The clarification of pathophysiology in Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder

• Project/Area Number: 15H04889
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Hirosaki University
• Principal Investigator: Nakamura Kazuhiko 弘前大学, 医学研究科, 教授 (80263911)
• Co-Investigator(Kenkyū-buntansha): 上野 伸哉 弘前大学, 医学研究科, 教授 (00312158) ; 斉藤 まなぶ 弘前大学, 医学部附属病院, 講師 (40568846) ; 古川 智範 弘前大学, 医学研究科, 助教 (60402369) ; 下山 修司 弘前大学, 医学研究科, 助教 (60736370) ; 尾崎 拓 岩手大学, 理工学部, 准教授 (70621069)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
• Keywords: Autism Spectrum Disorder / ADHD / 児童・思春期精神医学 / 自閉症スペクトラム / 注意欠如・多動性障害 / CNV / 精神医学

Outline of Final Research Achievements

Since ASD have been thought to be arisen from genetic factors, we examined genetic analysis in Japanese patients with autism spectrum disorder (ASD). This study revealed that the patients with ASD have the characteristic copy number variation region and these regions were overlapped with previous studies in Westerners patients with ASD. However, the odds ratio was higher than previous study. This result indicated that detected region was crucial for Japanese patients with ASD.

Research Products

• [Journal Article] Integrative Analyses of De Novo Mutations Provide Deeper Biological Insights into Autism Spectrum Disorder (2018)
  • Author(s): Takata A, Miyake N, Tsurusaki Y, Fukai R, Miyatake S, Koshimizu E, Kushima I, Okada T, ...Matsumoto N.
  • Journal Title: Cell Reports Volume: 22(3) Issue: 3 Pages: 734-747
  • DOI: 10.1016/j.celrep.2017.12.074
  • Peer Reviewed / Open Access
• [Journal Article] Differences in sleep problems between Japanese and Chinese preschoolers: a cross-cultural comparison within the Asian region (2018)
  • Author(s): Takahashi Michio、Wang Guanghai、Adachi Masaki、Jiang Fan、Jiang Yanrui、Saito Manabu、Nakamura Kazuhiko
  • Journal Title: Sleep medicine Volume: 印刷中 Pages: 42-48
  • DOI: 10.1016/j.sleep.2017.11.1145
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] MHC class I in dopaminergic neurons suppresses relapse to reward seeking. (2018)
  • Author(s): Murakami G, Edamura M, Furukawa T, Kawasaki H, Kosugi I, Fukuda A, Iwashita T, Nakahara D.
  • Journal Title: Sci Adv. Volume: 4（3）
  • Peer Reviewed / Open Access
• [Journal Article] Alteration of autophagy-related proteins in peripheral blood mononuclear cells of patients with Parkinson's disease (2018)
  • Author(s): Miki Yasuo、Shimoyama Shuji、Kon Tomoya、Ueno Tatsuya、Hayakari Ryo、Tanji Kunikazu、Matsumiya Tomoh、Tsushima Eiki、Mori Fumiaki、Wakabayashi Koichi、Tomiyama Masahiko
  • Journal Title: Neurobiology of aging Volume: 63 Pages: 33-43
  • DOI: 10.1016/j.neurobiolaging.2017.11.006
  • Peer Reviewed / Open Access
• [Journal Article] Poor motor-function recovery after spinal-cord injury in anxiety-model mice with phospholipase related catalytically inactive protein type 1 knockout. (2018)
  • Author(s): Taka Fujita, Gentaro Kumagai, Xizhe Liu, Kanichiro Wada, Toshihiro Tanaka, Hitoshi Kudo, Toru Asari, Tatsuhiro Fukutoku, Ayako Sasaki, Yohshiro Nitobe, Yoshikazu Nikaido, Ken-Ichi Furukawa, Masato Hirata, Takashi Kanematsu, Shinya Ueno, Yasuyuki Ishibash
  • Journal Title: Journal of Neurotrauma Volume: 印刷中 Issue: 12 Pages: 1379-1386
  • DOI: 10.1089/neu.2017.5492
  • Peer Reviewed / Open Access
• [Journal Article] The prevalence of sleep problems among Japanese preschoolers in a medium-sized city: A community-based survey using the Children’s Sleep Habits Questionnaire (2017)
  • Author(s): Takahashi M, Adachi M, Yasuda S, Osato-Kaneda A, Saito M, Kuribayashi M, Nakamura K., Article accepted on 14 March, 2017,
  • Journal Title: Pediatrics International (in press) Volume: 印刷中 Issue: 6 Pages: 747-750
  • DOI: 10.1111/ped.13281
  • Peer Reviewed / Open Access
• [Journal Article] Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice (2017)
  • Author(s): Morimura Naoko、Yasuda Hiroki、Yamaguchi Kazuhiko、Katayama Kei-ichi、Hatayama Minoru、Tomioka Naoko H.、Odagawa Maya、Kamiya Akiko、Iwayama Yoshimi、Maekawa Motoko、Nakamura Kazuhiko、Matsuzaki Hideo、Tsujii Masatsugu、Yamada Kazuyuki、Yoshikawa Takeo、Aruga Jun
  • Journal Title: Nature Communications Volume: 8 Issue: 1 Pages: 15800-15800
  • DOI: 10.1038/ncomms15800
  • Peer Reviewed / Open Access
• [Journal Article] Coordination difficulties in preschool-aged children are associated with maternal parenting stress: A community-based cross-sectional study. (2017)
  • Author(s): Takahashi M, Adachi M, Takayanagi N, Yasuda S, Tanaka M, Osato-Kaneda A, Masuda T, Nakai A, Saito M, Kuribayashi M, Nakamura K
  • Journal Title: Research inDevelopmental Disabilities. Volume: 70 Pages: 11-23
  • DOI: 10.1016/j.ridd.2017.08.002
  • Peer Reviewed / Open Access
• [Journal Article] Spine enlargement of pyramidal tract-type neurons in the motor cortex of a rat model of levodopa-induced dyskinesia (2017)
  • Author(s): Tatsuya Ueno, Haruo Nishijima, Shinya Ueno and Masahiko Tomiyama
  • Journal Title: Frontiers in Neuroscience Volume: 11 Pages: 206-206
  • DOI: 10.3389/fnins.2017.00206
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Propofol anesthesia is reduced in Phospholipase C-related inactive protein type-1 knockout mice (2017)
  • Author(s): Nikaido Y, Furukawa T, Shimoyama S, Yamada J, Migita K, Koga K, Kushikata T, Hirota K, Kanematsu T, Hirata M, Ueno S
  • Journal Title: The Journal of pharmacology and experimental therapeutics Volume: 361(3) Issue: 3 Pages: 367-374
  • DOI: 10.1124/jpet.116.239145
  • Peer Reviewed / Open Access
• [Journal Article] Morphological dendritic spine changes of medium spiny neurons in the nucleus accumbens in 6-hydroxydopamine-lesioned rats treated with levodopa. (2017)
  • Author(s): Funamizu Y, Nishijima H, Ueno T, Ueno S, Mizukami H, Yagihashi S, Tomiyama M.
  • Journal Title: Neurosci Res. Volume: 121 Pages: 49-53
  • DOI: 10.1016/j.neures.2017.03.010
  • Peer Reviewed / Open Access
• [Journal Article] Levodopa treatment and dendritic spine pathology. (2017)
  • Author(s): Nishijima H, Ueno T, Funamizu Y, Ueno S, Tomiyama M.
  • Journal Title: Mov Disord. Volume: 印刷中 Issue: 6 Pages: 877-888
  • DOI: 10.1002/mds.27172
  • Peer Reviewed / Open Access
• [Journal Article] Chronic diazepam administration increases the expression of Lcn2 in the CNS (2017)
  • Author(s): Tomonori Furukawa, Shuji Shimoyama, Yasuo Miki, Yoshikazu Nikaido, Kohei Koga, Kazuhiko Nakamura, Koichi Wakabayashi & Shinya Ueno
  • Journal Title: Pharmacology Research & Perspectives Volume: 5(1) Issue: 1 Pages: 1-12
  • DOI: 10.1002/prp2.283
  • NAID: 120006576912
  • Peer Reviewed / Open Access
• [Journal Article] Psychometric properties of the Japanese ADHD-RS in preschool children. (2016)
  • Author(s): Takayanagi N, Yoshida S, Yasuda S, Adachi M, Kaneda-Osato A, Tanaka M, Masuda T, Kuribayashi M, Saito M, Nakamura K.
  • Journal Title: Res Dev Disabil. Volume: 55 Pages: 268-78
  • DOI: 10.1016/j.ridd.2016.05.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comprehensive Review Of Current Findings of Callous and Unemotional Traits (2016)
  • Author(s): Yoshida S, Takayanagi N, Adachi M, Yasuda S, Nakamura, K.
  • Journal Title: Hirosaki Med Volume: 67 Pages: 1-12
  • NAID: 130008041711
  • Peer Reviewed
• [Journal Article] Enrichment of deleterious variants of mitochondrial DNA polymerase gene (POLG1) in bipolar disorder (2016)
  • Author(s): Kasahara T, Ishiwata M, Kakiuchi C, Fuke S, Iwata N, Ozaki N, Kunugi H, Minabe Y, Nakamura K, Iwata Y, Fujii K, Kanba S, Ujike H, Kusumi I, Kataoka M, Matoba N, Takata A, Iwamoto K, Yoshikawa T, Kato T
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: - Issue: 8 Pages: 518-529
  • DOI: 10.1111/pcn.12496
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 5歳児発達健診における発達障害の疫学 (2016)
  • Author(s): 斉藤まなぶ, 吉田 恵心 , 坂本 由唯 , 大里 絢子 , 足立 匡基 , 安田 小響 , 栗林 理人 , 中村 和彦
  • Journal Title: 日本生物学的精神医学会誌 Volume: 27（2） Pages: 60-64
  • NAID: 130006338396
  • Peer Reviewed
• [Journal Article] 特集 乳幼児精神医学 5歳児健診の現状と課題 (2016)
  • Author(s): 斉藤まなぶ, 吉田恵心, 高柳伸哉, 安田小響, 足立匡基, 大里絢子, 中村和彦
  • Journal Title: 児童青年精神医学とその近接領域 Volume: 57（2） Pages: 254-260
  • Peer Reviewed
• [Journal Article] ASSQ短縮版の5歳児適用における妥当性 (2016)
  • Author(s): 足立匡基, 高柳伸哉, 吉田恵心, 安田小響, 大里絢子, 田中勝則, 増田貴人, 栗林理人, 斉藤まなぶ, 中村和彦
  • Journal Title: 児童青年精神医学とその近接領域 Volume: 57（4） Pages: 603-617
  • NAID: 130006865848
  • Peer Reviewed
• [Journal Article] 自閉症スペクトラム障害の早期発見―5歳児健診 (特集 発達支援のアセスメント) -- (発達障害の早期発見のアセスメント) (2016)
  • Author(s): 斉藤まなぶ・吉田恵心・髙柳伸哉・安田小響・足立匡基・大里絢子・中村和彦
  • Journal Title: 臨床心理学 Volume: 16（2） Pages: 145-150
  • NAID: 40020748218
  • Peer Reviewed
• [Journal Article] Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies. (2015)
  • Author(s): Chie Shimamoto, Tetsuo Ohnishi, Motoko Maekawa, Akiko Watanabe, Hisako Ohba, Ryoichi Arai, Yoshimi Iwayama, Yasuko Hisano, Tomoko Toyota, Manabu Toyoshima, Katsuaki Suzuki, Yukihiko Shirayama, Kazuhiko Nakamura, Norio Mori, Yuji Owada, Tetsuyuki Kobayashi, Takeo Yoshikawa
  • Journal Title: Human Molecular Genetics Volume: 24(8) Issue: 8 Pages: 2409-2409
  • DOI: 10.1093/hmg/ddv011
  • Peer Reviewed / Open Access
• [Journal Article] Psychometric properties of the Repetitive Behavior Scale-Revised for individuals with autism spectrum disorder in Japan (2015)
  • Author(s): Inada N, Ito H, Yasunaga K, Kuroda M, Iwanaga R, Hagiwara T, Tani I, Yukihiro R, Uchiyama T, Ogasahara K, Hara K, Inoue M, Murakami T, Someki F, Nakamura K, Sugiyama T, Uchida H, Ichikawa H, Kawakubo Y, Kano Y, Tsujii M
  • Journal Title: Research in Autism Spectrum Disorder Volume: In press Pages: 60-68
  • DOI: 10.1016/j.rasd.2015.01.002
  • Peer Reviewed / Open Access
• [Journal Article] CNV Analysis and Exome Sequencing in Japanese Autism Spectrum Disorder Subjects (2015)
  • Author(s): Nakamura K, Thanseem I, Mori N, Tsujii M, Matsumoto N
  • Journal Title: NEUROPSYCHOPHARMACOLOGY Volume: 40
  • Peer Reviewed
• [Journal Article] Epidemiology of autism spectrum disorder and attention deficit hyperactivity disorder in a community-based population sample of five-year-olds children (2015)
  • Author(s): Saito M , Kaneda-osato A, Tanaka M, Masuda T, Takayanagi N , Yasuda S , Nakamura K
  • Journal Title: EUROPEAN CHILD & ADOLESCENT PSYCHIATRY Volume: 24
  • Peer Reviewed
• [Journal Article] 某市5歳児発達健診における発達障害の疫学 (2015)
  • Author(s): 斉藤 まなぶ,大里 絢子, 田中 勝則, 増田 貴人, 高柳 伸哉, 安田 小響, 中村 和彦
  • Journal Title: 精神神経学雑誌 Volume: 117（5） Pages: 372-372
  • Peer Reviewed
• [Presentation] The effect of chronic diazepam administration on hippocampal long-term potentiation and spine morphology. (2018)
  • Author(s): T. Furukawa, Y. Nikaido, S. Shimoyama, Y. Ogata, K. Nakamura, S. Ueno.
  • Organizer: 第95回日本生理学会大会
• [Presentation] Chronic diazepam administration increases the expression of Lcn2 in the CNS (2017)
  • Author(s): Tomonori Furukawa, Shuji Shimoyama, Yasuo Miki, Yoshikazu Nikaido, Kohei Koga, Kazuhiko Nakamura, Koichi Wakabayashi, and Shinya Ueno
  • Organizer: 第94回 日本生理学会
  • Place of Presentation: アクトシティ浜松（静岡県・浜松市）
  • Year and Date: 2017-03-28
• [Presentation] Chronic diazepam administration impairs acquisition of spatial reference memory in aged mice (2017)
  • Author(s): Yoshikazu Nikaido, Tomonori Furukawa, Shuji Shimoyama, Kohei Koga, and Shinya Ueno
  • Organizer: 第94回 日本生理学会
  • Place of Presentation: アクトシティ浜松（静岡県・浜松市）
  • Year and Date: 2017-03-28
• [Presentation] Gaze Abnormality Can Distinguish Between Autism Spectrum Disorder and Typically Developing Children through Screening in 5-Year-Old Children By a Double Study in a Japanese Community Based Population (2017)
  • Author(s): M.Saito,M.Adachi,S.Yoshida,S.Yasuda,M.Kuribayashi,Y.Sakamoto,K.Nakamura and N.Takayanagi,
  • Organizer: INTERNATIONAL MEETING FOR AUTISM RESEARCH(IMFAR2017)
  • Int'l Joint Research
• [Presentation] Prevalence and Comorbidities of Autism Spectrum Disorder and Study of the Method of the Developmental Health Checkup in a Japanese Community-Based Population Sample of Five-Year-Old Children (2017)
  • Author(s): Y.Sakamoto,M.S,aito,S.Yoshida,M.Adachi,N.Takayanagi,S.Yasuda,M.Kuribayashi,and K.Nakamura
  • Organizer: INTERNATIONAL MEETING FOR AUTISM RESEARCH(IMFAR2017)
  • Int'l Joint Research
• [Presentation] 自閉症の超早期療育-Early Start Denver Model-の紹介 (2017)
  • Author(s): 大里絢子、斉藤まなぶ、服巻智子、坂本由唯、松原侑里、中村和彦
  • Organizer: 第19回東北児童青年精医学会
• [Presentation] 小中学生におけるインターネット依存傾向と内在化・外在化問題・発達的特性との関連 (2017)
  • Author(s): 足立匡基・髙橋芳雄・安田小響・栗林理人・中村和彦
  • Organizer: 第19回東北児童青年精神医学会
• [Presentation] 市内小中学生におけるインターネット依存傾向の実態とメンタルヘルスとの関連について (2017)
  • Author(s): 髙橋芳雄、足立匡基、安田小響、栗林理人、中村和彦
  • Organizer: 第101回弘前医学会総会
• [Presentation] 注視点測定を用いた5歳児のASD傾向の検討 (2017)
  • Author(s): 斉藤まなぶ、大里絢子、土屋賢治、坂本由唯、松原侑里、吉田恵心、足立匡基、高橋芳雄、安田小響、松田侑子、増田貴人、栗林理人、中村和彦
  • Organizer: 第113回日本精神神経学会学術総会
• [Presentation] 注意欠如・多動性障害（ADHD)のEye Tracking Pattern (2017)
  • Author(s): 松原侑里、斉藤まなぶ、坂本由唯、吉田恵心、大里絢子、足立匡基、高橋芳雄、安田小響、栗林理人、土屋賢治、中村和彦
  • Organizer: 第113回日本精神神経学会学術総会
• [Presentation] 視線検出装置（Gazefinder)による女児自閉症スペクトラム障害（ASD）の早期診断の有用性 (2017)
  • Author(s): 坂本由唯、斉藤まなぶ、松原侑里、吉田恵心、大里絢子、足立匡基、高橋芳雄、安田小響、栗林理人、土屋賢治、中村和彦
  • Organizer: 第113回日本精神神経学会学術総会
• [Presentation] 児童期のADHDと成人期のADHDの連続性について 「成人期のADHDの脳画像研究について」（シンポジウム） (2017)
  • Author(s): 中村和彦
  • Organizer: 第113回日本精神神経学会学術総会
• [Presentation] Prevalence and Comorbidities of DCD Using DSM-5,Comparison of Motor and Cognitive functions at Preschool Age in a Japanese Community (2017)
  • Author(s): Kazutaka Yoshida,Michio Takahashi,Ayako Osato-Kaneda, Masanori Tanaka,Takahito Masuda,Satomi Yoshida, Yui Sakamoto,Yuri Matsubara, Nobuya Takayanagi, Masaki Adachi, Manabu Saito,Sayura Yasuda,Michito Kuribayashi,Akio Nakai, Motohide Miyahara,Kazuhiko Nakamura,
  • Organizer: International Conference for Developmental Coordination Disorder(DCD12）
  • Int'l Joint Research
• [Presentation] Behavioral problems in preschool children with Developmental Coordination Disorder. (2017)
  • Author(s): Adachi M, Takayanagi N, Takahashi M, Yasuda S, Yoshida S, Mikami M, Nakai A, Saito M, Nakamura K.
  • Organizer: International Conference for Developmental Coordination Disorder (DCD12）
  • Int'l Joint Research
• [Presentation] The parental and tescher’s recognition for Developmental Coordination Disorder in preschool-aged children. (2017)
  • Author(s): Mikami M, Saito M, Masuda T, Tanaka M, Osato A, Sakamoto Y, Yoshida S, Takayanagi N, Adachi M, Yasuda S, Kuribayashi M, Nakamura K.
  • Organizer: International Conference for Developmental Coordination Disorder (DCD12）
  • Int'l Joint Research
• [Presentation] Developmental Coordination Disorder trait in Japanese preschoolers impact on parenting stress. (2017)
  • Author(s): Takahashi M, Adachi M, Takayanagi N, Yasuda S, Osato-Kaneda A, Mikami M, Nakai A, Saito M, Kuribayashi M, Nakamura K.
  • Organizer: International Conference for Developmental Coordination Disorder. (DCD12)
  • Int'l Joint Research
• [Presentation] Evaluation of factor structure equivalence of the Developmental Coordination Disorder Questionnaire across genders in Japanese preschool children. (2017)
  • Author(s): Tanaka M, Saito M, Kaneda-Osato A, Masuda T, Takayanagi N, Takahashi M, Adachi M, Yasuda S, Yoshida S, Kuribayashi, M, Nakai A, Miyahara M, Nakamura K, Sakamoto Y.
  • Organizer: International Conference for Developmental Coordination Disorder. (DCD12)
  • Int'l Joint Research
• [Presentation] Epidemiology of Developmental Coordination Disorder, Prevalence and Comorbidities Using DSM-5, and Diagnostic predictability by Developmental Coordination Disorder Questionnaire (DCDQ)at Preschool Age in a Japanese Community. (2017)
  • Author(s): Manabu Saito,Ayako Osato-Kaneda, Masanori Tanaka, Takahito Masuda, Satomi Yoshida, Yui Sakamoto, Kazutaka Yoshida, Yuri Matsubara, Nobuya Takayanagi, Masaki Adachi, Michio Takahashi, Sayura Yasuda, Michito Kuribayashi, Akio Nakai, Kazuhiko Nakamura
  • Organizer: (The 9th Congress of The Asian Society for Child and Adlescent Psychiatry and Allied Professions (ASCAPAP)
  • Int'l Joint Research
• [Presentation] 発達性強調運動障害（DCD)の疫学及び認知特性 (2017)
  • Author(s): 吉田和貴、斉藤まなぶ、坂本由唯、大里絢子、三上美咲、足立匡基、安田小響、増田貴人、田中勝則、吉田恵心、栗林理人、中村和彦
  • Organizer: 第５８回日本児童青年精神医学会総会
• [Presentation] 注意欠如・多動性障害（ADHD)のGaze Tracking Pattern (2017)
  • Author(s): 斉藤まなぶ、坂本由唯、大里絢子、吉田恵心、足立匡基、安田小響、増田貴人、田中勝則、栗林理人、中村和彦
  • Organizer: 第５８回日本児童青年精神医学会総会
• [Presentation] Gaze Tracking Patternを用いた5歳児の閾値以下のASD特性と性差の検討 (2017)
  • Author(s): 斉藤まなぶ、坂本由唯、大里絢子、吉田恵心、足立匡基、安田小響、増田貴人、田中勝則、栗林理人、中村和彦
  • Organizer: 第５８回日本児童青年精神医学会総会
• [Presentation] Gaze Tracking Patternと既存の評価尺度を用いた5歳児自閉症スペクトラム障害（ASD）のスクリーニング及び診断ツールの有用性 (2017)
  • Author(s): 坂本由唯、斉藤まなぶ、大里絢子、吉田恵心、足立匡基、安田小響、増田貴人、田中勝則、栗林理人、中村和彦
  • Organizer: 第５８回日本児童青年精神医学会総会
• [Presentation] 日本語版Developmental Coordination Disorder Questionnaire(DCDQ)における予測的妥当性 (2017)
  • Author(s): 田中勝則、斉藤まなぶ、中井昭夫、大里絢子、増田貴人、高柳伸哉、高橋芳雄、足立匡基、安田小響、吉田恵心、坂本由唯、栗林理人、中村和彦
  • Organizer: 第５８回日本児童青年精神医学会総会
• [Presentation] The effect of chronic diazepam administration induced upregulation of Lcn2 expression on cognitive function (2017)
  • Author(s): Y. Ogata, T. Furukawa, Y. Nikaido, S. Shimoyama, K. Nakamura, S. Ueno.
  • Organizer: 第44回日本脳科学会
• [Presentation] 小中学生におけるインターネット依存傾向と内在化・外在化問題・ASD/ADHD特性との関連 (2017)
  • Author(s): 足立匡基・髙橋芳雄・栗林理人・斉藤まなぶ・中村和彦
  • Organizer: 第44回日本脳科学会
• [Presentation] 幼児期から成人期にかけてのブローカ野における灰白質体積の発達 (2017)
  • Author(s): 髙橋芳雄 松井三枝 中村和彦
  • Organizer: 第44回日本脳科学会
• [Presentation] 視線検出装置（Gazefinder）を用いた5歳児のASD傾向の検討 (2017)
  • Author(s): 斉藤まなぶ、土屋賢治、吉田和貴、足立匡基、髙橋芳雄、下山修司、山田 順子、上野 伸哉、中村 和彦
  • Organizer: 第44回日本脳科学会
• [Presentation] 自閉スペクトラム症児者の理解 (2017)
  • Author(s): 中村和彦
  • Organizer: 2017年度 一般社団法人日本LD学会 公開シンポジウム
  • Invited
• [Presentation] 自閉スペクトラム症児者のライフステージに応じた“つながる”支援(シンポジ ウム) (2017)
  • Author(s): 中村和彦
  • Organizer: 2017年度 一般社団法人日本LD学会 公開シンポジウム
• [Presentation] Phospholipase C-related inactive protein type-1 is involved in intravenous anesthetic-induced EEG changes in mice. (2017)
  • Author(s): Y. Nikaido, T. Furukawa, S. Shimoyama, T. Kushikata, K. Hirota, T. Kanematsu, M. Hirata, S. Ueno.
  • Organizer: 第40回神経科学学会
• [Presentation] The effect of chronic diazepam administration on Lcn2 expression and spine morphology. (2017)
  • Author(s): T. Furukawa, S. Shimoyama, Y. Nikaido, Y. Miki, K. Koga, K. Nakamura, K. Wakabayashi, S. Ueno.
  • Organizer: 第40回神経科学学会
• [Presentation] 視線検出装置（Gazefinder)を用いたASD早期診断の有用性の検討 (2017)
  • Author(s): 斉藤まなぶ、大里絢子、坂本由唯、吉田和貴、柞木田なつみ、松原侑里、吉田恵心、足立匡基、高橋芳雄、安田小響、栗林理人、中村和彦
  • Organizer: 第154回弘前医学会例会
  • Place of Presentation: 弘前大学医学部コミュニケーションセンター（青森県・弘前市）
• [Presentation] IGF-1を標的とした自閉症スペクトラム治療薬候補の探索 (2017)
  • Author(s): 下山修司
  • Organizer: 第4回 脳研×高度先進×COI合同セミナー
  • Place of Presentation: 弘前大学（青森県・弘前市）
• [Presentation] Gaze Fixation Patterns in Children With Autism Spectrum Disorder and Typical Development Screening From the Japanese Community Based 5-Year-Old Children (2016)
  • Author(s): Kazuhiko Nakamura, Manabu Saito
  • Organizer: The 55th American College of Neuropsychopharmcology (ACNP)
  • Place of Presentation: アメリカ フロリダ
  • Year and Date: 2016-12-04
  • Int'l Joint Research
• [Presentation] Prevalence and Comorbidities of DCD Using DSM-5, Comparison of Mortor and Cognitive function at Preschool Age in a Japanese Community. (2016)
  • Author(s): Kazutaka Yoshida, Manabu Saito, Junko Yamada, Shinya Ueno, Kazuhiko Nakamura
  • Organizer: 2016 International Symposium on Neurodegenerative Diseases ＆ the 43rd Annual Conference of Japan Brain Science Society
  • Place of Presentation: 中国 西安
  • Year and Date: 2016-11-10
  • Int'l Joint Research
• [Presentation] スクリーニングツールに基づく児童思春期におけるASD有病率の推計およびASD傾向と適応状態の関連 (2016)
  • Author(s): 足立匡基、高栁伸哉、安田小響、吉田恵心、栗林理人、大里絢子、斉藤まなぶ、中村和彦
  • Organizer: 第57回 日本児童青年精神医学会
  • Place of Presentation: 岡山コンベンションセンター（岡山県・岡山市）
  • Year and Date: 2016-10-27
• [Presentation] GazeFinder（Ka-o-TV）を用いた5歳児のASD特性の検討 (2016)
  • Author(s): 斉藤まなぶ、大里絢子、吉田恵心、高柳伸哉、足立匡基、安田小響、田中勝則、増田貴人、栗林理人、中村和彦
  • Organizer: 第57回 日本児童青年精神医学会
  • Place of Presentation: 岡山コンベンションセンター（岡山県・岡山市）
  • Year and Date: 2016-10-27
• [Presentation] 某市5歳児発達健診から見た運動機能と認知機能の関係 (2016)
  • Author(s): 大里絢子、斉藤まなぶ、坂本由唯、吉田恵心、高柳伸哉、足立匡基、安田小響、田中勝則、増田貴人、栗林理人、中村和彦
  • Organizer: 第57回 日本児童青年精神医学会
  • Place of Presentation: 岡山コンベンションセンター（岡山県・岡山市）
  • Year and Date: 2016-10-27
• [Presentation] 短縮版感覚プロファイルを用いた子どもの感覚の特異性と発達障害特性の関連 (2016)
  • Author(s): 安田小響、、足立匡基、斉藤まなぶ、大里絢子、吉田恵心、栗林理人、増田貴人、高栁伸哉、田中勝則、中村和彦
  • Organizer: 第57回 日本児童青年精神医学会
  • Place of Presentation: 岡山コンベンションセンター（岡山県・岡山市）
  • Year and Date: 2016-10-27
• [Presentation] 発達性協調運動障害への保護者・先生の気づきに関する検討 (2016)
  • Author(s): 三上美咲、斉藤まなぶ、増田貴人、田中勝則、大里絢子、坂本由唯、吉田恵心、高柳伸哉)、足立匡基、安田小響、栗林理人、中村和彦
  • Organizer: 第57回 日本児童青年精神医学会
  • Place of Presentation: 岡山コンベンションセンター（岡山県・岡山市）
  • Year and Date: 2016-10-27
• [Presentation] 5歳児の自閉スペクトラム障害における VLDL、IGF-1、オキシトシンの診断有用性の検討 (2016)
  • Author(s): 斉藤 まなぶ 、 下山 修司 、 吉田 恵心 、坂本 由唯 、大里 絢子 、 高柳 伸哉 、 足立 匡基 、 安田 小響 、 栗林 理人 、 中村 和彦
  • Organizer: 第112回 日本精神神経学会総会
  • Place of Presentation: 幕張メッセ（千葉県・千葉市）
  • Year and Date: 2016-06-02
• [Presentation] 遺伝子Tspo の発現調節メカニズムの解明 (2016)
  • Author(s): 下山修司、中村和彦、上野伸哉
  • Organizer: 日本生化学会 東北支部 第82回例会
  • Place of Presentation: 弘前大学（青森県・弘前市）
  • Year and Date: 2016-05-21
• [Presentation] Brain Dopamine D1 Receptor Binding in Young Adults with Autism Spectrum Disorder (2016)
  • Author(s): K. Suzuki, K. Nakamura, Y. Ouchi, K. Takebayashi, M. Yokokura, K. Nakaizumi, M. Tsujii, T. Sugiyama and N. Mori
  • Organizer: 2016 International Meeting for Autism Research
  • Place of Presentation: アメリカ ボルティモア
  • Year and Date: 2016-05-11
  • Int'l Joint Research
• [Presentation] Applicability of the Autism Spectrum Screening Questionnaire Parent Form to 5-Ye+C8:C13ar-Old Children (2016)
  • Author(s): M. Adachi, N. Takayanagi, S. Yasuda, S. Yoshida, M. Kuribayashi, A. Osato, T. Masuda, M. Tanaka, M. Saito and K. Nakamura
  • Organizer: 2016 International Meeting for Autism Research
  • Place of Presentation: アメリカ ボルティモア
  • Year and Date: 2016-05-11
  • Int'l Joint Research
• [Presentation] Risk and Protective Factors of Depression in Children with ASD Tendency in Japan. (2016)
  • Author(s): N. Takayanagi, M. Adachi, S. Yasuda, S. Yoshida, M. Kuribayashi and K. Nakamura
  • Organizer: 2016 International Meeting for Autism Research
  • Place of Presentation: アメリカ ボルティモア
  • Year and Date: 2016-05-11
  • Int'l Joint Research
• [Presentation] CNV Analysis and Exome Sequencing in Japanese Autism Spectrum Disorder Subjects (2016)
  • Author(s): K. Nakamura, I. Thanseem, M. Tsujii and N. Matsumoto
  • Organizer: 2016 International Meeting for Autism Research
  • Place of Presentation: アメリカ ボルティモア
  • Year and Date: 2016-05-11
  • Int'l Joint Research
• [Presentation] Prevalence of Autism Spectrum Disorder in a Japanese Community-Based Population Sample of Five-Year-Old Children (2016)
  • Author(s): M. Saito, N. Takayanagi, M. Adachi, A. Osato, S. Yasuda, T. Masuda, M. Tanaka, S. Yoshida, M. Kuribayashi and K. Nakamura
  • Organizer: 2016 International Meeting for Autism Research
  • Place of Presentation: アメリカ ボルティモア
  • Year and Date: 2016-05-11
  • Int'l Joint Research
• [Presentation] 5歳児発達健診における発達障害の疫学 (2016)
  • Author(s): 坂本由唯、斉藤まなぶ、中村和彦
  • Organizer: 第153回弘前医学会例会
  • Place of Presentation: 弘前大学医学部コミュニケーションセンター（青森県弘前市）
  • Year and Date: 2016-01-22
• [Presentation] CNV Analysis and Exome Sequencing in Japanese Autism Spectrum Disorder Subjects (2015)
  • Author(s): K. Nakamura, I. Thanseem, N. Mori, M. Tsujii and N. Matsumoto
  • Organizer: 54th Annual Meeting of the American College of Neuropsychopharmacology
  • Place of Presentation: フロリダ ハリウッド（アメリカ）
  • Year and Date: 2015-12-06
  • Int'l Joint Research
• [Presentation] 某市5歳児発達健診における発達性協調運動障害の疫学 (2015)
  • Author(s): 斉藤まなぶ、山田順子、下山修司、尾崎拓、上野伸哉、中村和彦
  • Organizer: 第42回日本脳科学会
  • Place of Presentation: ANAホリデイ・イン リゾート宮崎 （宮崎県宮崎市）
  • Year and Date: 2015-11-12
• [Presentation] 成人期ADHDの脳内における活性化ミクログリア (2015)
  • Author(s): 竹林淳和、中村和彦、尾内康臣、横倉正倫、岩田泰秀、森則夫
  • Organizer: 第42回日本脳科学会
  • Place of Presentation: ANAホリデイ・イン リゾート宮崎 （宮崎県宮崎市）
  • Year and Date: 2015-11-12
• [Presentation] 新規SERT制御因子としてのNSF~自閉症発現メカニズムへの関与～ (2015)
  • Author(s): 岩田圭子、松﨑秀夫、立花太郎、中村和彦、片山泰一、森則夫
  • Organizer: 第42回日本脳科学会
  • Place of Presentation: ANAホリデイ・イン リゾート宮崎 （宮崎県宮崎市）
  • Year and Date: 2015-11-12
• [Presentation] 某市５歳児発達健診における発達障害の疫学 (2015)
  • Author(s): 斉藤まなぶ、大里絢子、中村和彦
  • Organizer: 第５６回日本児童青年精神医学会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-09-29
• [Presentation] S3-1シンポジウム３発達障害の課題解決に向けた基礎・臨床研究の連携 【演題名：５歳児発達健診における発達障害の疫学】 (2015)
  • Author(s): 中村和彦
  • Organizer: 第４５回日本神経精神薬理学会第３７回日本生物学的精神医学会合同年会
  • Place of Presentation: タワーホール船堀（東京都江戸川区）
  • Year and Date: 2015-09-24
• [Presentation] Epidemiology of Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder in a community-based population sample of five-year olds children (2015)
  • Author(s): K. Nakamura,M.Saito, A. Kaneda-Osato, M.Tanaka,T.Masuda,N.Takayanagi, S.Yasuda, M.Adachi,Y.Sakamoto,S.Yoshida,M.Kuribayashi
  • Organizer: The 8th Congress of The Asian Society for Child and Adolescent Psychiatry and Allied Professions
  • Place of Presentation: クアラルンプール（マレーシア）
  • Year and Date: 2015-08-19
  • Int'l Joint Research
• [Presentation] 某市５歳児発達健診におけるWISC-IVの下位項目の検討 (2015)
  • Author(s): 大里絢子、斉藤まなぶ、増田貴人、田中勝則、中村和彦
  • Organizer: 第１７回東北児童青年精神医学会
  • Place of Presentation: 弘前大学医学部コミュニケーションセンター（青森県弘前市）
  • Year and Date: 2015-06-28
• [Presentation] 小中学生における抑うつの保護・悪化要因 (2015)
  • Author(s): 足立匡基、高柳伸哉、安田小響、吉田恵心、栗林理人、中村和彦
  • Organizer: 第１７回東北児童青年精神医学会
  • Place of Presentation: 弘前大学医学部コミュニケーションセンター（青森県弘前市）
  • Year and Date: 2015-06-28
• [Presentation] Epidemiology of autism spectrum disorder and attention deficit hyperactivity disorder in a community-based population sample of five-year olds children (2015)
  • Author(s): M. Saito, A. Kaneda-osato, M. Tanaka, T. Masuda, N. Takayanagi,S. Yasuda, K. Nakamura
  • Organizer: 16th International Congress of ESCAP European Society for Child and Adolescent Psychiatry
  • Place of Presentation: マドリード（スペイン）
  • Year and Date: 2015-06-20
  • Int'l Joint Research
• [Presentation] Analysis of Genomic Copy Number Variations and Exome Sequencing in Japanese Autism Spectrum Disorder Subjects (2015)
  • Author(s): K. Nakamura, I. Thanseem, N. Mori, M. Tsujii and N. Matsumoto,
  • Organizer: 14th the International Meeting for Autism Research (IMFAR) Annual Meeting
  • Place of Presentation: ソルトレークシティー（アメリカ）
  • Year and Date: 2015-05-13
  • Int'l Joint Research
• [Presentation] Abnormal Expression of a SERT-Binding Protein, NSF, in Autism: Implications for Pathophysiology in Autism (2015)
  • Author(s): K. Iwata, H. Matsuzaki, K. Nakamura, T. Katayama and N. Mori
  • Organizer: 14th the International Meeting for Autism Research(IMFAR) Annual Meeting
  • Place of Presentation: ソルトレークシティー（アメリカ）
  • Year and Date: 2015-05-13
  • Int'l Joint Research
• [Book] 大人のADHD臨床 アセスメントから治療まで (2016)
  • Author(s): 中村 和彦（編著）、
  • Total Pages: 196
  • Publisher: 金子書房