Elucidation of reoxygenation and energy metabolism in radiotherapy for clinical application
| Project/Area Number |
15H04908
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Gifu University |
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Principal Investigator |
Matsuo Masayuki 岐阜大学, 大学院医学系研究科, 教授 (40377669)
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| Co-Investigator(Kenkyū-buntansha) |
村井 太郎 名古屋市立大学, 大学院医学研究科, 助教 (00747602)
芝本 雄太 名古屋市立大学, 大学院医学研究科, 教授 (20144719)
河合 辰哉 名古屋市立大学, 大学院医学研究科, 研究員 (70597822)
杉江 愛生 名古屋市立大学, 大学院医学研究科, 准教授 (80509258)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
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| Keywords | 放射線治療 / 再酸素化 / 解糖系代謝 / 電子スピン共鳴画像 / 再酸素 / MRI |
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| Outline of Final Research Achievements |
To examine the relationship between local oxygen partial pressure and energy metabolism in the tumor, electron paramagnetic resonance imaging (EPRI) and magnetic resonance imaging (MRI) with hyperpolarized [1-13C] pyruvate were performed.
SCCVII and HT29 solid tumors were imaged by EPRI and 13C-MRI using hyperpolarized [1-13C] pyruvate. The effect of a single dose of 5 Gy irradiation on the pO2 and metabolism was also investigated by sequential imaging of EPRI and 13C-MRI in HT29 tumors. In vivo studies revealed SCCVII tumor had a significantly larger hypoxic fraction compared to HT29 tumor. The flux of pyruvate-to-lactate conversion was also higher in SCCVII than HT29. The lactate-to-pyruvate ratio in hypoxic regions 24 hours after 5-Gy irradiation was significantly higher than those without irradiation in HT29 tumor. The in vitro study showed an increase in extracellular acidification rate after irradiation.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Biological effects of hydrogen peroxide administered intratumorally with or without irradiation in murine tumors.2017
Author(s)
Takaoka T, Shibamoto Y, Matsuo M, Sugie C, Murai T, Ogawa Y, Miyakawa A, Manabe Y, Kondo T, Nakajima K, Okazaki D, Tsuchiya T.
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Journal Title
Cancer Sci.
Volume: 08(9)
Issue: 9
Pages: 1787-1792
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] KORTUC 基礎的検討：過酸化水素水の膵実質への影響について2017
Author(s)
松尾政之,田中秀和,山口尊弘,蜂谷可絵,三好利治,兵藤文紀,岩下拓司,清水雅仁,岩崎遼太,高須正規,森 崇
Organizer
日本放射線腫瘍学会第55回生物部会学術大会
Related Report
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[Presentation] 過酸化水素水注入下放射線療法（KORTUC療法）の基礎研究2017
Author(s)
高岡大樹,芝本雄太,松尾政之,杉江愛生,村井太郎,宮川聡史,眞鍋良彦,小川靖貴,近藤拓人,中嶌晃一朗,岡崎 大,土屋貴裕,廣瀬保次郎
Organizer
日本放射線腫瘍学会第46回放射線による制癌シンポジウム
Related Report
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[Presentation] KORTUCの基礎的検討②：膵実質の急性期障害について2017
Author(s)
松尾政之,田中秀和,山口尊弘,三好利治,庄田真一,兵藤文紀,岩下拓司,清水雅仁,岩崎遼太,高須正規,森 崇
Organizer
日本医学放射線学会 第162回中部地方会
Related Report
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[Presentation] KORTUC基礎的検討: 過酸化水素水の膵実質への影響について2017
Author(s)
松尾政之,田中秀和,山口尊弘,蜂谷可絵,三好利治,兵藤文紀,岩下拓司,清水雅仁,岩崎遼太,高須正規,森 崇
Organizer
第23回癌治療増感研究会
Related Report
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[Presentation] KORTUC基礎的検討: 過酸化水素水の膵実質への影響について2017
Author(s)
松尾政之,田中秀和,山口尊弘,蜂谷可絵,三好利治,兵藤文紀,岩下拓司,清水雅仁,岩崎遼太,高須正規,森 崇
Organizer
日本放射線腫瘍学会第30回学術大会
Related Report
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