• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of the mechanism of percutaneous sensitized food allergy and development of its control method

Research Project

Project/Area Number 15H04865
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Collagenous pathology/Allergology
Research InstitutionHyogo Medical University

Principal Investigator

Yoshimoto Tomohiro  兵庫医科大学, 医学部, 教授 (60241171)

Co-Investigator(Kenkyū-buntansha) 福岡 あゆみ  兵庫医科大学, 医学部, 助教 (30709754)
安田 好文  兵庫医科大学, 医学部, 講師 (50333539)
松下 一史  兵庫医科大学, 医学部, 講師 (20581549)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2015: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords食物アレルギー / 経皮感作 / 免疫寛容 / IL-33 / Treg細胞 / アレルギー / 免疫学
Outline of Final Research Achievements

We established "Epicutaneous sensitized food allergy mouse model" which closely resembles the characteristics of food allergy in infants, analyzed its onset mechanism and developed its control method. As a result, when ovalbumin (OVA) was applied after weakening the skin barrier, mice increased OVA-specific IgE(OVA-IgE) levels and showed anaphylactic symptoms with decreased core-body temperature immediately after oral challenge with OVA. Basophil-depleted or TSLP-receptor-deficient mice did not produce OVA-IgE and were protected from oral challenge-induced anaphylaxis. On the other hand, IL-33-deficient mice produced normal levels of OVA-IgE, however, they were protected from anaphylaxis. Administration of OVA intragastrically before epicutaneous sensitization induced OVA-specific oral tolerance. These mice showed Foxp3 mRNA up-regulation in the inguinal LNs after epicutaneous OVA application, as a result, they were protected completely from oral challenge-induced anaphylaxis.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (64 results)

All 2018 2017 2016 2015 Other

All Journal Article (19 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 9 results,  Open Access: 6 results,  Acknowledgement Compliant: 3 results) Presentation (40 results) (of which Int'l Joint Research: 6 results,  Invited: 7 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Journal Article] Barrier dysfunction in the nasal allergy2018

    • Author(s)
      Fukuoka Ayumi、Yoshimoto Tomohiro
    • Journal Title

      Allergology International

      Volume: 67 Issue: 1 Pages: 18-23

    • DOI

      10.1016/j.alit.2017.10.006

    • NAID

      130006322101

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections.2017

    • Author(s)
      Shimokawa C, Kanaya T, Hachisuka M, Ishiwata K, Hisaeda H, Kurashima Y, Kiyono H, Yoshimoto T, Kaisho T, Ohno H.
    • Journal Title

      Immunity

      Volume: 46 Issue: 5 Pages: 863-874

    • DOI

      10.1016/j.immuni.2017.04.017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ablation of IL-33 gene exacerbate myocardial remodeling in mice with heart failure induced by mechanical stress2017

    • Author(s)
      Veeraveedu Punniyakoti T.、Sanada Shoji、Okuda Keiji、Fu Hai Ying、Matsuzaki Takashi、Araki Ryo、Yamato Masaki、Yasuda Koubun、Sakata Yasushi、Yoshimoto Tomohiro、Minamino Tetsuo
    • Journal Title

      Biochemical Pharmacology

      Volume: 138 Pages: 73-80

    • DOI

      10.1016/j.bcp.2017.04.022

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of group 2 innate lymphoid cells exacerbates and confers corticosteroid resistance to mouse nasal type 2 inflammation2017

    • Author(s)
      Morikawa Taiyo、Fukuoka Ayumi、Matsushita Kazufumi、Yasuda Koubun、Iwasaki Naruhito、Akasaki Shoko、Fujieda Shigeharu、Yoshimoto Tomohiro
    • Journal Title

      International Immunology

      Volume: 29 Issue: 5 Pages: 221-233

    • DOI

      10.1093/intimm/dxx030

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MOLECULAR MECHANISMS FOR CUTANEOUSLY SENSITIZED FOOD ALLERGY : EXPERIMENTAL EVIDENCES FOR DUAL ALLERGEN EXPOSURE HYPOTHESIS2017

    • Author(s)
      善本 知広
    • Journal Title

      Japanese Journal of Allergology

      Volume: 66 Issue: 10 Pages: 1224-1229

    • DOI

      10.15036/arerugi.66.1224

    • NAID

      130006250599

    • ISSN
      0021-4884, 1347-7935
    • Related Report
      2017 Annual Research Report
  • [Journal Article] Allergen endotoxins induce T cell-dependent and non-IgE-mediated nasal hypersensitivity in mice.2017

    • Author(s)
      Iwasaki N, Matsushita K, Fukuoka A, Nakahira M, Matsumoto M, Akasaki S, Yasuda K, Shimizu T, Yoshimoto T.
    • Journal Title

      J. Allergy Clin. Immunol.

      Volume: 139 Issue: 1 Pages: 258-268

    • DOI

      10.1016/j.jaci.2016.03.023

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 【サイトカインによる整体応答制御】IL-332017

    • Author(s)
      安田好文, 善本知広
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 67 Pages: 30-36

    • Related Report
      2016 Annual Research Report
  • [Journal Article] IgEと寄生虫2016

    • Author(s)
      安田好文, 善本知広.
    • Journal Title

      アレルギー・免疫

      Volume: 23 Pages: 1676-1684

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 経皮感作食物アレルギー発症機序の解明2016

    • Author(s)
      善本知広
    • Journal Title

      上原記念生命科学財団研究報告集30巻

      Volume: 30 Pages: 30-36

    • NAID

      40021061507

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 【アレルギー疾患のすべて】アレルギー、アナフィラキシー、アトピーの概念2016

    • Author(s)
      善本知広
    • Journal Title

      日本医師会雑誌

      Volume: 145 Pages: 48-51

    • Related Report
      2016 Annual Research Report
  • [Journal Article] B細胞特異的なMyD88シグナルは肺への花粉曝露いおける抗原特異的IgE産生に必須である2016

    • Author(s)
      松下一史, 善本知広
    • Journal Title

      兵庫医科大学医学会雑誌

      Volume: 41 Pages: 21-24

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Diesel exhaust particles exacerbate allergic rhinitis in mice by disrupting the nasal epithelial barrier.2016

    • Author(s)
      Fukuoka A, Matsushita K, Morikawa T, Takano H, Yoshimoto T.
    • Journal Title

      Clinical&Experimental Allergy

      Volume: 46 Issue: 1 Pages: 142-152

    • DOI

      10.1111/cea.12597

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways.2016

    • Author(s)
      Akasaki S, Matsushita K, Kato Y, Fukuoka A, Iwasaki N, Nakahira M, Fujieda S, Yasuda K, Yoshimoto T.
    • Journal Title

      International Immunology

      Volume: 28 Issue: 2 Pages: 65-76

    • DOI

      10.1093/intimm/dxv055

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] アレルギー用語解説シリーズ 自然リンパ球.2016

    • Author(s)
      岩﨑成仁, 善本知広.
    • Journal Title

      アレルギー

      Volume: 65 Pages: 141-142

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Proallergic cytokines and group 2 innate lymphoid cells in allergic nasal diseases2015

    • Author(s)
      Kazufumi Matsushita , Yukinori Kato , Shoko Akasaki , Tomohiro Yoshimoto
    • Journal Title

      Allergology International

      Volume: 64 Issue: 3 Pages: 235-240

    • DOI

      10.1016/j.alit.2014.12.008

    • NAID

      130005290321

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] アレルギー用語解説シリーズ Toll-like receptors.2015

    • Author(s)
      福岡あゆみ, 善本知広.
    • Journal Title

      アレルギー

      Volume: 64 Pages: 737-738

    • Related Report
      2015 Annual Research Report
  • [Journal Article] アレルギーをめぐるトレンド ILC2.2015

    • Author(s)
      赤崎晶子, 善本知広.
    • Journal Title

      皮膚アレルギーフロンティア

      Volume: 13 Pages: 104-105

    • Related Report
      2015 Annual Research Report
  • [Journal Article] バリア機能とアレルギー性鼻炎.2015

    • Author(s)
      福岡あゆみ,善本知広.
    • Journal Title

      アレルギー

      Volume: 64 Pages: 1196-1203

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アレルギー用語解説シリーズ Local allergic rhinitis.2015

    • Author(s)
      岩﨑成仁, 善本知広.
    • Journal Title

      アレルギー

      Volume: 64 Pages: 1354-1356

    • Related Report
      2015 Annual Research Report
  • [Presentation] IL-33-dependent resistance of Strongyloides venezuelensis-experienced mice against Nippostrongylus brasiliensis infection2018

    • Author(s)
      Yasuda K, Matsumoto M, Nakanishi K, Yoshimoto T
    • Organizer
      第87回日本寄生虫学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ILC2s in Strongyloides venezuelensis-experienced mice contribute to the resistance against Nippostrongylus brasiliensis infection2018

    • Author(s)
      Yasuda K, Matsumoto M, Nakanishi K, Yoshimoto T
    • Organizer
      第11回寄生虫感染免疫研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Allergen endotoxins induce non-IgE-mediated nasal hypersensitivity in mice via monocyte/macrophage-dependent pathway2017

    • Author(s)
      Yoshimoto Tomohiro, Iwasaki Naruhito, Matsushita Kazufumi
    • Organizer
      EUROPEAN ACADEMY OF ALLERGY AND CLINICAL IMMUNOLOGY, SERIN2017
    • Place of Presentation
      Dusseldorf (Germany)
    • Year and Date
      2017-03-30
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ILC2-activation aggravates Th2-dependent nasal inflammation in mice2017

    • Author(s)
      Morikawa Taiyo, Fukuoka Ayumi, Matsushita Kazufumi, Fujieda Shigeharu , Yoshimoto Tomohiro.
    • Organizer
      EUROPEAN ACADEMY OF ALLERGY AND CLINICAL IMMUNOLOGY, SERIN2017
    • Place of Presentation
      Dusseldorf (Germany)
    • Year and Date
      2017-03-30
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IL-33-dependent resistance to Nippostrongylus brasiliensis infection in Strongyloides venezuelensis-experienced mice2017

    • Author(s)
      安田好文, 松本真琴, 中西憲司, 善本知広
    • Organizer
      第86回日本寄生虫学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アトピー性角結膜炎モデルとしてのIL-33過剰産生遺伝子改変マウスの有用性2017

    • Author(s)
      細谷 友雅, 今井 康友, 石川 裕人, 中村 隆宏, 安田 好文, 永井 諒, 實川 織江, 中西 憲司, 善本 知広, 山西 清文, 五味 文
    • Organizer
      第121回日本眼科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cystatin SN inhibits Japanese cedar pollen-induced allergic rhinitis in mice.2017

    • Author(s)
      Fukuoka A, Matsushita K, Morikawa T, Fujieda S, Yoshimoto T.
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] IL-33-dependent resistance of Strongyloides venezuelensis-experienced mice against Nippostrongylus brasiliensis infection2017

    • Author(s)
      Yasuda K, Matsumoto M, Nakanishi K, Yoshimoto T
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Purification and characterization of a unique DAMP of a potent inducer of IL-33 expression in non- hematopoietic cells2017

    • Author(s)
      Adachi T, Yasuda K, Yoshimoto T, Nakanishi K.
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A unique DAMP with IL-33-inducing activity increases IL-33-expressing alveolar epithelial type 2 cells in lungs and induces primary cultured fibroblasts to produce IL-33 in vitro.2017

    • Author(s)
      Adachi T, Yasuda K, Muto T, Serada S, Yoshimoto T, Naka T, Nakanishi K.
    • Organizer
      The 5th Annual Meeting of the International Cytokine and Interferon Society(ICIS 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Atopic keratoconjunctivitis spontaneously develop in a mouse model of atopic dermatitis expressing the mouse interleukin-33 gene driven by a keratin 14 promoter2017

    • Author(s)
      Imai Y, Hosotani Y, Kusakabe M, Yasuda K, Nagai M, Gomi F, Nakanishi K, Yoshimoto T, Nakamura T, Yamanishi K
    • Organizer
      2017 SID Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IL-33-dependent resistance to Nippostrongylus brasiliensis infection in Strongyloides venezuelensis infected mice2016

    • Author(s)
      Yasuda Koubun, Matsumoto Makoto, Nakanishi Kenji, Yoshimoto Tomohiro.
    • Organizer
      The 45th Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      沖縄コンベンションセンター (沖縄県, 宜野湾市))
    • Year and Date
      2016-12-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] A-novel non-IgE-mediated nasal hypersensitivity reaction2016

    • Author(s)
      Matsushita Kazufumi, Iwasaki Naruhito, Yoshimoto Tomohiro.
    • Organizer
      The 45th Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      ラグナガーデンホテル (沖縄県, 宜野湾市)
    • Year and Date
      2016-12-06
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Innate-type and Acquired-type Allergy2016

    • Author(s)
      Yoshimoto Tomohiro.
    • Organizer
      The 45th Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      ラグナガーデンホテル (沖縄県, 宜野湾市)
    • Year and Date
      2016-12-06
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] IL-33を表皮で過剰に発現するマウスのアトピー性皮膚炎の発症には好塩基球も関与している2016

    • Author(s)
      今井 康友, 安田 好文<, 山本 雅章, 羽田 孝司, 永井 諒, 善本 知広, 山西 清文.
    • Organizer
      第46回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2016-11-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] S.venezuelensis排虫完了後にみられるIL-33 依存症のN.brasiliensis感染抵抗性2016

    • Author(s)
      安田好文, 松本真琴, 中西憲司, 善本知広.
    • Organizer
      第72回日本寄生虫学会西日本支部大会
    • Place of Presentation
      岐阜大学(岐阜県, 岐阜市)
    • Year and Date
      2016-10-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 経口免疫寛容の分子メカニズム(二重抗原曝露仮説の実験的エビデンス)2016

    • Author(s)
      善本知広, 松下一史.
    • Organizer
      第65回日本アレルギー学会学術大会
    • Place of Presentation
      東京ファーラム(東京都)
    • Year and Date
      2016-06-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] エンドトキシンを引き金としたIgE非依存性鼻炎症状の誘導2016

    • Author(s)
      岩﨑成仁, 松下一史, 清水猛史, 善本知広.
    • Organizer
      第65回日本アレルギー学会学術大会
    • Place of Presentation
      東京ファーラム(東京都)
    • Year and Date
      2016-06-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Local allergic rhinitis の実験的エビデンス2016

    • Author(s)
      善本知広.
    • Organizer
      第65回日本アレルギー学会学術大会
    • Place of Presentation
      東京ファーラム(東京都)
    • Year and Date
      2016-06-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 糞線虫感染排虫後のIL-33依存性 N.brasiliensis 感染抵抗性の獲得2016

    • Author(s)
      安田 好文, 松本真琴, 中西憲司, 善本知広.
    • Organizer
      第81回 日本インターフェロン・サイトカイン学会
    • Place of Presentation
      長崎大学(長崎県, 長崎市)
    • Year and Date
      2016-05-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 鼻アレルギーのフェノタイプと分子メカニズム2016

    • Author(s)
      善本 知広, 松下一史.
    • Organizer
      第81回 日本インターフェロン・サイトカイン学会
    • Place of Presentation
      長崎大学(長崎県, 長崎市)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Allergen endotoxins induce T cell-dependent and non-IgE-mediated nasal hypersensitivity in mice2016

    • Author(s)
      Yoshimoto Tomohiro, Iwasaki Naruhito, Matsushita Kazufum
    • Organizer
      31st Symposium of the Collegium Internationale Allergologicum
    • Place of Presentation
      Charleston, South Carolina (USA)
    • Year and Date
      2016-04-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 基礎医学から見たアレルギーのトピックス.2015

    • Author(s)
      善本知広.
    • Organizer
      第73回 関西耳鼻咽喉科アレルギー研究会
    • Place of Presentation
      薬業年金会館(大阪市)
    • Year and Date
      2015-12-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] Endotoxin containing allergens induce T-cell-dependent non-IgE-mediated nasal hypersensitivity in mice.2015

    • Author(s)
      Iwasaki Naruhito, Matsushita Kazufumi, Yoshimoto Tomohiro.
    • Organizer
      The 44th Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] B-cell-intrinsic myD88 signaling is essential for IgE responses in lungs exposed to pollen allergens.2015

    • Author(s)
      Matsushita Kazufumi, Yoshimoto Tomohiro.
    • Organizer
      The 44th Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Diesel exhaust particles exacerbate allergic rhinitis in mice by disrupting the nasal epithelial barrier.2015

    • Author(s)
      Fukuoka Ayumi, Matsushita Kazufumi, Morikawa Taiyo, Takano Hirohisa, Yoshimoto Tomohiro.
    • Organizer
      The 44th Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP-and IL-33-signaling pathways.2015

    • Author(s)
      Akasaki Syoko, Matsushita Kazufumi, Yoshimoto Tomohiro
    • Organizer
      The 44th Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Role of IL-33 and ILC2 in an aluminium adjuvant-induced eosinophilic inflammation.2015

    • Author(s)
      Yasuda Koubun, Muto Taichiro, Imai Yasutomo, Nakanishi Kenji, Yoshimoto Tomohiro.
    • Organizer
      The 44th Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] アレルギー疾患研究へのアプローチとその限界2015

    • Author(s)
      善本知広.
    • Organizer
      第43回日本臨床免疫学会総会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2015-10-23
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 環境微粒因子とアレルギー性鼻炎:モデルマウスも用いた増悪メカニズムの解明と治療技術の開発.2015

    • Author(s)
      善本知広.
    • Organizer
      第22回日本免疫毒性学術年回
    • Place of Presentation
      京都大学(京都市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] アレルギー性鼻炎モデルマウスにおけるTSLPの役割.2015

    • Author(s)
      赤崎晶子, 加藤幸宜, 松下一史, 善本知広.
    • Organizer
      第80回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      東京工業大学(東京都)
    • Year and Date
      2015-07-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Strongyloides venezuelensis 感染による好酸球性肺炎発症におけるTh2サイトカインの役割.2015

    • Author(s)
      安田好文, 松本真琴, 中西憲司, 善本知広.
    • Organizer
      第80回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      東京工業大学(東京都)
    • Year and Date
      2015-07-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肺への花粉抗原曝露によるIgE産生誘導におけるIL-1ファミリーサイトカインとB細胞特異的MyD88シグナル伝達の役割.2015

    • Author(s)
      松下一史, 善本知広
    • Organizer
      第80回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      東京工業大学(東京都)
    • Year and Date
      2015-07-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] アレルギー性鼻炎モデルマウスにおけるTSLPの役割.2015

    • Author(s)
      赤崎晶子, 加藤幸宜, 松下一史, 善本知広.
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都)
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] ディーゼル排気粒子がアレルギー性鼻炎に与える影響2015

    • Author(s)
      福岡あゆみ, 松下一史, 高野裕久, 善本知広.
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都)
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] IL-22産生 superTh1細胞によって誘導される乾癬様皮膚炎.2015

    • Author(s)
      中平雅清, 中西憲司, 善本知広
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都)
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] LSPを引き金としたIgE非依存性鼻炎症状の誘導.2015

    • Author(s)
      岩﨑成仁, 松下一史, 清水猛史, 善本知広.
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都)
    • Year and Date
      2015-05-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 気道への花粉曝露によるIL-1ファミリーサイトカインを介した抗原特異的IgEの誘導.2015

    • Author(s)
      松下一史, 善本知広
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都)
    • Year and Date
      2015-05-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] The roles of basophils,TSLP and IL-33 in cutaneously sensitized food allergy.2015

    • Author(s)
      Yoshimoto Tomohiro ,Muto Taichiro, Fukuioka Ayumi, Matsushita Kazufumi.
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都)
    • Year and Date
      2015-05-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Innate-type and acquired-type allergy regulated by IL-33.2015

    • Author(s)
      Yoshimoto Tomohiro.
    • Organizer
      East Asia Allregy Symposium
    • Place of Presentation
      Seoul (Korea)
    • Year and Date
      2015-05-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] 分子細胞免疫学 原著第9版2018

    • Author(s)
      Abul K.Abbas/ Andrew H.Lichtman/ Shiv Pillai/原著 中尾篤人/監訳 善本知広/翻訳
    • Total Pages
      650
    • Publisher
      エルゼビア・ジャパン
    • ISBN
      9784860349172
    • Related Report
      2017 Annual Research Report
  • [Remarks] 兵庫医科大学 免疫学講座

    • URL

      http://www.hyo-med.ac.jp/department/immn/index.html

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 子宮内膜症または子宮腺筋症の処置用医薬、および子宮内膜症または子宮腺筋症の処置用 医薬のスクリーニング方法2017

    • Inventor(s)
      善本知広、安田好文
    • Industrial Property Rights Holder
      善本知広、安田好文
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-169783
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] IL-33アンタゴニストを含む子宮内膜症治療剤.A therapeutic agent for endometriosis comprising IL-33 antagonist.2017

    • Inventor(s)
      善本知広,Palumbo JM, Stone YI.
    • Industrial Property Rights Holder
      善本知広,Palumbo JM, Stone YI.
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] タイトジャンクション機能低下に起因する疾患の予防及び/又は治療剤.2017

    • Inventor(s)
      善本知広, 福岡あゆみ, 松下一史.
    • Industrial Property Rights Holder
      善本知広, 福岡あゆみ, 松下一史.
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-051126
    • Filing Date
      2017-03-16
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi