Insight into mechanisims undelying Primary aldosteronism

• Project/Area Number: 15H04852
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Gunma University
• Principal Investigator: Masanobu Yamada 群馬大学, 大学院医学系研究科, 教授 (90261833)
• Co-Investigator(Kenkyū-buntansha): 小澤 厚志 群馬大学, 大学院医学系研究科, 助教 (10573496) ; 堀口 和彦 群馬大学, 医学部附属病院, 医員 (10737943) ; 佐藤 哲郎 群馬大学, 医学部附属病院, 講師 (40302484) ; 桑原 正靖 群馬大学, 大学院理工学府, 准教授 (40334130) ; 石井 角保 群馬大学, 医学部附属病院, 助教 (60638112) ; 中島 康代 群馬大学, 医学部附属病院, 助教 (70707017) ; 渋沢 信行 群馬大学, 医学部附属病院, 助教 (90396622)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000); Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
• Keywords: 原発性アルドステロン症 / 高血圧症 / 腫瘍発生 / KCNJ5変異 / モデル動物 / 心脳血管障害誘発因子

Outline of Final Research Achievements

Hypertension is the greatest cause of arteriosclerotic disease that accounts for about 1/3 of the cause of death in Japan. In recent years, it was revealed that about 10% of it is caused by primary aldosteronism (PA). In this study, we made model mice and cell lines introducing somatic mutations of aldosterone producing adenomas, and also performed a proteome analysis of serum before and after the surgery to investigate mechanisms underlying tumorigenesis of PA and cause of high occurrence of cardiovascular disorders in patients with PA.

Research Products

• [Journal Article] GNAS mutations in adrenal aldosterone-producing adenomas (2016)
  • Author(s): Nakajima Y, Okamura T, Horiguchi K, Gohko T, Miyamoto T, Satoh T, Ozawa A, Ishii S, Yamada E, Hashimoto K, Okada S, Takata D, Horiguchi J, Yamada M.
  • Journal Title: Endocr J. Volume: 63 Pages: 199-204
  • Peer Reviewed / Open Access / Acknowledgement Compliant