Identification and characterization of Allergin-1 ligand
| Project/Area Number |
15H04862
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
Tahara Satoko 筑波大学, 生命領域学際研究センター, 講師 (20360589)
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| Research Collaborator |
HITOMI Kaori 筑波大学, 医学医療系, 研究員
NIIZUMA Kouta 筑波大学, ヒューマンバイオロジー学位プログラム, 大学院生
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | アレルギー / IgE / 肥満細胞 / 喘息 / アラジン－１ / House dust mite / アレルギー性喘息 / 脱顆粒反応 / ITIM |
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| Outline of Final Research Achievements |
Allergin-1 is an immunoglobulin-like receptor that contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in the cytoplasmic region and is highly expressed on mast cells in both human and mice. Allergin-1 recuits the Src homology 2 domain-containing tyrosine phoshphatases-1 (SHP-1), which inhibit high-affinity receptor for IgE-mediated signaling in mast cells and suppress IgE-mediated systemic anaphylaxis in mice. To further elucidate the physiological roles of Allergin-1, it is essential to identify the ligand for Allergin-1. To achieve this issue, a chimeric protein consisting of extracellular portion of Allergin-1 fused to Fc portion of human IgG1 was use to detect the Allergin-1 ligand.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces2016
Author(s)
Nakahashi-Oda C, Udayanga KGS, Nakamura Y, Nakazawa Y, Miki H, Iino S, Tahara-Hanaoka S, Shibuya K, Shibuya A.
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Journal Title
Nature Immunol, 17(4):441-453, 2016
Volume: 17
Issue: 4
Pages: 441-453
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Inhibition of house dust mite-induced Th2 responses by Allergin-1 immunoreceptor on dendritic cells.2017
Author(s)
Tahara-Hanaoka S, Miki H, Hitomi K, Almeida MS, Iwata K,, Kanemaru K, Shibayama S, Kubo M, Sumida T, Shibuya A.
Organizer
第46回日本免疫学会総会・学術集会 仙台国際センター（宮城県仙台市）2017.12.12
Related Report
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