Attempt of 4D-IGRT by Volume Matching Method of 4D-CBCT and Therapy Planning CT

• Project/Area Number: 15H04899
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: Shimizu Shinichi 北海道大学, 医学研究院, 教授 (50463724)
• Co-Investigator(Kenkyū-buntansha): 梅垣 菊男 北海道大学, 工学研究院, 教授 (40643193) ; 高尾 聖心 北海道大学, 大学病院, 助教 (10614216) ; 松浦 妙子 北海道大学, 工学研究院, 准教授 (90590266) ; 宮本 直樹 北海道大学, 大学病院, 助教 (00552879) ; 西岡 健太郎 北海道大学, 大学病院, 特任助教 (80463743) ; 木下 留美子 北海道大学, 大学病院, 助教 (70507582) ; 加藤 徳雄 北海道大学, 大学病院, 助教 (80572495)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000); Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
• Keywords: 放射線治療 / 粒子線治療 / 陽子線治療 / 動体追跡装置 / 四次元放射線治療 / 4D-CT / 4D-CBCT / 医学物理(学) / 医学物理(学） / 4次元CT / CBCT / ゲーティング照射 / コーンビームCT

Outline of Final Research Achievements

We conduct research using 2 axis of diagnostic X-ray fluoroscope that consist real-time tumour-tracking (RTRT) system installed in a proton beam treatment gantry. With the use of the system, we conduct a research aimed constructing a 4D-IGRT radiotherapy system that can treat cancer in consideration of spatial and temporal fluctuations and also respiratory movement of tumors. Four-dimensional cone beam CT (4D-CBCT) image is obtained from the fluoroscopic image of the RTRT system. From the 4D-CBCT image group composed of a plurality of respiratory phases, a CT image that represent the same respiratory phase as the CT image used for the treatment plan is selected. We develop an advanced real time image guidance system aiming marker-less 4D-RT using selected CBCT image and its source image.

Research Products

• [Journal Article] Prospective study to evaluate the safety of the world-first spot-scanning dedicated, small 360-degree gantry, synchrotron-based proton beam therapy system. (2018)
  • Author(s): K. Nishioka, A. Prayongrat, K. Ono, S. Onodera, T. Hashimoto, N. Katoh, T. Inoue, R. Kinoshita, K. Yasuda, T. Mori, R. Onimaru, H. Shirato, and S. Shimizu
  • Journal Title: Journal of Radiation Research Volume: vol. 59 Issue: suppl_1 Pages: 63-71
  • DOI: 10.1093/jrr/rrx083
  • NAID: 120006466469
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of inter- and intra fractional partial bladder wall movement using implanted fiducial markers (2017)
  • Author(s): Nishioka Kentaro、Shimizu Shinichi、Shinohara Nobuo、Ito Yoichi M.、Abe Takashige、Maruyama Satoru、Katoh Norio、Kinoshita Rumiko、Hashimoto Takayuki、Miyamoto Naoki、Onimaru Rikiya、Shirato Hiroki
  • Journal Title: Radiation oncology Volume: 12 Issue: 1 Pages: 44-44
  • DOI: 10.1186/s13014-017-0778-z
  • NAID: 120005981373
  • Peer Reviewed / Open Access
• [Journal Article] Impact of Real-Time Image Gating on Spot Scanning Proton Therapy for Lung Tumors: A Simulation Study. (2017)
  • Author(s): Kanehira T, Matsuura T, Takao S, Matsuzaki Y, Fujii Y, Fujii T, Ito YM, Miyamoto N, Inoue T, Katoh N, Shimizu S, Umegaki K, Shirato H
  • Journal Title: Int J Radiat Oncol Biol Phys. Volume: 97(1) Issue: 1 Pages: 173-181
  • DOI: 10.1016/j.ijrobp.2016.09.027
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of the motion of lung tumors during stereotactic body radiation therapy (SBRT) with four-dimensional computed tomography (4DCT) using real-time tumor-tracking radiotherapy system (RTRT) (2016)
  • Author(s): Harada K, Katoh N, Suzuki R, Ito YM, Shimizu S, Onimaru R, Inoue T, Miyamoto N, Shirato H
  • Journal Title: Phys. Medica Volume: 32(2) Issue: 2 Pages: 305-311
  • DOI: 10.1016/j.ejmp.2015.10.093
  • NAID: 120005757985
  • Peer Reviewed
• [Journal Article] NTCP modeling analysis of acute hematologic toxicity in whole pelvic radiation therapy for gynecologic malignancies - A dosimetric comparison of IMRT and spot-scanning proton therapy (SSPT). (2016)
  • Author(s): Yoshimura T, Kinoshita R, Onodera S, Toramatsu C, Suzuki R, Ito YM, Takao S, Matsuura T, Matsuzaki Y, Umegaki K, Shirato H, Shimizu S
  • Journal Title: Phys Med. Volume: 32(9) Issue: 9 Pages: 1098-1102
  • DOI: 10.1016/j.ejmp.2016.08.007
  • NAID: 120005972937
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Optimization and evaluation of multiple gating beam delivery in a synchrotron-based proton beam scanning system using a real-time imaging technique. (2016)
  • Author(s): Yamada T, Miyamoto N, Matsuura T, Takao S, Fujii Y, Matsuzaki Y, Koyano H, Umezawa M, Nihongi H, Shimizu S, Shirato H, Umegaki K
  • Journal Title: Phys Med. Volume: 32(7) Issue: 7 Pages: 932-937
  • DOI: 10.1016/j.ejmp.2016.06.002
  • NAID: 120006313432
  • Peer Reviewed / Open Access
• [Journal Article] Intrafractional baseline shift/drift of lung tumor motion during gated radiotherapy with a real-time tumor-tracking system (2016)
  • Author(s): Seishin Takao, Naoki Miyamoto, Taeko Matsuura, Rikiya Onimaru, Norio Katoh, Tetsuya Inoue, Kenneth Lee Sutherland, Ryusuke Suzuki, Hiroki Shirato, Shinichi Shimizu
  • Journal Title: International Journal of Radiation Oncology Biology Physics Volume: 94(1) Issue: 1 Pages: 172-180
  • DOI: 10.1016/j.ijrobp.2015.09.024
  • Peer Reviewed
• [Journal Article] Development and evaluation of a short-range applicator for treating superficial moving tumors with respiratory-gated spot-scanning proton therapy using real-time image guidance (2016)
  • Author(s): Taeko Matsuura, Yusuke Fujii, Seishin Takao, Takahiro Yamada, Yuka Matsuzaki, Naoki Miyamoto, Taisuke Takayanagi, Shinichiro Fujitaka, Shinichi Shimizu, Hiroki Shirato
  • Journal Title: Physics in Medicine and Biology Volume: 62 Issue: 4 Pages: 1515-1531
  • DOI: 10.1088/0031-9155/61/4/1515
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 放射線治療における数値指標の医学物理的利用 (2018)
  • Author(s): 清水伸一、小橋啓司、伊藤陽一、Anussara Prayongrat、加藤徳雄、安田耕一、出倉康裕、木元拓也、白土博樹
  • Organizer: 第31回 高精度放射線外部照射部会学術大会
• [Presentation] Evaluation of measurement accuracy of novel monoscopic X-ray imaging technique for three-dimensional target localization using multiple internal fiducial markers (2017)
  • Author(s): Naoki Miyamoto, Ryusuke Suzuki, Seishin Takao, Taeko Matsuura, Shusuke Hirayama, Takaaki Fujii, Satoshi Tomioka, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
  • Organizer: 第114回医学物理学会
• [Presentation] Incidental radiation dose to internal mammary lymph node in tangential breast irradiation: comparison of calculation algorithm (2017)
  • Author(s): Rumiko Kinoshita, Yukiko Nishikawa, Kentaro Nishioka, Takayuki Hashimoto, Shinichi Shimizu, Ryusuke Suzuki, Hiroki Shirato
  • Organizer: The 76th Annual meeting of the Japan Radiological Society
• [Presentation] Monoscopic X-ray imaging for real-time three-dimensional target localization using multiple internal fiducial markers (2017)
  • Author(s): Naoki Miyamoto, Ryusuke Suzuki, Seishin Takao, Taeko Matsuura, Takaaki Fujii, Yusuke Hirayama, Hidenori Koyano, Shinichi Shimizu, Kikuo Umegaki and Hiroki Shirato
  • Organizer: 2017 AAPM 59th Annual Meeting
  • Int'l Joint Research
• [Presentation] Development of a System for Evaluating the Actual Dose Distribution in Respiratory-Gated Spot-Scanning Proton Therapy Using Real-Time Image Guidance (2017)
  • Author(s): T. Matsuura, S. Hirayama, H. Koyano, S. Takao, T. Fujii, T. Yamada, Y.Fujii, H. Nihongi, S. Shimizu, K. Umegaki, H. Shirato
  • Organizer: 2017 AAPM 59th Annual Meeting
  • Int'l Joint Research
• [Presentation] A prospective study to evaluate the safety of the world-first spot-scanning dedicated, small 360-degree gantry, synchrotron-based proton beam therapy system (2017)
  • Author(s): Kentaro Nishioka, Shinichi Shimizu, Koichi Yasuda, Kota Ono, Takayuki Hashimoto, Norio Katoh, Tetsuya Inoue, Kazuhiko Tsuchiya, Rikiya Onimaru, Hiroki Shirato
  • Organizer: 56th Annual Conference of the Particle Therapy Co-Operative Group
  • Int'l Joint Research
• [Presentation] An Organ Motion and Acute Toxicity Study of Image-guided Spot-Scanning Proton Beam Therapy with An Internal Fiducial Marker for Pancreatic Cancers (2017)
  • Author(s): Uchinami Y, Katoh N, Abo D, Harada K, Nishikawa Y, Inoue T, Hashimoto T, Onimaru R, Miyamoto N, Sakuhara Y, Shimizu S, Shirato H
  • Organizer: 2017 ASTRO 59th Annual Meeting
  • Int'l Joint Research
• [Presentation] Analysis of Threshold Doses for Radiation Induced Liver Parenchymal Changes on MRI After Real-Time-Image Gated Spot-Scanning Proton Beam Therapy of Hepatocellular Carcinoma (2017)
  • Author(s): Norio Katoh, Yusuke Uchinami, Seishin Takao, Koichi Yasuda, Keiichi Harada, Tetsuya Inoue, Taeko Matsuura, Takayuki Hashimoto, Shinichi Shimizu, Hiroki Shirato
  • Organizer: 2017 ASTRO 59th annual meeting
  • Int'l Joint Research
• [Presentation] The time performance evaluation of Real-time-image gated spot-scanning proton therapy system for clinical use (2017)
  • Author(s): Shinichi Shimizu, Takaaki Yoshimura, Norio Katoh, Takayuki Hashimoto, Hiroshi Tamura, Yuto Matsuo, Taeko Matsuura, Seishin Takao, Kikuo Umegaki, Hiroki Shirato
  • Organizer: 56th Annual Conference of the Particle Therapy Co-Operative Group
  • Int'l Joint Research
• [Presentation] 陽子線の現状と今後 (2017)
  • Author(s): 清水伸一
  • Organizer: 北海道放射線治療研究会
  • Invited
• [Presentation] Treatment Time and Dose Rate Analysis for Respiratory Moving Liver Tumor Using Real-time-image Gated Spot Scanning Proton Beam Therapy System (2016)
  • Author(s): Shimizu S, Katoh N, Takao S, Matsuura T, Miyamoto N, Hashimoto T, Nishioka K, Yoshimura T, Umegaki K, Shirato H
  • Organizer: ASTRO 2016 Annual Meeting
  • Place of Presentation: Boston, USA
  • Year and Date: 2016-09-25
  • Int'l Joint Research
• [Presentation] Radiation dose to internal mammary lymph node in standard tangential breast irradiation (2016)
  • Author(s): Kinoshita R, Shimizu S, Nishikawa Y, Nishioka K, Hashimoto T, Suzuki R, Shirato H
  • Organizer: ASTRO 2016 Annual Meeting
  • Place of Presentation: Boston, USA
  • Year and Date: 2016-09-25
  • Int'l Joint Research
• [Presentation] Stereotactic Body Radiation Therapy Using a Real-time Tumor-Tracking Radiation Therapy System for Hepatocellular Carcinomas (2016)
  • Author(s): Uchinami Y, Katoh N, Abo D, Harada K, Inoue T, Taguchi H, Onimaru R, Shimizu S, Sakuhara Y, Ogawa K, Kamiyama T, Shirato H
  • Organizer: ASTRO 2016 Annual Meeting
  • Place of Presentation: Boston, USA
  • Year and Date: 2016-09-25
  • Int'l Joint Research
• [Presentation] Spot-scanning proton beam therapy (SSPT) with or without the use of a real-time tumor-tracking function: Clinical Experience (2016)
  • Author(s): Katoh N, Shimizu S, Nishioka K, Hashimoto T, Inoue T, Matsuura T, Takao S, Onimaru R, Umegaki K, Shirato H
  • Organizer: 第75回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2016-04-14
• [Presentation] 呼吸性移動を持った肝腫瘍に対する実時間画像同期陽子線治療の線量率および照射時間に関する検討 (2016)
  • Author(s): 清水伸一、加藤徳雄、高尾聖心、松浦妙子、宮本直樹、橋本孝之、西岡健太郎、吉村高明、梅垣菊男、白土博樹
  • Organizer: 第75回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2016-04-14
• [Presentation] Initial clinical experience of spot-scanning proton beam therapy using real-time-image gated proton-beam therapy system (2015)
  • Author(s): Shimizu S, Katoh N, Kentaro N, Hashimoto T, Inoue T, Matsuura T, Takao S, Matsuzaki Y,Fujii Y, Tamura M, Onimaru R, Umegaki K, Shirato H
  • Organizer: 4D Treatment Planning Workshop 2015
  • Place of Presentation: Dresden(Germany)
  • Year and Date: 2015-11-26
  • Int'l Joint Research
• [Presentation] Real time image-gated proton beam therapy (2015)
  • Author(s): Shimizu S
  • Organizer: The 14th Seoul Radiation Oncology Symposium: Updates in Image-Guided Radiation Therapy
  • Place of Presentation: Seoul(South Korea)
  • Year and Date: 2015-10-30
  • Int'l Joint Research / Invited
• [Presentation] Treatment of respiratory moving liver tumor using gated spot scanning proton beam therapy system with real-time tumor-tracking function (2015)
  • Author(s): Shimizu S, Katoh N, Takao S, Matsuura T, Miyamoto N, Hashimoto T, Nishioka K, Yoshimura T, Matsuzaki Y, Kinoshita R, Nishikawa Y, Onimaru R, Umegaki K, Shirato H
  • Organizer: 57th Annual Meeting of American Society of Therapeutic Radiology and Oncology
  • Place of Presentation: San Antonio(USA)
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] 最先端陽子線治療装置に託された使命 (2015)
  • Author(s): 清水伸一
  • Organizer: 第54回全国自治体病院学会 特別講演
  • Place of Presentation: 花びしホテル(北海道・函館市)
  • Year and Date: 2015-10-09
  • Invited
• [Presentation] 光子線治療学から粒子線治療学へ (2015)
  • Author(s): 清水伸一
  • Organizer: 第51回日本医学放射線学会秋季臨床大会 シンポジウム
  • Place of Presentation: アイーナいわて県民情報交流センター(岩手県・盛岡市)
  • Year and Date: 2015-10-02
• [Book] がん・放射線療法２０１７ 改訂第７版 (2017)
  • Author(s): 清水伸一・西岡健太郎
  • Total Pages: 1336
  • Publisher: 学研メディカル秀潤社
  • ISBN: 4780909430