Investigation of molecular mechanisms of endothelial dysfunction underlying CKD and aging kidney
| Project/Area Number |
15H04838
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
春名 克祐 川崎医科大学, 医学部, 講師 (40341094)
佐藤 稔 川崎医科大学, 医学部, 准教授 (70449891)
長洲 一 川崎医科大学, 医学部, 講師 (40412176)
城所 研吾 川崎医科大学, 医学部, 講師 (50435020)
桑原 篤憲 川崎医科大学, 医学部, 講師 (50368627)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2015: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 血管内皮障害 / 慢性炎症 / 線維化 / インフラマソーム / Nrf2 / 酸化ストレス / 慢性腎臓病 / Wnt / 内皮障害 / 酸化ストレアス / 加齢 / 認知機能障害 / 炎症 / 内皮機能障害 / ポドサイト / 一酸化窒素 / アルブミン尿 / in vivo imaging / 多光子レーザー顕微鏡 |
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| Outline of Final Research Achievements |
The endothelium and epithelial cells are in close proximity, and there is functional interaction (endothelium / epithelium connection) mutually. We have elucidated the followings; 1) Endothelial dysfunction disrupts endothelium / epithelium relationship, causing two major pathologies of progression of chronic kidney disease, "inflammation" and "fibrosis". 2) NLRP 3-inlammasome pathway and Wnt / β-catenin pathway are involved in this process. 3) NO / cGMP / PKG pathway suppresses NLRP3-inflammasome activation(deeply involved in chronic inflammation) and Wnt / β-catenin pathway activation (fibrosis). 4) Endothelial / epithelial interaction plays an important role in pathogenesis of glomerular lesions and tubulointerstitial injuries in CKD. It is expected that these findings will be utilized in the development of novel strategy to cope with CKD.
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Report
(4 results)
Research Products
(82 results)
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[Journal Article] Infiltration of M1, but not M2, macrophages is impaired after unilateral ureter obstruction in Nrf2-deficient mice.2017
Author(s)
Sogawa Y, Nagasu H, Iwae S, Ihoriya C, Itano S, Uchida A, Kidokoro K, Taniguchi S, Takahashi M, Satoh M, Sasaki T, Suzuki T, Yamamoto M, Horng T and Kashihara N.
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Journal Title
Scientific Reports
Volume: 7
Issue: 1
Pages: 8801-8801
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The Effect of Sitagliptin on Carotid Artery Atherosclerosis in Type 2 Diabetes: The PROLOGUE Randomized Controlled Trial.2016
Author(s)
Oyama J, Murohara T, Kitakaze M, Ishizu T, Sato Y, Kitagawa K, Kamiya H, Ajioka M, Ishihara M, Dai K, Nanasato M, Sata M, Maemura K, Tomiyama H, Higashi Y, Kaku K, Yamada H, Matsuhisa M, Yamashita K, Bando YK, Kashihara N, Ueda S, Inoue T, Tanaka A, Node K; PROLOGUE Study Investigators
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Journal Title
Plos Med
Volume: 13
Issue: 6
Pages: e1002051-e1002051
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Effect of Single Pill-Based Combination Therapy of Olmesartan and Azelnidipine on Variability of Home Blood Pressure in Hypertensive Outpatients.2016
Author(s)
Satoh M, Yorimitsu D, Kuwabara A, Haruna Y, Namikoshi T, Fujimoto S, Komai N, Sasaki T, Kashihara N
Organizer
HYPERTENSION SEOUL 2016 (26th Scientific Meeting of the ISH)
Place of Presentation
Coex,Seoul,Korea
Year and Date
2016-09-24
Related Report
Int'l Joint Research
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[Presentation] 酸化ストレスと腎障害2015
Author(s)
佐藤稔、柏原直樹
Organizer
第58回日本腎臓学会学術総会
Place of Presentation
名古屋国際会議場､愛知県名古屋市
Year and Date
2015-06-06
Related Report
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