Yokoi F, Makiyama T, Harita T, Yamamoto Y, Hayano M, Nishiuchi S, Kohjitani H, Wuriyanghai Y, Hirose S, Toyoda F, Yoshida Y, Makita N、Horie M, Kimura T
    • Organizer
      APHRS2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Drug-Induced Long QT Syndrome in a Patient with an ANK2 Mutation.2017

    • Author(s)
      Kyodo A, Sakatani T, Shimoo S, Takamatsu K, Tsuji Y, Mera K, Koide M, Isodono K, Tsubakimoto Y, Matsuo A, Inoue K, Fujita H, Ichikawa M, Ohno S, Horie M
    • Organizer
      APHRS2017.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ankyrin-B mutation identified in a patient with chronic atrial fibrillation, atrioventricular conduction disturbance and left ventricular dysfunction2017

    • Author(s)
      Imai Y, Higashi Y, Yoshino T, Tarutani Y, Ichikawa M, Ohno S, Horie M.
    • Organizer
      APHRS2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Inherited Primary Arrhythmia Syndrome Presenting with Phenotypic Features of Catecholaminergic Polymorphic Ventricular Tachycardia Plus Prominent U-Waves.2017

    • Author(s)
      Dharmawan T, Nakajima T, Ohno S, Iizuka T, Irie T, Kaneko Y, Horie M, Kurabayashi M.
    • Organizer
      APHRS2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Score System for Diagnosis of Syncope after Alcohol Intake in Brugada Syndrome.2017

    • Author(s)
      Wu Q, Hira D, Hayashi H, Sonoda K, Ohno S, Makiyama T, Terada T, Horie M.
    • Organizer
      APHRS2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Non-Paroxysmal Atrial Fibrillation Wave Dynamics Were Determined by Age Rather than Echocardiographic Measurements or BNP: Extra Mapping Project.2017

    • Author(s)
      Sakata K, Ozawa T, Okuyama Y, Haraguchi R, Tsuchiya T, Horie M, Ashihara T.
    • Organizer
      APHRS2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Extra Mapping-Guided Ablation Targeting NonPassively Activated Area Is Very Effective for Long-Standing Persistent Atrial Fibrillation.2017

    • Author(s)
      Ashihara T, Sakata K, Okuyama Y, Ozawa T, Haraguchi R, Fukui A, Yamaguchi T, Tsuchiya T, Horie M.
    • Organizer
      APHRS2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ex Dependent Risk of Sudden Death or Sick Sinus Syndrome in a Family with Brugada Syndrome.2017

    • Author(s)
      Aizawa Y, Fujisawa T, Katsumata Y, Ohno S, Sonoda K, Hayashi H, Hojo R, Fukamizu S, Nakajima K, Kunitomi A, Nishiyama T, Kimura T, Nishiyama N, Kurita Y, Takatsuki S, Ogwa S, Kosaki K, Nakazato Y, Horie M, Fukuda K
    • Organizer
      APHRS2017.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Severe Phenotype of Catecholaminergic Polymorphic Ventricular Tachycardia Caused by Double RYR2 Mutations.2017

    • Author(s)
      Takayama K, Ohno S, Horie M
    • Organizer
      APHRS2017.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Is Cardiac Resynchronization Therapy Able to Improve Mortality of Heart Failure in Patients with Laminopathy?2017

    • Author(s)
      Nakajima K, Aiba T, Nishiuchi S, Makiyama T, Onoue K, Kamakura T, Wada M, Ishibashi K, Inoue Y, Miyamoto K, Okamura H, Nagase S, Noda T, Ohno S, Miyamoto Y, Saito Y, Horie M, Kimura T, Shimizu W, Kusano K.
    • Organizer
      APHRS2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel RYR2 Mutations Causative for Long QT Syndromes.2017

    • Author(s)
      Fukuyama M, Ohno S, Takayama K, Ichikawa M, Fukumoto D, Horie M.
    • Organizer
      APHRS2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] CALM2-D134H Mutation Associated with Long-QT Syndrome Prevents Inactivation of L-type Ca2+ Currents in Human iPS Cell Derived Cardiomyocytes.2017

    • Author(s)
      Yamamoto Y, Makiyama T, Harita T, Hayano M, Nishiuchi S, Wuriyanghai Y, Kohjitani H, Hirose S, Yokoi F, Ishikawa T, Ohno S, Chinabayashi K, Suda K, Yoshida Y, Horie M, Makita N, Kimura T.
    • Organizer
      APHRS2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Next-Generation Sequencing Is One of the Promising Ways for Identifying Copy Number Variations in Patients with Inherited Primary Arrhythmia Syndromes.2017

    • Author(s)
      Ichikawa M, Ohno S, Fukumoto D, Takayama K, Wada Y, Fukuyama M, Makiyama T, Itoh H, Horie M
    • Organizer
      APHRS2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SCN10A Mutations Related with Bradycardia and Conduction Block in Young Patients.2017

    • Author(s)
      Aoki H, Ohno S, Fukuyama M, Yoshinaga M, Horie M.
    • Organizer
      ESC Congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Using large-tip ablation catheter markedly decreases bipolar signal amplitude near spiral wave center but this is not the case with using multi-electrode mapping catheter: A simulation study.2017

    • Author(s)
      Sakata K, Okuyama Y, Ozawa T, Haraguchi R, Horie M, Ashihara T
    • Organizer
      ESC Congress 2017.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Non-paroxysmal atrial fibrillation wave dynamics were determined by age rather than echocardiographic measurements and BNP: A clinical study using the ExTRa Mapping system.2017

    • Author(s)
      Sakata K, Ozawa T, Okuyama Y, Haraguchi R, Tsuchiya T, Horie M, Ashihara T
    • Organizer
      ESC Congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Not all non-paroxysmal atrial fibrillation drivers are included in complex fractionated electrogram area or low-voltage area: ExTRa Mapping project. The 39th Annual Congress of the European Society of Cardiology2017

    • Author(s)
      Sakata K, Ozawa T, Okuyama Y, Haraguchi R, Tsuchiya T, Horie M, Ashihara T
    • Organizer
      ESC Congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel RYR2 mutations causative for long QT syndromes.2017

    • Author(s)
      Fukuyama M, Ohno S, Takayama K, Ichikawa M, Horie M
    • Organizer
      ESC Congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of copy number variations by next generation sequencer in patients with inherited primary arrhythmia syndromes.2017

    • Author(s)
      Ichikawa M, Ohno S, Fukumoto D, Takayama K, Wada Y, Fukuyama M, Makiyama T, Itoh H, Horie M
    • Organizer
      ESC Congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Human iPSC-Derived Myocyte Mmodel of SCN5A-D1275N-Related Cardiac Sodium Channelopathy Reveals Diminished Sodium Currents Resulting From Enhanced Protein Degradation.2017

    • Author(s)
      Hayano M,Makiyama T, Kamakura T, Watanabe H, Sasaki K, Funakoshi S, Wuriyanghai Y, Nishiguchi S, Harita T, Yamamoto Y,.Kohjitani H, Hirose S, Yokoi F, Chen J, Baba O, Horie T, Chonabayahi K, Ohno S, Toyoda F, Yoshida Y, Ohno K, Horie M, Kimura T.
    • Organizer
      AHA2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] CALM2-D134H Mutation Associated with Long-QT Syndrome Delayed Inactivation of L-type Ca2+ Currents in Human iPS Cells Derived Cardiomyocytes.2017

    • Author(s)
      Yamamoto Y, Makiyama T, Harita T, Hayano M, Suguru N, Wuriyanghai Y, Kohjitani H, Hirose S, Yokoi F, Ishikawa T, Ohno S, Chonabayashi K, Suda K, Yoshida Y, Horie M, Makita N, Kimura T.
    • Organizer
      AHA2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Establishment of Homozygous LMNA Knockout Human Induced Pluripotent Stem Cells For Analyzing Disease-causing Mechanism of Laminopathies.2017

    • Author(s)
      Wuriyanghai Y.
    • Organizer
      AHA2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Early Repolarization Syndrome Caused by a de novo KCND3 Gain-of-Function Mutation.2017

    • Author(s)
      Takayama K, Ohno S, Ding W-G, Kise H, Hoshiai M, Matsuura H, Horie M.
    • Organizer
      AHA2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Propranolol Inhibits Late Sodium Current in Long-QT Syndrome Type 3 Human Induced Pluripotent Stem Cell-drived Myocyte Model.2017

    • Author(s)
      irose S, Makiyama T, Melgari D, Wu J, Yokoi F, Wuriyanghai Y, Yamamoto Y, Kohjitani H, Nishiguchi S, Harita T, Hayano M, Yoshimoto J, Ohno S, Yoshida Y, Horie M, Kimura T.
    • Organizer
      AHA2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel Mathematical Modeling of Human Induced Pluripotent Stem Cell Derived Cardiomyocyte can Recapitulate Action Potentials of All Subtypes Including Nodal Like Cells, and Reproduced Drug Testing and Gene Mutation Model Accurately.2017

    • Author(s)
      Kohjitani K, Kouda S, Himeno Y, Makiyama T, Hirose S, Wuriyanghai Y, Yamamoto Y, Horie M, Kimura T, Noma A, Amano A.
    • Organizer
      AHA2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SMOKING ASSOCIATES WITH HIGHER INCIDENCE AND PROGRESSION OF CORONARY ATHEROSCLEROSIS IN A COMMUNITY-BASED SAMPLE OF JAPANESE MEN: THE SHIGA EPIDEMIOLOGICAL STUDY OF SUBCLINICAL ATHEROSCLEROSIS (SESSA).2017

    • Author(s)
      Pham T, Fujiyoshi A, Hisamatsu T, Kadota A, Kadowaki S, Zaid M, Horie M, Miura K, Ueshima H, for the SESSA Research Group.
    • Organizer
      VJSE 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ot all non-paroxysmal atrial fibrillation drivers are included in complex fractionated electrogram area or low voltage area: ExTRa Mapping project.2017

    • Author(s)
      Sakata K, Ozawa T, Okuyama Y, Haraguchi R, Tsuchiya T, Horie M, Ashihara T
    • Organizer
      ICE, ISHNE
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analyzing vectorcardiograms synthesized from 12-lead electrocardiogram to predict the origin of sinus rhythm and premature contraction.2017

    • Author(s)
      Inada S, Inoue Y, Shibata N, Yamamoto T, Ashihara T, Aiba T, Kusano K, Ikeda T, Mitsui K, Nakazawa K
    • Organizer
      ICE, ISHNE
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Human iPS cell-engineered heart tissue to reproduce “Torsade de Pointes” arrhythmia in vitro.2017

    • Author(s)
      Kawatou M, Masumoto H, Fukushima H, Morinaga G, Sakata R, Ashihara T, Yamashita JK
    • Organizer
      ISSCR
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Not all non-paroxysmal atrial fibrillation drivers are included in complex fractionated electrogram area or low-voltage area: ExTRa Mapping Project.2017

    • Author(s)
      Sakata K, Ozawa T, Okuyama Y, Haraguchi R, Tsuchiya T, Horie M, Ashihara T
    • Organizer
      ISSCR
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ExTRa Mapping-guided ablation targeting non-passively activated area is very effective for long-standing persistent atrial fibrillation.2017

    • Author(s)
      Ashihara T, Sakata K, Okuyama Y, Ozawa T, Haraguchi R, Fukui A, Yamaguchi T, Tsuchiya T, Horie M
    • Organizer
      ISSCR
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of Skeletal Muscle in Ventilatory Response to Exercise: Comparison between Myocardial Infarction and Diabetes Mellitus.2016

    • Author(s)
      Hayashi H, Tobita R, Iwai K, Horie M
    • Organizer
      AHA2016
    • Place of Presentation
      New Orleans
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High prevalence of late onset T in patients with long QT syndrome type 8.2016

    • Author(s)
      Ohno S, Ozawa J, Fukuyama M, Makiyama T, Horie M.
    • Organizer
      AHA2016
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Unique Genetic Background and Prognostic Impact on Non-Caucasian ARVD/C Probands2016

    • Author(s)
      Wada Y, Ohno S, Aiba T, Horie M
    • Organizer
      AHA2016
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ECG Screening of 1-Month-Old Infants May Prevent Out-of-Hospital Cardiac Arrest in Infancy2016

    • Author(s)
      Yoshinaga M, Ohno S, Ushinohama H, Sato S, Miyamoto T, Tauchi N, Horigome H, Sumitomo N, Shiraishi H, Ichida F, Hata T, Nomura Y, Horie M, Makita N, Nagashima M
    • Organizer
      AHA2016
    • Place of Presentation
      New Orleans
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Allele-specific Disruption Rescues Electrophysiological Abnormalities in Human iPS Cell Model of Long-QT Syndrome With a CALM2 Mutation2016

    • Author(s)
      Yamamoto Y, Makiyama T, Harita T, Sasaki K, Hayano M, Nishiuchi S, Wuriyanghai Y, Kohjitani H, Hirose S, Chen J, Ishikawa T, Motomura H, Ohno S, Chonabayashi K, Yoshida Y, Horie M, Makita N, Kimura T.
    • Organizer
      AHA2016,
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] KCNH2 mutation in patients with long QT syndrome type 2.2016

    • Author(s)
      Fukumoto D, Ohno S, Wada Y, Fujii Y, Ichikawa M, Ito H, Ding WG, Matsuura H, Horie M
    • Organizer
      9th APHRS Scientific Session.
    • Place of Presentation
      Korea
    • Year and Date
      2016-10-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Generation of lmna knock out human induced pluripotent stem cells using the crispr-cas9 nickase system.2016

    • Author(s)
      Wuriyanghai Y, Makiyama T, Nishiuchi S, Yokoi F, Hayano M, Yamamoto Y, Harita T, Kohjitani H, Hirose A, Ohno S, Yoshida Y, Horie M, Kimura T
    • Organizer
      9th APHRS Scientific Session
    • Place of Presentation
      Korea
    • Year and Date
      2016-10-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Various ANK2 mutations in patients with inherited primary arrhythmia syndromes.2016

    • Author(s)
      Ichikawa M, Aiba T, Ohno S, Shigemizu D, Ozawa J, Sonoda K, Fukuyama M, Itoh H, Miyamoto Y, Tsunoda T, Makiyama T, Tanaka T, Shimizu W, Horie M
    • Organizer
      9th APHRS Scientific Session
    • Place of Presentation
      Korea
    • Year and Date
      2016-10-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Non desmosomal mutations detected in japanese patients with arrhythmogenic right ventricular cardiomyopathy.2016

    • Author(s)
      Takayama K, Ohno S, Wada Y, Horie M
    • Organizer
      9th APHRS Scientific Session
    • Place of Presentation
      Korea
    • Year and Date
      2016-10-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The RYR2 Mutations Identified Not Only in CPVT But Also Short Coupled Variant of Torsade De Pointes and LQTS.2016

    • Author(s)
      Ohno S
    • Organizer
      APHRS2016
    • Place of Presentation
      Korea
    • Year and Date
      2016-10-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SIMULATION OF IQ-CSRC PROSPECTIVE STUDY USING INTEGRATED IN SILICO 2-DIMENSIONAL TRANSMURAL HUMAN VENTRICULAR WEDGE PREPARATION MODEL.2016

    • Author(s)
      Kubo T, Ashihara T, Tsubouchi T, Bando K, Horie M
    • Organizer
      Safety Pharmacology Society.
    • Place of Presentation
      Canada
    • Year and Date
      2016-09-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A novel CACNA1C mutation identified in a patient with atypical Timothy syndrome exerts both loss- and gain-of-function effects on Cav1.2.2016

    • Author(s)
      Ozawa J, Ohno S, Toyoda F, Itoh H, Fukuyama M, Harita T, Makiyama T, Hiroshi Suzuki, Akihiko Saitoh, Matsuura H, Horie M
    • Organizer
      ESC CONGRESS 2016
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Triple mutations in three major genes for long QT syndrome are very rare but produce severe phenotypes.2016

    • Author(s)
      Ohno S, Wu J, Sonoda K, Itoh H, Makiyama T, Horie M
    • Organizer
      ESC CONGRESS 2016
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Rare Single Nucleotide Polymorphism of SCN10A in Patients with Inherited Primary Arrhythmia Syndromes.2016

    • Author(s)
      Fukuyama M, Ohno S, Ichikawa M, Makiyama T, Horie M
    • Organizer
      ESC CONGRESS 2016
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Specific Phenotypes Caused by RYR2 Mutations Relate with Bradycardia but not with Mutation Locations in RYR2.2016

    • Author(s)
      Ohno S, Ozawa J, Fujii Y, Itoh H, Horie M
    • Organizer
      ESC CONGRESS 2016
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Copy Number Variations in SCN5A associated with Brugada Syndrome.2016

    • Author(s)
      Sonoda K, Ohno S, Ozawa J, Hayano M, Ichikawa M, Ito H, Makiyama T, Horie M
    • Organizer
      ESC CONGRESS 2016
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Triple mutations in three major genes for long QT syndrome are very rare and cause complicated phenotypes with ventricular arrhythmia.2016

    • Author(s)
      Ohno S, Wu J, Mizusawa Y, Sonoda K, Itoh H, Makiyama T, Horie M
    • Organizer
      ESC2016
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Copy number variations in SCN5A associated with Brugada syndrome.2016

    • Author(s)
      Sonoda K, Ohno S, Ozawa J, Hayano M, Ito H, Makiyama T, Horie M
    • Organizer
      ESC2016
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Quickly remapping by novel online phase mapping system complemented by in silico prediction of excitations is very useful for confirming the effectiveness of non-PAF ablation (ExTRa Mapping Project)2016

    • Author(s)
      Ashihara T, Sakata K, Ozawa T, Tsuchiya T, Haraguchi R, Inada S, Nakazawa K, Horie M
    • Organizer
      ESC2016
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] New insights in molecular therapeutic mechanism of statin in heart failure using high-throughput tanscriptome analysis.2016

    • Author(s)
      Wada A, Matsumoto T, Fujii M, Taniguchi A, Hara T, Kinoshita M, Horie M
    • Organizer
      ESC2016
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] l-cis diltiazem rescues impaired calcium channel inactivation in a patient-specific stem cell model of long QT syndrome with a CACNA1C mutation.2016

    • Author(s)
      Harita T, Makiyama T, Toyoda F, Nishiuchi S, Hayano M, Yamamoto Y, Wuriyanghai Y, Kohjitani H, Ohno S, Yoshida Y, Ueyama T, Yamanaka S, Shimizu A, Horie M, Kimura T
    • Organizer
      ESC2016
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Flecainide suppresses an arrhythmogenic substrate in Andersen-Tawil syndrome-induced pluripotent stem cell-derived cardiomyocytes.2016

    • Author(s)
      Kuroda Y, Yuasa S, Watanabe Y, Ito S, Egashira T, Seki T, Aizawa Y, Hattori T, Okata S, Tanaka A, Horigome H, Kokubun N, Horie M, Kamiya K, Fukuda K
    • Organizer
      ESC2016
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical characteristics and long-term prognosis of patients with genotype-unknown long-QT syndrome.2016

    • Author(s)
      Shimamoto K, Aiba T, Ishibashi K, Kamakura T, Wada M, Miyamoto K, Inoue-Yamada Y, Okamura H, Nagase S, Noda T, Kamakura S, Miyamoto Y, Horie M, Shimizu W, Kusano K
    • Organizer
      ESC2016
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Specific phenotypes caused by RYR2 mutations relate with bradycardia but not with mutation locations in RYR2.2016

    • Author(s)
      Ohno S, Ozawa J, Fujii Y, Itoh H, Horie M
    • Organizer
      ESC2016
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Rare single nucleotide polymorphism of scn10a in patients with inherited primary arrhythmia syndromes.2016

    • Author(s)
      Fukuyama M, Ohno S, Ichikawa M, Makiyama T, Horie M
    • Organizer
      ESC2016
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] RYR2 mutations underlying in patients with short-coupled variant of torsade de pointes.2016

    • Author(s)
      Fujii Y, Itoh H, Ohno S, Blancard M, Aoki H, Nakagawa Y, Yamamoto S, Matsui Y, Ichikawa M, Sonoda K, Ozawa T, Ohkubo K, Watanabe I, Guicheney P, Horie M
    • Organizer
      ESC2016
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Incidence of heart failure hospitalization in patients with ST-segment elevation myocardial infarction who underwent primary percutaneous coronary intervention.2016

    • Author(s)
      Taniguchi T, Shiomi H, Morimoto T, Furukawa Y, Nakagawa Y, Horie M, Kimura T
    • Organizer
      ESC2016
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A clinical observational study employing a novel real-time phase mapping system (ExTRa Mapping).2016

    • Author(s)
      Sakata K, Ashihara T, Ozawa T, Tsuchiya T, Haraguchi R, Inada S, Nakazawa K, Horie M
    • Organizer
      Heart Rhythm 2016
    • Place of Presentation
      San Francisco
    • Year and Date
      2016-05-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] RYR2 mutations underlying in patients with short-coupled variant of torsade de pointes.2016

    • Author(s)
      Fujii Y, Itoh H, Ohno S, Blancard M, Aoki H, Nakagawa Y, Yamamoto S, Matsui Y, Ichikawa M, sonoda K, Ozawa T, Ohkubo K, Watanabe I, Guicheney P, Horie M.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Various ANK2 Mutations in Japanese Patients with Inherited Primary Arrhythmia Syndromes2016

    • Author(s)
      Ichikawa M, Ohno S, Fujii Y, Ozwa J, Sonoda K, Fukuyama M, Kato K, Kimura H, Hayashi H, Horie M
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] AKAP9 mutations identified in young patients with idiopathic ventricular fibrillation or polymorphic ventricular tachycardia2016

    • Author(s)
      Sonoda K, Ohno S, Wada Y, Ichikawa M, Fujii Y, Ozawa J, Itoh H, Ashihara T, Hayashi H, Horie M:
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Differential Diagnosis of Catecholaminergic Polymorphic Ventricular Tachycardia vs. Long QT Syndrome Type 1: A Modified Schwartz Scoring2015

    • Author(s)
      Ozawa J, Ohno S, Fujii Y, Makiyama T, Suzuki H, Saitoh A, Horie M.
    • Organizer
      AHA Scientific Sessions 2015
    • Place of Presentation
      アメリカ合衆国
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Modelling Long-QT Syndrome Associated With a Calmodulin Mutation Using Human Induced Pluripotent Stem Cells2015

    • Author(s)
      Yamamoto Y, Makiyama T, Harita T, Sasaki K, Hayano H, Nishiuchi S, Wuriyanghai Y, Kohjitani H, Hirose S, Chen J, Ishikawa T, Ohno S, Yoshida Y, Horie M, Makita N, Kimura T.
    • Organizer
      AHA Scientific Sessions 2015
    • Place of Presentation
      アメリカ合衆国
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] AKAP9 mutations identified in young patientswith idiopathic ventricular fibrillation or polymorphic ventricular tachycardia2015

    • Author(s)
      Sonoda K, Ohno S, Ichikawa M, Fujii Y, Wang Q, Kato K, Fukuyama M, Ito H, Hayashi H, Horie M:
    • Organizer
      ESC CONGRESS 2015
    • Place of Presentation
      イギリス
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cardiac sodium channel mutation associated with epinephrine-induced QT prolongation and sinus node dysfunction.2015

    • Author(s)
      Chen J, Makiyama T, Wuriyanghai Y, Ohno S, Ueyama T, Shimizu A, Horie M, Kimur T.
    • Organizer
      ESC CONGRESS 2015
    • Place of Presentation
      イギリス
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Abnormal expression of cardiac ion channels-associated genes in lamin A/C-related cardiomyopathy-specific induced pluripotent stem cell derived cardiomyocytes2015

    • Author(s)
      Nishiuchi S, Makiyama T, Sasaki K, Kohjitani Y, Ohno S, Yoshida Y, Doi T, Shizuta S, Horie.M, Kimura T
    • Organizer
      ESC CONGRESS 2015
    • Place of Presentation
      イギリス
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nonsense-Mediated mRNA Decay due to a CACNA1C Splicing Mutation in a Patient with Brugada Syndrome2015

    • Author(s)
      Fukuyama M, Ohno S, Wang Q, ShirayamaT,Itoh H, Horie M:
    • Organizer
      第30回日本不整脈学会学術大会
    • Place of Presentation
      京都
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Arrhythmogenic Right Ventricular Cardiomyopathy from the Genetic Basis to the Clinical Symptoms2015

    • Author(s)
      Ohno S, Wada Y, Sonoda K, Horie M
    • Organizer
      第30回日本不整脈学会学術大会
    • Place of Presentation
      京都
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Comparison ofcircadian, weekly and seasonal variations between electrical storms versus single VF events in patients with Brugada syndrome2015

    • Author(s)
      Aizawa Y, Takatsuki S, Nakajima K, Kashimura S, Kunitomi A, Katsumata Y, Nishiyama T, Kimura T, Nishiyama N, Fukumoto K, Tanimoto Y, Kaneko Y, Niwano S,Kurita T, Mitsuhashi T, Noda T, Kamakura S, Shimizu A, Horie M, Aizawa Y,Fukuda K
    • Organizer
      第30回日本不整脈学会学術大会
    • Place of Presentation
      京都
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Drug challenge test and genetic test for the diagnosis and management ofinherited primary arrhythmia syndromes2015

    • Author(s)
      Ueyama T, Shimizu A, Yoshiga Y, Ono M,Kato T, Fumimoto T, Ishiguchi H, Ohno S, Makiyama T, Horie M, Yano M
    • Organizer
      第30回日本不整脈学会学術大会
    • Place of Presentation
      京都
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Study oflong QT syndrome type 3 using human iPS cell-derived cardiomyocytes2015

    • Author(s)
      Furukawa T, Okata S, Yuasa S, Suzuki T, Makita N, Kurokawa J, Egashira, Yamakawa H, Seki T,Aizawa Y, Hashimoto H, Kuroda Y, Tanaka A, Yae K, Murata M, Aiba T, Shimizu W, Horie M, Kamiya K, Fukuda K
    • Organizer
      第30回日本不整脈学会学術大会
    • Place of Presentation
      京都
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Lamin A/C-related cardiomyopthy―From Bench to Bedside―2015

    • Author(s)
      Makiyama T, Nishiuchi S, Kohjitani H, Ohno S, Horie M, Kimura T
    • Organizer
      第30回日本不整脈学会学術大会
    • Place of Presentation
      京都
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] A novel KCNJ3 mutation as a susceptibility for ventricular arrhythmias in long-QT Syndrome2015

    • Author(s)
      Aiba T , Ono M, Toyoda F, Miake J, Hagiwara S, Shinohara T, Ishibashi K, Wada M, Nakajima I, Miyamoto K, Okamura H, Noda T, Kamakura S, Kusano K, Sekine A, Tanaka T, Miyamoto Y, Matsuura H, Horie M, Shimizu W
    • Organizer
      第30回日本不整脈学会学術大会
    • Place of Presentation
      京都
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] ML277 shortens prolonged action potential durations in a patientspecific induced pluripotent stem cell-based model of long-QT syndrome type 12015

    • Author(s)
      Wuriyanghai Y, Makiyama T, Sasaki K, Kamakura T, Chen J, Hayano M, Yamamoto Y, Harita T, Nishiuchi S, Kohjitani H, Ohno S, Watanabe K, Kimura T, Horie M
    • Organizer
      第30回日本不整脈学会学術大会
    • Place of Presentation
      京都
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Arrhythmogenic ventricular cardiomyopathy with peculiar ventricular aneurysm and TMEM43 mutations2015

    • Author(s)
      Ichikawa M, Ohno S, Fujii Y, Ozawa J, Sonoda K, Fukuyama M, Kato K, Itoh H,Horie M
    • Organizer
      EUROPACE- CARDIOSTIM 2015
    • Place of Presentation
      イタリア
    • Year and Date
      2015-06-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SCN10A polymorphisms are associated with the clinical severity of probands with sodium channelopathies.2015

    • Author(s)
      Fukuyama M, Ohno S, Ichikawa M, Makiyama T, Horie M
    • Organizer
      EUROPACE- CARDIOSTIM 2015
    • Place of Presentation
      イタリア
    • Year and Date
      2015-06-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 集学的治療により在宅復帰できた重症家族性拡張型心筋症の一例.2015

    • Author(s)
      飛田 良、澁川武志、木下妙子、前川昭次、川口民郎、林 秀樹、浅井 徹、堀江 稔
    • Organizer
      第119回日本循環器学会近畿地方会
    • Place of Presentation
      大阪
    • Year and Date
      2015-06-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Progress in Diagnosis and Treatment of Malignant Ventricular Arrhythmias.2015

    • Author(s)
      Horie M
    • Organizer
      Fourth Conference on Severe Heart Diseases in China
    • Place of Presentation
      中国
    • Year and Date
      2015-06-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The genetics underlying the acquired long QT syndrome. Impact on management.2015

    • Author(s)
      Itoh H, Spazzolini C, Crotti L, Aiba T, Denjoy I, Fressart V, Hayashi K, Nakajima T, Ohno S, Makiyama T, Wu J, Hasegawa K, Mastantuono E, Dagradi F, Pedrazzini M, Yamagishi M, Berthet M, Murakami Y, Shimizu W, Guicheney P, Schwartz PJ, Horie M.
    • Organizer
      The Heart Rhythm Society's 36th Annual Scientific Sessions
    • Place of Presentation
      アメリカ合衆国
    • Year and Date
      2015-05-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] desmosome gene mutations cause or modify the Brugada syndrome?2015

    • Author(s)
      Ohno S, Aizawa Y,Fukuyama M,Makiyama T,Kosaki K,Fukuda K,Horie M
    • Organizer
      The Heart Rhythm Society's 36th Annual Scientific Sessions
    • Place of Presentation
      アメリカ合衆国
    • Year and Date
      2015-05-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Quantitative Analysisof PKP2 and Neighboring Genesin a Patient with Arrhythmogenic Right Ventricular Cardiomyopathy Caused by Heterozygous PKP2 Deletion2015

    • Author(s)
      Sonoda K,Ohno S,Otsuki S,Yagihara N,Watanabe H,Horie M
    • Organizer
      The Heart Rhythm Society's 36th Annual Scientific Sessions
    • Place of Presentation
      アメリカ合衆国
    • Year and Date
      2015-05-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Quantitative Analysis of PKP2 and Neighboring Genes in a Patient with Arrhythmogenic Right Ventricular Cardiomyopathy Caused by Heterozygous PKP2 Deletion.2015

    • Author(s)
      Sonoda K,Ohno S,Ohtsuki S, Yagihara N,Watanabe H,Horie M
    • Organizer
      第79回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Usefulness of Benchtop Next Generation Sequencer in Research of Inherited Primary Arrhythmia Syndromes2015

    • Author(s)
      Ohno S,Fukuyama M,Itoh H,Makiyama T,Horie M
    • Organizer
      第79回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] The Screening of Calmodulin Genes in Genotype-negative Long QT Syndrome Patients2015

    • Author(s)
      Ichikawa M,Ohno S,Fujii Y,Ozawa J,Sonoda K,Fukuyama M,Kato K,Kimura H, Horie M
    • Organizer
      第79回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] SY11-6 What is Needed for Cardiologists Who Engage Themselves in Childcar2015

    • Author(s)
      Ohno S, Horie M
    • Organizer
      第79回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Genotype-Phenotype Correlation in Brugada Syndromes Differs from that in Long QT Syndromes2015

    • Author(s)
      HorieM.
    • Organizer
      第79回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Identification of Novel SCN10A Mutations in Brugada Syndrome Patients.2015

    • Author(s)
      Fukuyama M,Ohno S,Makiyama T,Horie M
    • Organizer
      第79回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] High Frequency of J Wave in Hypercalcemia2015

    • Author(s)
      Sonoda K,Watanabe H,Ohno S, Horie M, Minamino T.
    • Organizer
      第79回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Genetics of Early Repolarization Syndromes2015

    • Author(s)
      Horie M
    • Organizer
      Expert Consensus Symposium on J Wave Syndrome
    • Place of Presentation
      中国
    • Year and Date
      2015-04-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] 循環器疾患最新の治療2018-20192018

    • Author(s)
      永井 良三、伊藤 浩、山下 武志
    • Total Pages
      540
    • Publisher
      南江堂
    • ISBN
      9784524252183
    • Related Report
      2017 Annual Research Report
  • [Book] 別冊医学のあゆみ 不整脈を科学する2017

    • Author(s)
      堀江 稔
    • Total Pages
      100
    • Publisher
      医歯薬出版
    • Related Report
      2017 Annual Research Report
  • [Book] 先進医薬研究振興財団2016年度研究成果報告集.2017

    • Author(s)
      堀江 稔
    • Publisher
      先進医薬研究振興財団.
    • Related Report
      2017 Annual Research Report
  • [Book] Chapter 4: Genetic basis for Early Repolarization Syndrome. In J Wave Syndromes: Brugada and Early Repolarization Syndromes 1st ed.2017

    • Author(s)
      Horie M, Sonoda K, Ohno S
    • Publisher
      Antzelevitch and G-X Yan, Springer, Co
    • Related Report
      2016 Annual Research Report
  • [Book] 最近の不整脈診療の進歩-心房細動治療のパラダイムシフト2016

    • Author(s)
      堀江 稔
    • Total Pages
      78
    • Publisher
      大津医師会
    • Related Report
      2016 Annual Research Report
  • [Book] 遺伝性不整脈と突然死. 特集 遺伝性不整脈と心臓突然死2016

    • Author(s)
      堀江 稔
    • Publisher
      科学評論社
    • Related Report
      2016 Annual Research Report
  • [Book] 別冊医学のあゆみ ・イオンチャネル病のすべて2016

    • Author(s)
      堀江 稔
    • Total Pages
      156
    • Publisher
      医歯薬出版
    • Related Report
      2016 Annual Research Report
  • [Book] 心不全における不整脈の治療. 循環器疾患最新の治療2016-20172016

    • Author(s)
      林 秀樹,堀江 稔
    • Total Pages
      636
    • Publisher
      南江堂
    • Related Report
      2016 Annual Research Report
  • [Book] はじめに. 医学のあゆみ・心臓突然死の先制医療2016

    • Author(s)
      堀江 稔
    • Total Pages
      70
    • Publisher
      医歯薬出版
    • Related Report
      2016 Annual Research Report
  • [Book] 心筋症における心臓突然死を予測する2016

    • Author(s)
      大野聖子
    • Total Pages
      70
    • Publisher
      医歯薬出版
    • Related Report
      2016 Annual Research Report
  • [Book] 心房細動に対応する 「重症心不全の患者さんが来ました」2016

    • Author(s)
      堀江 稔
    • Publisher
      中外医学社
    • Related Report
      2015 Annual Research Report
  • [Book] 乳幼児突然死症候群(SIDS)および乳幼児突発性危急事態(ALTE)の病態解明等と死亡数減少のための研究.2015

    • Author(s)
      堀江 稔(分担研究),加藤稲子(代表研究)
    • Total Pages
      129
    • Publisher
      平成26年度厚生労働科学研究費補助金,成育疾患克服等次世代育成基盤研究事業
    • Related Report
      2015 Annual Research Report
  • [Book] 循環器内科2015

    • Author(s)
      堀江 稔
    • Total Pages
      594
    • Publisher
      科学評論社
    • Related Report
      2015 Annual Research Report
  • [Book] 不整脈治療update2015

    • Author(s)
      伊藤英樹、藤居祐介、堀江 稔
    • Total Pages
      224
    • Publisher
      医薬ジャーナル社
    • Related Report
      2015 Annual Research Report
  • [Book] 不整脈症候群2015

    • Author(s)
      堀江 稔
    • Total Pages
      204
    • Publisher
      南江堂
    • Related Report
      2015 Annual Research Report
  • [Remarks] 滋賀医科大学呼吸循環器内科

    • URL

      http://www.shiga-med.ac.jp/~hqmed1/

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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