Metabolic Reprogramming and Hypoxic Memory in Kidney Disease
| Project/Area Number |
15H04835
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
川上 貴久 東京大学, 医学部附属病院, 助教 (10722093)
稲城 玲子 東京大学, 医学部附属病院, 特任准教授 (50232509)
田中 哲洋 東京大学, 医学部附属病院, 講師 (90508079)
加藤 秀樹 東京大学, 医学部附属病院, 講師 (90625237)
正路 久美 東京大学, 医学部附属病院, 病院診療医 (00439423)
三村 維真理 東京大学, 医学部附属病院, 助教 (00727084)
和田 健彦 東海大学, 医学部, 准教授 (90447409)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 低酸素 / ＨＩＦ / 慢性腎臓病 / 腎不全 / エネルギー代謝 / エピジェネティクス / 低酸素応答 / エピジェネティックス / 線維化 / エピジェネティック / HIF / エピゲノム |
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| Outline of Final Research Achievements |
Cultured tubular cells and endothelial cells exposed to hypoxia demonstrated changes in expression levels of genes related to energy metabolism and fibrosis. Fibrogenic responses by tubular cells cultured under hypoxic conditions are likely to be regulated by synergistic effects of transcriptional factors.
We developed a novel phosphorescence probe that allows accurate measurement of oxygen tensions of the kidney in vivo. We observed decreases in oxygen tensions in the kidney of animals with anemia or diabetes, and we also found hypoxia of the kidney after acute kidney injury leading to fibrosis. Furthermore, we improved this hypoxia-induced fibrosis after acute kidney injury by performing epigenetic interventions.
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] Quantitating intracellular oxygen tension in vivo by phosphorescence lifetime measurement2015
Author(s)
Hirakawa Y, Yoshihara T, Kamiya M, Mimura I, Fujikura D, Masuda T, Kikuchi R, Takahashi I, Urano Y, Tobita S, Nangaku M.
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Journal Title
Sci Rep
Volume: 5
Issue: 1
Pages: 17838-17838
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Sirtuin1 Maintains Actin Cytoskeleton by Deacetylation of Cortactin in Injured Podocytes.2015
Author(s)
Motonishi S, Nangaku M, Wada T, Ishimoto Y, Ohse T, Matsusaka T, Kubota N, Shimizu A, Kadowaki T, Tobe K, Inagi R.
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Journal Title
J Am Soc Nephrol.
Volume: 26・8
Issue: 8
Pages: 1939-59
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] 腎性貧血とHIF2015
Author(s)
南学正臣
Organizer
第60回日本透析医学会学術集会
Place of Presentation
パシフィコ横浜国際会議場（神奈川県横浜市）
Year and Date
2015-06-27
Related Report
Invited
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