Development of new boron drugs and molecular imaging targeting for cancer stem cell

• Project/Area Number: 15H04906
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Okayama University
• Principal Investigator: Matsui Hideki 岡山大学, 医歯薬学総合研究科, 教授 (30157234)
• Co-Investigator(Kenkyū-buntansha): 道上 宏之 岡山大学, 中性子医療研究センター, 准教授 (20572499)
• Co-Investigator(Renkei-kenkyūsha): MIYATAKE Shin-ichi 大阪医科大学, 医学部, 特別職務担当教員(教授) (90209916) ; MATSUSHITA Hiroaki 岡山大学, 大学院医歯薬学総合研究科, 助教 (60732394) ; KITAMATSU Mizuki 近畿大学, 理工学部, 講師 (60379716)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000); Fiscal Year 2017: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
• Keywords: 薬剤送達法 / ペプチドシグナル / ホウ素中性子捕捉療法 / 脳腫瘍 / がん幹細胞 / 自己会合ペプチド / がん治療 / ＢＮＣＴ / ホウ素薬剤 / 粒子線治療 / ＤＤＳ / 放射線治療 / ホウ素薬剤開発 / 創薬研究 / 癌 / BNCT / ホウ素中性子捕捉療法（BNCT） / 悪性脳腫瘍 / 細胞膜通過ペプチド / 陽電子放射断層撮影（PET)

Outline of Final Research Achievements

We developed a new drug delivery method which deliver boron into cancer cells. The method showed an efficient delivery of 10B into cultured Glioblastoma and Mammary cancer cell lines. The efficiency and the specificity were higher for cancer stem cells than ordinary cancer cells. We further developed molecular agent for PET imaging of boron compound.

Research Products

• [Journal Article] Oxytocin inhibits corticosterone-induced apoptosis in primary hippocampal neurons. (2018)
  • Author(s): Hein Min Latt, Hiroaki Matsushita, Miku Morino, Yuuri Koga, Hiroyuki Michiue, Teiichi Nishiki, Kazuhito Tomizawa, Hideki Matsui
  • Journal Title: Neuroscience Volume: - Pages: 383-389
  • DOI: 10.1016/j.neuroscience.2018.03.025
  • Peer Reviewed / Open Access
• [Journal Article] Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization. (2016)
  • Author(s): Hayashi K, Michiue H, Yamada H, Takata K, Nakayama H, Wei FY, Fujimura A, Tazawa H, Asai A, Ogo N, Miyachi H, Nishiki T, Tomizawa K, Takei K, Matsui H.
  • Journal Title: Sci Rep. Volume: 6 Issue: 1 Pages: 23372-23372
  • DOI: 10.1038/srep23372
  • Peer Reviewed / Open Access
• [Journal Article] Tumor-specific delivery of BSH-3R for boron neutron capture therapy and positron emission tomography imaging in a mouse brain tumor model. (2015)
  • Author(s): Iguchi Y, Michiue H, Kitamatsu M, Hayashi Y, Takenaka F, Nishiki T, Matsui H.
  • Journal Title: Biomaterials. Volume: 56 Pages: 10-7
  • DOI: 10.1016/j.biomaterials.2015.03.061
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] A scientific journey from the protein theraphy to BNCT (2018)
  • Author(s): Matsui Hideki
  • Organizer: 第95回日本生理学会大会・特別講演
  • Invited
• [Presentation] The function of brain tumor stem cell (2018)
  • Author(s): Michiue Hiroyuki, Fujimura Atsushi, Matsushita Hiroyuki, Nishiki Tei-ichi, Matsui Hideki
  • Organizer: 第95回日本生理学会大会・学会企画シンポジウム
• [Presentation] Expression and Localization of Doc2B in podocytes in rat kidney glomeruli (2018)
  • Author(s): Yamada Yuya, Iwafuji Ryouta, Matsushita Hiroyuki, Michiue Hiroyuki, Fujimura Atsushi, Matsui Hideki, Nishiki Tei-ichi
  • Organizer: 第95回日本生理学会大会
• [Presentation] Oxytocin prevents corticosterone-induced dendritic atrophy in the primary mouse hippocampal neurons. (2017)
  • Author(s): Sato A, Hein ML, Matsushita H, Michiue, H, Nishiki T, Matsui H
  • Organizer: 第94回 日本生理学会大会
• [Presentation] The novel drug screening method with drug repositioning against actin polymerization (2017)
  • Author(s): Michiue H, Hayashi K, Matsushita H, Nishiki T, Matsui H
  • Organizer: 第94回 日本生理学会大会
• [Presentation] Oxytocin prevents corticosterone-induced dendritic atrophy in mouse hippocampal neurons (2017)
  • Author(s): Hein Min Latt、佐藤亜紀、古賀裕梨、松下博昭、道上宏之、藤村篤史、西木禎一、松井秀樹
  • Organizer: 第69回日本生理学会中国四国地方会
• [Presentation] 抗うつ薬フルボキサミンを用いた悪性グリオーマ治療法の開発 (2016)
  • Author(s): 道上宏之 林桂一郎 山田浩司 黒住和彦 市川智継 松下博昭 西木禎一 松井秀樹
  • Organizer: 第34回日本脳腫瘍学会学術大会
  • Place of Presentation: 山梨県甲府市
  • Year and Date: 2016-12-04
• [Presentation] Fluvoxamine (SSRI), inhibits glioblastoma invasion by inhibition of actin polymerization (2016)
  • Author(s): Michiue H, Hayashi K., Matsushita H., Nishiki T., Matsui H.
  • Organizer: European Association of Neuro-Oncology, 2016
  • Place of Presentation: Mannheim, Germany
  • Year and Date: 2016-10-12
  • Int'l Joint Research
• [Presentation] BSH-peptide delivery system and drug pharmacokinetics by positron emission tomography (PET) imaging (2015)
  • Author(s): Hiroyuki Michiue, Yoshiya Iguchi, Mizuki Kitamatsu, Hiroaki Matsushita, Tei-ichi Nishiki, Hideki Matsuil
  • Organizer: 8th Young Boron Neutron Capture Therapy
  • Place of Presentation: Pavia in Italy
  • Year and Date: 2015-09-13
  • Int'l Joint Research
• [Presentation] Development of the New Boron Agent, BSH-peptide, Towards Clinical Application (2015)
  • Author(s): Matsui Hideki
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2015-05-25
  • Int'l Joint Research / Invited
• [Presentation] Development of the new boron agent, BSH-peptide, towards clinical application (2015)
  • Author(s): Hiroyuki Michiue, Yoshiya Iguchi, Mizuki Kitamatsu, Hiroaki Matsushita, Tei-ichi Nishiki, Hideki Matsui
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Remarks] 中性子医療研究センター
  • URL: https://www.okayama-u.ac.jp/user/ntrc/index.html
• [Patent(Industrial Property Rights)] 細胞膜透過型ホウ素ペプチド (2015)
  • Inventor(s): 松井秀樹 道上宏之
  • Industrial Property Rights Holder: 松井秀樹 道上宏之
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-04-01
  • Acquisition Date: 2016-09-23