Development of anti-PD chemicals modulating autophagic activity based on lysosomal function
| Project/Area Number |
15H04843
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Juntendo University |
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Principal Investigator |
Shinji Saiki 順天堂大学, 医学部, 准教授 (00339996)
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| Co-Investigator(Kenkyū-buntansha) |
住吉 克彦 常磐大学, 人間科学部, 准教授 (10445471)
福原 武志 順天堂大学, 医学部, その他 (20359673)
笹澤 有紀子 順天堂大学, 医学部, 学振特別研究員(RPD) (20594922)
古屋 徳彦 順天堂大学, 医学(系)研究科(研究院), 助教 (50401188)
井本 正哉 慶應義塾大学, 理工学部(矢上), 教授 (60213253)
赤松 和土 順天堂大学, 医学(系)研究科(研究院), 特任教授 (60338184)
石川 景一 順天堂大学, 医学部, 非常勤助教 (90733973)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Keywords | 神経内科学 / オートファジー / リソソーム / パーキンソン病 / 内科 / 脳・神経 / 神経変性 / 神経変性疾患 |
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| Outline of Final Research Achievements |
In this study, we aim to develop small chemicals for Parkinson's disease therapy by modulating lysosomal functions including its localization control.
First of all, we have identified polyamine metabolites inhibiting mTORC1 activity by lysosomal redistribution without any effects on lysosomal acidification. Also, we detected acetylated polyamine was elevated in serum of Parkinson's disease. I am preparing for a paper submission.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Serum caffeine and metabolites are reliable biomarkers of early Parkinson’s disease.2018
Author(s)
3.Fujimaki M, Saiki S*, Li Y, Kaga N, Taka H, Hatano T, Ishikawa KI, Oji Y, Mori A, Okuzumi A, Koinuma T, Ueno SI, Imamichi Y, Ueno T, Miura Y, Funayama M, Hattori N
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Journal Title
Related Report
Peer Reviewed / Open Access
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[Journal Article] Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson's disease.2017
Author(s)
Saiki S, Hatano T, Fujimaki M, Ishikawa K, Mori A, Oji Y, Okuzumi A, Fukuhara T, Koinuma T, Nagumo M, Furuya N, Nojiri S, Amo T, Yamashiro K, Hattori N.
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Journal Title
Scientific Reports
Volume: 7
Issue: 1
Pages: 7328-7328
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Ethambutol neutralizes lysosomes and causes lysosomal zinc accumulation.2015
Author(s)
Yamada D, Saiki S, Furuya N, Ishikawa K, Imamichi Y, Kambe T, Fujimura T, Ueno T, Koike M, Sumiyoshi K, Hattori N
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Journal Title
Biochem Biophys Res Commun.
Volume: 471
Issue: 1
Pages: 109-116
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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