Molecular imaging of amyloid-associated depression
| Project/Area Number |
15H04896
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | Nippon Medical School |
|---|
Principal Investigator |
Okubo Yoshiro 日本医科大学, 大学院医学研究科, 大学院教授 (20213663)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
鈴木 秀典 日本医科大学, 大学院医学研究科, 大学院教授 (30221328)
舘野 周 日本医科大学, 医学部, 准教授 (50297917)
肥田 道彦 日本医科大学, 医学部, 講師 (60434130)
上田 諭 日本医科大学, 医学部, 講師 (80465294)
|
|---|
| Project Period (FY) |
2015-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
|
|---|
| Keywords | 分子イメージング / アミロイドイメージング / タウイメージング / アルツハイマー病 / うつ病 / タウオパチー / ドパミントランスポーター / セロトニン１B受容体 / 高齢者 / 認知症 / 軽度認知障害 / PET / アミロイド / タウ / ＰＥＴ / ポジトロンCT |
|---|
| Outline of Final Research Achievements |
We aimed to develop a diagnostic method of depression as a precursor symptom of dementia such as Alzheimer's disease (AD) using novel molecular imaging techniques. First, we conducted a 20-month follow-up survey on patients with mild cognitive impairment and depression. As a result, it was confirmed that there were more cases of transition to dementia in the amyloid positive group. Next, we introduced tau imaging and confirmed that there were cases with strong tau accumulation among depressive patients. Some of these cases appeared to have depression as a precursor to AD and other tauopathy. Furthermore, we found that mild to moderate decline in dopamine transporter was observed in elderly depression, and introduced serotonin 1B receptor imaging as a novel biomarker of depression.
|
| Academic Significance and Societal Importance of the Research Achievements |
アミロイドイメージングに加えて、タウおよびセロトニン、ドパミンイメージングなど新規分子イメージング技術を駆使することによって、アルツハイマー病などの認知症の前駆症状としてのうつ病の早期の病態診断が可能になる。さらに、早期の病態診断が可能になることによって、より有効なうつ病、認知症の予防法、治療法の開発に役立てられる。
|
Report
(5 results)
Research Products
(45 results)
-
-
-
-
-
-
[Journal Article] Anatomical relationships between serotonin 5-HT2A and dopamine D2 receptors in living human brain.2017
Author(s)
Ishii T, Kimura Y, Ichise M, Takahata K, Kitamura S, Moriguchi S, Kubota M, Zhang MR, Yamada M, Higuchi M, Okubo Y, Suhara T.
-
Journal Title
PLoS One.
Volume: 12
Issue: 12
Pages: e0189318-e0189318
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
[Journal Article] Indications of success: Strategies for utilizing neuroimaging biomarkers in CNS drug discovery and development: CINP/JSNP working group report.2017
Author(s)
Suhara T, Chaki S, Kimura H, Furusawa M, Matsumoto M, Ogura H, Negishi T, Saijo T, Higuchi M, Omura T, Watanabe R, Miyoshi S, Nakatani N, Yamamoto N, Liou SY, Takado Y, Maeda J, Okamoto Y, Okubo Y, Yamada M, Ito H, Walton NM, et al.
-
Journal Title
Int J Neuropsychopharmacol.
Volume: 20(4)
Pages: 285-294
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Comparison of imaging biomarkers for Alzheimer's disease: amyloid imaging with [18F]florbetapir positron emission tomography and magnetic resonance imaging voxel-based analysis for entorhinal cortex atrophy2014
Author(s)
Tateno A, Sakayori T, Kawashima Y, Higuchi M, Suhara T, Mizumura S, Mintun MA, Skovronsky DM, Honjo K, Ishihara K, Kumita S, Suzuki H, Okubo Y.
-
Journal Title
International Journal of Geriatric Psychiatry
Volume: 30
Issue: 5
Pages: 505-513
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
