Role of Mechano-Sensing Signals in the Pathogenesis of Joint Contracture
| Project/Area Number |
15H04966
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | National Rehabilitation Center for Persons with Disabilities |
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Principal Investigator |
Nakamura Kozo 国立障害者リハビリテーションセンター(研究所), 研究所, 顧問 (60126133)
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| Co-Investigator(Kenkyū-buntansha) |
澤田 泰宏 国立障害者リハビリテーションセンター(研究所), 研究所 運動機能系障害研究部, 研究部長 (50313135)
江面 陽一 東京医科歯科大学, 難治疾患研究所, 准教授 (50333456)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
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| Keywords | 身体不活動 / ロコモティブシンドローム / メカニカルストレス / 筋萎縮 / 関節固定 / 拘縮 / 不動性筋萎縮 / メカノバイオロジー / 動物モデル / リハビリテーション / 運動器科学 / 関節拘縮 / 炎症 |
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| Outline of Final Research Achievements |
We have found that massage-like mechanical interventions modulate immobilization-induced pro-inflammatory responses of macrophages in situ and alleviate muscle atrophy. Local cyclical compression (LCC) on mouse calves, which generates intramuscular pressure waves with amplitude of 50 mmHg, partially restores the thickness of calf muscle fibers, which is decreased by hindlimb immobilization using spiral wiring. LCC tempers the increases in the number of macrophage and the expressions of pro-inflammatory proteins in situ. The reversing effect of LCC on immobilization-induced thinning of muscle fibers is almost completely nullified when phagocytic macrophages are depleted. These results suggest that mechanical modulation of macrophage function is involved in physical inactivity-induced muscle atrophy and inflammation. Our findings may open a new path to develop a novel therapeutic or preventative strategy against disuse muscle atrophy, utilizing mechanical interventions.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] The serum phosphorylated neurofilament heavy subunit as a predictive marker for outcome in adult patients after traumatic brain injury2016
Author(s)
Shibahashi K, Doi T, Tanaka S, Hoda H, Chikuda H, Sawada Y, Takasu Y, Chiba K, Nozaki T, Hamabe Y, Ogata T
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Journal Title
Journal of Neurotrauma
Volume: 未定
Issue: 20
Pages: 1826-1833
DOI
Related Report
Peer Reviewed
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