Development of novel imaging biomarker using highly-sensitive tau PET probes

• Project/Area Number: 15H04900
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tohoku Medical and Pharmaceutical University (2016-2017); Tohoku University (2015)
• Principal Investigator: OKAMURA Nobuyuki 東北医科薬科大学, 医学部, 教授 (40361076)
• Co-Investigator(Renkei-kenkyūsha): FURUKAWA Katsutoshi 東北医科薬科大学, 医学部, 教授 (30241631) ; TASHIRO Manabu 東北大学, サイクロトロンRIセンター, 教授 (00333477)
• Research Collaborator: HARADA Ryuichi ; FURUMOTO Shozo ; KUDO Yukitsuka
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
• Keywords: アルツハイマー病 / 進行性核上性麻痺 / PET / タウ / モノアミン酸化酵素 / グリオーシス / 認知症 / 画像診断 / アストロサイト / 痴呆 / 神経科学 / 放射線 / 脳神経疾患 / 老化

Outline of Final Research Achievements

Longitudinal 18F-THK5351 PET studies were conducted in patients with Alzheimer's disease. In patients with Alzheimer's disease, significant radiotracer retention was observed in the frequent areas of neurofibrillary tangle formation. The amount and spatial extension of radiotracer binding was closely associated with clinical severity and progression of dementia. Significant THK5351 retention was also observed in the globus pallidus and midbrain of patients with progressive supranuclear palsy. THK5351 retention in the basal ganglia was additionally observed in healthy control subjects and associated with radiotracer binding to monoamine oxidase B. Imaging-autopsy correlation analysis revealed that THK5351 retention was associated with both paired helical filament of tau and astrogliosis in the brain.

Research Products

• [Int'l Joint Research] カロリンスカ研究所/ウプサラ大学(スウェーデン)
• [Int'l Joint Research] ミュンヘン大学(ドイツ)
• [Int'l Joint Research] 嘉泉大学校(韓国)
• [Int'l Joint Research] ウィスコンシン大学/ニューヨーク大学(米国)
• [Int'l Joint Research] 長庚紀念医院(台湾)
• [Int'l Joint Research]
• [Int'l Joint Research] カロリンスカ研究所/ウプサラ大学(スウェーデン)
• [Int'l Joint Research] マギル大学(カナダ)
• [Int'l Joint Research] UC Berkeley/ウィスコンシン大学/ニューヨーク大学(米国)
• [Int'l Joint Research] メルボルン大学(オーストラリア)
• [Int'l Joint Research] ミュンヘン大学(ドイツ)
• [Int'l Joint Research]
• [Int'l Joint Research] Karolinska Institutet/Uppsala University/Lund University(Sweden)
• [Int'l Joint Research] University of Munich(Germany)
• [Int'l Joint Research] University of Melbourne(Australia)
• [Int'l Joint Research] University of Wisconsin/New York University/Columbia University(米国)
• [Int'l Joint Research] Chang Gung Memorial Hospital(Taiwan)
• [Int'l Joint Research]
• [Journal Article] A comparison of five partial volume correction methods for Tau and Amyloid PET imaging with [(18)F]THK5351 and [(11)C]PIB. (2018)
  • Author(s): Shidahara M, Thomas BA, Okamura N, Ibaraki M, Matsubara K, Oyama S, Ishikawa Y, Watanuki S, Iwata R, Furumoto S, Tashiro M, Yanai K, Gonda K, Watabe H.
  • Journal Title: Ann Nucl Med. Volume: 59 Issue: 7 Pages: 671-674
  • DOI: 10.1007/s12149-017-1185-0
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Correlations of (18)F-THK5351 PET with Postmortem Burden of Tau and Astrogliosis in Alzheimer Disease. (2018)
  • Author(s): Harada R, Furukawa K, et al.
  • Journal Title: J Nucl Med Volume: 59 Issue: 4 Pages: 671-674
  • DOI: 10.2967/jnumed.117.197426
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] [18F]-THK5351 PET correlates with topology and symptom severity in progressive supranuclear palsy. (2018)
  • Author(s): Brendel M, Schoneckerr S, Hoglinger G, Lindner S, Havla J, Blautzik J, Sauerbeck J, Rohrer G, Zach C, Vettermann F, Lang AE, Golbe L, Nubling G, Bartenstein P, Furukawa K, Ishiki A, Botzel K, Danek A, Okamura N, Levin J, Rominger A.
  • Journal Title: Front Aging Neurosci. Volume: 9 Pages: 440-440
  • DOI: 10.3389/fnagi.2017.00440
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Case of progressive supranuclear palsy detected by tau imaging with [18F]THK-5351 before the appearance of characteristic clinical features. (2018)
  • Author(s): Shimizu S, Imabayashi E, Takenoshita N, Okamura N, Furumoto S, Kudo Y, Matsuda H, Hanyu H.
  • Journal Title: Geriatr Gerontol Int. Volume: 18 Issue: 3 Pages: 501-502
  • DOI: 10.1111/ggi.13229
  • Peer Reviewed
• [Journal Article] In vivo comparison of tau radioligands 18F-THK-5351 and 18F-THK-5317. (2017)
  • Author(s): Betthauser T, Lao PJ, Murali D, Barnhart TE, Furumoto S, Okamura N, Stone CK, Johnson SC, Christian BT.
  • Journal Title: J Nucl Med. Volume: - Issue: 6 Pages: 996-1002
  • DOI: 10.2967/jnumed.116.182980
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prediction of the clinical standardized uptake value ratio in amyloid PET imaging using a biomathematical modeling approach towards the efficient development of a radioligand. (2017)
  • Author(s): Arakawa Y, Nai Y, Shidahara M, Furumoto S, Seki C, Okamura N, Tashiro M, Kudo Y, Yanai K, Gonda K, Watabe H.
  • Journal Title: J Nucl Med. Volume: - Issue: 8 Pages: 1285-1292
  • DOI: 10.2967/jnumed.116.183566
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Brain imaging: Applications of tau PET imaging. (2017)
  • Author(s): Okamura N, Yanai K.
  • Journal Title: Nat Rev Neurol. Volume: 13 Issue: 4 Pages: 197-198
  • DOI: 10.1038/nrneurol.2017.38
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] CSF clearance in Alzheimer Disease measured with dynamic PET. (2017)
  • Author(s): de Leon MJ, Li Y, Okamura N, Tsui WH, Saint Louis LA, Glodzik L, Osorio RS, Fortea J, Butler T, Pirraglia E, Fossati S, Kim HJ, Carare RO, Nedergaard M, Benveniste H, Rusinek H.
  • Journal Title: J Nucl Med. Volume: - Issue: 9 Pages: 1471-1476
  • DOI: 10.2967/jnumed.116.187211
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Biodistribution and radiation dosimetry for the tau tracer 18F-THK-5351 in healthy human subjects. (2017)
  • Author(s): Hsiao IT, Lin KJ, Huang KL, Huang CC, Chen HS, Wey SP, Yen TC, Okamura N, Hsu JL.
  • Journal Title: J Nucl Med. Volume: - Issue: 9 Pages: 1498-1503
  • DOI: 10.2967/jnumed.116.189126
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Regional tau deposition and subregion atrophy of medial temporal structures in early Alzheimer's disease: A combined positron emission tomography/magnetic resonance imaging study (2017)
  • Author(s): Sone Daichi、Imabayashi Etsuko、Maikusa Norihide、Okamura Nobuyuki、Furumoto Shozo、Kudo Yukitsuka、Ogawa Masayo、Takano Harumasa、Yokoi Yuma、Sakata Masuhiro、Tsukamoto Tadashi、Kato Koichi、Matsuda Hiroshi
  • Journal Title: Alzheimers Dement (Amst) Volume: 9 Issue: 1 Pages: 35-40
  • DOI: 10.1016/j.dadm.2017.07.001
  • Peer Reviewed / Open Access
• [Journal Article] Tau positron emission tomography using [18F]THK5351 and cerebral glucose hypometabolism in Alzheimer's disease. (2017)
  • Author(s): Kang JM, Lee SY, Seo S, Jeong HJ, Woo SH, Lee H, Lee YB, Yeon BK, Shin DH, Park KH, Kang H, Okamura N, Furumoto S, Yanai K, Villemagne VL, Seong JK, Na DL, Ido T, Cho J, Lee KM, Noh Y.
  • Journal Title: Neurobiol Aging. Volume: 59 Pages: 210-219
  • DOI: 10.1016/j.neurobiolaging.2017.08.008
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Characterization of the radiosynthesis and purification of [ 18 F]THK-5351, a PET ligand for neurofibrillary tau (2017)
  • Author(s): Betthauser Tobey J.、Ellison Paul A.、Murali Dhanabalan、Lao Patrick J.、Barnhart Todd E.、Furumoto Shozo、Okamura Nobuyuki、Johnson Sterling C.、Engle Jonathan W.、Nickles Robert J.、Christian Bradley T.
  • Journal Title: Applied Radiation and Isotopes Volume: 130 Pages: 230-237
  • DOI: 10.1016/j.apradiso.2017.10.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Histamine N-methyltransferase regulates aggression and the sleep-wake cycle (2017)
  • Author(s): Naganuma Fumito、Nakamura Tadaho、Yoshikawa Takeo、Iida Tomomitsu、Miura Yamato、Karpati Aniko、Matsuzawa Takuro、Yanai Atushi、Mogi Asuka、Mochizuki Takatoshi、Okamura Nobuyuki、Yanai Kazuhiko
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 15899-15899
  • DOI: 10.1038/s41598-017-16019-8
  • Peer Reviewed / Open Access
• [Journal Article] Comparative binding properties of the tau PET tracers THK5117, THK5351, PBB3, and T807 in postmortem Alzheimer brains. (2017)
  • Author(s): Lemoine L, Gillberg PG, Svedberg M, Stepanov V, Jia Z, Huang J, Nag S, Tian H, Ghetti B, Okamura N, Higuchi M, Halldin C, Nordberg A.
  • Journal Title: Alzheimers Res Ther. Volume: 9 Issue: 1 Pages: 96-96
  • DOI: 10.1186/s13195-017-0325-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Tau positron emission tomography using [18F]THK5351 and cerebral glucose hypometabolism in Alzheimer's disease (2017)
  • Author(s): Kang JM, Lee SY, Seo S, Jeong HJ, Woo SH, Lee H, Lee YB, Yeon BK, Shin DH, Park KH, Kang H, Okamura N, Furumoto S, Yanai K, Villemagne VL, Seong JK, Na DL, Ido T, Cho J, Lee KM, Noh Y
  • Journal Title: Neurobiology of Aging Volume: 59 Issue: 1 Pages: 210-219
  • DOI: 10.1097/wad.0000000000000216
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 18F-Labeled 2-Arylquinoline Derivatives for Tau Imaging: Chemical, Radiochemical, Biological and Clinical Features. (2017)
  • Author(s): Furumoto S, Tago T, Harada R, Kudo Y, Okamura N.
  • Journal Title: Curr Alzheimer Res. Volume: 14 Pages: 178-185
  • Peer Reviewed
• [Journal Article] Tau imaging with [18F]THK-5351 in progressive supranuclear palsy. (2017)
  • Author(s): Ishiki A, Harada R, Okamura N, Tomita N, Rowe CC, Villemagne VL, Yanai K, Kudo Y, Arai H, Furumoto S, Tashiro M, Furukawa K.
  • Journal Title: Eur J Neurol. Volume: 24 Issue: 1 Pages: 130-136
  • DOI: 10.1111/ene.13164
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A report of the automated radiosynthesis of the tau PET radiopharmaceutical, [18F]-THK-5351. (2017)
  • Author(s): Neelamegam R, Yokell DL, Rice PA, Furumoto S, Kudo Y, Okamura N, El Fakhri G.
  • Journal Title: J Labelled Comp Radiopharm. Volume: 60 Issue: 2 Pages: 140-146
  • DOI: 10.1002/jlcr.3482
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain. (2017)
  • Author(s): Ng KP, Pascoal TA, Mathotaarachchi S, Therriault J, Kang MS, Shin M, Guiot MC, Guo Q, Harada R, Comley RA, Massarweh G, Soucy JP, Okamura N, Gauthier S, Rosa-Neto P.
  • Journal Title: Alzheimers Res Ther. Volume: 9:25 Issue: 1 Pages: 25-25
  • DOI: 10.1186/s13195-017-0253-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Structure-Activity Relationship of 2-Arylquinolines as PET Imaging Tracers for Tau Pathology in Alzheimer’s Disease (2016)
  • Author(s): Tetsuro Tago, Shozo Furumoto, Nobuyuki Okamura, Ryuichi Harada, Hajime Adachi, Yoichi Ishikawa, Kazuhiko Yanai, Ren Iwata, and Yukitsuka Kudo
  • Journal Title: Journal of Nuclear Medicine Volume: 57(4) Issue: 4 Pages: 608-614
  • DOI: 10.2967/jnumed.115.166652
  • Peer Reviewed
• [Journal Article] Advances in the development of tau PET radiotracers and their clinical applications. (2016)
  • Author(s): Okamura N, Harada R, Furukawa K, Furumoto S, Tago T, Yanai K, Arai H, Kudo Y.
  • Journal Title: Ageing Res Rev. Volume: - Pages: 107-113
  • DOI: 10.1016/j.arr.2015.12.010
  • Peer Reviewed
• [Journal Article] microPET Imaging of Tau Pathology with [18F]-THK5117 in two Transgenic Mouse Models. (2016)
  • Author(s): Brendel M, Jaworska A, Probst F, Overhoff F, Korzhova V, Lindner S, Carlsen J, Bartenstein P, Harada R, Kudo Y, Haass C, van Leuven F, Okamura N, Herms J, Rominger A.
  • Journal Title: J Nucl Med Volume: 印刷中 Issue: 5 Pages: 792-798
  • DOI: 10.2967/jnumed.115.163493
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Introduction and overview of the special issue "Brain imaging and aging": The new era of neuroimaging in aging research. (2016)
  • Author(s): Furukawa K, Ishiki A, Tomita N, Onaka Y, Saito H, Nakamichi T, Hara K, Kusano Y, Ebara M, Arata Y, Sakota M, Miyazawa I, Totsune T, Okinaga S, Okamura N, Kudo Y, Arai H.
  • Journal Title: Ageing Res Rev Volume: - Pages: 1-3
  • DOI: 10.1016/j.arr.2016.02.005
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Dynamic PET measures of tau accumulation in cognitively normal older adults and Alzheimer's disease patients measured using [18F]THK-5351. (2016)
  • Author(s): Lockhart SN, Baker SL, Okamura N, Furukawa K, Ishiki A, Furumoto S, Tashiro M, Yanai K, Arai H, Kudo Y, Harada R, Tomita N, Hiraoka K, Watanuki S, Jagust WJ.
  • Journal Title: PLoS One. Volume: 11 Issue: 6 Pages: e0158460-e0158460
  • DOI: 10.1371/journal.pone.0158460
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Characterization of the radiolabeled metabolite of tau PET tracer 18F-THK5351. (2016)
  • Author(s): Harada R, Furumoto S, Tago T, Furukawa K, Ishiki A, Tomita N, Iwata R, Tashiro M, Arai H, Yanai K, Kudo Y, Okamura N.
  • Journal Title: Eur J Nucl Med Mol Imaging. Volume: 43 Issue: 12 Pages: 2211-2218
  • DOI: 10.1007/s00259-016-3453-y
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Untangling tau imaging. (2016)
  • Author(s): Villemagne VL, Okamura N, Rowe CC.
  • Journal Title: Alzheimers Dement (Amst) Volume: 4 Issue: 1 Pages: 39-42
  • DOI: 10.1016/j.dadm.2016.05.001
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Applied multimodal diagnostics in a case of presenile dementia. (2016)
  • Author(s): Schonecker S, Brendel M, Huber M, Vollmar C, Huppertz HJ, Teipel S, Okamura N, Levin J, Rominger A, Danek A.
  • Journal Title: BMC Neurol. Volume: 16 Issue: 1 Pages: 131-131
  • DOI: 10.1186/s12883-016-0647-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] In vivo visualization of tau pathology using 18F-THK5351 PET in corticobasal syndrome. (2016)
  • Author(s): Kikuchi A, Okamura N, Hasegawa T, Harada R, Watanuki S, Funaki Y, Kobayashi M, Tano O, Baba T, Sugeno N, Oshima R, Yoshida S, Kobayashi J, Ezura M, Hiraoka K, Mugikura S, Takase K, Iwata R, Taki Y, Furukawa K, HArai H, Furumoto S, Tashiro M, Yanai K, Kudo Y, Takeda A，Aoki M.
  • Journal Title: Neurology Volume: 87 Issue: 22 Pages: 2309-2316
  • DOI: 10.1212/wnl.0000000000003375
  • Peer Reviewed
• [Journal Article] Development of [11C]/[3H]THK-5351 - A potential novel carbon-11 tau imaging PET radioligand. (2016)
  • Author(s): Stepanov V, Svedberg M, Jia Z, Krasikova R, Lemoine L, Okamura N, Furumoto S, Mitsios N, Mulder J, Langstrom B, Nordberg A, Halldin C.
  • Journal Title: Nucl Med Biol. Volume: 46 Pages: 50-53
  • DOI: 10.1016/j.nucmedbio.2016.12.004
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Characteristics of Tau and Its Ligands in PET Imaging (2016)
  • Author(s): Ryuichi Harada, Nobuyuki Okamura, Shozo Furumoto, Tetsuro Tago, Kazuhiko Yanai, Hiroyuki Arai, Yukitsuka Kudo
  • Journal Title: Biomolecules Volume: 6 Issue: 1 Pages: 1-15
  • DOI: 10.3390/biom6010007
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease (2016)
  • Author(s): Harada R, Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Tago T, Hiraoka K, Watanuki S, Shidahara M, Miyake M, Ishikawa Y, Matsuda R, Inami A, Yoshikawa T, Funaki Y, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y
  • Journal Title: J Nucl Med Volume: 57 Issue: 2 Pages: 208-214
  • DOI: 10.2967/jnumed.115.164848
  • Peer Reviewed
• [Journal Article] Tau imaging in the study of ageing, Alzheimer's disease, and other neurodegenerative conditions. (2016)
  • Author(s): Villemagne VL, Okamura N.
  • Journal Title: Current Opinion in Neurology Volume: 36 Pages: 43-51
  • DOI: 10.1016/j.conb.2015.09.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Preclinical evaluation of [18F]THK-5015 enantiomers: effects of chirality on its effectiveness as a tau imaging radiotracer. (2015)
  • Author(s): Tago T., Furumoto S., Okamura N., Harada R., Adachi H., Ishikawa Y., Yanai K., Iwata R., Kudo Y.
  • Journal Title: Mol. Imaging Biol. Volume: 未定 Issue: 2 Pages: 258-266
  • DOI: 10.1007/s11307-015-0879-8
  • Peer Reviewed
• [Journal Article] Longitudinal Assessment of Tau Pathology in Patients with Alzheimer's Disease Using [18F]THK-5117 Positron Emission Tomography (2015)
  • Author(s): Ishiki, Aiko Okamura, Nobuyuki Furukawa, Katsutoshi Furumoto, Shozo Harada, Ryuichi Tomita, Naoki Hiraoka, Kotaro Watanuki, Shoichi Ishikawa, Yoichi Tago, Tetsuro Funaki, Yoshihito Iwata, Ren Tashiro, Manabu Yanai, Kazuhiko Kudo, Yukitsuka Arai, Hiroyuki
  • Journal Title: PLoS One Volume: 10 Issue: 10 Pages: 1-9
  • DOI: 10.1371/journal.pone.0140311
  • Peer Reviewed / Open Access
• [Journal Article] Visualization of regional tau deposits using 3H-THK5117 in Alzheimer brain tissue (2015)
  • Author(s): Lemoine L, Saint-Aubert L, Marutle A, Antoni G, Eriksson JP, Ghetti B, Okamura N, Nennesmo I, Gillberg PG, Nordberg A
  • Journal Title: Acta Neuropathologica Communications Volume: 3 Issue: 1 Pages: 40-40
  • DOI: 10.1186/s40478-015-0220-4
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] [18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease. (2014)
  • Author(s): Harada R, Furukawa K, et al.
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 42 Issue: 7 Pages: 1052-1061
  • DOI: 10.1007/s00259-015-3035-4
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Structure-binding relationship of quinoline derivatives on monoamine oxidase B. (2018)
  • Author(s): Okamura N.
  • Organizer: The 12th Human Amyloid Imaging (HAI) meeting
  • Int'l Joint Research
• [Presentation] Amyloid and Tau Imaging in Neurodegenerative Diseases. (2017)
  • Author(s): Okamura N.
  • Organizer: XXIII World Congress of Neurology
  • Int'l Joint Research / Invited
• [Presentation] THK5351 PET imaging in Alzheimer’s disease and non-AD tauopathies. (2017)
  • Author(s): Okamura N.
  • Organizer: International tau symposium
• [Presentation] Imaging tau and astrocyte with 18F-THK5351 - analysis of autopsy cases -. (2017)
  • Author(s): Okamura N.
  • Organizer: Society of Nuclear Medicine and Molecular Imaging
  • Int'l Joint Research
• [Presentation] 認知症を標的とした分子イメージングプローブ開発の現状 (2017)
  • Author(s): 岡村信行
  • Organizer: 第32回日本老年精神医学会
  • Invited
• [Presentation] THK5351-PETイメージングの有用性と課題 (2017)
  • Author(s): 岡村信行
  • Organizer: 第36回日本認知症学会学術集会
• [Presentation] 認知症を標的とした分子イメージングプローブ開発の現状 (2017)
  • Author(s): 岡村信行
  • Organizer: 第60回日本脳循環代謝学会学術集会
• [Presentation] Longitudinal analysis of [18F]THK5351 tau PET images in patients with Alzheimer's disease and corticobasal syndrome. (2016)
  • Author(s): Okamura N, Harada R, Ishiki A, Furukawa K, Kikuchi A, Hasegawa T, Aoki M, Furumoto S, Tashiro M, Yanai K, Arai H, Kudo Y.
  • Organizer: CTAD 2016
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-12-10
  • Int'l Joint Research
• [Presentation] タウPETイメージングの現状と可能性 (2016)
  • Author(s): 岡村信行、原田龍一
  • Organizer: 第35回日本認知症学会学術集会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2016-12-02
• [Presentation] 認知症患者における神経原線維変化の画像化に関する研究 (2016)
  • Author(s): 岡村信行
  • Organizer: 第35回日本認知症学会学術集会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2016-12-01
• [Presentation] Impact of tau PET on dementia research. (2016)
  • Author(s): 岡村信行
  • Organizer: 第56回日本核医学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2016-11-05
  • Invited
• [Presentation] Novel PET Probes for Imaging of Tau in Alzheimer's Disease. (2016)
  • Author(s): Okamura N.
  • Organizer: Symposium of Medical Imaging; PET/MR and Molecular Images
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2016-10-29
  • Int'l Joint Research / Invited
• [Presentation] Development of THK tau tracers. (2016)
  • Author(s): Okamura N.
  • Organizer: Tau PET Futures Meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2016-10-13
  • Int'l Joint Research / Invited
• [Presentation] [F-18]THK5351 retention is associated with the progression of brain atrophy in patients with Alzheimer's disease. (2016)
  • Author(s): Okamura N, Ishiki A, Furukawa K, Harada R, Tomita N, Furumoto S, Tashiro M, Yanai K, Arai H, Kudo Y.
  • Organizer: AAIC 2016
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2016-07-22
  • Int'l Joint Research
• [Presentation] タウPETイメージング：最近の進歩 (2016)
  • Author(s): 岡村信行
  • Organizer: AAJ関東甲信越エリアシンポジウム
  • Place of Presentation: 大手町サンケイプラザ（東京都千代田区）
  • Year and Date: 2016-07-03
  • Invited
• [Presentation] アルツハイマー病の分子イメージング (2016)
  • Author(s): 岡村信行、長沼史登、中村正帆
  • Organizer: 第32回日本DDS学会学術集会
  • Place of Presentation: 静岡県コンベンションアーツセンター（静岡市駿河区）
  • Year and Date: 2016-06-30
  • Invited
• [Presentation] 認知症におけるタウPETイメージング (2016)
  • Author(s): 岡村信行
  • Organizer: 第12回認知症ファイヤーカンファレンス
  • Place of Presentation: 愛知県産業労働センター（愛知県名古屋市）
  • Year and Date: 2016-06-18
  • Invited
• [Presentation] Recent clinical studies with THK tau tracers. (2016)
  • Author(s): Okamura N.
  • Organizer: SNMMI 2016 Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-06-13
  • Int'l Joint Research / Invited
• [Presentation] アルツハイマー病のPET診断 (2016)
  • Author(s): 岡村信行
  • Organizer: 第11回日本分子イメージング学会総会・学術集会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2016-05-28
• [Presentation] Tau imaging. (2016)
  • Author(s): Okamura N
  • Organizer: AONeuro Symposium - Neurotrauma
  • Place of Presentation: 仙台市立病院（宮城県仙台市）
  • Year and Date: 2016-02-28
  • Int'l Joint Research / Invited
• [Presentation] Tau PET Imaging. Current status and future directions. (2016)
  • Author(s): Okamura N
  • Organizer: Mind Brain Conference "From Molecules to the Universe: Advancing Biomedical Sciences and Engineering"
  • Place of Presentation: グランドホテル浜松（静岡県浜松市）
  • Year and Date: 2016-02-24
  • Int'l Joint Research / Invited
• [Presentation] Distinct patterns of [18F]THK-5351 retention in AD and non-AD tauopathies. (2016)
  • Author(s): Okamura N, Kikuchi A, Furukawa K, Ishiki A, Harada R, Hasegawa T, Takeda A, Furumoto S, Iwata R, Tashiro M, Yanai K, Aoki M, Arai H, Kudo Y.
  • Organizer: The 10th Human Amyloid Imaging (HAI) meeting
  • Place of Presentation: Miami (USA)
  • Year and Date: 2016-01-13
  • Int'l Joint Research
• [Presentation] Experience with Tau PET. (2015)
  • Author(s): Okamura N
  • Organizer: Busan Paik Hospital Neurodegenerative Disease Symposium
  • Place of Presentation: Busan (South Korea)
  • Year and Date: 2015-11-27
  • Int'l Joint Research / Invited
• [Presentation] Tau PET imaging with THK tau tracers. (2015)
  • Author(s): Okamura N.
  • Organizer: 2015 IPA 17th International Congress
  • Place of Presentation: Berlin (Germany)
  • Year and Date: 2015-10-15
  • Int'l Joint Research / Invited
• [Presentation] Distribution of tau pathology in the patients with mild cognitive impairment and Alzheimer’s disease measured with [18F]THK-5351 PET. (2015)
  • Author(s): Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Harada R, Tashiro M, Yanai K, Arai H, Kudo Y.
  • Organizer: AAIC 2015
  • Place of Presentation: Washington D.C. (USA)
  • Year and Date: 2015-07-22
  • Int'l Joint Research
• [Presentation] PET imaging of tau pathology in mild cognitive impairment and Alzheimer's disease with [18F]THK-5351. (2015)
  • Author(s): Okamura N, Furumoto S, Furukawa K, Ishiki A, Harada R, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y.
  • Organizer: SNMMI 2015 Annual Meeting
  • Place of Presentation: Baltimore (USA)
  • Year and Date: 2015-06-08
  • Int'l Joint Research
• [Presentation] Tau imaging in dementia. (2015)
  • Author(s): Okamura N
  • Organizer: Molecular Imaging of Dementia: Beyond Amyloid PET
  • Place of Presentation: Baltimore (USA)
  • Year and Date: 2015-06-06
  • Int'l Joint Research / Invited
• [Book] Neuroimaging Diagnosis for Alzheimer’s Disease and Other Dementias. (2017)
  • Author(s): Okamura N, Harada R, Furumoto S, Kudo Y.
  • Total Pages: 279
  • Publisher: Springer
  • ISBN: 9784431551331