Development of personalized lung cancer vaccine targeting neoantigens
| Project/Area Number |
15H04942
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Respiratory surgery
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
Nakajima Jun 東京大学, 医学部附属病院, 教授 (90188954)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
長山 和弘 東京大学, 医学部附属病院, 助教 (00647935)
小原 收 公益財団法人かずさDNA研究所, その他部局等, 副所長 (20370926)
垣見 和宏 東京大学, 医学部附属病院, 特任教授 (80273358)
松下 博和 東京大学, 医学部附属病院, 特任講師 (80597782)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
|
|---|
| Keywords | 肺癌 / 遺伝子変異 / neoantigen / 個別化医療 / 網羅的遺伝子解析 / 腫瘍免疫 / 癌ワクチン / 原発性肺癌 / 癌免疫療法 / 次世代シーケンス / イムノグラム |
|---|
| Outline of Final Research Achievements |
The aim of this study was to develop personalized lung cancer vaccine targeting neoantigens. We established an algorithm to estimate individual potential neoantigens from cancer specimens using somatic mutation analysis and MHC binding predictions. Potential neoantigens were further prioritized using RNAseq data. Immunogenicity of predicted neoantigens were evaluated using healthy donor PBMC. Additionally, aiming for the personalized immunotherapy of lung cancer including neoantigen vaccines, we developed an immunogram to evaluate and visualize cancer-immunity cycle status in each patient.
|
Report
(4 results)
Research Products
(42 results)
-
-
[Journal Article] Model of lung cancer surgery risk derived from a Japanese nationwide web-based database of 78594 patients during 2014-2015.2017
Author(s)
Endo S, Ikeda N, Kondo T, Nakajima J, Kondo H, Yokoi K, Chida M, Sato M, Toyooka S, Yoshida K, Okada Y, Sato Y, Okada M, Okumura M, Chihara K, Fukuchi E, Miyata H.
-
Journal Title
European Journal of Cardio-Thoracic Surgery.
Volume: 52（6）
Issue: 6
Pages: 1182-1189
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
[Journal Article] The frequency of neoantigens per somatic mutation rather than overall mutational load or number of predicted neoantigens per se is a prognostic factor in ovarian clear cell carcinoma.2017
Author(s)
Matsushita H, Hasegawa K, Oda K, Yamamoto S, Nishijima A, Imai Y, Asada K, Ikeda Y, Karasaki T, Fujiwara K, Aburatani H, Kakimi K.
-
Journal Title
Oncoimmunology
Volume: 6
Issue: 8
Pages: e1338996-e1338996
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
[Journal Article] Prediction and prioritization of neoantigens: integration of RNA sequencing data with whole-exome sequencing.2017
Author(s)
Karasaki T, Nagayama K, Kuwano H, Nitadori JI, Sato M, Anraku M, Hosoi A, Matsushita H, Takazawa M, Ohara O, Nakajima J, Kakimi K.
-
Journal Title
Cancer Sci.
Volume: 108(2)
Issue: 2
Pages: 170-177
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
[Journal Article] Identification of Individual Cancer-Specific Somatic Mutations for Neoantigen-Based Immunotherapy of Lung Cancer.2016
Author(s)
Karasaki T, Nagayama K, Kawashima M, Hiyama N, Murayama T, Kuwano H, Nitadori J, Anraku M, Sato M, Miyai M, Hosoi A, Matsushita H, Kikugawa S, Matoba R, Ohara O, Kakimi K, Nakajima J
-
Journal Title
Journal of Thoracic Oncology
Volume: 11(3)
Issue: 3
Pages: 324-33
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Detection and Tracking of NY-ESO-1-Specific CD8+ T Cells by High-Throughput T Cell Receptor β (TCRB) Gene Rearrangements Sequencing in a Peptide-Vaccinated Patient.2015
Author(s)
Miyai M, Eikawa S, Hosoi A, Iino T, Matsushita H, Isobe M, Uenaka A, Udono H, Nakajima J, Nakayama E, Kakimi K.
-
Journal Title
PLoS One
Volume: 10(8)
Issue: 8
Pages: e0136086-e0136086
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
[Presentation] Assessment of cancer immunity status in each patient using immunoguram.2017
Author(s)
Karasaki T, Nagayama K, Fukumoto K, Kitano K, Nitadori J, Sato M, Anraku M, Hosoi A, Matsushita H, Kakimi K, Nakajima J.
Organizer
18th World Conference on Lung Cancer
Related Report
Int'l Joint Research
-
-
-
-
[Presentation] イムノグラムを用いた肺癌治療の最適化2017
Author(s)
唐崎 隆弘. 長山 和弘, 中尾 啓太, 乾 雅人, 長野 匡晃, 川島 光明, 桧山 紀子, 桑野 秀規, 似鳥 純一, 佐藤 雅昭, 安樂 真樹, 松下 博和, 垣見 和宏, 中島 淳。
Organizer
第117回日本外科学会定期学術集会
Related Report
-
-
[Presentation] Immunogram for Cancer-Immunity Cycle towards Personalized Immunotherapy of Lung Cancer2016
Author(s)
Takahiro Karasaki, Kazuhiro Nagayama, Hideki Kuwano, Jun-ichi Nitadori, Masaaki Sato, Masaki Anraku, Akihiro Hosoi, Hirokazu Matsushita, Yasuyuki Morishita, Kosuke Kashiwabara, Masaki Takazawa, Osamu Ohara, Kazuhiro Kakimi, Jun Nakajima
Organizer
IASLC 17th World Conference on Lung Cancer
Place of Presentation
Messe Wien Exhibition & Congress Center
Year and Date
2016-12-07
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
