Analyses of epithelial-immune barrier functions in the pathogenesis of asthma
| Project/Area Number |
15H04828
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
玉地 智宏 千葉大学, 大学院医学研究院, 助教 (20456015)
須藤 明 千葉大学, 大学院医学研究院, 准教授 (50447306)
廣瀬 晃一 千葉大学, 大学院医学研究院, 准教授 (90400887)
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| Research Collaborator |
HIROSE Koichi
ITO Takashi
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 喘息 / IL-22 / Reg3g / 気道上皮 / Reg3gamma / アレルギー・ぜんそく / 糖鎖修飾 / 気道上皮細胞 / レクチン受容体 / IkBNS |
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| Outline of Final Research Achievements |
We analyzed the role of IL-22 in regulating allergic airway inflammation. We show that allergic airway inflammation and Th2 and Th17 cytokine production upon intratracheal administration of house dust mite extract (HDM) were exacerbated in IL-22-deficient mice. We also found that IL-22 induces Reg3g production from lung epithelial cells through STAT3 activation and that neutralization of Reg3g significantly exacerbates HDM-induced eosinophilic airway inflammation and Th2 cytokine induction. Moreover, EXTL3, a functional Reg3g binding protein, is expressed in lung epithelial cells, and intratracheal administration of recombinant Reg3g suppresses HDM-induced TSLP and IL-33 expression and accumulation of type 2 innate lymphoid cells in the lung. Taken together, these results suggest that IL-22 induces Reg3g production from lung epithelial cells and inhibits the development of HDM-induced allergic airway inflammation possibly by inhibiting cytokine production from lung epithelial cells.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Helios enhances regulatory T cell function in cooperation with Foxp32015
Author(s)
Takatori H, Kawashima H, Matsuki A, Meguro K, Tanaka S, Iwamoto T, Sanayama Y, Nishikawa N, Tamachi T, Ikeda K, Suto A, Suzuki K, Kagami S, Hirose K, Kubo M, Hori S, Nakajima H
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Journal Title
Arthritis Rheumatol
Volume: 67
Issue: 6
Pages: 1491-502
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] MMP12 is produced by M2 monocytes-macrophages and plays important roles in the development of contact hypersensitivity2015
Author(s)
Nakagomi D, Suzuki K, Meguro K, Hosokawa J, Tamachi T, Takatori H, Suto A, Matsue H, Ohara O, Nakayama T, Shimada S, Nakajima H
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Journal Title
J Allergy Clin Immunol
Volume: 135
Issue: 5
Pages: 1397-400
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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