Development of a new therapy through the clarification of innate immune receptor for PAMPs in children with vasculitis
| Project/Area Number |
15H04877
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Fukuoka Children’s Hospital (2017)
Kyushu University (2015-2016) |
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Principal Investigator |
Hara Toshiro 地方独立行政法人福岡市立病院機構福岡市立こども病院(臨床研究部), 臨床研究部, 院長 (40150445)
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| Co-Investigator(Kenkyū-buntansha) |
西尾 壽乘 九州大学, 大学病院, 助教 (00507783)
宮本 智文 九州大学, 薬学研究院, 准教授 (40182050)
山崎 晶 九州大学, 生体防御医学研究所, 教授 (40312946)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 自然免疫 / 川崎病 / PAMPs / 液体クロマトグラフィー質量分析法 / 川崎病特異物質 / 冠動脈病変 / 血管炎 / ＰＡＭＰｓ / 病原体関連分子パターン / IgA血管炎 / マススペクトロメトリー |
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| Outline of Final Research Achievements |
With the improvement of extraction method and by the comprehensive high resolution LC-MS analysis of 10 independent KD samples, we selected KD-specific molecules with levels significantly higher than those of controls at least in 2 different periods.
We prospectively analyzed these molecules in 7 independent KD clusters. The KD-specific molecules were detected in all, except for one incomplete case. Some KD-specific molecules were significantly associated with the degree of inflammation, and the formation of coronary artery lesions. Some of the KD-specific molecules showed MS/MS fragments similar to those of biofilm products from Yersinia pseudotuberculosis. KD-specific molecules appear to be involved in the pathophysiology of KD and the development of coronary artery lesions.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Clarithromycin Plus Intravenous Immunoglobulin Therapy Can Reduce the Relapse Rate of Kawasaki Disease: A Phase 2, Open-Label, Randomized Control Study.2017
Author(s)
Nanishi E, Nishio H, Takada H, Yamamura K, Fukazawa M, Furuno K, Mizuno Y, Saigo K, Kadoya R, Ohbuchi N, Onoe Y, Yamashita H, Nakayama H, Hara T, Ohno T, Takahashi Y, Hatae K, Harada T, Shimose T, Kishimoto J, Ohga S, Hara T.
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Journal Title
J Am Heart Assoc
Volume: 6
Issue: 7
DOI
Related Report
Peer Reviewed
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