Analysis of the regulation of energy matabolism in skeletal muscle by PGC1alpha
| Project/Area Number |
15H04848
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
Ogawa Wataru 神戸大学, 医学研究科, 教授 (40294219)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NOMURA Kazuhiro 神戸大学, 医学部附属病院, 医員 (70450236)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
|
|---|
| Keywords | 骨格筋 / エネルギー代謝 / 肥満 / 糖代謝 / 運動 / インスリン抵抗性 / エネルギー消費 |
|---|
| Outline of Final Research Achievements |
We have identified novel isoforms of the transcriptional coactivator PGC-1alpha which expression is robustly upregulated in skeletal muscle in response to exercise. Mice that lack the novel isoforms of PGC-1 -alpha develop obesity due to the decreased energy expenditure during exercise and are not able to maintain their body temperature on exposure to cold circumstance. We have found that beta-adrenergic stimulus plays an important role in the upregulation of the PGC-1alpha isoforms in skeletal muscle during exercise. In obese mice models or in aged mice, exercise-induced upregulation of the PGC1alpha isoforms is impaired, which is attributable to the decrease in the sensitivity of skeletal muscle to the PGC-1alpha isoforms. Whereas the expression of the transcription factor KLF15 is regulated by the PGC1-alpha isoforms, the downstream pathway of PGC-1-alpha isoforms that lead to the regulation of energy metabolism during exercise is independent of KLF15.
|
Report
(4 results)
Research Products
(10 results)
