Vulnerability Assessment of Atherosclerosis by PET

• Project/Area Number: 15H04898
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyoto Prefectural University of Medicine (2017); Hokkaido University (2015-2016)
• Principal Investigator: Tamaki Nagara 京都府立医科大学, 医学(系)研究科(研究院), 特任教授 (30171888)
• Co-Investigator(Kenkyū-buntansha): 小川 美香子 北海道大学, 薬学研究院, 教授 (20344351) ; 納谷 昌直 北海道大学, 医学(系)研究科(研究院), 助教 (20455637) ; 吉永 恵一郎 北海道大学, 医学研究院, 客員研究員 (30435961) ; 中山 若樹 北海道大学, 医学研究院, 講師 (40421961) ; 久下 裕司 北海道大学, アイソトープ総合センター, 教授 (70321958) ; 真鍋 徳子 北海道大学, 大学病院, 講師 (70463742) ; 西嶋 剣一 北海道大学, 大学病院, 薬剤師 (60364254)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
• Keywords: PET / 動脈硬化 / 治療戦略 / 画像診断 / 放射線 / 循環器 / 心血管疾患

Outline of Final Research Achievements

PET permits molecular imaging and quantitative assessment of vascular function. We performed quantitative assessment for experimental and clinical atherosclerosis by PET. FDG as a marker of macrophage and FMISO as a hypoxic marker showed altered glucose metabolism and hypoxic response in diabetic atherosclerosis in rabbits. The PET studies indicated reduced myocardial flow reserve (MFR) in relation to altered FFR in patients with coronary artery disease. In addition, impaired peripheral endothelial function was suggested by oscillometry which was correlated with coronary endothelial dysfunction in smokers. Furthermore, active cardiac sarcoidosis was identified by FDG-PET. Thus, PET permits identification of active atherosclerosis and quantitative assessment of vascular dysfunction. PET should play an important role for risk assessment and patient management in the near future.

Research Products

• [Journal Article] Altered glucose metabolism and hypoxic response in alloxan-induced diabetic atherosclerosis in rabbits. (2017)
  • Author(s): Matsuura Y, Yamashita A, Zhao Y, Iwakiri T, Yamasaki K, Sugita C, Koshimoto C, Kitamura K, Kawai K, Tamaki N, Zhao S, Kuge Y, Asada Y.
  • Journal Title: PLos One. Volume: 12(4)
  • Peer Reviewed
• [Journal Article] Immunoglobulin G (IgG)-based imaging probe accumulates in M1 macrophage-infiltrated atherosclerotic plaques independent of IgG target molecule expression. (2017)
  • Author(s): Shimizu Y, Hanzawa H, Zhao Y, Fukura S, Nishijima KI, Sakamoto T, Zhao S, Tamaki N, Ogawa M, Kuge Y.
  • Journal Title: Mol Imaging Biol. Volume: 19(4) Pages: 531-539
  • NAID: 120006491485
  • Peer Reviewed
• [Journal Article] Feasibility of PET for the management of coronary artery disease: Comparison between CFR and FFR (2017)
  • Author(s): Manabe Osamu、Naya Masanao、Tamaki Nagara
  • Journal Title: Journal of Cardiology Volume: 70 Issue: 2 Pages: 135-140
  • DOI: 10.1016/j.jjcc.2017.03.002
  • Peer Reviewed
• [Journal Article] 18F-fluoromisonidazole (FMISO) PET may have the potential to detect cardiac sarcoidosis. (2017)
  • Author(s): Manabe O, Hirata K, Shozo O, Shiga T, Uchiyama Y, Kobayashi K, Watanabe S, Toyonaga T, Kikuchi H, Oyama-Manabe N, Tamaki N.
  • Journal Title: J Nucl Cardiol Volume: 24 Issue: 1 Pages: 329-331
  • DOI: 10.1007/s12350-016-0495-2
  • Peer Reviewed
• [Journal Article] The effects of 18-h fasting with low-carbohydrate diet preparation on suppressed physiological myocardial 18F-fluorodeoxyglucose (FDG) uptake and possible minimal effects of unfractionated heparin use in patients with suspected cardiac involvement sarcoidosis. (2016)
  • Author(s): Manabe O, Yoshinaga K, Ohira H, Masuda A, Sato T, Tsujino I, Yamada A, Oyama-Manabe N, Hirata K, Nishimura M, Tamaki N.
  • Journal Title: J Nucl Cardiol Volume: 23 Issue: 2 Pages: 244-252
  • DOI: 10.1007/s12350-015-0226-0
  • NAID: 120005753717
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparison of (18)F-fluorodeoxyglucose positron emission tomography (FDG PET) and cardiac magnetic resonance (CMR) in corticosteroid-naive patients with conduction system disease due to cardiac sarcoidosis. (2016)
  • Author(s): Ohira H, Birnie DH, Pena E, Bernick J, Mc Ardle B, Leung E, Wells GA, Yoshinaga K, Tsujino I, Sato T, Manabe O, Oyama-Manabe N, Nishimura M, Tamaki N, Dick A, Dennie C, Klein R, Renaud J, deKemp RA, Ruddy TD, Chow BJ, Davies R, Hessian R, Liu P, Beanlands RS, Nery PB.
  • Journal Title: Eur J Nucl Med Mol Imaging. Volume: 43 Issue: 2 Pages: 259-269
  • DOI: 10.1007/s00259-015-3181-8
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] PEG modification on (111)In-labeled phosphatidyl serine liposomes for imaging of atherosclerotic plaques. (2015)
  • Author(s): Ogawa M, Uchino R, Kawai A, Kosugi M, Magata Y
  • Journal Title: Nucl Med Biol Volume: 42 Issue: 3 Pages: 299-304
  • DOI: 10.1016/j.nucmedbio.2014.12.004
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Combined Plasma and Tissue Proteomic Study of Atherogenic Model Mouse: Approach To Elucidate Molecular Determinants in Atherosclerosis Development. (2015)
  • Author(s): Hanzawa H, Sakamoto T, Kaneko A, Manri N, Zhao Y, Zhao S, Tamaki N, Kuge Y
  • Journal Title: J Proteome Res. Volume: 14 Issue: 10 Pages: 4257-4269
  • DOI: 10.1021/acs.jproteome.5b00405
  • Peer Reviewed / Int'l Joint Research
• [Presentation] How to optimize myocardial glucose metabolism for assessing inflammation /injection. (2017)
  • Author(s): Tamaki N
  • Organizer: International Conference on Nuclear Cardiology and Cardiac CT.
  • Int'l Joint Research / Invited
• [Presentation] Emerging role of cardiac perfusion PET and CFR. In Multimodal Imaging for Myocardial Perfusion Evaluation. (2017)
  • Author(s): Tamaki N
  • Organizer: The 61st Annual Scinetific Meeting of the Korean Society of Cardiology. (Educational Seminar)
  • Int'l Joint Research / Invited
• [Presentation] Future Direction of Nuclear Cardiology (特別講演) (2017)
  • Author(s): 玉木長良
  • Organizer: 第27回日本心臓核医学会総会
• [Presentation] 循環器画像診断の進歩: PET/CT. (教育講演) (2017)
  • Author(s): 玉木長良
  • Organizer: 第65回日本心臓病学会学術集会
  • Invited
• [Presentation] 症例から学ぶ心サルコイドーシスのMRI所見 (2016)
  • Author(s): 真鍋徳子
  • Organizer: AIMS cardiac imaging
  • Place of Presentation: イイノホールカンファレンスセンター(東京都千代田区）
  • Int'l Joint Research / Invited
• [Book] Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy (2016)
  • Author(s): Shimizu Y, Hanzawa H, Zhao Y, Nishijima K, Fukura S, Sakamoto T, Zhao S, Tamaki N, Kuge Y. (Kuge Y, Shiga T, Tamaki, eds)
  • Total Pages: 326
  • Publisher: Springer