Dissecting pancreatic cancer cell evolution at single cell level.
| Project/Area Number |
15H04922
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
武部 貴則 横浜市立大学, 先端医科学研究センター, 教授 (20612625)
谷口 英樹 横浜市立大学, 医学研究科, 教授 (70292555)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 膵癌 / オルガノイド / 癌 / 細胞・組織 / 癌幹細胞 |
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| Outline of Final Research Achievements |
Pancreatic cancer is a refractory cancer with extremely poor prognosis because it has poor characteristic clinical symptoms and it is very difficult to detect early. Even when treatment is performed patient with pancreatic cancer exhibit a high recurrence rate and metastasis rate.
In this study, we developed an in vitro culture system capable of reproducing pancreatic cancer microenvironments with the aim of understanding and controlling the process from the development of pancreatic cancer to acquisition of drug resistance ability and acquisition of metastatic potential. We succeeded in extracting multiple candidate molecules possibly involved in the resistance to treatment against anticancer drugs and possibly involved in intercellular interaction between cancer stem cells and microenvironment.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Multilineage communication regulates human liver bud self-organization from pluripotency.2017
Author(s)
Camp JG, Sekine K, Gerber T, Loeffler-Wirth H, Binder H, Gac M, Kanton S, Kageyama J, Damm G, Seehofer D, Belicova L, Bickle M, Barsacchi R, Okuda R, Yoshizawa E, Kimura M, Ayabe H, Taniguchi H, Takebe T*, Treutlein B
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Journal Title
Nature
Volume: 546
Issue: 7659
Pages: 533-534
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells.2017
Author(s)
Takebe T*, Sekine K, Kimura M, Yoshizawa E, Funayama S, Nakanishi N, Hisai T, Kobayashi T, Mori A, Ayano S, Ejiri Y, Amimoto N, Yamazaki Y, Ogawa S, Ishikawa M, Kiyota Y, Ueno Y, Taniguchi H
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Journal Title
Cell Reports
Volume: 21
Issue: 10
Pages: 2661-2670
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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